Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDL074C
Length:
700
Number of sequences:
5887
Description:
YDL074C BRE1 SGDID:S000002232, Chr IV from 326149-324047, Genome Release 64-1-1, reverse complement, Verified ORF, "E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
61D2GXS7    744   TRIM2_AILME Tripartite motif-containing prote...460.049     40.8     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043526; P:neuroprotection; ISS:UniProtKB.
62D3ZQG6    744   TRIM2_RAT Tripartite motif-containing protein...460.05     40.8     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043526; P:neuroprotection; IMP:UniProtKB.
63Q9ESN6    744   TRIM2_MOUSE Tripartite motif-containing prote...460.05     40.8     33     50GO:0005737; C:cytoplasm; NAS:UniProtKB.
GO:0017022; F:myosin binding; NAS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0043526; P:neuroprotection; IMP:UniProtKB.
64Q9C040    744   TRIM2_HUMAN Tripartite motif-containing prote...460.05     40.4     33     50GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0043526; P:neuroprotection; ISS:UniProtKB.
65Q86WT6    500   TRI69_HUMAN Tripartite motif-containing prote...430.05     40.4     37     63GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
66P51950    324   MAT1_MARGL CDK-activating kinase assembly fac...530.055     40     32     43GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.
67Q7YR34    539   TRI26_PANTR Tripartite motif-containing prote...640.062     40     31     47
GO:0008270; F:zinc ion binding; IEA:InterPro.
68Q12899    539   TRI26_HUMAN Tripartite motif-containing prote...640.062     40     31     47
GO:0003677; F:DNA binding; NAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
69Q6ZMN7    1036   PZRN4_HUMAN PDZ domain-containing RING finger...510.065     40.4     33     47
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
70Q5AVC5    332   CWC24_EMENI Pre-mRNA-splicing factor cwc24 OS...390.071     39.7     41     59GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
71Q99PN3    545   TRI26_MOUSE Tripartite motif-containing prote...640.077     40     31     47GO:0005737; C:cytoplasm; IDA:MGI.
GO:0008270; F:zinc ion binding; IEA:InterPro.
72P62603    542   TRI26_RAT Tripartite motif-containing protein...640.079     39.7     31     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
73Q05568    337   PEX10_YEAST Peroxisome biogenesis factor 10 O...550.085     39.3     33     49GO:0005779; C:integral to peroxisomal membrane; IEA:InterPro.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016558; P:protein import into peroxisome matrix; IMP:SGD.
74Q6CHI1    344   RAD18_YARLI Postreplication repair E3 ubiquit...390.086     39.3     36     51GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
75O55735    89   121R_IIV6 Putative RING finger protein 121R O...550.098     37     35     47
GO:0008270; F:zinc ion binding; IEA:InterPro.
76Q6BIP2    1190   RAD5_DEBHA DNA repair protein RAD5 OS=0083 / ...520.11     39.7     31     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
77P22682    913   CBL_MOUSE E3 ubiquitin-protein ligase CBL OS=...430.12     39.3     33     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0001784; F:phosphotyrosine binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IPI:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045453; P:bone resorption; ISS:UniProtKB.::GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.::GO:0006468; P:protein phosphorylation; ISS:UniProtKB.
78Q8HXW8    326   PEX10_MACFA Peroxisome biogenesis factor 10 O...1180.12     38.9     25     45GO:0005779; C:integral to peroxisomal membrane; ISS:UniProtKB.
GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016558; P:protein import into peroxisome matrix; ISS:UniProtKB.
79Q00940    295   PEX10_PICAN Peroxisome biogenesis factor 10 O...700.14     38.5     31     47GO:0005779; C:integral to peroxisomal membrane; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016558; P:protein import into peroxisome matrix; IEA:InterPro.
80Q8TFH8    343   PEX12_SCHPO Peroxisome assembly protein 12 OS...400.15     38.5     38     50GO:0005779; C:integral to peroxisomal membrane; IEA:InterPro.
GO:0008022; F:protein C-terminus binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006625; P:protein targeting to peroxisome; IEA:InterPro.
81Q5M807    180   RNF5_RAT E3 ubiquitin-protein ligase RNF5 OS=...540.16     37.7     24     50GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
82O35445    180   RNF5_MOUSE E3 ubiquitin-protein ligase RNF5 O...540.16     37.7     24     50GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0071712; P:ER-associated misfolded protein catabolic process; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.
83Q99942    180   RNF5_HUMAN E3 ubiquitin-protein ligase RNF5 O...540.16     37.7     24     50GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0071712; P:ER-associated misfolded protein catabolic process; IMP:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.
84P22681    906   CBL_HUMAN E3 ubiquitin-protein ligase CBL OS=...430.19     38.9     33     56GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:InterPro.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0001784; F:phosphotyrosine binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.::GO:0017124; F:SH3 domain binding; IPI:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; TAS:HGNC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:HGNC.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0014068; P:positive regulation of phosphatidylinositol 3-kinase cascade; IMP:BHF-UCL.::GO:0048260; P:positive regulation of receptor-mediated endocytosis; TAS:HGNC.
85Q804S5    1030   MIB1_DANRE E3 ubiquitin-protein ligase mib1 O...730.21     38.9     33     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
86Q6GNY1    1011   MIB1_XENLA E3 ubiquitin-protein ligase mib1 O...730.21     38.5     33     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
87Q4WUA0    339   CWC24_ASPFU Pre-mRNA-splicing factor cwc24 OS...390.21     38.1     38     59GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
88O00237    685   RN103_HUMAN E3 ubiquitin-protein ligase RNF10...420.23     38.5     38     52GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007417; P:central nervous system development; TAS:ProtInc.::GO:0030433; P:ER-associated protein catabolic process; IDA:UniProtKB.
89Q80SY4    1006   MIB1_MOUSE E3 ubiquitin-protein ligase MIB1 O...730.23     38.5     33     47GO:0031410; C:cytoplasmic vesicle; IDA:MGI.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001568; P:blood vessel development; IMP:MGI.::GO:0001947; P:heart looping; IMP:MGI.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0045665; P:negative regulation of neuron differentiation; IMP:MGI.::GO:0001841; P:neural tube formation; IMP:MGI.::GO:0007219; P:Notch signaling pathway; IMP:MGI.::GO:0045807; P:positive regulation of endocytosis; IDA:MGI.::GO:0001756; P:somitogenesis; IMP:MGI.
90Q9R1W3    683   RN103_MOUSE E3 ubiquitin-protein ligase RNF10...420.24     38.5     38     52GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
91Q9CQJ4    336   RING2_MOUSE E3 ubiquitin-protein ligase RING2...480.25     38.1     38     50GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0016604; C:nuclear body; IDA:MGI.::GO:0001739; C:sex chromatin; IDA:MGI.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0009948; P:anterior/posterior axis specification; IMP:MGI.::GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.::GO:0000278; P:mitotic cell cycle; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
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