Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDL230W
Length:
335
Number of sequences:
5887
Description:
YDL230W PTP1 SGDID:S000002389, Chr IV from 42700-43707, Genome Release 64-1-1, Verified ORF, "Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P25044    335   PTP1_YEAST Tyrosine-protein phosphatase 1 OS=...3350     707     100     100GO:0005739; C:mitochondrion; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:SGD.
GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.::GO:0007124; P:pseudohyphal growth; IMP:SGD.
2P27574    550   PYP1_SCHPO Tyrosine-protein phosphatase 1 OS=...3115e-40     152     34     49GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0004725; F:protein tyrosine phosphatase activity; TAS:PomBase.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045930; P:negative regulation of mitotic cell cycle; IMP:PomBase.::GO:0032873; P:negative regulation of stress-activated MAPK cascade; TAS:PomBase.::GO:0045014; P:negative regulation of transcription by glucose; IMP:PomBase.
3P32586    711   PYP2_SCHPO Tyrosine-protein phosphatase 2 OS=...3253e-38     148     38     48GO:0005829; C:cytosol; IDA:PomBase.::GO:0005739; C:mitochondrion; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005515; F:protein binding; IPI:PomBase.::GO:0004725; F:protein tyrosine phosphatase activity; TAS:PomBase.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0010972; P:negative regulation of G2/M transition of mitotic cell cycle; IGI:PomBase.::GO:0045835; P:negative regulation of meiosis; IMP:PomBase.::GO:0051403; P:stress-activated MAPK cascade; IGI:PomBase.
4P32587    303   PYP3_SCHPO Tyrosine-protein phosphatase 3 OS=...2835e-38     142     36     51GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0004725; F:protein tyrosine phosphatase activity; IDA:PomBase.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase.::GO:0007165; P:signal transduction; IC:PomBase.
5Q13332    1948   PTPRS_HUMAN Receptor-type tyrosine-protein ph...2922e-29     124     32     44GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
6P23468    1912   PTPRD_HUMAN Receptor-type tyrosine-protein ph...2828e-28     119     31     45GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc.
GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; TAS:ProtInc.
7Q64487    1912   PTPRD_MOUSE Receptor-type tyrosine-protein ph...2827e-28     119     31     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
8Q64605    1907   PTPRS_RAT Receptor-type tyrosine-protein phos...2925e-30     126     32     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IDA:RGD.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
9B0V2N1    1907   PTPRS_MOUSE Receptor-type tyrosine-protein ph...2925e-30     126     32     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0021549; P:cerebellum development; IMP:MGI.::GO:0021987; P:cerebral cortex development; IMP:MGI.::GO:0022038; P:corpus callosum development; IMP:MGI.::GO:0021766; P:hippocampus development; IMP:MGI.::GO:0021510; P:spinal cord development; IMP:MGI.
10P35992    1631   PTP10_DROME Tyrosine-protein phosphatase 10D ...2809e-33     134     33     50GO:0045177; C:apical part of cell; IDA:FlyBase.::GO:0030424; C:axon; IDA:FlyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IDA:FlyBase.
GO:0007417; P:central nervous system development; IGI:FlyBase.::GO:0007616; P:long-term memory; IMP:FlyBase.::GO:0008045; P:motor axon guidance; IGI:FlyBase.::GO:0007424; P:open tracheal system development; IGI:FlyBase.
11Q64604    1898   PTPRF_RAT Receptor-type tyrosine-protein phos...2822e-28     121     32     47GO:0005768; C:endosome; IDA:RGD.::GO:0060076; C:excitatory synapse; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD.
GO:0005158; F:insulin receptor binding; IDA:RGD.::GO:0042301; F:phosphate ion binding; IDA:RGD.::GO:0030971; F:receptor tyrosine kinase binding; IPI:RGD.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; IDA:RGD.
GO:0007156; P:homophilic cell adhesion; IDA:RGD.::GO:0031345; P:negative regulation of cell projection organization; IMP:RGD.::GO:0008285; P:negative regulation of cell proliferation; IMP:RGD.::GO:0001960; P:negative regulation of cytokine-mediated signaling pathway; IMP:RGD.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IMP:RGD.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:RGD.::GO:0051387; P:negative regulation of nerve growth factor receptor signaling pathway; IMP:RGD.::GO:0050775; P:positive regulation of dendrite morphogenesis; IMP:RGD.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.::GO:0050803; P:regulation of synapse structure and activity; IMP:RGD.
12P10586    1907   PTPRF_HUMAN Receptor-type tyrosine-protein ph...2825e-29     123     32     46GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc.
GO:0007185; P:transmembrane receptor protein tyrosine phosphatase signaling pathway; TAS:ProtInc.
13A2A8L5    1898   PTPRF_MOUSE Receptor-type tyrosine-protein ph...2821e-28     122     32     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
14A7MBJ4    1898   PTPRF_BOVIN Receptor-type tyrosine-protein ph...2921e-28     122     32     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
15P29350    595   PTN6_HUMAN Tyrosine-protein phosphatase non-r...3142e-32     130     31     46GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; TAS:ProtInc.::GO:0005634; C:nucleus; IDA:BHF-UCL.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; IDA:UniProtKB.
GO:0006915; P:apoptotic process; TAS:ProtInc.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0030154; P:cell differentiation; IDA:UniProtKB.::GO:0008283; P:cell proliferation; IDA:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:BHF-UCL.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; IDA:UniProtKB.::GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IMP:BHF-UCL.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060338; P:regulation of type I interferon-mediated signaling pathway; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome.
16A4IFW2    1909   PTPRF_DANRE Receptor-type tyrosine-protein ph...2825e-28     120     32     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
17Q03348    796   PTPRA_RAT Receptor-type tyrosine-protein phos...2932e-25     111     30     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005792; C:microsome; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:RGD.
GO:0032403; F:protein complex binding; IDA:RGD.::GO:0004725; F:protein tyrosine phosphatase activity; IDA:RGD.
GO:0048709; P:oligodendrocyte differentiation; IEP:RGD.::GO:0048714; P:positive regulation of oligodendrocyte differentiation; IMP:RGD.::GO:0006468; P:protein phosphorylation; IEA:InterPro.
18O13016    434   PTN1_CHICK Tyrosine-protein phosphatase non-r...2884e-32     129     30     48GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0030968; P:endoplasmic reticulum unfolded protein response; ISS:UniProtKB.::GO:0030100; P:regulation of endocytosis; ISS:UniProtKB.::GO:0009966; P:regulation of signal transduction; ISS:UniProtKB.
19P81718    613   PTN6_RAT Tyrosine-protein phosphatase non-rec...3155e-32     129     31     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0046703; F:natural killer cell lectin-like receptor binding; IPI:RGD.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; ISS:UniProtKB.
GO:0030154; P:cell differentiation; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0009611; P:response to wounding; IEP:RGD.
20Q05909    1442   PTPRG_MOUSE Receptor-type tyrosine-protein ph...1040.00002     50.1     35     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0042802; F:identical protein binding; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; ISS:UniProtKB.
21P23470    1445   PTPRG_HUMAN Receptor-type tyrosine-protein ph...2920.00002     50.4     26     36GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0042802; F:identical protein binding; IPI:UniProtKB.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc.
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc.
22P16621    2029   LAR_DROME Tyrosine-protein phosphatase Lar OS...2821e-29     125     31     45GO:0030424; C:axon; IDA:FlyBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005875; C:microtubule associated complex; IDA:FlyBase.
GO:0004725; F:protein tyrosine phosphatase activity; IDA:FlyBase.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0032093; F:SAM domain binding; IPI:FlyBase.
GO:0007412; P:axon target recognition; IMP:FlyBase.::GO:0007155; P:cell adhesion; IMP:FlyBase.::GO:0001700; P:embryonic development via the syncytial blastoderm; NAS:FlyBase.::GO:0008045; P:motor axon guidance; IMP:FlyBase.::GO:0048477; P:oogenesis; IMP:FlyBase.::GO:0008594; P:photoreceptor cell morphogenesis; IMP:FlyBase.::GO:0045467; P:R7 cell development; IMP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0031290; P:retinal ganglion cell axon guidance; IMP:FlyBase.::GO:0051124; P:synaptic growth at neuromuscular junction; IMP:FlyBase.
23P28192    1159   PTP2_CAEEL Tyrosine-protein phosphatase 2 OS=...2741e-31     130     31     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
24P18433    802   PTPRA_HUMAN Receptor-type tyrosine-protein ph...2982e-27     117     31     45GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc.
GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006468; P:protein phosphorylation; IEA:InterPro.
25P23471    2315   PTPRZ_HUMAN Receptor-type tyrosine-protein ph...2320.0000000003     65.5     31     41GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0008330; F:protein tyrosine/threonine phosphatase activity; NAS:UniProtKB.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; TAS:ProtInc.
GO:0007417; P:central nervous system development; TAS:ProtInc.
26Q62656    2316   PTPRZ_RAT Receptor-type tyrosine-protein phos...2320.0000000003     65.1     31     41GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
27P29351    595   PTN6_MOUSE Tyrosine-protein phosphatase non-r...3141e-31     128     31     46GO:0042105; C:alpha-beta T cell receptor complex; IDA:MGI.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0001784; F:phosphotyrosine binding; IPI:MGI.::GO:0042169; F:SH2 domain binding; IDA:MGI.::GO:0017124; F:SH3 domain binding; IDA:MGI.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; ISS:UniProtKB.
GO:0050853; P:B cell receptor signaling pathway; IMP:MGI.::GO:0030154; P:cell differentiation; ISS:UniProtKB.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0019221; P:cytokine-mediated signaling pathway; TAS:MGI.::GO:0035556; P:intracellular signal transduction; IDA:MGI.::GO:0042267; P:natural killer cell mediated cytotoxicity; IMP:MGI.::GO:0002924; P:negative regulation of humoral immune response mediated by circulating immunoglobulin; IMP:MGI.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:MGI.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0050732; P:negative regulation of peptidyl-tyrosine phosphorylation; IMP:MGI.::GO:0042130; P:negative regulation of T cell proliferation; IMP:MGI.::GO:0050860; P:negative regulation of T cell receptor signaling pathway; IMP:MGI.::GO:0045577; P:regulation of B cell differentiation; IMP:MGI.::GO:0070372; P:regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
28P35233    416   PTN2_RAT Tyrosine-protein phosphatase non-rec...2862e-31     126     33     45GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; TAS:RGD.::GO:0004726; F:non-membrane spanning protein tyrosine phosphatase activity; IDA:RGD.
29P17706    415   PTN2_HUMAN Tyrosine-protein phosphatase non-r...2812e-31     126     33     45GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0060334; P:regulation of interferon-gamma-mediated signaling pathway; TAS:Reactome.
30Q16827    1216   PTPRO_HUMAN Receptor-type tyrosine-protein ph...2872e-31     130     32     49GO:0016324; C:apical plasma membrane; ISS:UniProtKB.::GO:0030424; C:axon; ISS:UniProtKB.::GO:0043197; C:dendritic spine; ISS:UniProtKB.::GO:0030426; C:growth cone; ISS:UniProtKB.::GO:0016021; C:integral to membrane; TAS:UniProtKB.::GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0016328; C:lateral plasma membrane; ISS:UniProtKB.
GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004725; F:protein tyrosine phosphatase activity; TAS:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; NAS:UniProtKB.::GO:0017147; F:Wnt-protein binding; ISS:UniProtKB.
GO:0007411; P:axon guidance; ISS:UniProtKB.::GO:0072112; P:glomerular visceral epithelial cell differentiation; ISS:UniProtKB.::GO:0030032; P:lamellipodium assembly; ISS:UniProtKB.::GO:0002548; P:monocyte chemotaxis; IMP:UniProtKB.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0010812; P:negative regulation of cell-substrate adhesion; ISS:UniProtKB.::GO:0003105; P:negative regulation of glomerular filtration; ISS:UniProtKB.::GO:0010977; P:negative regulation of neuron projection development; ISS:UniProtKB.::GO:0090260; P:negative regulation of retinal ganglion cell axon guidance; ISS:UniProtKB.::GO:0036060; P:slit diaphragm assembly; ISS:UniProtKB.
31Q98936    1422   PTPRG_CHICK Receptor-type tyrosine-protein ph...2260.00001     50.8     27     38GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
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