Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDL134C
Length:
369
Number of sequences:
5887
Description:
YDL134C PPH21 SGDID:S000002292, Chr IV from 220771-219662, Genome Release 64-1-1, reverse complement, Verified ORF, "Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P23594    369   PP2A1_YEAST Serine/threonine-protein phosphat...3690     775     100     100GO:0000159; C:protein phosphatase type 2A complex; IDA:SGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004722; F:protein serine/threonine phosphatase activity; IMP:SGD.
GO:0007015; P:actin filament organization; TAS:SGD.::GO:0007117; P:budding cell bud growth; TAS:SGD.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; IPI:SGD.::GO:0006470; P:protein dephosphorylation; TAS:SGD.::GO:0006417; P:regulation of translation; IPI:SGD.
2P23595    377   PP2A2_YEAST Serine/threonine-protein phosphat...3770     697     88     93GO:0000780; C:condensed nuclear chromosome, centromeric region; IDA:SGD.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:SGD.
GO:0007015; P:actin filament organization; TAS:SGD.::GO:0007117; P:budding cell bud growth; TAS:SGD.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; IPI:SGD.::GO:0006470; P:protein dephosphorylation; IDA:SGD.::GO:0006417; P:regulation of translation; IPI:SGD.
3P48580    327   PP2A1_NEUCR Serine/threonine-protein phosphat...3160     522     76     86
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
4Q9HFQ2    329   PP2A1_EMENI Serine/threonine-protein phosphat...3190     513     74     85
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
5A3C4N5    314   PP2A4_ORYSJ Serine/threonine-protein phosphat...3000     512     77     89GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
6P0C5D7    315   PP2A4_ORYSI Putative serine/threonine-protein...3001e-180     511     76     89GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
7P23636    322   PP2A2_SCHPO Major serine/threonine-protein ph...3092e-180     511     75     87GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; TAS:PomBase.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045930; P:negative regulation of mitotic cell cycle; IGI:PomBase.::GO:0006470; P:protein dephosphorylation; IMP:PomBase.::GO:0007165; P:signal transduction; NAS:PomBase.
8Q8X178    328   PP2A2_ERYGR Serine/threonine-protein phosphat...3194e-180     510     73     85
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
9P48463    309   PP2AA_CHICK Serine/threonine-protein phosphat...3021e-179     508     76     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
10P11611    309   PP2AB_RABIT Serine/threonine-protein phosphat...3073e-179     507     74     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
11Q07100    313   PP2A4_ARATH Serine/threonine-protein phosphat...3005e-179     507     76     88GO:0005737; C:cytoplasm; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
12Q9XGH7    312   PP2A_TOBAC Serine/threonine-protein phosphata...3006e-179     506     76     88GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
13P62716    309   PP2AB_RAT Serine/threonine-protein phosphatas...3028e-179     506     75     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:RGD.
GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:RGD.::GO:0006470; P:protein dephosphorylation; IDA:RGD.
14P62715    309   PP2AB_MOUSE Serine/threonine-protein phosphat...3028e-179     506     75     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; TAS:MGI.::GO:0000159; C:protein phosphatase type 2A complex; IDA:MGI.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.::GO:0010468; P:regulation of gene expression; IMP:MGI.::GO:0046677; P:response to antibiotic; IMP:MGI.::GO:0042542; P:response to hydrogen peroxide; IMP:MGI.
15P62714    309   PP2AB_HUMAN Serine/threonine-protein phosphat...3028e-179     506     75     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000159; C:protein phosphatase type 2A complex; TAS:UniProtKB.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0006470; P:protein dephosphorylation; TAS:UniProtKB.
16P67777    309   PP2AA_RABIT Serine/threonine-protein phosphat...3029e-179     506     75     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.
17P67776    309   PP2AA_PIG Serine/threonine-protein phosphatas...3029e-179     506     75     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.
18P67775    309   PP2AA_HUMAN Serine/threonine-protein phosphat...3029e-179     506     75     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005739; C:mitochondrion; NAS:UniProtKB.::GO:0005634; C:nucleus; NAS:UniProtKB.::GO:0000159; C:protein phosphatase type 2A complex; IDA:UniProtKB.::GO:0005625; C:soluble fraction; NAS:UniProtKB.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
GO:0006672; P:ceramide metabolic process; NAS:UniProtKB.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0000188; P:inactivation of MAPK activity; NAS:UniProtKB.::GO:0006917; P:induction of apoptosis; TAS:UniProtKB.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0030308; P:negative regulation of cell growth; NAS:UniProtKB.::GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.::GO:0042518; P:negative regulation of tyrosine phosphorylation of Stat3 protein; NAS:UniProtKB.::GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.::GO:0071902; P:positive regulation of protein serine/threonine kinase activity; IMP:BHF-UCL.::GO:0006470; P:protein dephosphorylation; TAS:UniProtKB.::GO:0030155; P:regulation of cell adhesion; NAS:UniProtKB.::GO:0006275; P:regulation of DNA replication; NAS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; NAS:UniProtKB.::GO:0030111; P:regulation of Wnt receptor signaling pathway; NAS:UniProtKB.::GO:0008380; P:RNA splicing; NAS:UniProtKB.::GO:0019932; P:second-messenger-mediated signaling; NAS:UniProtKB.
19P67774    309   PP2AA_BOVIN Serine/threonine-protein phosphat...3029e-179     506     75     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.
20P63331    309   PP2AA_RAT Serine/threonine-protein phosphatas...3021e-178     506     75     87GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008022; F:protein C-terminus binding; IPI:RGD.::GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; IDA:RGD.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0006470; P:protein dephosphorylation; IDA:RGD.::GO:0070208; P:protein heterotrimerization; IMP:MGI.::GO:0031952; P:regulation of protein autophosphorylation; IMP:MGI.::GO:0042176; P:regulation of protein catabolic process; IMP:MGI.::GO:0010469; P:regulation of receptor activity; IMP:MGI.
21P63330    309   PP2AA_MOUSE Serine/threonine-protein phosphat...3021e-178     506     75     87GO:0000775; C:chromosome, centromeric region; IDA:UniProtKB.::GO:0005829; C:cytosol; IDA:MGI.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:MGI.::GO:0000159; C:protein phosphatase type 2A complex; IDA:MGI.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0008022; F:protein C-terminus binding; IPI:MGI.::GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB.::GO:0004722; F:protein serine/threonine phosphatase activity; TAS:MGI.
GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007498; P:mesoderm development; IMP:MGI.::GO:0006470; P:protein dephosphorylation; TAS:MGI.::GO:0051726; P:regulation of cell cycle; TAS:MGI.
22P48578    313   PP2A3_ARATH Serine/threonine-protein phosphat...3001e-178     506     75     88GO:0005829; C:cytosol; IDA:TAIR.::GO:0005730; C:nucleolus; IDA:TAIR.::GO:0000159; C:protein phosphatase type 2A complex; TAS:TAIR.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
GO:0006470; P:protein dephosphorylation; TAS:TAIR.
23Q0P594    309   PP2AB_BOVIN Serine/threonine-protein phosphat...3002e-178     505     76     88GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
24Q06009    313   PP2A_MEDSA Serine/threonine-protein phosphata...3007e-178     504     75     88
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
25Q10BT5    307   PP2A2_ORYSJ Serine/threonine-protein phosphat...3001e-177     503     76     88GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
26A2XN40    307   PP2A2_ORYSI Serine/threonine-protein phosphat...3001e-177     503     76     88GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
27O04860    314   PP2A5_TOBAC Serine/threonine-protein phosphat...3003e-176     500     75     87GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
28P23696    309   PP2A_DROME Serine/threonine-protein phosphata...3076e-176     499     73     85GO:0005737; C:cytoplasm; IDA:FlyBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019208; F:phosphatase regulator activity; IDA:FlyBase.::GO:0004722; F:protein serine/threonine phosphatase activity; IMP:FlyBase.
GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0055059; P:asymmetric neuroblast division; IGI:FlyBase.::GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:FlyBase.::GO:0007155; P:cell adhesion; IMP:FlyBase.::GO:0051298; P:centrosome duplication; IMP:FlyBase.::GO:0007059; P:chromosome segregation; IMP:FlyBase.::GO:0090162; P:establishment of epithelial cell polarity; IEP:FlyBase.::GO:0007067; P:mitosis; IMP:FlyBase.::GO:0007406; P:negative regulation of neuroblast proliferation; IMP:FlyBase.::GO:0048477; P:oogenesis; IMP:FlyBase.::GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.::GO:0045880; P:positive regulation of smoothened signaling pathway; IGI:FlyBase.::GO:0006470; P:protein dephosphorylation; IMP:FlyBase.::GO:0007465; P:R7 cell fate commitment; IGI:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0009416; P:response to light stimulus; IGI:FlyBase.::GO:0051225; P:spindle assembly; IMP:FlyBase.
29P48577    307   PP2A_ACECL Serine/threonine-protein phosphata...3039e-175     496     73     88
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
30P23635    309   PP2A1_SCHPO Minor serine/threonine-protein ph...3044e-174     494     73     86GO:0005634; C:nucleus; IDA:PomBase.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; TAS:PomBase.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006470; P:protein dephosphorylation; IMP:PomBase.::GO:2000765; P:regulation of cytoplasmic translation; ISS:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IMP:PomBase.::GO:0007165; P:signal transduction; NAS:PomBase.
31P11493    293   PP2AB_PIG Serine/threonine-protein phosphatas...2932e-173     492     76     88GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004721; F:phosphoprotein phosphatase activity; IEA:UniProtKB-KW.
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