Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDL074C
Length:
700
Number of sequences:
5887
Description:
YDL074C BRE1 SGDID:S000002232, Chr IV from 326149-324047, Genome Release 64-1-1, reverse complement, Verified ORF, "E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
121A6NGJ6    449   TRI64_HUMAN Tripartite motif-containing prote...550.4     37.4     35     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
122P14404    1042   EVI1_MOUSE MDS1 and EVI1 complex locus protei...740.41     37.7     30     41GO:0016607; C:nuclear speck; ISS:UniProtKB.
GO:0003677; F:DNA binding; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0035115; P:embryonic forelimb morphogenesis; IMP:MGI.::GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI.::GO:0030900; P:forebrain development; IMP:MGI.::GO:0071425; P:hemopoietic stem cell proliferation; IMP:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0006954; P:inflammatory response; IMP:MGI.::GO:0046329; P:negative regulation of JNK cascade; ISS:UniProtKB.::GO:0043069; P:negative regulation of programmed cell death; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0001780; P:neutrophil homeostasis; IMP:MGI.::GO:0060039; P:pericardium development; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.::GO:0009791; P:post-embryonic development; IMP:MGI.::GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.::GO:0042127; P:regulation of cell proliferation; IMP:MGI.::GO:0009617; P:response to bacterium; IMP:MGI.::GO:0009605; P:response to external stimulus; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
123P53769    259   CWC24_YEAST Pre-mRNA-splicing factor CWC24 OS...440.41     37     36     57GO:0005684; C:U2-type spliceosomal complex; IDA:SGD.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0034247; P:snoRNA splicing; IMP:SGD.
124Q21313    3672   EPI1_CAEEL Laminin-like protein epi-1 OS=Caen...3080.43     37.7     19     44GO:0005604; C:basement membrane; IEA:InterPro.
GO:0007155; P:cell adhesion; IEA:InterPro.
125A6NI03    449   TR64B_HUMAN Putative tripartite motif-contain...550.44     37.4     35     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
126Q06587    406   RING1_HUMAN E3 ubiquitin-protein ligase RING1...480.45     37.4     38     50GO:0005737; C:cytoplasm; IDA:HPA.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0035518; P:histone H2A monoubiquitination; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
127Q66J69    344   RNG2A_XENLA E3 ubiquitin-protein ligase RING2...460.45     37     39     50GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
128A2T6X5    377   RING1_PANTR E3 ubiquitin-protein ligase RING1...480.46     37.4     38     50GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
129A1YFY1    377   RING1_PANPA E3 ubiquitin-protein ligase RING1...480.46     37.4     38     50GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
130Q8WMN5    377   RING1_MACMU E3 ubiquitin-protein ligase RING1...480.46     37.4     38     50GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
131A1YER5    377   RING1_GORGO E3 ubiquitin-protein ligase RING1...480.46     37.4     38     50GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
132Q6MGB6    406   RING1_RAT E3 ubiquitin-protein ligase RING1 O...480.48     37.4     38     50GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
133Q5TJF3    406   RING1_CANFA E3 ubiquitin-protein ligase RING1...480.48     37     38     50GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
134Q5XI59    802   RNF10_RAT RING finger protein 10 OS=Rattus no...540.49     37.4     33     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010626; P:negative regulation of Schwann cell proliferation; IDA:UniProtKB.::GO:0031643; P:positive regulation of myelination; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
135Q5BK82    499   TRI69_RAT Tripartite motif-containing protein...430.5     37.4     33     60GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
136Q6Q0C0    670   TRAF7_HUMAN E3 ubiquitin-protein ligase TRAF7...380.5     37.4     42     50GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0000185; P:activation of MAPKKK activity; IDA:UniProtKB.::GO:0006915; P:apoptotic process; IDA:MGI.::GO:0043410; P:positive regulation of MAPK cascade; IDA:MGI.::GO:0042981; P:regulation of apoptotic process; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
137Q7ZWM8    343   RNG2B_XENLA E3 ubiquitin-protein ligase RING2...460.53     37     39     50GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
138O35730    406   RING1_MOUSE E3 ubiquitin-protein ligase RING1...480.54     37     38     50GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0001739; C:sex chromatin; IDA:MGI.::GO:0000151; C:ubiquitin ligase complex; IDA:MGI.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.::GO:0048593; P:camera-type eye morphogenesis; IGI:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
139Q6GQL0    918   CBLBA_XENLA E3 ubiquitin-protein ligase CBL-B...430.56     37.4     33     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:InterPro.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0001784; F:phosphotyrosine binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.::GO:0023051; P:regulation of signaling; IEA:InterPro.
140Q0WX00    460   RNG1B_ARATH Putative E3 ubiquitin-protein lig...640.57     37     33     47GO:0035102; C:PRC1 complex; IPI:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0001709; P:cell fate determination; IMP:UniProtKB.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0010076; P:maintenance of floral meristem identity; IMP:UniProtKB.::GO:0010077; P:maintenance of inflorescence meristem identity; IMP:UniProtKB.::GO:0010492; P:maintenance of shoot apical meristem identity; IMP:UniProtKB.::GO:0045814; P:negative regulation of gene expression, epigenetic; IGI:TAIR.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IGI:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
141Q6CJM4    1114   RAD5_KLULA DNA repair protein RAD5 OS=1267 / ...650.6     37.4     28     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
142Q6TEM9    472   MYLIA_DANRE E3 ubiquitin-protein ligase MYLIP...530.61     37     36     53GO:0005856; C:cytoskeleton; IEA:InterPro.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007369; P:gastrulation; IMP:UniProtKB.::GO:0030178; P:negative regulation of Wnt receptor signaling pathway; IGI:UniProtKB.
143Q922B6    594   TRAF7_MOUSE E3 ubiquitin-protein ligase TRAF7...380.63     37     42     50GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000185; P:activation of MAPKKK activity; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
144O60683    326   PEX10_HUMAN Peroxisome biogenesis factor 10 O...510.66     36.6     27     51GO:0005779; C:integral to peroxisomal membrane; IEA:InterPro.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016558; P:protein import into peroxisome matrix; IDA:UniProtKB.
145A0JNG4    556   RN207_BOVIN RING finger protein 207 OS=Bos ta...690.68     37     28     35GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
146Q9SYU4    381   PEX10_ARATH Peroxisome biogenesis factor 10 O...560.68     36.6     29     50GO:0005829; C:cytosol; IDA:TAIR.::GO:0005779; C:integral to peroxisomal membrane; IEA:InterPro.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010381; P:attachment of peroxisome to chloroplast; IMP:TAIR.::GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.::GO:0006635; P:fatty acid beta-oxidation; IMP:TAIR.::GO:0009853; P:photorespiration; IMP:TAIR.::GO:0016558; P:protein import into peroxisome matrix; IMP:TAIR.
147O88196    1979   TTC3_MOUSE E3 ubiquitin-protein ligase TTC3 O...520.69     37     38     56GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005773; C:vacuole; IDA:MGI.
GO:0005515; F:protein binding; IPI:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0010771; P:negative regulation of cell morphogenesis involved in differentiation; IDA:MGI.::GO:0045665; P:negative regulation of neuron differentiation; IDA:MGI.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
148Q6DFR2    982   CBLB_XENTR E3 ubiquitin-protein ligase CBL-B ...430.69     37     33     56GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:InterPro.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0001784; F:phosphotyrosine binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.::GO:0023051; P:regulation of signaling; IEA:InterPro.
149Q61382    470   TRAF4_MOUSE TNF receptor-associated factor 4 ...380.7     36.6     42     61GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046330; P:positive regulation of JNK cascade; ISS:UniProtKB.::GO:0045860; P:positive regulation of protein kinase activity; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.::GO:0007585; P:respiratory gaseous exchange; IMP:MGI.::GO:0030323; P:respiratory tube development; IMP:MGI.::GO:0007165; P:signal transduction; IEA:InterPro.
150Q9BUZ4    470   TRAF4_HUMAN TNF receptor-associated factor 4 ...380.72     36.6     42     61GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; TAS:ProtInc.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0050699; F:WW domain binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046330; P:positive regulation of JNK cascade; IDA:UniProtKB.::GO:0090073; P:positive regulation of protein homodimerization activity; IDA:UniProtKB.::GO:0045860; P:positive regulation of protein kinase activity; IDA:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.::GO:0007165; P:signal transduction; TAS:ProtInc.
151B7HJ25    158   ISPF_BACC4 2-C-methyl-D-erythritol 2,4-cyclod...740.73     35.4     28     51
GO:0008685; F:2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
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