Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDL240W
Length:
1017
Number of sequences:
5887
Description:
YDL240W LRG1 SGDID:S000002399, Chr IV from 22823-25876, Genome Release 64-1-1, Verified ORF, "Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q54J98    563   GACX_DICDI Rho GTPase-activating protein gacX...1610.00000000002     71.6     30     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
32Q9PT60    655   RBP1A_XENLA RalA-binding protein 1-A OS=Xenop...1810.00000000002     71.6     29     49GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0017160; F:Ral GTPase binding; IPI:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; IMP:UniProtKB.::GO:0001702; P:gastrulation with mouth forming second; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IPI:UniProtKB.
33Q2TCH4    506   TGFI1_XENLA Transforming growth factor beta-1...314.3     34.7     42     52GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
34Q68EM7    881   RHG17_HUMAN Rho GTPase-activating protein 17 ...1850.00000000003     71.2     27     50GO:0005829; C:cytosol; TAS:Reactome.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
35Q8BN58    729   RHG28_MOUSE Rho GTPase-activating protein 28 ...1860.00000000003     70.9     27     52
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
36Q54WY8    611   GACN_DICDI Rho GTPase-activating protein gacN...1480.00000000005     70.5     34     58GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
37Q99N37    858   RHG17_RAT Rho GTPase-activating protein 17 OS...1850.00000000006     70.5     26     49GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005626; C:insoluble fraction; IDA:MGI.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007015; P:actin filament organization; IDA:MGI.::GO:0017156; P:calcium ion-dependent exocytosis; IDA:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.
38Q62796    647   RBP1_RAT RalA-binding protein 1 OS=Rattus nor...1920.00000000007     70.1     28     49GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:InterPro.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.::GO:0019717; C:synaptosome; IDA:RGD.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006897; P:endocytosis; IMP:RGD.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007052; P:mitotic spindle organization; IDA:RGD.::GO:0048662; P:negative regulation of smooth muscle cell proliferation; IMP:RGD.::GO:0007264; P:small GTPase mediated signal transduction; IPI:RGD.
39Q3UIA2    846   RHG17_MOUSE Rho GTPase-activating protein 17 ...1850.00000000007     70.1     26     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
40Q63744    1091   RHG07_RAT Rho GTPase-activating protein 7 OS=...2020.00000000009     69.7     26     50GO:0005737; C:cytoplasm; NAS:UniProtKB.
GO:0043274; F:phospholipase binding; IPI:RGD.::GO:0005100; F:Rho GTPase activator activity; IDA:RGD.::GO:0017166; F:vinculin binding; IPI:RGD.
GO:0007202; P:activation of phospholipase C activity; IDA:RGD.::GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.::GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0007266; P:Rho protein signal transduction; NAS:RGD.
41Q9R0Z9    1092   RHG07_MOUSE Rho GTPase-activating protein 7 O...2040.0000000001     69.7     25     50GO:0005737; C:cytoplasm; NAS:UniProtKB.
GO:0005100; F:Rho GTPase activator activity; NAS:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; IMP:MGI.::GO:0048041; P:focal adhesion assembly; IMP:MGI.::GO:0030900; P:forebrain development; IMP:MGI.::GO:0003007; P:heart morphogenesis; IMP:MGI.::GO:0021575; P:hindbrain morphogenesis; IMP:MGI.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0001843; P:neural tube closure; IMP:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.
42O75112    727   LDB3_HUMAN LIM domain-binding protein 3 OS=Ho...906.3     34.3     29     41GO:0005856; C:cytoskeleton; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0031143; C:pseudopodium; IEA:UniProtKB-SubCell.::GO:0030018; C:Z disc; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
43Q66H76    586   PAXI_RAT Paxillin OS=Rattus norvegicus (Rat)....564.8     34.7     32     45GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:RGD.
GO:0005178; F:integrin binding; IPI:RGD.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
44P49023    591   PAXI_HUMAN Paxillin OS=Homo sapiens (Human). ...564.6     34.7     32     46GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:BHF-UCL.::GO:0030027; C:lamellipodium; IDA:BHF-UCL.::GO:0005875; C:microtubule associated complex; TAS:ProtInc.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.::GO:0017166; F:vinculin binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0034614; P:cellular response to reactive oxygen species; IEP:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0060396; P:growth hormone receptor signaling pathway; IDA:BHF-UCL.::GO:0006936; P:muscle contraction; TAS:Reactome.::GO:0007172; P:signal complex assembly; TAS:ProtInc.
45Q6ZUM4    889   RHG27_HUMAN Rho GTPase-activating protein 27 ...2060.0000000002     68.9     24     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; ISS:HGNC.::GO:0017124; F:SH3 domain binding; ISS:HGNC.
GO:0043089; P:positive regulation of Cdc42 GTPase activity; ISS:HGNC.::GO:0006898; P:receptor-mediated endocytosis; ISS:HGNC.::GO:0007165; P:signal transduction; IEA:InterPro.
46Q5R7I1    591   PAXI_PONAB Paxillin OS=Pongo abelii (Sumatran...564.7     34.7     32     46GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
47Q9P2F6    1191   RHG20_HUMAN Rho GTPase-activating protein 20 ...2060.0000000002     68.9     26     44GO:0005829; C:cytosol; TAS:Reactome.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
48Q8VI36    591   PAXI_MOUSE Paxillin OS=Mus musculus (Mouse). ...584.3     35     31     45GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:MGI.
GO:0051435; F:BH4 domain binding; IPI:MGI.::GO:0030159; F:receptor signaling complex scaffold activity; TAS:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000187; P:activation of MAPK activity; IDA:MGI.::GO:0048754; P:branching morphogenesis of a tube; IDA:MGI.::GO:0006928; P:cellular component movement; IMP:MGI.::GO:0007010; P:cytoskeleton organization; IMP:MGI.::GO:0048041; P:focal adhesion assembly; IDA:MGI.::GO:0007229; P:integrin-mediated signaling pathway; IMP:MGI.::GO:0030032; P:lamellipodium assembly; IDA:MGI.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.
49Q6INU3    421   PDLI7_XENLA PDZ and LIM domain protein 7 OS=X...652.5     35.4     37     46GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
50P55194    601   3BP1_MOUSE SH3 domain-binding protein 1 OS=Mu...1380.0000000002     68.2     31     54GO:0005737; C:cytoplasm; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IPI:MGI.
GO:0007165; P:signal transduction; IEA:InterPro.
51P49024    559   PAXI_CHICK Paxillin OS=Gallus gallus (Chicken...564.7     34.7     32     46GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
52Q9P2N2    729   RHG28_HUMAN Rho GTPase-activating protein 28 ...1850.0000000003     68.2     26     49GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
53Q99N69    386   LPXN_MOUSE Leupaxin OS=Mus musculus (Mouse). ...1300.00000002     61.6     30     42GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0002102; C:podosome; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003712; F:transcription cofactor activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0050859; P:negative regulation of B cell receptor signaling pathway; IDA:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
54Q54TH9    721   GACY_DICDI Rho GTPase-activating protein gacY...1920.0000000003     68.2     30     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
55Q54XT6    783   GACR_DICDI Rho GTPase-activating protein gacR...1840.0000000003     67.8     32     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
56Q96QB1    1528   RHG07_HUMAN Rho GTPase-activating protein 7 O...2010.0000000003     68.2     25     50GO:0005901; C:caveola; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005925; C:focal adhesion; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005100; F:Rho GTPase activator activity; IDA:UniProtKB.::GO:0042169; F:SH2 domain binding; IPI:UniProtKB.
GO:0030036; P:actin cytoskeleton organization; ISS:UniProtKB.::GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:UniProtKB.::GO:0048041; P:focal adhesion assembly; ISS:UniProtKB.::GO:0030900; P:forebrain development; ISS:UniProtKB.::GO:0003007; P:heart morphogenesis; ISS:UniProtKB.::GO:0021575; P:hindbrain morphogenesis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; IDA:UniProtKB.::GO:0030336; P:negative regulation of cell migration; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0035024; P:negative regulation of Rho protein signal transduction; IMP:UniProtKB.::GO:0051497; P:negative regulation of stress fiber assembly; IDA:UniProtKB.::GO:0001843; P:neural tube closure; ISS:UniProtKB.::GO:0035307; P:positive regulation of protein dephosphorylation; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
57A7E300    1112   RHG07_BOVIN Rho GTPase-activating protein 7 O...2010.0000000004     67.8     25     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
58Q9Y3L3    701   3BP1_HUMAN SH3 domain-binding protein 1 OS=Ho...1570.0000000004     67.4     29     51GO:0005737; C:cytoplasm; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
59Q54YV1    817   GACII_DICDI Rho GTPase-activating protein gac...1370.0000000005     67.4     31     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0007165; P:signal transduction; IEA:InterPro.
60Q8C170    2542   MYO9A_MOUSE Unconventional myosin-IXa OS=Mus ...1500.0000000005     67.8     25     57GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
61Q6TLK4    869   RHG27_RAT Rho GTPase-activating protein 27 OS...2060.0000000005     67.4     24     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030675; F:Rac GTPase activator activity; IDA:HGNC.::GO:0017124; F:SH3 domain binding; IDA:HGNC.
GO:0043089; P:positive regulation of Cdc42 GTPase activity; IDA:HGNC.::GO:0006898; P:receptor-mediated endocytosis; IMP:HGNC.::GO:0007165; P:signal transduction; IEA:InterPro.
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