Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YDL008W
Length:
165
Number of sequences:
5887
Description:
YDL008W APC11 SGDID:S000002166, Chr IV from 433497-433994, Genome Release 64-1-1, Verified ORF, "Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2 domain that is required for activity"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1Q12157    165   APC11_YEAST Anaphase-promoting complex subuni...1652e-121     346     100     100GO:0005680; C:anaphase-promoting complex; IDA:SGD.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; IMP:SGD.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
2Q9M9L0    84   APC11_ARATH Anaphase-promoting complex subuni...1027e-25     97.1     42     61GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.
3Q9UT86    94   APC11_SCHPO Anaphase-promoting complex subuni...982e-23     94     47     55GO:0005680; C:anaphase-promoting complex; IDA:PomBase.
GO:0005515; F:protein binding; IPI:PomBase.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; IC:PomBase.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0008054; P:cyclin catabolic process; IC:PomBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0030071; P:regulation of mitotic metaphase/anaphase transition; IC:PomBase.
4Q9CPX9    84   APC11_MOUSE Anaphase-promoting complex subuni...1021e-21     88.6     44     56GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
5Q3ZCF6    84   APC11_BOVIN Anaphase-promoting complex subuni...1023e-21     87.8     43     56GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
6Q5R8A2    84   APC11_PONAB Anaphase-promoting complex subuni...1023e-21     87.4     44     55GO:0005680; C:anaphase-promoting complex; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.
7Q9NYG5    84   APC11_HUMAN Anaphase-promoting complex subuni...1023e-21     87.4     44     55GO:0005680; C:anaphase-promoting complex; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; TAS:UniProtKB.::GO:0007094; P:mitotic cell cycle spindle assembly checkpoint; TAS:Reactome.::GO:0051436; P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.
8Q54L48    87   APC11_DICDI Anaphase-promoting complex subuni...1028e-17     75.9     39     55GO:0005680; C:anaphase-promoting complex; ISS:dictyBase.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:dictyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:dictyBase.
9O13959    107   RBX1_SCHPO RING-box protein pip1 OS=Schizosac...690.0000009     48.1     35     52GO:0031465; C:Cul4B-RING ubiquitin ligase complex; TAS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:PomBase.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10Q54K33    104   RBX1_DICDI RING-box protein 1 OS=Dictyosteliu...690.000001     47.8     35     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
11Q8QG64    108   RBX1_SALSA RING-box protein 1 OS=Salmo salar ...690.000001     47.8     35     52GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0031464; C:Cul4A-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0031465; C:Cul4B-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
GO:0019788; F:NEDD8 ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.::GO:0045116; P:protein neddylation; ISS:UniProtKB.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.
12Q940X7    118   RBX1A_ARATH RING-box protein 1a OS=Arabidopsi...690.000002     47.4     35     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; IPI:TAIR.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; TAS:TAIR.::GO:0009733; P:response to auxin stimulus; IMP:TAIR.
13P62878    108   RBX1_MOUSE E3 ubiquitin-protein ligase RBX1 O...690.000002     47.4     35     52GO:0005680; C:anaphase-promoting complex; TAS:UniProtKB.::GO:0031463; C:Cul3-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0031464; C:Cul4A-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0031465; C:Cul4B-RING ubiquitin ligase complex; ISS:UniProtKB.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
GO:0008190; F:eukaryotic initiation factor 4E binding; TAS:UniProtKB.::GO:0019788; F:NEDD8 ligase activity; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.::GO:0045116; P:protein neddylation; ISS:UniProtKB.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
14P62877    108   RBX1_HUMAN E3 ubiquitin-protein ligase RBX1 O...690.000002     47.4     35     52GO:0031462; C:Cul2-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0031463; C:Cul3-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0031464; C:Cul4A-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0031465; C:Cul4B-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0031466; C:Cul5-RING ubiquitin ligase complex; IDA:UniProtKB.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
GO:0019788; F:NEDD8 ligase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.::GO:0045116; P:protein neddylation; IDA:UniProtKB.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome.
15Q23457    110   RBX1_CAEEL RING-box protein 1 OS=Caenorhabdit...690.000002     47     36     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008595; P:anterior/posterior axis specification, embryo; IMP:WormBase.::GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0008406; P:gonad development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0007138; P:meiotic anaphase II; IMP:WormBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0035046; P:pronuclear migration; IMP:WormBase.::GO:0051759; P:sister chromosome movement towards spindle pole involved in meiotic sister chromatid segregation; IMP:WormBase.
16Q9W5E1    108   RBX1A_DROME RING-box protein 1A OS=Drosophila...690.000003     47     35     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:FlyBase.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0008283; P:cell proliferation; IMP:FlyBase.::GO:0019915; P:lipid storage; IDA:FlyBase.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006508; P:proteolysis; IMP:FlyBase.::GO:0007224; P:smoothened signaling pathway; NAS:UniProtKB.
17Q9NHX0    122   RBX1B_DROME RING-box protein 1B OS=Drosophila...740.00001     45.8     36     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; IDA:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IGI:FlyBase.::GO:0008283; P:cell proliferation; ISS:UniProtKB.::GO:0019915; P:lipid storage; IDA:FlyBase.::GO:0030317; P:sperm motility; IMP:FlyBase.
18Q9UBF6    113   RBX2_HUMAN RING-box protein 2 OS=Homo sapiens...700.00001     45.1     33     51GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0005634; C:nucleus; NAS:UniProtKB.
GO:0005507; F:copper ion binding; TAS:ProtInc.::GO:0019788; F:NEDD8 ligase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0006916; P:anti-apoptosis; TAS:ProtInc.::GO:0008631; P:induction of apoptosis by oxidative stress; TAS:ProtInc.::GO:0045116; P:protein neddylation; IDA:UniProtKB.::GO:0051775; P:response to redox state; TAS:ProtInc.
19Q9WTZ1    113   RBX2_MOUSE RING-box protein 2 OS=Mus musculus...700.00002     45.1     33     51GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
GO:0019788; F:NEDD8 ligase activity; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:MGI.::GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0008637; P:apoptotic mitochondrial changes; IDA:MGI.::GO:0008631; P:induction of apoptosis by oxidative stress; IDA:MGI.::GO:0045116; P:protein neddylation; ISS:UniProtKB.
20Q9M2B0    115   RBX1B_ARATH RING-box protein 1b OS=Arabidopsi...680.00002     44.7     37     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
21Q08273    121   RBX1_YEAST RING-box protein HRT1 OS=Saccharom...690.00004     43.9     33     49GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:SGD.::GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:SGD.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:SGD.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:SGD.
22Q5UQ40    1297   UBC4_MIMIV Probable bifunctional E2/E3 enzyme...1170.00007     45.4     31     45GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
23O74349    1610   LTN1_SCHPO E3 ubiquitin-protein ligase lister...630.0001     45.1     33     46GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006342; P:chromatin silencing; NAS:PomBase.::GO:0070481; P:nuclear-transcribed mRNA catabolic process, non-stop decay; ISS:PomBase.
24A0JM49    1696   LTN1_XENTR E3 ubiquitin-protein ligase lister...580.0002     44.3     36     52
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
25E1C231    1766   LTN1_CHICK E3 ubiquitin-protein ligase lister...580.0003     43.9     36     52
GO:0008270; F:zinc ion binding; IEA:InterPro.
26Q555H8    1864   LTN1_DICDI E3 ubiquitin-protein ligase lister...580.0005     43.1     41     55
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
27Q6A009    1767   LTN1_MOUSE E3 ubiquitin-protein ligase lister...580.0008     42.4     36     50
GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
28O94822    1766   LTN1_HUMAN E3 ubiquitin-protein ligase lister...580.0008     42.4     36     50
GO:0008270; F:zinc ion binding; IEA:InterPro.
29Q3T0W3    153   RN181_BOVIN E3 ubiquitin-protein ligase RNF18...1000.001     40.4     26     40
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
30Q8LE94    231   RING3_ARATH E3 ubiquitin-protein ligase At3g0...670.003     40.4     30     46GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
31Q9R049    643   AMFR_MOUSE E3 ubiquitin-protein ligase AMFR O...910.005     40     29     41GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030433; P:ER-associated protein catabolic process; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
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