Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCR066W
Length:
487
Number of sequences:
5887
Description:
YCR066W RAD18 SGDID:S000000662, Chr III from 231500-232963, Genome Release 64-1-1, Verified ORF, "E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
211Q6NZ21    419   RNFT1_DANRE RING finger and transmembrane dom...380.025     40.4     45     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
212Q99PQ1    284   TR12A_MOUSE Tripartite motif-containing prote...880.026     40     28     44GO:0005737; C:cytoplasm; IDA:MGI.
GO:0008270; F:zinc ion binding; IEA:InterPro.
213P0CQ64    329   CWC24_CRYNJ Pre-mRNA-splicing factor CWC24 OS...380.026     40.4     39     45GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
214P0CQ65    329   CWC24_CRYNB Pre-mRNA-splicing factor CWC24 OS...380.026     40.4     39     45GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.::GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
215O88846    194   RNF4_RAT E3 ubiquitin-protein ligase RNF4 OS=...470.027     39.7     40     49GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; IPI:RGD.::GO:0003677; F:DNA binding; IDA:UniProtKB.::GO:0030331; F:estrogen receptor binding; IDA:RGD.::GO:0031491; F:nucleosome binding; IDA:UniProtKB.::GO:0033142; F:progesterone receptor binding; IPI:RGD.::GO:0032184; F:SUMO polymer binding; IPI:UniProtKB.::GO:0017025; F:TBP-class protein binding; TAS:RGD.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; IMP:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; IDA:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; IDA:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; IDA:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0090234; P:regulation of kinetochore assembly; ISS:UniProtKB.::GO:0090169; P:regulation of spindle assembly; ISS:UniProtKB.::GO:0046685; P:response to arsenic-containing substance; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
216P78317    190   RNF4_HUMAN E3 ubiquitin-protein ligase RNF4 O...470.027     39.7     40     49GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0050681; F:androgen receptor binding; NAS:UniProtKB.::GO:0003677; F:DNA binding; ISS:UniProtKB.::GO:0031491; F:nucleosome binding; ISS:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.::GO:0032184; F:SUMO polymer binding; ISS:UniProtKB.::GO:0003713; F:transcription coactivator activity; NAS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; TAS:ProtInc.
GO:0030521; P:androgen receptor signaling pathway; NAS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0090234; P:regulation of kinetochore assembly; IMP:UniProtKB.::GO:0090169; P:regulation of spindle assembly; IMP:UniProtKB.::GO:0046685; P:response to arsenic-containing substance; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
217Q6PJ69    517   TRI65_HUMAN Tripartite motif-containing prote...660.028     40.4     35     47GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
218Q7ZUK0    364   RN146_DANRE E3 ubiquitin-protein ligase rnf14...540.03     40.4     37     44GO:0005829; C:cytosol; ISS:UniProtKB.
GO:0072572; F:poly-ADP-D-ribose binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0090263; P:positive regulation of canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
219Q9QZS2    194   RNF4_MOUSE E3 ubiquitin-protein ligase RNF4 O...470.03     39.3     40     49GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
GO:0003677; F:DNA binding; ISS:UniProtKB.::GO:0031491; F:nucleosome binding; ISS:UniProtKB.::GO:0032184; F:SUMO polymer binding; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:MGI.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0051865; P:protein autoubiquitination; ISS:UniProtKB.::GO:0070979; P:protein K11-linked ubiquitination; ISS:UniProtKB.::GO:0070936; P:protein K48-linked ubiquitination; ISS:UniProtKB.::GO:0085020; P:protein K6-linked ubiquitination; ISS:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; ISS:UniProtKB.::GO:0090234; P:regulation of kinetochore assembly; ISS:UniProtKB.::GO:0090169; P:regulation of spindle assembly; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
220Q00940    295   PEX10_PICAN Peroxisome biogenesis factor 10 O...470.031     40     38     51GO:0005779; C:integral to peroxisomal membrane; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016558; P:protein import into peroxisome matrix; IEA:InterPro.
221Q6J2U6    229   RN114_RAT RING finger protein 114 OS=Rattus n...390.031     39.7     41     59
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
222Q9C8E1    622   ORTH4_ARATH Putative E3 ubiquitin-protein lig...402.2     34.7     40     45GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.::GO:0010428; F:methyl-CpNpG binding; ISS:UniProtKB.::GO:0010429; F:methyl-CpNpN binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0010424; P:DNA methylation on cytosine within a CG sequence; ISS:UniProtKB.
223Q680I0    623   ORTH5_ARATH E3 ubiquitin-protein ligase ORTHR...402.2     34.7     40     45GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0008327; F:methyl-CpG binding; ISS:UniProtKB.::GO:0010428; F:methyl-CpNpG binding; ISS:UniProtKB.::GO:0010429; F:methyl-CpNpN binding; ISS:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0090309; P:positive regulation of methylation-dependent chromatin silencing; IMP:UniProtKB.
224Q6BWW6    691   BRE1_DEBHA E3 ubiquitin-protein ligase BRE1 O...480.033     40.4     35     50GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
225Q5C8U3    515   TRIM5_CERTA Tripartite motif-containing prote...750.033     40.4     25     48GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
226Q9CQ29    239   RN151_MOUSE RING finger protein 151 OS=Mus mu...430.034     39.7     42     44GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:MGI.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
227P93030    193   RMA2_ARATH E3 ubiquitin-protein ligase RMA2 O...630.034     39.3     33     44GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005515; F:protein binding; IPI:TAIR.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
228Q3ZEE5    493   TRIM5_HYLLA Tripartite motif-containing prote...710.035     40.4     28     49GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
229Q5M7Z0    435   RNFT1_HUMAN RING finger and transmembrane dom...380.035     40     39     53GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0008270; F:zinc ion binding; IEA:InterPro.
230Q7TPM3    477   TRI17_MOUSE E3 ubiquitin-protein ligase TRIM1...260.036     40     54     65GO:0005622; C:intracellular; IEA:InterPro.
GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
231Q6P9F5    258   TRI40_HUMAN Tripartite motif-containing prote...570.037     39.7     35     51GO:0005622; C:intracellular; IEA:InterPro.
GO:0008270; F:zinc ion binding; IEA:InterPro.
232Q12933    501   TRAF2_HUMAN TNF receptor-associated factor 2 ...490.039     40     35     57GO:0035631; C:CD40 receptor complex; ISS:BHF-UCL.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0009898; C:internal side of plasma membrane; ISS:BHF-UCL.
GO:0005174; F:CD40 receptor binding; ISS:BHF-UCL.::GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; NAS:ProtInc.::GO:0046625; F:sphingolipid binding; IDA:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; TAS:Reactome.::GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IMP:UniProtKB.::GO:0008633; P:activation of pro-apoptotic gene products; TAS:Reactome.::GO:0043623; P:cellular protein complex assembly; ISS:BHF-UCL.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:2001238; P:positive regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.::GO:0032743; P:positive regulation of interleukin-2 production; IMP:UniProtKB.::GO:0043507; P:positive regulation of JUN kinase activity; IDA:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0050870; P:positive regulation of T cell activation; IC:UniProtKB.::GO:0002726; P:positive regulation of T cell cytokine production; IMP:UniProtKB.::GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.::GO:0070207; P:protein homotrimerization; IPI:UniProtKB.::GO:0070534; P:protein K63-linked ubiquitination; IDA:UniProtKB.::GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IDA:UniProtKB.
233Q32L15    230   RN141_BOVIN RING finger protein 141 OS=Bos ta...420.039     39.3     36     52
GO:0008270; F:zinc ion binding; IEA:InterPro.
234Q8RXD6    878   BRE1A_ARATH E3 ubiquitin-protein ligase BRE1-...520.04     40.4     35     48GO:0005739; C:mitochondrion; IDA:TAIR.::GO:0005634; C:nucleus; IDA:UniProtKB.
GO:0042803; F:protein homodimerization activity; IPI:TAIR.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:TAIR.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051301; P:cell division; IMP:TAIR.::GO:0016049; P:cell growth; IMP:TAIR.::GO:0009817; P:defense response to fungus, incompatible interaction; IMP:TAIR.::GO:0033523; P:histone H2B ubiquitination; IMP:TAIR.::GO:0010390; P:histone monoubiquitination; IMP:TAIR.::GO:0009965; P:leaf morphogenesis; IMP:TAIR.::GO:0010389; P:regulation of G2/M transition of mitotic cell cycle; IMP:TAIR.::GO:0010162; P:seed dormancy process; IMP:TAIR.::GO:0010228; P:vegetative to reproductive phase transition of meristem; IMP:TAIR.
235Q9ET26    229   RN114_MOUSE RING finger protein 114 OS=Mus mu...390.041     39.3     41     59
GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
236Q587N7    515   TRIM5_CHLAE Tripartite motif-containing prote...750.041     40     25     48GO:0000932; C:cytoplasmic mRNA processing body; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
237Q8IYM9    498   TRI22_HUMAN E3 ubiquitin-protein ligase TRIM2...730.042     40     27     47GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc.::GO:0003714; F:transcription corepressor activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006955; P:immune response; TAS:ProtInc.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0070206; P:protein trimerization; IDA:UniProtKB.::GO:0009615; P:response to virus; TAS:ProtInc.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
238Q5R7K8    230   RN141_PONAB RING finger protein 141 OS=Pongo ...420.044     39.3     36     52
GO:0008270; F:zinc ion binding; IEA:InterPro.
239Q8WVD5    230   RN141_HUMAN RING finger protein 141 OS=Homo s...420.044     39.3     36     52
GO:0008270; F:zinc ion binding; IEA:InterPro.
240Q1XH18    477   TRI72_RABIT Tripartite motif-containing prote...710.044     40     25     44GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.::GO:0042383; C:sarcolemma; ISS:UniProtKB.
GO:0001786; F:phosphatidylserine binding; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0007517; P:muscle organ development; ISS:UniProtKB.::GO:0003012; P:muscle system process; ISS:UniProtKB.::GO:0001778; P:plasma membrane repair; ISS:UniProtKB.::GO:0051260; P:protein homooligomerization; ISS:UniProtKB.
241Q9Y577    477   TRI17_HUMAN E3 ubiquitin-protein ligase TRIM1...260.044     40     54     65GO:0005622; C:intracellular; IEA:InterPro.
GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0051865; P:protein autoubiquitination; IDA:UniProtKB.
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