Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCR066W
Length:
487
Number of sequences:
5887
Description:
YCR066W RAD18 SGDID:S000000662, Chr III from 231500-232963, Genome Release 64-1-1, Verified ORF, "E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
511Q7TMI3    803   UHRF2_MOUSE E3 ubiquitin-protein ligase UHRF2...731.8     35     25     48GO:0005720; C:nuclear heterochromatin; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:HGNC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; ISS:HGNC.::GO:0008283; P:cell proliferation; ISS:HGNC.::GO:0071158; P:positive regulation of cell cycle arrest; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:HGNC.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:HGNC.
512A6NMD1    445   TR43C_HUMAN Putative tripartite motif-contain...421.8     34.7     43     52GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
513Q5TJF3    406   RING1_CANFA E3 ubiquitin-protein ligase RING1...461.8     34.7     46     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
514Q96S55    665   WRIP1_HUMAN ATPase WRNIP1 OS=Homo sapiens (Hu...291.8     35     48     59GO:0005739; C:mitochondrion; IDA:HPA.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016887; F:ATPase activity; IMP:UniProtKB.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0000731; P:DNA synthesis involved in DNA repair; IDA:UniProtKB.::GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IDA:UniProtKB.
515Q9LS86    480   DRIPH_ARATH Probable E3 ubiquitin protein lig...791.9     34.7     33     48
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
516Q86Y13    1208   DZIP3_HUMAN E3 ubiquitin-protein ligase DZIP3...531.9     35     40     45GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0019902; F:phosphatase binding; IDA:UniProtKB.::GO:0031593; F:polyubiquitin binding; IDA:UniProtKB.::GO:0003723; F:RNA binding; IDA:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
517Q3ZCC3    542   TRAF6_BOVIN TNF receptor-associated factor 6 ...312     34.7     48     58GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
518Q8R079    450   BFAR_MOUSE Bifunctional apoptosis regulator O...402     34.7     38     48GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
519Q8LBL5    410   PRT1_ARATH E3 ubiquitin-protein ligase PRT1 O...275.8     33.1     44     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
520Q3C1W6    446   YK031_HUMAN Tripartite motif-containing prote...532     34.7     30     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
521B5DF45    530   TRAF6_RAT TNF receptor-associated factor 6 OS...442.1     34.7     39     55GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:RGD.::GO:0007254; P:JNK cascade; IMP:RGD.::GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:RGD.::GO:0006461; P:protein complex assembly; IMP:RGD.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
522A2AWP0    285   BIRC7_MOUSE Baculoviral IAP repeat-containing...472.1     34.3     38     45GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0004869; F:cysteine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042127; P:regulation of cell proliferation; ISS:UniProtKB.::GO:0070247; P:regulation of natural killer cell apoptotic process; ISS:UniProtKB.
523P70196    530   TRAF6_MOUSE TNF receptor-associated factor 6 ...312.1     34.7     48     58GO:0035631; C:CD40 receptor complex; IDA:BHF-UCL.::GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0009898; C:internal side of plasma membrane; IDA:BHF-UCL.::GO:0005624; C:membrane fraction; IDA:UniProtKB.
GO:0004871; F:signal transducer activity; TAS:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IMP:MGI.::GO:0045453; P:bone resorption; IMP:UniProtKB.::GO:0048468; P:cell development; IMP:MGI.::GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:UniProtKB.::GO:0043011; P:myeloid dendritic cell differentiation; IMP:MGI.::GO:0001843; P:neural tube closure; IMP:UniProtKB.::GO:0042475; P:odontogenesis of dentin-containing tooth; IMP:MGI.::GO:0001503; P:ossification; IMP:MGI.::GO:0030316; P:osteoclast differentiation; IMP:UniProtKB.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.::GO:0045084; P:positive regulation of interleukin-12 biosynthetic process; IMP:MGI.::GO:0045410; P:positive regulation of interleukin-6 biosynthetic process; IMP:MGI.::GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; IMP:UniProtKB.::GO:0042102; P:positive regulation of T cell proliferation; IMP:UniProtKB.::GO:0051865; P:protein autoubiquitination; TAS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.::GO:0051023; P:regulation of immunoglobulin secretion; IDA:MGI.::GO:0042088; P:T-helper 1 type immune response; IMP:MGI.
524Q6ZWI9    263   RFPLB_HUMAN Ret finger protein-like 4B OS=Hom...492.1     34.3     33     49
GO:0008270; F:zinc ion binding; IEA:InterPro.
525A7XUJ6    541   TRAF6_PIG TNF receptor-associated factor 6 OS...312.1     34.7     48     58GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
526A2T6X5    377   RING1_PANTR E3 ubiquitin-protein ligase RING1...462.1     34.3     46     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
527A1YFY1    377   RING1_PANPA E3 ubiquitin-protein ligase RING1...462.1     34.3     46     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
528Q8WMN5    377   RING1_MACMU E3 ubiquitin-protein ligase RING1...462.1     34.3     46     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
529A1YER5    377   RING1_GORGO E3 ubiquitin-protein ligase RING1...462.1     34.3     46     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
530Q3UE17    643   MEX3D_MOUSE RNA-binding protein MEX3D OS=Mus ...402.1     34.7     38     53GO:0005634; C:nucleus; ISS:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL.
GO:0017091; F:AU-rich element binding; ISS:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0061157; P:mRNA destabilization; NAS:BHF-UCL.::GO:0045767; P:regulation of anti-apoptosis; NAS:BHF-UCL.
531Q5F3B2    244   RN166_CHICK RING finger protein 166 OS=Gallus...702.1     33.9     31     46GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
532Q9Y4K3    522   TRAF6_HUMAN TNF receptor-associated factor 6 ...312.2     34.7     48     58GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.::GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0010008; C:endosome membrane; TAS:Reactome.::GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL.::GO:0031965; C:nuclear membrane; IDA:HPA.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:UniProtKB.::GO:0043422; F:protein kinase B binding; IPI:UniProtKB.::GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000187; P:activation of MAPK activity; TAS:Reactome.::GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IMP:UniProtKB.::GO:0006916; P:anti-apoptosis; TAS:Reactome.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007249; P:I-kappaB kinase/NF-kappaB cascade; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0007254; P:JNK cascade; TAS:Reactome.::GO:0031293; P:membrane protein intracellular domain proteolysis; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0070423; P:nucleotide-binding oligomerization domain containing signaling pathway; TAS:Reactome.::GO:0001503; P:ossification; IEA:UniProtKB-KW.::GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.::GO:0032743; P:positive regulation of interleukin-2 production; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; NAS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:0045672; P:positive regulation of osteoclast differentiation; IDA:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; IC:UniProtKB.::GO:0002726; P:positive regulation of T cell cytokine production; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:2000679; P:positive regulation of transcription regulatory region DNA binding; IDA:BHF-UCL.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0070555; P:response to interleukin-1; IDA:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; IMP:UniProtKB.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome.
533Q7ZUL9    529   MGRN1_DANRE Probable E3 ubiquitin-protein lig...472.4     34.3     34     47
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
534Q505D9    768   TRI67_MOUSE Tripartite motif-containing prote...362.4     34.7     33     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
535A6NGJ6    449   TRI64_HUMAN Tripartite motif-containing prote...432.4     34.3     40     51GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
536B6CJY4    522   TRAF6_CERAT TNF receptor-associated factor 6 ...312.5     34.3     48     58GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
537A6NI03    449   TR64B_HUMAN Putative tripartite motif-contain...432.5     34.3     40     51GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
538B6CJY5    522   TRAF6_MACMU TNF receptor-associated factor 6 ...312.5     34.3     48     58GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
539Q9M9Y4    421   DRIP1_ARATH E3 ubiquitin protein ligase DRIP1...432.5     34.3     35     49GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
540Q6ZTA4    783   TRI67_HUMAN Tripartite motif-containing prote...292.5     34.7     38     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
541Q69Z36    601   MEX3B_MOUSE RNA-binding protein MEX3B OS=Mus ...402.7     34.3     38     53GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
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