Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCR066W
Length:
487
Number of sequences:
5887
Description:
YCR066W RAD18 SGDID:S000000662, Chr III from 231500-232963, Genome Release 64-1-1, Verified ORF, "E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
271Q4P400    355   CWC24_USTMA Pre-mRNA-splicing factor CWC24 OS...880.065     39.3     28     40GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
272Q5ZM74    230   RN141_CHICK RING finger protein 141 OS=Gallus...380.065     38.9     39     58
GO:0008270; F:zinc ion binding; IEA:InterPro.
273Q2T9Z0    475   TRI17_BOVIN E3 ubiquitin-protein ligase TRIM1...260.065     39.3     54     65GO:0005622; C:intracellular; IEA:InterPro.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
274O17917    384   RN113_CAEEL RING finger protein 113 homolog O...380.065     39.3     34     47
GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0007281; P:germ cell development; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0042127; P:regulation of cell proliferation; IMP:WormBase.::GO:0040020; P:regulation of meiosis; IMP:WormBase.
275Q5D7H7    547   TRIM5_LAGLA Tripartite motif-containing prote...540.067     39.3     37     48GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
276Q6J1I8    228   RN114_PIG RING finger protein 114 OS=Sus scro...390.068     38.5     41     59GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
277Q5EBN2    209   TRI61_HUMAN Putative tripartite motif-contain...550.071     38.5     40     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
278Q9VRP9    1044   BRE1_DROME E3 ubiquitin-protein ligase Bre1 O...510.073     39.7     37     47GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0016874; F:ligase activity; IMP:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016574; P:histone ubiquitination; IMP:UniProtKB.::GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.::GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.::GO:0006513; P:protein monoubiquitination; IMP:UniProtKB.
279Q9UKV5    643   AMFR2_HUMAN E3 ubiquitin-protein ligase AMFR ...380.077     39.3     39     55GO:0030176; C:integral to endoplasmic reticulum membrane; IDA:UniProtKB.::GO:0000299; C:integral to membrane of membrane fraction; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030968; P:endoplasmic reticulum unfolded protein response; IMP:UniProtKB.::GO:0030433; P:ER-associated protein catabolic process; IDA:UniProtKB.::GO:0051259; P:protein oligomerization; IDA:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.
280Q66JE4    316   RN146_XENTR E3 ubiquitin-protein ligase rnf14...670.078     38.9     36     43GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0072572; F:poly-ADP-D-ribose binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
281Q3KPU8    241   RN166_XENLA RING finger protein 166 OS=Xenopu...500.078     38.5     42     54GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
282Q6J212    228   RN114_PANTR RING finger protein 114 OS=Pan tr...390.079     38.5     41     59GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
283Q8IS11    944   GEFO_DICDI Ras guanine nucleotide exchange fa...450.081     39.3     42     58GO:0005622; C:intracellular; IEA:InterPro.
GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
284P87176    269   SLX8_SCHPO E3 ubiquitin-protein ligase comple...420.082     38.5     40     52GO:0033768; C:SUMO-targeted ubiquitin ligase complex; IPI:PomBase.
GO:0005515; F:protein binding; IPI:PomBase.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0000077; P:DNA damage checkpoint; IMP:PomBase.::GO:0006310; P:DNA recombination; IGI:PomBase.::GO:0033234; P:negative regulation of protein sumoylation; IMP:PomBase.
285Q9R049    643   AMFR_MOUSE E3 ubiquitin-protein ligase AMFR O...380.084     39.3     39     55GO:0030176; C:integral to endoplasmic reticulum membrane; ISS:UniProtKB.
GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004872; F:receptor activity; IEA:UniProtKB-KW.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030433; P:ER-associated protein catabolic process; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; ISS:UniProtKB.
286Q9Y508    228   RN114_HUMAN RING finger protein 114 OS=Homo s...390.086     38.5     41     59GO:0005622; C:intracellular; IDA:LIFEdb.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
287Q80Z37    1033   TOPRS_MOUSE E3 ubiquitin-protein ligase Topor...660.089     39.3     33     47GO:0016607; C:nuclear speck; ISS:UniProtKB.::GO:0016605; C:PML body; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:MGI.::GO:0019789; F:SUMO ligase activity; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006915; P:apoptotic process; IDA:MGI.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IGI:MGI.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0016925; P:protein sumoylation; ISS:UniProtKB.::GO:0042127; P:regulation of cell proliferation; IDA:MGI.
288A1L3F4    507   MEX3B_XENLA RNA-binding protein MEX3B OS=Xeno...400.093     38.9     45     53GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
289Q5ACX1    1084   RAD5_CANAL DNA repair protein RAD5 OS=Candida...480.095     39.3     42     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0004386; F:helicase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
290Q9NS56    1045   TOPRS_HUMAN E3 ubiquitin-protein ligase Topor...660.098     39.3     33     47GO:0016607; C:nuclear speck; IDA:UniProtKB.::GO:0016605; C:PML body; IDA:UniProtKB.
GO:0003823; F:antigen binding; IPI:UniProtKB.::GO:0003677; F:DNA binding; IDA:UniProtKB.::GO:0044547; F:DNA topoisomerase binding; IPI:UniProtKB.::GO:0019789; F:SUMO ligase activity; IDA:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; IDA:UniProtKB.::GO:0051457; P:maintenance of protein location in nucleus; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0016925; P:protein sumoylation; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; NAS:UniProtKB.
291Q5C8U1    494   TRIM5_SAGLB Tripartite motif-containing prote...640.1     38.9     33     48GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
292D3ZXK7    1318   RN123_RAT E3 ubiquitin-protein ligase RNF123 ...380.1     38.9     42     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
293Q1ACD5    494   TRIM5_SAGOE Tripartite motif-containing prote...640.11     38.9     33     48GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
294Q02084    625   A33_PLEWA Zinc-binding protein A33 OS=Pleurod...420.11     38.9     38     50GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0003723; F:RNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
295Q6FXX1    226   CWC24_CANGA Pre-mRNA-splicing factor CWC24 OS...400.11     38.1     35     53GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
296Q5ACW2    216   CWC24_CANAL Pre-mRNA-splicing factor CWC24 OS...450.11     37.7     36     47GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
297Q923T7    510   TRIM7_MOUSE Tripartite motif-containing prote...250.11     38.5     52     64GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; IDA:MGI.
GO:0008270; F:zinc ion binding; IEA:InterPro.
298P29590    882   PML_HUMAN Protein PML OS=Homo sapiens (Human)...410.11     38.9     41     51GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.::GO:0042406; C:extrinsic to endoplasmic reticulum membrane; ISS:UniProtKB.::GO:0005626; C:insoluble fraction; IDA:UniProtKB.::GO:0016363; C:nuclear matrix; IDA:UniProtKB.::GO:0031965; C:nuclear membrane; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0016605; C:PML body; IDA:UniProtKB.
GO:0050897; F:cobalt ion binding; IDA:UniProtKB.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0046982; F:protein heterodimerization activity; IDA:UniProtKB.::GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.::GO:0032183; F:SUMO binding; IPI:UniProtKB.::GO:0003713; F:transcription coactivator activity; IDA:UniProtKB.::GO:0031625; F:ubiquitin protein ligase binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0007050; P:cell cycle arrest; IDA:UniProtKB.::GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; ISS:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; ISS:UniProtKB.::GO:0008630; P:DNA damage response, signal transduction resulting in induction of apoptosis; IDA:UniProtKB.::GO:0032469; P:endoplasmic reticulum calcium ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; IDA:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0051457; P:maintenance of protein location in nucleus; IDA:MGI.::GO:0016525; P:negative regulation of angiogenesis; IMP:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IMP:BHF-UCL.::GO:0045930; P:negative regulation of mitotic cell cycle; IDA:UniProtKB.::GO:2000059; P:negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0051974; P:negative regulation of telomerase activity; IMP:UniProtKB.::GO:0032211; P:negative regulation of telomere maintenance via telomerase; IMP:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0032938; P:negative regulation of translation in response to oxidative stress; IDA:UniProtKB.::GO:0030578; P:PML body organization; IMP:UniProtKB.::GO:0002230; P:positive regulation of defense response to virus by host; IMP:UniProtKB.::GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0031065; P:positive regulation of histone deacetylation; IDA:UniProtKB.::GO:0006461; P:protein complex assembly; IDA:UniProtKB.::GO:0050821; P:protein stabilization; IDA:UniProtKB.::GO:0006605; P:protein targeting; IDA:UniProtKB.::GO:0010522; P:regulation of calcium ion transport into cytosol; ISS:UniProtKB.::GO:0001932; P:regulation of protein phosphorylation; ISS:UniProtKB.::GO:0001666; P:response to hypoxia; IDA:UniProtKB.::GO:0009615; P:response to virus; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
299Q5XPI3    1314   RN123_MOUSE E3 ubiquitin-protein ligase RNF12...380.11     38.9     42     45GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
300Q5XPI4    1314   RN123_HUMAN E3 ubiquitin-protein ligase RNF12...380.11     38.9     42     45GO:0005737; C:cytoplasm; IDA:LIFEdb.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
301Q6LFN2    1103   ZNRF1_PLAF7 RING finger protein PFF0165c OS=P...550.12     38.9     31     51
GO:0008270; F:zinc ion binding; IEA:InterPro.
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