Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDL074C
Length:
700
Number of sequences:
5887
Description:
YDL074C BRE1 SGDID:S000002232, Chr IV from 326149-324047, Genome Release 64-1-1, reverse complement, Verified ORF, "E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
91Q9CQJ4    336   RING2_MOUSE E3 ubiquitin-protein ligase RING2...480.25     38.1     38     50GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0016604; C:nuclear body; IDA:MGI.::GO:0001739; C:sex chromatin; IDA:MGI.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0009948; P:anterior/posterior axis specification; IMP:MGI.::GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.::GO:0000278; P:mitotic cell cycle; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
92Q03601    974   NHL1_CAEEL RING finger protein nhl-1 OS=Caeno...790.25     38.5     32     38
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IMP:WormBase.
93Q13191    982   CBLB_HUMAN E3 ubiquitin-protein ligase CBL-B ...430.25     38.5     33     56
94Q99496    336   RING2_HUMAN E3 ubiquitin-protein ligase RING2...480.25     38.1     38     50GO:0071339; C:MLL1 complex; IDA:UniProtKB.::GO:0035102; C:PRC1 complex; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0071535; F:RING-like zinc finger domain binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0035518; P:histone H2A monoubiquitination; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
95Q86YT6    1006   MIB1_HUMAN E3 ubiquitin-protein ligase MIB1 O...730.25     38.5     33     47GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031965; C:nuclear membrane; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007219; P:Notch signaling pathway; TAS:Reactome.
96Q803I4    336   RING2_DANRE E3 ubiquitin-protein ligase RING2...480.25     37.7     38     50GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
97Q3TTA7    982   CBLB_MOUSE E3 ubiquitin-protein ligase CBL-B ...430.26     38.5     33     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0001784; F:phosphotyrosine binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.::GO:0006955; P:immune response; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0046642; P:negative regulation of alpha-beta T cell proliferation; IMP:MGI.::GO:0050860; P:negative regulation of T cell receptor signaling pathway; IMP:MGI.::GO:0045732; P:positive regulation of protein catabolic process; IMP:MGI.::GO:0002669; P:positive regulation of T cell anergy; IMP:MGI.::GO:0042110; P:T cell activation; IMP:MGI.
98Q9EPZ8    682   RN103_RAT E3 ubiquitin-protein ligase RNF103 ...420.26     38.1     38     52GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
99Q5R9J5    336   RING2_PONAB E3 ubiquitin-protein ligase RING2...480.26     37.7     38     50GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0016567; P:protein ubiquitination; ISS:GOC.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
100A7GJZ8    158   ISPF_BACCN 2-C-methyl-D-erythritol 2,4-cyclod...740.28     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
101Q4KLY4    308   RING2_RAT E3 ubiquitin-protein ligase RING2 O...480.29     37.7     38     50GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0016567; P:protein ubiquitination; ISS:GOC.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
102Q73FC0    158   ISPF_BACC1 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
103A9VN99    158   ISPF_BACWK 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
104Q6HPT1    158   ISPF_BACHK 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
105Q63HB3    158   ISPF_BACCZ 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
106Q81J62    158   ISPF_BACCR 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
107B9IZH1    158   ISPF_BACCQ 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
108B7HQS1    158   ISPF_BACC7 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
109C1ET16    158   ISPF_BACC3 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
110B7ISZ6    158   ISPF_BACC2 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
111B7JK94    158   ISPF_BACC0 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
112Q81VV4    158   ISPF_BACAN 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
113A0R8F8    158   ISPF_BACAH 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
114C3LJ59    158   ISPF_BACAC 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
115C3P9N2    158   ISPF_BACAA 2-C-methyl-D-erythritol 2,4-cyclod...740.3     36.6     28     53
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
116P10862    487   RAD18_YEAST Postreplication repair E3 ubiquit...510.32     37.7     31     43GO:0000790; C:nuclear chromatin; IDA:SGD.
GO:0003684; F:damaged DNA binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0003697; F:single-stranded DNA binding; IDA:SGD.::GO:0004842; F:ubiquitin-protein ligase activity; IPI:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0042275; P:error-free postreplication DNA repair; IGI:SGD.::GO:0070987; P:error-free translesion synthesis; IGI:SGD.::GO:0042276; P:error-prone translesion synthesis; IGI:SGD.::GO:0006513; P:protein monoubiquitination; IMP:SGD.
117Q8K4S7    938   CBLB_RAT E3 ubiquitin-protein ligase CBL-B OS...430.32     38.1     33     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0005634; C:nucleus; IEA:InterPro.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0001784; F:phosphotyrosine binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.::GO:0023051; P:regulation of signaling; IEA:InterPro.::GO:0009629; P:response to gravity; IEP:RGD.::GO:0009725; P:response to hormone stimulus; IEP:RGD.
118Q5ACX1    1084   RAD5_CANAL DNA repair protein RAD5 OS=Candida...590.32     38.1     27     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
119Q03112    1051   EVI1_HUMAN MDS1 and EVI1 complex locus protei...740.34     38.1     30     41GO:0016607; C:nuclear speck; IDA:UniProtKB.
GO:0003677; F:DNA binding; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0042803; F:protein homodimerization activity; IDA:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0071425; P:hemopoietic stem cell proliferation; ISS:UniProtKB.::GO:0046329; P:negative regulation of JNK cascade; IMP:UniProtKB.::GO:0043069; P:negative regulation of programmed cell death; IMP:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0051726; P:regulation of cell cycle; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
120Q6BLM3    491   RAD18_DEBHA Postreplication repair E3 ubiquit...430.37     37.7     35     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003684; F:damaged DNA binding; IEA:InterPro.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
121A6NGJ6    449   TRI64_HUMAN Tripartite motif-containing prote...550.4     37.4     35     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
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