UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YDL205C

Length:

327

Number of sequences:

5887

Description:

YDL205C HEM3 SGDID:S000002364, Chr IV from 93745-92762, Genome Release 64-1-1, reverse complement, Verified ORF, "Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
31	P19356	361	HEM3_RAT Porphobilinogen deaminase OS=Rattus ...	287	2e-72	234	42	66	GO:0030424; C:axon; IDA:RGD.::GO:0005737; C:cytoplasm; IDA:RGD.::GO:0005634; C:nucleus; IDA:RGD.
									GO:0043176; F:amine binding; IPI:RGD.::GO:0031406; F:carboxylic acid binding; IPI:RGD.::GO:0050662; F:coenzyme binding; IPI:RGD.::GO:0004418; F:hydroxymethylbilane synthase activity; IDA:RGD.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004852; F:uroporphyrinogen-III synthase activity; IDA:RGD.
									GO:0048708; P:astrocyte differentiation; IEP:RGD.::GO:0071418; P:cellular response to amine stimulus; IEP:RGD.::GO:0071236; P:cellular response to antibiotic; IEP:RGD.::GO:0071243; P:cellular response to arsenic-containing substance; IEP:RGD.::GO:0071345; P:cellular response to cytokine stimulus; IEP:RGD.::GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.::GO:0071284; P:cellular response to lead ion; IEP:RGD.::GO:0006783; P:heme biosynthetic process; IEA:UniProtKB-KW.::GO:0031100; P:organ regeneration; IEP:RGD.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0043200; P:response to amino acid stimulus; IEP:RGD.::GO:0009743; P:response to carbohydrate stimulus; IEP:RGD.::GO:0032025; P:response to cobalt ion; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0032355; P:response to estradiol stimulus; IEP:RGD.::GO:0001666; P:response to hypoxia; IEP:RGD.::GO:0051597; P:response to methylmercury; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0033273; P:response to vitamin; IEP:RGD.::GO:0010043; P:response to zinc ion; IEP:RGD.
32	A6VL87	309	HEM3_ACTSZ Porphobilinogen deaminase OS=Actin...	321	3e-72	232	43	58
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
33	Q8DIE4	320	HEM3_THEEB Porphobilinogen deaminase OS=Therm...	316	5e-71	229	42	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
34	Q54P93	325	HEM3_DICDI Porphobilinogen deaminase OS=Dicty...	319	3e-70	228	40	63
									GO:0004418; F:hydroxymethylbilane synthase activity; ISS:UniProtKB.
									GO:0006783; P:heme biosynthetic process; ISS:UniProtKB.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
35	A9BEB6	316	HEM3_PROM4 Porphobilinogen deaminase OS=Proch...	318	4e-70	227	42	60
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
36	Q3SFT5	306	HEM3_THIDA Porphobilinogen deaminase OS=Thiob...	317	1e-69	226	41	57
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
37	Q31PM2	320	HEM3_SYNE7 Porphobilinogen deaminase OS=Synec...	316	1e-69	226	44	60
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
38	Q7NGF7	328	HEM3_GLOVI Porphobilinogen deaminase OS=Gloeo...	318	1e-69	226	41	61
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0015995; P:chlorophyll biosynthetic process; IEA:UniProtKB-KW.::GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.
39	A1WVT9	310	HEM3_HALHL Porphobilinogen deaminase OS=halop...	322	2e-66	217	39	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
40	Q65VX7	310	HEM3_MANSM Porphobilinogen deaminase OS=Mannh...	319	4e-66	216	41	57
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
41	B0UWZ8	321	HEM3_HAES2 Porphobilinogen deaminase OS=Haemo...	325	7e-66	216	40	58
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
42	Q0I178	321	HEM3_HAES1 Porphobilinogen deaminase OS=Haemo...	325	7e-66	216	40	58
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
43	O66621	304	HEM3_AQUAE Porphobilinogen deaminase OS=Aquif...	316	8e-66	215	40	60
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
44	Q7VVU9	314	HEM3_BORPE Porphobilinogen deaminase OS=Borde...	318	2e-65	214	41	56
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
45	A0LN73	309	HEM3_SYNFM Porphobilinogen deaminase OS=Syntr...	325	2e-65	214	39	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
46	Q9JVS4	311	HEM3_NEIMA Porphobilinogen deaminase OS=Neiss...	321	8e-65	213	39	57
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
47	Q9K0P6	311	HEM3_NEIMB Porphobilinogen deaminase OS=Neiss...	321	9e-65	213	39	57
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
48	A6TJD5	316	HEM3_ALKMQ Porphobilinogen deaminase OS=Alkal...	320	2e-64	213	38	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
49	C1D679	308	HEM3_LARHH Porphobilinogen deaminase OS=Larib...	315	2e-64	212	38	57
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
50	Q48AW8	317	HEM3_COLP3 Porphobilinogen deaminase OS=psych...	321	2e-64	212	40	56
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
51	Q7W785	314	HEM3_BORPA Porphobilinogen deaminase OS=Borde...	318	2e-64	212	40	55
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
52	Q7WKM1	314	HEM3_BORBR Porphobilinogen deaminase OS=(Alca...	318	2e-64	212	40	55
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
53	Q479S8	311	HEM3_DECAR Porphobilinogen deaminase OS=Dechl...	319	2e-64	212	40	55
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
54	Q1GXA1	310	HEM3_METFK Porphobilinogen deaminase OS=Methy...	317	3e-64	211	40	58
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
55	Q2SQ70	311	HEM3_HAHCH Porphobilinogen deaminase OS=Hahel...	322	2e-63	209	39	56
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
56	Q5X1F2	309	HEM3_LEGPA Porphobilinogen deaminase OS=Legio...	321	2e-63	209	39	58
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
57	Q5QUS3	313	HEM3_IDILO Porphobilinogen deaminase OS=Idiom...	318	2e-63	209	39	58
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
58	Q82WS2	308	HEM3_NITEU Porphobilinogen deaminase OS=Nitro...	317	3e-63	209	40	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
59	B5ERN6	306	HEM3_ACIF5 Porphobilinogen deaminase OS=ferro...	284	5e-63	208	39	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
60	B7JBH8	306	HEM3_ACIF2 Porphobilinogen deaminase OS=8455)...	284	5e-63	208	39	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.
61	Q1INI6	311	HEM3_KORVE Porphobilinogen deaminase OS=Korib...	318	5e-63	208	40	59
									GO:0004418; F:hydroxymethylbilane synthase activity; IEA:EC.
									GO:0018160; P:peptidyl-pyrromethane cofactor linkage; IEA:InterPro.::GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:UniProtKB-KW.

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