UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YDL205C

Length:

327

Number of sequences:

5887

Description:

YDL205C HEM3 SGDID:S000002364, Chr IV from 93745-92762, Genome Release 64-1-1, reverse complement, Verified ORF, "Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P28789	327	HEM3_YEAST Porphobilinogen deaminase OS=Sacch...	327	0	669	100	100	GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
									GO:0004418; F:hydroxymethylbilane synthase activity; IMP:SGD.
									GO:0006783; P:heme biosynthetic process; IMP:SGD.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
2	Q6FNR4	329	HEM3_CANGA Porphobilinogen deaminase OS=NRRL ...	326	0	518	74	90
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
3	Q6CT60	327	HEM3_KLULA Porphobilinogen deaminase OS=1267 ...	323	4e-165	470	71	84
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
4	Q75DY0	326	HEM3_ASHGO Porphobilinogen deaminase OS=Y-105...	323	3e-155	445	65	81
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
5	Q6BM23	361	HEM3_DEBHA Porphobilinogen deaminase OS=0083 ...	323	1e-127	376	60	75
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
6	Q6C097	338	HEM3_YARLI Porphobilinogen deaminase OS=lipol...	324	2e-127	375	60	75
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
7	O94048	340	HEM3_CANAL Porphobilinogen deaminase OS=Candi...	321	4e-125	369	60	74
									GO:0004418; F:hydroxymethylbilane synthase activity; IMP:CGD.
									GO:0006783; P:heme biosynthetic process; IMP:CGD.::GO:0009405; P:pathogenesis; IMP:CGD.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
8	Q6MW51	337	HEM3_NEUCR Porphobilinogen deaminase OS=1257 ...	330	6e-96	294	50	68
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
9	A8G3L1	318	HEM3_PROM2 Porphobilinogen deaminase OS=Proch...	316	1e-79	251	46	63
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
10	A2C7L8	317	HEM3_PROM3 Porphobilinogen deaminase OS=Proch...	316	2e-78	248	45	62
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
11	P73660	320	HEM3_SYNY3 Porphobilinogen deaminase OS=Synec...	317	3e-78	248	44	63
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
12	Q7V697	317	HEM3_PROMM Porphobilinogen deaminase OS=Proch...	316	5e-78	247	45	61
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
13	A2BVF7	316	HEM3_PROM5 Porphobilinogen deaminase OS=Proch...	316	1e-77	246	44	64
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
14	Q8YVU6	323	HEM3_NOSS1 Porphobilinogen deaminase OS=Nosto...	317	1e-77	246	43	62
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
15	A3PBM0	316	HEM3_PROM0 Porphobilinogen deaminase OS=Proch...	316	2e-77	246	45	63
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
16	Q31C38	316	HEM3_PROM9 Porphobilinogen deaminase OS=Proch...	316	2e-77	246	45	62
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
17	A2BPX7	316	HEM3_PROMS Porphobilinogen deaminase OS=Proch...	316	1e-76	244	45	62
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
18	Q7V2I1	316	HEM3_PROMP Porphobilinogen deaminase OS=Proch...	316	7e-76	242	44	62
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
19	P08397	361	HEM3_HUMAN Porphobilinogen deaminase OS=Homo ...	339	2e-75	242	39	60	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0004418; F:hydroxymethylbilane synthase activity; IDA:UniProtKB.
									GO:0006783; P:heme biosynthetic process; IC:UniProtKB.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
20	Q7U5C2	317	HEM3_SYNPX Porphobilinogen deaminase OS=Synec...	321	2e-75	241	44	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
21	A5GSE0	317	HEM3_SYNR3 Porphobilinogen deaminase OS=Synec...	321	4e-75	240	43	61
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
22	A2C0V4	315	HEM3_PROM1 Porphobilinogen deaminase OS=Proch...	325	1e-74	239	43	61
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
23	Q09899	336	HEM3_SCHPO Porphobilinogen deaminase OS=Schiz...	322	1e-74	239	40	62	GO:0005737; C:cytoplasm; IDA:PomBase.::GO:0005634; C:nucleus; ISS:PomBase.
									GO:0004418; F:hydroxymethylbilane synthase activity; ISS:PomBase.
									GO:0006783; P:heme biosynthetic process; ISS:PomBase.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
24	Q46GS7	315	HEM3_PROMT Porphobilinogen deaminase OS=Proch...	325	1e-74	238	43	61
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
25	Q2KIN5	361	HEM3_BOVIN Porphobilinogen deaminase OS=Bos t...	286	4e-74	239	42	65
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
26	Q3ALS9	317	HEM3_SYNSC Porphobilinogen deaminase OS=Synec...	321	7e-74	237	42	60
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
27	Q0I8I3	316	HEM3_SYNS3 Porphobilinogen deaminase OS=Synec...	321	2e-73	235	43	60
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
28	Q3AWQ4	317	HEM3_SYNS9 Porphobilinogen deaminase OS=Synec...	316	5e-73	234	43	60
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
29	P22907	361	HEM3_MOUSE Porphobilinogen deaminase OS=Mus m...	287	1e-72	235	41	66
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
30	Q7VD89	315	HEM3_PROMA Porphobilinogen deaminase OS=Proch...	285	2e-72	233	45	63
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
31	P19356	361	HEM3_RAT Porphobilinogen deaminase OS=Rattus ...	287	2e-72	234	42	66	GO:0030424; C:axon; IDA:RGD.::GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.
									GO:0043176; F:amine binding; IPI:RGD.::GO:0031406; F:carboxylic acid binding; IPI:RGD.::GO:0050662; F:coenzyme binding; IPI:RGD.::GO:0004418; F:hydroxymethylbilane synthase activity; IDA:RGD.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004852; F:uroporphyrinogen-III synthase activity; IDA:RGD.
									GO:0048708; P:astrocyte differentiation; IEP:RGD.::GO:0071418; P:cellular response to amine stimulus; IEP:RGD.::GO:0071236; P:cellular response to antibiotic; IEP:RGD.::GO:0071243; P:cellular response to arsenic-containing substance; IEP:RGD.::GO:0071345; P:cellular response to cytokine stimulus; IEP:RGD.::GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.::GO:0071284; P:cellular response to lead ion; IEP:RGD.::GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0043200; P:response to amino acid stimulus; IEP:RGD.::GO:0009743; P:response to carbohydrate stimulus; IEP:RGD.::GO:0032025; P:response to cobalt ion; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0032355; P:response to estradiol stimulus; IEP:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.::GO:0051597; P:response to methylmercury; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0033273; P:response to vitamin; IEP:RGD.::GO:0010043; P:response to zinc ion; IEP:RGD.

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