FGC: Single Locus Summary

UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YDL066W

Length:

428

Number of sequences:

5887

Description:

YDL066W IDP1 SGDID:S000002224, Chr IV from 334835-336121, Genome Release 64-1-1, Verified ORF, "Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P21954	428	IDHP_YEAST Isocitrate dehydrogenase [NADP], m...	428	0	887	100	100	GO:0042645; C:mitochondrial nucleoid; IDA:SGD.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0006537; P:glutamate biosynthetic process; IMP:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
2	O13285	430	IDH1_CANTR Isocitrate dehydrogenase [NADP], m...	423	0	646	74	85	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
3	P41939	412	IDHC_YEAST Isocitrate dehydrogenase [NADP] cy...	411	0	638	73	87	GO:0005829; C:cytosol; IDA:SGD.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006537; P:glutamate biosynthetic process; TAS:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IMP:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
4	P79089	498	IDHP_ASPNG Isocitrate dehydrogenase [NADP], m...	425	0	640	72	83	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
5	O13294	411	IDH2_CANTR Isocitrate dehydrogenase [NADP] pe...	411	0	625	72	84	GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
6	P53982	420	IDHH_YEAST Isocitrate dehydrogenase [NADP] OS...	405	0	601	70	84	GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005777; C:peroxisome; IDA:SGD.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006635; P:fatty acid beta-oxidation; IMP:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; TAS:SGD.::GO:0006740; P:NADPH regeneration; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
7	O14254	439	IDHP_SCHPO Probable isocitrate dehydrogenase ...	424	0	572	66	79	GO:0005739; C:mitochondrion; IDA:PomBase.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006537; P:glutamate biosynthetic process; ISS:PomBase.::GO:0006102; P:isocitrate metabolic process; ISS:PomBase.::GO:0006740; P:NADPH regeneration; ISS:PomBase.::GO:0006099; P:tricarboxylic acid cycle; IC:PomBase.
8	P41562	414	IDHC_RAT Isocitrate dehydrogenase [NADP] cyto...	404	0	555	67	80	GO:0005777; C:peroxisome; IDA:HGNC.::GO:0005625; C:soluble fraction; IDA:RGD.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050661; F:NADP binding; IDA:RGD.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0008585; P:female gonad development; IEP:RGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0014070; P:response to organic cyclic compound; IDA:RGD.::GO:0048545; P:response to steroid hormone stimulus; IDA:RGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
9	Q5R9C5	414	IDHC_PONAB Isocitrate dehydrogenase [NADP] cy...	401	0	553	67	81
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
10	O75874	414	IDHC_HUMAN Isocitrate dehydrogenase [NADP] cy...	401	0	552	67	81	GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005782; C:peroxisomal matrix; TAS:Reactome.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
									GO:0006103; P:2-oxoglutarate metabolic process; IDA:UniProtKB.::GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IDA:UniProtKB.::GO:0006740; P:NADPH regeneration; TAS:Reactome.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
11	Q6XUZ5	414	IDHC_SHEEP Isocitrate dehydrogenase [NADP] cy...	402	0	551	67	80	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
12	O88844	414	IDHC_MOUSE Isocitrate dehydrogenase [NADP] cy...	404	0	551	67	80	GO:0005829; C:cytosol; IDA:MGI.::GO:0005739; C:mitochondrion; IDA:MGI.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; IMP:MGI.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; IDA:MGI.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
13	P50218	415	IDHC_TOBAC Isocitrate dehydrogenase [NADP] OS...	411	0	547	65	77	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
14	Q9Z2K8	414	IDHC_MICOH Isocitrate dehydrogenase [NADP] cy...	404	0	546	66	79	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
15	P50217	416	IDHC_SOLTU Isocitrate dehydrogenase [NADP] OS...	413	0	546	64	77	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
16	Q9XSG3	414	IDHC_BOVIN Isocitrate dehydrogenase [NADP] cy...	402	0	545	67	80	GO:0005829; C:cytosol; ISS:AgBase.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; ISS:AgBase.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:AgBase.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
17	P50215	406	IDH_SPHYA Isocitrate dehydrogenase [NADP] OS=...	407	0	545	64	79
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
18	Q9Z2K9	414	IDHC_MICME Isocitrate dehydrogenase [NADP] cy...	404	0	545	66	79	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
19	Q40345	433	IDHP_MEDSA Isocitrate dehydrogenase [NADP], c...	421	0	545	63	77	GO:0009507; C:chloroplast; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
20	Q06197	413	IDHC_SOYBN Isocitrate dehydrogenase [NADP] OS...	416	0	542	64	76	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
21	Q75JR2	428	IDHP_DICDI Isocitrate dehydrogenase [NADP], m...	430	0	541	61	77	GO:0005739; C:mitochondrion; ISS:dictyBase.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
22	P33198	421	IDHP_PIG Isocitrate dehydrogenase [NADP], mit...	420	0	540	62	77	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
23	P54071	452	IDHP_MOUSE Isocitrate dehydrogenase [NADP], m...	417	0	538	63	77	GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
24	Q04467	452	IDHP_BOVIN Isocitrate dehydrogenase [NADP], m...	417	0	537	62	76	GO:0005743; C:mitochondrial inner membrane; ISS:AgBase.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
25	P56574	452	IDHP_RAT Isocitrate dehydrogenase [NADP], mit...	417	0	534	62	76
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
26	Q4R502	452	IDHP_MACFA Isocitrate dehydrogenase [NADP], m...	419	0	532	62	76	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
27	P48735	452	IDHP_HUMAN Isocitrate dehydrogenase [NADP], m...	417	0	531	62	76	GO:0005759; C:mitochondrial matrix; TAS:Reactome.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; TAS:Reactome.
28	P65097	409	IDH_MYCTU Isocitrate dehydrogenase [NADP] OS=...	408	0	519	62	76	GO:0005886; C:plasma membrane; IDA:MTBBASE.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IDA:MTBBASE.::GO:0000287; F:magnesium ion binding; IDA:MTBBASE.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:MTBBASE.::GO:0008270; F:zinc ion binding; IDA:MTBBASE.
									GO:0006097; P:glyoxylate cycle; IDA:MTBBASE.::GO:0006102; P:isocitrate metabolic process; IDA:MTBBASE.::GO:0006099; P:tricarboxylic acid cycle; IDA:MTBBASE.
29	P65098	409	IDH_MYCBO Isocitrate dehydrogenase [NADP] OS=...	408	0	519	62	76
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
30	Q75JR3	412	IDHC_DICDI Isocitrate dehydrogenase [NADP] cy...	414	2e-177	509	60	76	GO:0005829; C:cytosol; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
31	Q55BI2	354	IDHA_DICDI Isocitrate dehydrogenase [NAD] reg...	433	0.00000001	60.1	24	40	GO:0005739; C:mitochondrion; ISS:UniProtKB.
									GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.

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