Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDL131W
Length:
440
Number of sequences:
5887
Description:
YDL131W LYS21 SGDID:S000002289, Chr IV from 227393-228715, Genome Release 64-1-1, Verified ORF, "Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q12122    440   HOSM_YEAST Homocitrate synthase, mitochondria...4400     906     100     100GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:SGD.
GO:0004410; F:homocitrate synthase activity; IEA:EC.
GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IMP:SGD.
2P48570    428   HOSC_YEAST Homocitrate synthase, cytosolic is...4190     792     92     95GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
GO:0004410; F:homocitrate synthase activity; IDA:SGD.
GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IGI:SGD.
3Q12726    446   HOSM_YARLI Homocitrate synthase, mitochondria...3930     732     89     95GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004410; F:homocitrate synthase activity; IEA:EC.
GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
4Q9Y823    418   HOSM_SCHPO Homocitrate synthase, mitochondria...3990     667     78     88GO:0005829; C:cytosol; IDA:PomBase.::GO:0005739; C:mitochondrion; ISS:PomBase.::GO:0005634; C:nucleus; ISS:PomBase.
GO:0004410; F:homocitrate synthase activity; IMP:PomBase.
GO:0006091; P:generation of precursor metabolites and energy; NAS:PomBase.::GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IMP:PomBase.
5O94225    474   HOSM_PENCW Homocitrate synthase, mitochondria...4090     653     77     86GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
GO:0004410; F:homocitrate synthase activity; IEA:EC.
GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
6O87198    376   HOSC_THET2 Homocitrate synthase OS=Thermus th...3753e-142     419     54     74GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004410; F:homocitrate synthase activity; IEA:EC.
GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
7Q971S5    460   HOSA_SULTO Putative homocitrate synthase OS=S...3636e-67     227     39     56GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
8Q58595    518   LEU1_METJA 2-isopropylmalate synthase OS=JCM ...3762e-64     222     36     55
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
9Q8TYB1    499   LEU1_METKA Probable 2-isopropylmalate synthas...3744e-64     220     34     54
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
10C3NDV7    461   HOSA_SULIY Putative homocitrate synthase OS=S...3849e-64     218     35     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
11C3NHU6    461   HOSA_SULIN Putative homocitrate synthase OS=S...3849e-64     218     35     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
12C3MYM1    461   HOSA_SULIM Putative homocitrate synthase OS=S...3849e-64     218     35     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
13C4KGW9    461   HOSA_SULIK Putative homocitrate synthase OS=S...3849e-64     218     35     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
14C3N5A3    461   HOSA_SULIA Putative homocitrate synthase OS=S...3849e-64     218     35     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
15C3MPM7    461   HOSA_SULIL Putative homocitrate synthase OS=S...3844e-63     216     35     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
16Q58787    491   CIMA_METJA (R)-citramalate synthase CimA OS=J...3739e-60     208     33     57
GO:0043714; F:(R)-citramalate synthase activity; IEA:InterPro.::GO:0003852; F:2-isopropylmalate synthase activity; IEA:InterPro.
GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.::GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
17Q57926    406   AKSA_METJA Probable homocitrate synthase AksA...3785e-59     204     33     53
GO:0004410; F:homocitrate synthase activity; IEA:EC.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
18Q8RCF9    384   LEU12_THETN 2-isopropylmalate synthase 2 OS=1...3665e-58     201     33     53
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.::GO:0004410; F:homocitrate synthase activity; IEA:InterPro.
GO:0051188; P:cofactor biosynthetic process; IEA:InterPro.::GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
19Q97ZE0    461   HOSA_SULSO Putative homocitrate synthase OS=P...3847e-58     202     34     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
20Q9V1J1    361   HOSA_PYRAB Putative homocitrate synthase OS=P...3331e-57     199     33     55
GO:0004410; F:homocitrate synthase activity; IEA:EC.::GO:0046912; F:transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer; IEA:InterPro.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
21O30020    503   LEU1_ARCFU Probable 2-isopropylmalate synthas...3552e-57     202     34     55
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
22O27525    505   LEU1_METTH Probable 2-isopropylmalate synthas...3567e-56     198     33     51
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
23O27667    391   AKSA_METTH Putative homocitrate synthase AksA...3488e-55     192     35     53
GO:0004410; F:homocitrate synthase activity; IEA:EC.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
24O59390    361   HOSA_PYRHO Putative homocitrate synthase OS=N...3458e-55     192     32     54
GO:0004410; F:homocitrate synthase activity; IEA:EC.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
25Q8THA5    515   LEU1_METAC Probable 2-isopropylmalate synthas...3686e-54     193     30     53
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
26O29305    489   CIMA_ARCFU Putative (R)-citramalate synthase ...3571e-53     192     32     55
GO:0043714; F:(R)-citramalate synthase activity; IEA:InterPro.::GO:0003852; F:2-isopropylmalate synthase activity; IEA:InterPro.
GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.::GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
27P58968    516   LEU1_METMA Probable 2-isopropylmalate synthas...3681e-53     192     31     52
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
28Q8TW28    397   AKSA_METKA Putative homocitrate synthase AksA...3502e-51     184     33     52
GO:0004410; F:homocitrate synthase activity; IEA:EC.
GO:0019752; P:carboxylic acid metabolic process; IEA:InterPro.
29A8AB61    399   LEU1_IGNH4 Probable 2-isopropylmalate synthas...3673e-51     183     33     50
GO:0003852; F:2-isopropylmalate synthase activity; IEA:EC.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
30O26819    496   CIMA_METTH Putative (R)-citramalate synthase ...3714e-50     182     32     50
GO:0043714; F:(R)-citramalate synthase activity; IEA:InterPro.::GO:0003852; F:2-isopropylmalate synthase activity; IEA:InterPro.
GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.::GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
31B8GEI1    500   CIMA_METPE Putative (R)-citramalate synthase ...3571e-49     181     32     50
GO:0043714; F:(R)-citramalate synthase activity; IEA:InterPro.::GO:0003852; F:2-isopropylmalate synthase activity; IEA:InterPro.
GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.::GO:0009098; P:leucine biosynthetic process; IEA:InterPro.
records
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