| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P06784 | 515 | STE7_YEAST Serine/threonine-protein kinase ST... | 515 | 0 | 1056 | 100 | 100 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071508; P:activation of MAPK activity involved in conjugation with cellular fusion; IDA:SGD.::GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.::GO:0000196; P:MAPK cascade involved in cell wall biogenesis; IGI:SGD.::GO:0071507; P:MAPK cascade involved in conjugation with cellular fusion; IDA:SGD.::GO:0007124; P:pseudohyphal growth; IMP:SGD.::GO:0010525; P:regulation of transposition, RNA-mediated; IMP:SGD.::GO:0001402; P:signal transduction involved in filamentous growth; IMP:SGD. | 2 | P36506 | 400 | MP2K2_RAT Dual specificity mitogen-activated ... | 342 | 1e-66 | 226 | 38 | 57 | GO:0005938; C:cell cortex; IDA:RGD.::GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005769; C:early endosome; TAS:UniProtKB.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0005794; C:Golgi apparatus; TAS:UniProtKB.::GO:0005770; C:late endosome; TAS:UniProtKB.::GO:0005739; C:mitochondrion; TAS:UniProtKB.::GO:0005634; C:nucleus; TAS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0004708; F:MAP kinase kinase activity; IDA:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.::GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.::GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB. | 3 | P29678 | 393 | MP2K1_RABIT Dual specificity mitogen-activate... | 335 | 2e-66 | 226 | 38 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 4 | Q02750 | 393 | MP2K1_HUMAN Dual specificity mitogen-activate... | 335 | 2e-66 | 226 | 38 | 56 | GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005769; C:early endosome; TAS:UniProtKB.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0005794; C:Golgi apparatus; TAS:UniProtKB.::GO:0005770; C:late endosome; TAS:UniProtKB.::GO:0005739; C:mitochondrion; TAS:UniProtKB.::GO:0005634; C:nucleus; TAS:UniProtKB.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:Reactome.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007050; P:cell cycle arrest; IMP:BHF-UCL.::GO:0090398; P:cellular senescence; IMP:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0008285; P:negative regulation of cell proliferation; IDA:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.::GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.::GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 5 | Q01986 | 393 | MP2K1_RAT Dual specificity mitogen-activated ... | 335 | 2e-66 | 226 | 38 | 57 | GO:0033267; C:axon part; IDA:RGD.::GO:0005938; C:cell cortex; IDA:RGD.::GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0032839; C:dendrite cytoplasm; IDA:RGD.::GO:0005769; C:early endosome; TAS:UniProtKB.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0005794; C:Golgi apparatus; TAS:UniProtKB.::GO:0005770; C:late endosome; TAS:UniProtKB.::GO:0005739; C:mitochondrion; TAS:UniProtKB.::GO:0005634; C:nucleus; TAS:UniProtKB.::GO:0043204; C:perikaryon; IDA:RGD.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0004708; F:MAP kinase kinase activity; IDA:RGD.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IDA:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.::GO:0017016; F:Ras GTPase binding; IPI:RGD. | | | | | | | | | | GO:0008283; P:cell proliferation; IDA:RGD.::GO:0048313; P:Golgi inheritance; IMP:RGD.::GO:0032402; P:melanosome transport; IDA:RGD.::GO:0007067; P:mitosis; IDA:RGD.::GO:0034111; P:negative regulation of homotypic cell-cell adhesion; IMP:RGD.::GO:0048812; P:neuron projection morphogenesis; IMP:RGD.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0032320; P:positive regulation of Ras GTPase activity; IMP:RGD.::GO:0046579; P:positive regulation of Ras protein signal transduction; IMP:MGI.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; IMP:RGD.::GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.::GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.::GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB.::GO:0003056; P:regulation of vascular smooth muscle contraction; IMP:RGD.::GO:0048678; P:response to axon injury; IMP:RGD.::GO:0051384; P:response to glucocorticoid stimulus; IDA:RGD.::GO:0006979; P:response to oxidative stress; IDA:RGD.::GO:0047496; P:vesicle transport along microtubule; IDA:RGD. | 6 | Q91447 | 388 | MP2K1_SERCA Dual specificity mitogen-activate... | 337 | 2e-66 | 225 | 37 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 7 | P31938 | 393 | MP2K1_MOUSE Dual specificity mitogen-activate... | 335 | 2e-66 | 225 | 38 | 57 | GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005769; C:early endosome; TAS:UniProtKB.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0005794; C:Golgi apparatus; TAS:UniProtKB.::GO:0005770; C:late endosome; TAS:UniProtKB.::GO:0005739; C:mitochondrion; TAS:UniProtKB.::GO:0005634; C:nucleus; TAS:UniProtKB.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; IMP:MGI.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.::GO:0004728; F:receptor signaling protein tyrosine phosphatase activity; IMP:MGI. | | | | | | | | | | GO:0048870; P:cell motility; IMP:MGI.::GO:0030216; P:keratinocyte differentiation; IMP:MGI.::GO:0060711; P:labyrinthine layer development; IMP:MGI.::GO:0060674; P:placenta blood vessel development; IMP:MGI.::GO:0045597; P:positive regulation of cell differentiation; IDA:MGI.::GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.::GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.::GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB. | 8 | Q99078 | 435 | FUZ7_USTMA Dual specificity protein kinase FU... | 351 | 3e-66 | 226 | 40 | 54 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 9 | Q63932 | 401 | MP2K2_MOUSE Dual specificity mitogen-activate... | 343 | 3e-66 | 225 | 38 | 57 | GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005769; C:early endosome; TAS:UniProtKB.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0005794; C:Golgi apparatus; TAS:UniProtKB.::GO:0005770; C:late endosome; TAS:UniProtKB.::GO:0005739; C:mitochondrion; TAS:UniProtKB.::GO:0005634; C:nucleus; TAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0032947; F:protein complex scaffold; IDA:BHF-UCL.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:2000147; P:positive regulation of cell motility; IDA:BHF-UCL.::GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.::GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.::GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB. | 10 | P0CY25 | 589 | STE7_CANAX Serine/threonine-protein kinase ST... | 384 | 4e-66 | 230 | 39 | 55 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 11 | C4YLK8 | 589 | STE7_CANAW Serine/threonine-protein kinase ST... | 384 | 4e-66 | 230 | 39 | 55 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 12 | Q5A6T5 | 589 | STE7_CANAL Serine/threonine-protein kinase ST... | 384 | 4e-66 | 230 | 39 | 55 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; IGI:CGD.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035690; P:cellular response to drug; IMP:CGD.::GO:0031505; P:fungal-type cell wall organization; IMP:CGD.::GO:0030448; P:hyphal growth; IMP:CGD.::GO:0071507; P:MAPK cascade involved in conjugation with cellular fusion; IMP:CGD. | 13 | Q05116 | 395 | MP2K1_XENLA Dual specificity mitogen-activate... | 332 | 2e-65 | 223 | 37 | 57 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 14 | Q9XT09 | 393 | MP2K1_PANTR Dual specificity mitogen-activate... | 335 | 4e-65 | 222 | 37 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 15 | Q90891 | 398 | MP2K2_CHICK Dual specificity mitogen-activate... | 340 | 1e-64 | 221 | 37 | 58 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035419; P:activation of MAPK activity involved in innate immune response; TAS:Reactome.::GO:0070371; P:ERK1 and ERK2 cascade; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0035681; P:toll-like receptor 15 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0035682; P:toll-like receptor 21 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0034146; P:toll-like receptor 5 signaling pathway; TAS:Reactome.::GO:0034154; P:toll-like receptor 7 signaling pathway; TAS:Reactome. | 16 | Q63980 | 393 | MP2K1_CRIGR Dual specificity mitogen-activate... | 335 | 2e-64 | 220 | 37 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 17 | Q1HG70 | 400 | MP2K2_CANFA Dual specificity mitogen-activate... | 340 | 3e-64 | 220 | 37 | 57 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 18 | P36507 | 400 | MP2K2_HUMAN Dual specificity mitogen-activate... | 340 | 1e-63 | 218 | 36 | 56 | GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005769; C:early endosome; TAS:UniProtKB.::GO:0005576; C:extracellular region; NAS:UniProtKB.::GO:0005925; C:focal adhesion; TAS:UniProtKB.::GO:0005794; C:Golgi apparatus; TAS:UniProtKB.::GO:0005770; C:late endosome; TAS:UniProtKB.::GO:0005739; C:mitochondrion; TAS:UniProtKB.::GO:0005634; C:nucleus; TAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; NAS:UniProtKB.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0070371; P:ERK1 and ERK2 cascade; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.::GO:2000641; P:regulation of early endosome to late endosome transport; TAS:UniProtKB.::GO:0090170; P:regulation of Golgi inheritance; TAS:UniProtKB.::GO:0032872; P:regulation of stress-activated MAPK cascade; TAS:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 19 | Q24324 | 396 | DSOR1_DROME Dual specificity mitogen-activate... | 302 | 4e-63 | 217 | 42 | 58 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; TAS:FlyBase.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.::GO:0004702; F:receptor signaling protein serine/threonine kinase activity; NAS:FlyBase. | | | | | | | | | | GO:0007298; P:border follicle cell migration; IGI:FlyBase.::GO:0042386; P:hemocyte differentiation; IGI:FlyBase.::GO:0007362; P:terminal region determination; IMP:FlyBase. | 20 | Q90321 | 397 | MP2K2_CYPCA Dual specificity mitogen-activate... | 340 | 2e-61 | 213 | 36 | 56 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 21 | Q13163 | 448 | MP2K5_HUMAN Dual specificity mitogen-activate... | 316 | 1e-57 | 203 | 41 | 57 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:BHF-UCL.::GO:0071363; P:cellular response to growth factor stimulus; ISS:BHF-UCL.::GO:0071499; P:cellular response to laminar fluid shear stress; TAS:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; ISS:BHF-UCL.::GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; ISS:BHF-UCL.::GO:2000342; P:negative regulation of chemokine (C-X-C motif) ligand 2 production; ISS:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:BHF-UCL.::GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; ISS:BHF-UCL.::GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; ISS:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:BHF-UCL.::GO:0060761; P:negative regulation of response to cytokine stimulus; ISS:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051247; P:positive regulation of protein metabolic process; ISS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:BHF-UCL. | 22 | Q62862 | 448 | MP2K5_RAT Dual specificity mitogen-activated ... | 332 | 7e-57 | 201 | 40 | 56 | GO:0005829; C:cytosol; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0004708; F:MAP kinase kinase activity; IC:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071363; P:cellular response to growth factor stimulus; IMP:BHF-UCL.::GO:0070375; P:ERK5 cascade; IMP:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:BHF-UCL.::GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IMP:BHF-UCL.::GO:2000342; P:negative regulation of chemokine (C-X-C motif) ligand 2 production; IMP:BHF-UCL.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:BHF-UCL.::GO:0034115; P:negative regulation of heterotypic cell-cell adhesion; IMP:BHF-UCL.::GO:0045415; P:negative regulation of interleukin-8 biosynthetic process; IMP:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0060761; P:negative regulation of response to cytokine stimulus; IMP:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0030307; P:positive regulation of cell growth; IMP:RGD.::GO:0050679; P:positive regulation of epithelial cell proliferation; IDA:RGD.::GO:0051247; P:positive regulation of protein metabolic process; IMP:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL. | 23 | P10506 | 340 | BYR1_SCHPO Protein kinase byr1 OS=Schizosacch... | 266 | 2e-56 | 197 | 45 | 62 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; TAS:PomBase.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000751; P:cell cycle arrest in response to pheromone; TAS:PomBase.::GO:0006995; P:cellular response to nitrogen starvation; IGI:PomBase.::GO:0032005; P:signal transduction involved in conjugation with cellular fusion; IGI:PomBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW. | 24 | P33886 | 605 | WIS1_SCHPO Protein kinase wis1 OS=Schizosacch... | 306 | 3e-56 | 203 | 38 | 56 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; NAS:PomBase.::GO:0005515; F:protein binding; IPI:PomBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0070301; P:cellular response to hydrogen peroxide; IMP:PomBase.::GO:0071470; P:cellular response to osmotic stress; TAS:PomBase.::GO:0070314; P:G1 to G0 transition; IMP:PomBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase.::GO:0043555; P:regulation of translation in response to stress; IMP:PomBase.::GO:0046685; P:response to arsenic-containing substance; IMP:PomBase.::GO:0051403; P:stress-activated MAPK cascade; TAS:PomBase. | 25 | Q9WVS7 | 448 | MP2K5_MOUSE Dual specificity mitogen-activate... | 332 | 3e-56 | 200 | 40 | 56 | GO:0005819; C:spindle; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007507; P:heart development; IMP:MGI. | 26 | Q9Y884 | 363 | SKH1_SCHPO MAP kinase kinase skh1/pek1 OS=Sch... | 282 | 9e-53 | 188 | 40 | 60 | GO:0030428; C:cell septum; IDA:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; TAS:PomBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0033205; P:cell cycle cytokinesis; NAS:PomBase.::GO:0006883; P:cellular sodium ion homeostasis; NAS:PomBase.::GO:0031505; P:fungal-type cell wall organization; NAS:PomBase.::GO:0050850; P:positive regulation of calcium-mediated signaling; IMP:PomBase.::GO:0008360; P:regulation of cell shape; NAS:PomBase. | 27 | Q5E9X2 | 334 | MP2K6_BOVIN Dual specificity mitogen-activate... | 320 | 2e-52 | 186 | 37 | 54 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 28 | Q10664 | 387 | MEK2_CAEEL Dual specificity mitogen-activated... | 327 | 4e-52 | 187 | 34 | 53 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; IDA:WormBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0001703; P:gastrulation with mouth forming first; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0007265; P:Ras protein signal transduction; IGI:WormBase.::GO:0040025; P:vulval development; IGI:WormBase. | 29 | P32490 | 508 | MKK1_YEAST MAP kinase kinase MKK1/SSP32 OS=Sa... | 287 | 6e-52 | 189 | 39 | 56 | GO:0005934; C:cellular bud tip; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0030242; P:peroxisome degradation; IGI:SGD.::GO:0007165; P:signal transduction; IMP:SGD. | 30 | P52564 | 334 | MP2K6_HUMAN Dual specificity mitogen-activate... | 320 | 7e-52 | 185 | 36 | 53 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004708; F:MAP kinase kinase activity; TAS:ProtInc.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007050; P:cell cycle arrest; TAS:ProtInc.::GO:0006975; P:DNA damage induced protein phosphorylation; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0042692; P:muscle cell differentiation; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0051149; P:positive regulation of muscle cell differentiation; TAS:Reactome.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 31 | P70236 | 334 | MP2K6_MOUSE Dual specificity mitogen-activate... | 320 | 2e-51 | 184 | 36 | 53 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; IDA:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0060048; P:cardiac muscle contraction; IMP:MGI.::GO:0000165; P:MAPK cascade; IPI:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
