Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCR066W
Length:
487
Number of sequences:
5887
Description:
YCR066W RAD18 SGDID:S000000662, Chr III from 231500-232963, Genome Release 64-1-1, Verified ORF, "E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
451Q5RBG2    492   TRI35_PONAB Tripartite motif-containing prote...420.6     36.2     38     48GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
452Q08DF2    628   RN112_BOVIN RING finger protein 112 OS=Bos ta...530.62     36.2     38     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
453Q2YEN0    495   TRIM5_MACNE Tripartite motif-containing prote...730.63     36.2     25     47GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
454Q922B6    594   TRAF7_MOUSE E3 ubiquitin-protein ligase TRAF7...260.63     36.2     54     62GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000185; P:activation of MAPKKK activity; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0042981; P:regulation of apoptotic process; ISS:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
455Q9ULX5    631   RN112_HUMAN RING finger protein 112 OS=Homo s...450.64     36.2     42     51GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0003924; F:GTPase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; NAS:UniProtKB.
456Q9NZS9    450   BFAR_HUMAN Bifunctional apoptosis regulator O...400.64     36.2     38     48GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0005624; C:membrane fraction; IDA:MGI.
GO:0005198; F:structural molecule activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
457Q7T308    474   RN168_DANRE E3 ubiquitin-protein ligase RNF16...390.69     36.2     41     51GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0043130; F:ubiquitin binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006302; P:double-strand break repair; ISS:UniProtKB.::GO:0070535; P:histone H2A K63-linked ubiquitination; ISS:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
458Q6BYU0    232   CWC24_DEBHA Pre-mRNA-splicing factor CWC24 OS...420.69     35.4     38     45GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
459Q91648    326   BMI1A_XENLA Polycomb complex protein BMI-1-A ...540.71     35.8     33     50GO:0031519; C:PcG protein complex; ISS:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
460Q60953    885   PML_MOUSE Protein PML OS=Mus musculus (Mouse)...410.75     36.2     41     49GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0042406; C:extrinsic to endoplasmic reticulum membrane; IDA:UniProtKB.::GO:0005626; C:insoluble fraction; ISS:UniProtKB.::GO:0016363; C:nuclear matrix; IDA:MGI.::GO:0005730; C:nucleolus; ISS:UniProtKB.::GO:0016605; C:PML body; IMP:UniProtKB.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0046332; F:SMAD binding; IDA:MGI.::GO:0003713; F:transcription coactivator activity; TAS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:MGI.::GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.::GO:0007569; P:cell aging; IMP:UniProtKB.::GO:0007050; P:cell cycle arrest; IMP:UniProtKB.::GO:0045165; P:cell fate commitment; IMP:MGI.::GO:0007182; P:common-partner SMAD protein phosphorylation; IMP:MGI.::GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IMP:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; IMP:UniProtKB.::GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; IMP:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0030099; P:myeloid cell differentiation; IMP:MGI.::GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0030578; P:PML body organization; IDA:MGI.::GO:0031065; P:positive regulation of histone deacetylation; ISS:UniProtKB.::GO:0006461; P:protein complex assembly; ISS:UniProtKB.::GO:0010522; P:regulation of calcium ion transport into cytosol; IMP:UniProtKB.::GO:0045343; P:regulation of MHC class I biosynthetic process; IDA:MGI.::GO:0001932; P:regulation of protein phosphorylation; IMP:UniProtKB.::GO:0010332; P:response to gamma radiation; IMP:MGI.::GO:0001666; P:response to hypoxia; ISS:UniProtKB.::GO:0009411; P:response to UV; IMP:MGI.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.::GO:0048384; P:retinoic acid receptor signaling pathway; IMP:MGI.::GO:0007184; P:SMAD protein import into nucleus; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:MGI.
461Q86XN8    651   MEX3D_HUMAN RNA-binding protein MEX3D OS=Homo...520.76     36.2     37     48GO:0005634; C:nucleus; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0017091; F:AU-rich element binding; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0061157; P:mRNA destabilization; NAS:BHF-UCL.::GO:0010609; P:posttranscriptional regulation of gene expression by mRNA localization; NAS:BHF-UCL.::GO:0045767; P:regulation of anti-apoptosis; NAS:BHF-UCL.
462Q6FWF3    693   BRE1_CANGA E3 ubiquitin-protein ligase BRE1 O...430.77     36.2     35     47GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
463Q7ZWM8    343   RNG2B_XENLA E3 ubiquitin-protein ligase RING2...460.78     35.8     46     52GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
464Q80VI1    734   TRI56_MOUSE E3 ubiquitin-protein ligase TRIM5...420.79     36.2     38     50GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051607; P:defense response to virus; IMP:UniProtKB.::GO:0032608; P:interferon-beta production; IMP:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0034340; P:response to type I interferon; IDA:UniProtKB.
465Q9C029    511   TRIM7_HUMAN Tripartite motif-containing prote...250.81     35.8     48     60GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0008270; F:zinc ion binding; IEA:InterPro.
466Q66J69    344   RNG2A_XENLA E3 ubiquitin-protein ligase RING2...460.83     35.8     46     52GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
467Q8WVD3    245   RN138_HUMAN E3 ubiquitin-protein ligase RNF13...420.84     35.4     40     52GO:0005622; C:intracellular; IEA:InterPro.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
468Q9CQE0    245   RN138_MOUSE E3 ubiquitin-protein ligase RNF13...540.85     35.4     39     50GO:0005622; C:intracellular; IEA:InterPro.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
469Q99496    336   RING2_HUMAN E3 ubiquitin-protein ligase RING2...460.89     35.4     43     52GO:0071339; C:MLL1 complex; IDA:UniProtKB.::GO:0035102; C:PRC1 complex; IDA:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; IDA:UniProtKB.
GO:0071535; F:RING-like zinc finger domain binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0035518; P:histone H2A monoubiquitination; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
470Q28DS3    257   RN170_XENTR RING finger protein 170 OS=Xenopu...430.89     35.4     37     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
471P40072    274   SLX8_YEAST E3 ubiquitin-protein ligase comple...500.9     35.4     32     46GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0000151; C:ubiquitin ligase complex; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0016925; P:protein sumoylation; IMP:SGD.::GO:0000723; P:telomere maintenance; IMP:SGD.
472Q8VDF2    782   UHRF1_MOUSE E3 ubiquitin-protein ligase UHRF1...550.91     35.8     31     45GO:0000792; C:heterochromatin; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0008283; P:cell proliferation; TAS:MGI.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
473Q3U827    592   RN180_MOUSE E3 ubiquitin-protein ligase RNF18...600.91     35.8     33     48GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0031227; C:intrinsic to endoplasmic reticulum membrane; IDA:MGI.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
GO:0031624; F:ubiquitin conjugating enzyme binding; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032436; P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process; IDA:MGI.
474Q5R9J5    336   RING2_PONAB E3 ubiquitin-protein ligase RING2...460.92     35.4     43     52GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0035102; C:PRC1 complex; ISS:UniProtKB.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0016567; P:protein ubiquitination; ISS:GOC.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
475Q9CQJ4    336   RING2_MOUSE E3 ubiquitin-protein ligase RING2...460.93     35.4     43     52GO:0071339; C:MLL1 complex; ISS:UniProtKB.::GO:0016604; C:nuclear body; IDA:MGI.::GO:0001739; C:sex chromatin; IDA:MGI.::GO:0000151; C:ubiquitin ligase complex; ISS:UniProtKB.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:MGI.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0009948; P:anterior/posterior axis specification; IMP:MGI.::GO:0001702; P:gastrulation with mouth forming second; IMP:MGI.::GO:0000278; P:mitotic cell cycle; IMP:MGI.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
476Q9TSW0    461   TRI15_PIG Tripartite motif-containing protein...450.94     35.8     38     51GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
477Q6DJN2    556   TRF6B_XENLA TNF receptor-associated factor 6-...440.94     35.8     41     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
478P24271    1041   RAG1_CHICK V(D)J recombination-activating pro...910.96     35.8     30     45GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0004519; F:endonuclease activity; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0030183; P:B cell differentiation; ISS:UniProtKB.::GO:0010390; P:histone monoubiquitination; ISS:UniProtKB.::GO:0033077; P:T cell differentiation in thymus; ISS:UniProtKB.::GO:0033151; P:V(D)J recombination; ISS:UniProtKB.
479Q7Z4K8    759   TRI46_HUMAN Tripartite motif-containing prote...1618.4     32.7     23     41GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
480Q75JQ3    423   PEX2_DICDI Peroxisome biogenesis factor 2 OS=...450.97     35.4     38     53GO:0005779; C:integral to peroxisomal membrane; IC:dictyBase.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007031; P:peroxisome organization; ISS:dictyBase.
481Q7KRW1    809   TRC8_DROME Protein TRC8 homolog OS=Drosophila...381     35.8     39     50GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045926; P:negative regulation of growth; IMP:UniProtKB.::GO:0007418; P:ventral midline development; IMP:UniProtKB.
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