Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCR066W
Length:
487
Number of sequences:
5887
Description:
YCR066W RAD18 SGDID:S000000662, Chr III from 231500-232963, Genome Release 64-1-1, Verified ORF, "E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
481Q7KRW1    809   TRC8_DROME Protein TRC8 homolog OS=Drosophila...381     35.8     39     50GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045926; P:negative regulation of growth; IMP:UniProtKB.::GO:0007418; P:ventral midline development; IMP:UniProtKB.
482A8Y4B2    622   HRD1_CAEBR E3 ubiquitin-protein ligase hrd-1 ...411     35.8     37     51GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
483Q7TNM2    759   TRI46_MOUSE Tripartite motif-containing prote...421     35.8     33     52GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
484Q803I4    336   RING2_DANRE E3 ubiquitin-protein ligase RING2...461     35.4     43     52GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
485Q91829    1045   RAG1_XENLA V(D)J recombination-activating pro...411.1     35.8     37     51GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0004519; F:endonuclease activity; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0030183; P:B cell differentiation; ISS:UniProtKB.::GO:0010390; P:histone monoubiquitination; ISS:UniProtKB.::GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.::GO:0033151; P:V(D)J recombination; ISS:UniProtKB.
486Q4KLY4    308   RING2_RAT E3 ubiquitin-protein ligase RING2 O...461.1     35     43     52GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0016567; P:protein ubiquitination; ISS:GOC.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
487Q96PU4    802   UHRF2_HUMAN E3 ubiquitin-protein ligase UHRF2...731.2     35.4     26     48GO:0005720; C:nuclear heterochromatin; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:HGNC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEP:HGNC.::GO:0008283; P:cell proliferation; IEP:HGNC.::GO:0071158; P:positive regulation of cell cycle arrest; IDA:UniProtKB.::GO:0051865; P:protein autoubiquitination; IDA:HGNC.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IDA:HGNC.
488P19474    475   RO52_HUMAN E3 ubiquitin-protein ligase TRIM21...431.2     35.4     40     47GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:0090086; P:negative regulation of protein deubiquitination; IMP:UniProtKB.::GO:0045787; P:positive regulation of cell cycle; IMP:UniProtKB.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0031648; P:protein destabilization; IMP:UniProtKB.::GO:0006513; P:protein monoubiquitination; IDA:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.::GO:0070206; P:protein trimerization; IDA:UniProtKB.
489Q9SPL2    334   CIP8_ARATH E3 ubiquitin-protein ligase CIP8 O...501.2     35     30     52GO:0005737; C:cytoplasm; IDA:TAIR.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016567; P:protein ubiquitination; IDA:TAIR.
490A6NLI5    447   TR64C_HUMAN Putative tripartite motif-contain...431.2     35.4     42     53GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
491Q7TPV2    1204   DZIP3_MOUSE E3 ubiquitin-protein ligase DZIP3...401.2     35.8     45     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0019902; F:phosphatase binding; ISS:UniProtKB.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
492O00635    465   TRI38_HUMAN Tripartite motif-containing prote...681.2     35.4     29     40GO:0005622; C:intracellular; IEA:InterPro.
GO:0004871; F:signal transducer activity; IMP:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; IMP:UniProtKB.
493Q9VB08    435   RING1_DROME E3 ubiquitin-protein ligase RING1...461.3     35     46     52GO:0008278; C:cohesin complex; IDA:UniProtKB.::GO:0035102; C:PRC1 complex; TAS:FlyBase.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006342; P:chromatin silencing; IDA:UniProtKB.::GO:0030708; P:germarium-derived female germ-line cyst encapsulation; IMP:FlyBase.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0022008; P:neurogenesis; IMP:FlyBase.::GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase.::GO:0045498; P:sex comb development; IDA:UniProtKB.::GO:0007062; P:sister chromatid cohesion; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
494O35730    406   RING1_MOUSE E3 ubiquitin-protein ligase RING1...461.3     35     46     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0001739; C:sex chromatin; IDA:MGI.::GO:0000151; C:ubiquitin ligase complex; IDA:MGI.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.::GO:0048593; P:camera-type eye morphogenesis; IGI:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
495Q9C6H4    366   SINL1_ARATH E3 ubiquitin-protein ligase SINA-...591.4     35     36     53GO:0005634; C:nucleus; IEA:InterPro.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007275; P:multicellular organismal development; IEA:InterPro.::GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:InterPro.
496Q5RAG4    444   RNFT2_PONAB RING finger and transmembrane dom...371.4     35     35     54GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
497Q6MGB6    406   RING1_RAT E3 ubiquitin-protein ligase RING1 O...461.5     35     46     52GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
498Q5ZMD4    408   TRI59_CHICK Tripartite motif-containing prote...341.6     35     38     56GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
499Q32LN5    245   RN138_BOVIN E3 ubiquitin-protein ligase RNF13...421.6     34.3     40     52GO:0005622; C:intracellular; IEA:InterPro.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
500E1BD59    732   TRI56_BOVIN E3 ubiquitin-protein ligase TRIM5...621.6     35     37     52GO:0005737; C:cytoplasm; ISS:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051607; P:defense response to virus; ISS:UniProtKB.::GO:0032608; P:interferon-beta production; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0034340; P:response to type I interferon; ISS:UniProtKB.
501Q5PQN2    450   BFAR_RAT Bifunctional apoptosis regulator OS=...401.7     34.7     38     48GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
502P09309    467   IE61_VZVD E3 ubiquitin-protein ligase IE61 OS...1381.7     34.7     26     34
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
503Q28DL4    558   TRAF6_XENTR TNF receptor-associated factor 6 ...441.7     35     39     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro.
504Q06587    406   RING1_HUMAN E3 ubiquitin-protein ligase RING1...461.7     34.7     46     52GO:0005737; C:cytoplasm; IDA:HPA.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.::GO:0035102; C:PRC1 complex; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
GO:0035518; P:histone H2A monoubiquitination; IDA:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
505O60177    1040   YG42_SCHPO Uncharacterized ATP-dependent heli...871.7     35     26     46GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0000790; C:nuclear chromatin; ISS:PomBase.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0006281; P:DNA repair; ISS:PomBase.
506Q91XU0    660   WRIP1_MOUSE ATPase WRNIP1 OS=Mus musculus (Mo...291.7     35     48     59GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016887; F:ATPase activity; ISS:UniProtKB.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0000731; P:DNA synthesis involved in DNA repair; ISS:UniProtKB.::GO:0030174; P:regulation of DNA-dependent DNA replication initiation; ISS:UniProtKB.
507Q7YRV4    469   RO52_BOVIN E3 ubiquitin-protein ligase TRIM21...581.8     34.7     33     45GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0090086; P:negative regulation of protein deubiquitination; ISS:UniProtKB.::GO:0045787; P:positive regulation of cell cycle; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0031648; P:protein destabilization; ISS:UniProtKB.::GO:0006513; P:protein monoubiquitination; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
508Q7XI73    321   BAHL2_ORYSJ Probable E3 ubiquitin-protein lig...311.8     34.7     45     58
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
509Q8CG07    660   WRIP1_RAT ATPase WRNIP1 OS=Rattus norvegicus ...291.8     35     48     59GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0016887; F:ATPase activity; ISS:UniProtKB.::GO:0003677; F:DNA binding; IEA:InterPro.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0006260; P:DNA replication; IEA:UniProtKB-KW.::GO:0000731; P:DNA synthesis involved in DNA repair; ISS:UniProtKB.::GO:0030174; P:regulation of DNA-dependent DNA replication initiation; ISS:UniProtKB.
510B8B5U8    321   BAHL2_ORYSI Probable E3 ubiquitin-protein lig...311.8     34.7     45     58
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
511Q7TMI3    803   UHRF2_MOUSE E3 ubiquitin-protein ligase UHRF2...731.8     35     25     48GO:0005720; C:nuclear heterochromatin; IDA:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:HGNC.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; ISS:HGNC.::GO:0008283; P:cell proliferation; ISS:HGNC.::GO:0071158; P:positive regulation of cell cycle arrest; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:HGNC.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:HGNC.
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