Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCR065W
Length:
564
Number of sequences:
5887
Description:
YCR065W HCM1 SGDID:S000000661, Chr III from 229310-231004, Genome Release 64-1-1, Verified ORF, "Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
211Q9WVH3    505   FOXO4_MOUSE Forkhead box protein O4 OS=Mus mu...780.0000000000002     76.3     47     59GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:MGI.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.
GO:0007050; P:cell cycle arrest; ISS:UniProtKB.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0000080; P:G1 phase of mitotic cell cycle; ISS:UniProtKB.::GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007095; P:mitotic cell cycle G2/M transition DNA damage checkpoint; IDA:MGI.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0051151; P:negative regulation of smooth muscle cell differentiation; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
212Q66JJ0    626   FOXO1_XENTR Forkhead box protein O1 OS=Xenopu...950.0000000000003     76.3     44     55GO:0005829; C:cytosol; IBA:RefGenome.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0001568; P:blood vessel development; IBA:RefGenome.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0008286; P:insulin receptor signaling pathway; IBA:RefGenome.::GO:0032873; P:negative regulation of stress-activated MAPK cascade; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0042127; P:regulation of cell proliferation; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0006974; P:response to DNA damage stimulus; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
213Q6EUW2    631   FOXO1_XENLA Forkhead box protein O1 OS=Xenopu...950.0000000000004     75.9     44     55GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0006916; P:anti-apoptosis; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
214O43524    673   FOXO3_HUMAN Forkhead box protein O3 OS=Homo s...920.0000000000006     75.1     43     55GO:0005829; C:cytosol; IBA:RefGenome.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0001547; P:antral ovarian follicle growth; IBA:RefGenome.::GO:0006915; P:apoptotic process; IDA:UniProtKB.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0042593; P:glucose homeostasis; IBA:RefGenome.::GO:0006917; P:induction of apoptosis; IBA:RefGenome.::GO:0001544; P:initiation of primordial ovarian follicle growth; IBA:RefGenome.::GO:0008286; P:insulin receptor signaling pathway; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0001556; P:oocyte maturation; IBA:RefGenome.::GO:0001542; P:ovulation from ovarian follicle; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0048015; P:phosphatidylinositol-mediated signaling; TAS:Reactome.::GO:0045648; P:positive regulation of erythrocyte differentiation; IDA:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0042127; P:regulation of cell proliferation; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0006417; P:regulation of translation; IDA:UniProtKB.::GO:0009888; P:tissue development; IBA:RefGenome.
215Q28GC4    515   FOXH1_XENTR Forkhead box protein H1 OS=Xenopu...1100.0000000000006     74.7     40     55GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
GO:0032924; P:activin receptor signaling pathway; ISS:UniProtKB.::GO:0007369; P:gastrulation; IEA:UniProtKB-KW.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
216B3LYS5    600   FOXO_DROAN Forkhead box protein O OS=Drosophi...950.0000000000006     75.1     42     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
217B4HF64    609   FOXO_DROSE Forkhead box protein O OS=Drosophi...950.0000000000007     75.1     42     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
218B3P0K6    615   FOXO_DROER Forkhead box protein O OS=Drosophi...950.0000000000007     74.7     42     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
219Q95V55    613   FOXO_DROME Forkhead box protein O OS=Drosophi...950.0000000000007     74.7     42     58GO:0005829; C:cytosol; IBA:RefGenome.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:FlyBase.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0034599; P:cellular response to oxidative stress; IMP:FlyBase.::GO:0009267; P:cellular response to starvation; IMP:FlyBase.::GO:0001745; P:compound eye morphogenesis; IMP:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:FlyBase.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0042593; P:glucose homeostasis; IMP:UniProtKB.::GO:0005977; P:glycogen metabolic process; IMP:FlyBase.::GO:0008286; P:insulin receptor signaling pathway; IGI:FlyBase.::GO:0030308; P:negative regulation of cell growth; IMP:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.::GO:0045792; P:negative regulation of cell size; IMP:FlyBase.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IMP:UniProtKB.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:FlyBase.::GO:0040027; P:negative regulation of vulval development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0019216; P:regulation of lipid metabolic process; IMP:UniProtKB.::GO:0016241; P:regulation of macroautophagy; IMP:FlyBase.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009617; P:response to bacterium; IMP:FlyBase.::GO:0006974; P:response to DNA damage stimulus; IMP:FlyBase.::GO:0009888; P:tissue development; IBA:RefGenome.
220Q9WVH4    672   FOXO3_MOUSE Forkhead box protein O3 OS=Mus mu...920.0000000000008     74.7     43     55GO:0005829; C:cytosol; IBA:RefGenome.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:MGI.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0001547; P:antral ovarian follicle growth; IMP:MGI.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0030330; P:DNA damage response, signal transduction by p53 class mediator; IDA:MGI.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0042593; P:glucose homeostasis; IMP:MGI.::GO:0006917; P:induction of apoptosis; IMP:MGI.::GO:0001544; P:initiation of primordial ovarian follicle growth; IMP:MGI.::GO:0008286; P:insulin receptor signaling pathway; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0001556; P:oocyte maturation; IMP:MGI.::GO:0001542; P:ovulation from ovarian follicle; IMP:MGI.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045648; P:positive regulation of erythrocyte differentiation; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0042127; P:regulation of cell proliferation; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0006417; P:regulation of translation; ISS:UniProtKB.::GO:0009888; P:tissue development; IBA:RefGenome.
221B4PTD3    628   FOXO_DROYA Forkhead box protein O OS=Drosophi...950.0000000000008     74.7     42     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
222B4G4S8    629   FOXO_DROPE Forkhead box protein O OS=Drosophi...950.000000000001     74.3     42     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
223A8MYZ6    492   FOXO6_HUMAN Forkhead box protein O6 OS=Homo s...780.000000000001     73.9     46     62GO:0005829; C:cytosol; IBA:RefGenome.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009790; P:embryo development; IBA:RefGenome.::GO:0008286; P:insulin receptor signaling pathway; IBA:RefGenome.::GO:0016525; P:negative regulation of angiogenesis; IBA:RefGenome.::GO:0008285; P:negative regulation of cell proliferation; IBA:RefGenome.::GO:0051151; P:negative regulation of smooth muscle cell differentiation; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0006974; P:response to DNA damage stimulus; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
224Q298W7    644   FOXO_DROPS Forkhead box protein O OS=Drosophi...950.000000000001     74.3     42     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
225Q70KY4    559   FOXO6_MOUSE Forkhead box protein O6 OS=Mus mu...780.000000000001     74.3     46     62GO:0005829; C:cytosol; IBA:RefGenome.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019901; F:protein kinase binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009790; P:embryo development; IBA:RefGenome.::GO:0008286; P:insulin receptor signaling pathway; IBA:RefGenome.::GO:0016525; P:negative regulation of angiogenesis; IBA:RefGenome.::GO:0008285; P:negative regulation of cell proliferation; IBA:RefGenome.::GO:0051151; P:negative regulation of smooth muscle cell differentiation; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0006974; P:response to DNA damage stimulus; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
226B4NFR1    628   FOXO_DROWI Forkhead box protein O OS=Drosophi...950.000000000001     74.3     42     58GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
227B4KBF6    563   FOXO_DROMO Forkhead box protein O OS=Drosophi...950.000000000008     71.6     41     57GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
228Q8JIT7    344   FAST3_XENLA Forkhead activin signal transduce...780.000000000008     70.5     47     58GO:0032444; C:activin responsive factor complex; IDA:UniProtKB.
GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0046332; F:SMAD binding; IPI:UniProtKB.
GO:0001702; P:gastrulation with mouth forming second; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:UniProtKB.
229B4MB78    609   FOXO_DROVI Forkhead box protein O OS=Drosophi...810.00000000001     71.2     43     62GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
230B4JSC2    630   FOXO_DROGR Forkhead box protein O OS=Drosophi...950.00000000001     71.2     41     56GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042593; P:glucose homeostasis; ISS:UniProtKB.::GO:0010259; P:multicellular organismal aging; ISS:UniProtKB.::GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0019216; P:regulation of lipid metabolic process; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
231P70056    518   FOXH1_XENLA Forkhead box protein H1 OS=Xenopu...920.00000000006     68.6     39     54GO:0032444; C:activin responsive factor complex; IDA:UniProtKB.
GO:0051219; F:phosphoprotein binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.::GO:0046332; F:SMAD binding; IDA:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO:0032924; P:activin receptor signaling pathway; IMP:UniProtKB.::GO:0001702; P:gastrulation with mouth forming second; IMP:UniProtKB.::GO:0007501; P:mesodermal cell fate specification; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
232Q28H65    293   FOXN5_XENTR Forkhead box protein N5 OS=Xenopu...870.0000000001     66.6     33     55GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
233Q3BJS0    295   FOXN5_XENLA Forkhead box protein N5 OS=Xenopu...870.0000000002     65.9     33     55GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
234Q3UTB7    268   FOXR1_MOUSE Forkhead box protein R1 OS=Mus mu...730.0000000002     65.1     40     58GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009790; P:embryo development; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
235O75593    365   FOXH1_HUMAN Forkhead box protein H1 OS=Homo s...780.0000000004     65.5     40     56GO:0032444; C:activin responsive factor complex; IDA:BHF-UCL.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0070412; F:R-SMAD binding; IPI:BHF-UCL.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0048318; P:axial mesoderm development; IBA:RefGenome.::GO:0001568; P:blood vessel development; IBA:RefGenome.::GO:0042074; P:cell migration involved in gastrulation; IBA:RefGenome.::GO:0035054; P:embryonic heart tube anterior/posterior pattern specification; IBA:RefGenome.::GO:0021508; P:floor plate formation; IBA:RefGenome.::GO:0001947; P:heart looping; IBA:RefGenome.::GO:1900164; P:nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry; NAS:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0010159; P:specification of organ position; IBA:RefGenome.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; TAS:UniProtKB.
236Q6PIV2    292   FOXR1_HUMAN Forkhead box protein R1 OS=Homo s...860.0000000004     64.7     36     52GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009790; P:embryo development; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
237P39521    936   FHL1_YEAST Pre-rRNA-processing protein FHL1 O...780.0000000004     66.2     44     58GO:0000790; C:nuclear chromatin; IDA:SGD.::GO:0005730; C:nucleolus; IDA:SGD.::GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0070491; F:repressing transcription factor binding; IPI:SGD.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
GO:0010688; P:negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter; IMP:SGD.::GO:0060963; P:positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter; IMP:SGD.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
238O88621    401   FOXH1_MOUSE Forkhead box protein H1 OS=Mus mu...960.000000001     63.9     35     53GO:0032444; C:activin responsive factor complex; IDA:UniProtKB.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0019904; F:protein domain specific binding; IBA:RefGenome.::GO:0070412; F:R-SMAD binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IDA:MGI.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0048318; P:axial mesoderm development; IMP:MGI.::GO:0001568; P:blood vessel development; IBA:RefGenome.::GO:0042074; P:cell migration involved in gastrulation; IBA:RefGenome.::GO:0035054; P:embryonic heart tube anterior/posterior pattern specification; IMP:MGI.::GO:0021508; P:floor plate formation; IBA:RefGenome.::GO:0001947; P:heart looping; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IGI:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0010159; P:specification of organ position; IBA:RefGenome.::GO:0007179; P:transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.
239Q3UM89    302   FOXR2_MOUSE Forkhead box protein R2 OS=Mus mu...1010.0000002     56.6     32     50GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009790; P:embryo development; IBA:RefGenome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
240Q6PJQ5    311   FOXR2_HUMAN Forkhead box protein R2 OS=Homo s...1220.0001     48.1     24     52GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009790; P:embryo development; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
241Q19802    461   FKH5_CAEEL Putative forkhead-related transcri...600.017     41.6     33     57GO:0005667; C:transcription factor complex; IBA:RefGenome.
GO:0008301; F:DNA binding, bending; IBA:RefGenome.::GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.::GO:0010843; F:promoter binding; IBA:RefGenome.::GO:0003705; F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.::GO:0003704; F:specific RNA polymerase II transcription factor activity; IBA:RefGenome.::GO:0016566; F:specific transcriptional repressor activity; IBA:RefGenome.::GO:0016563; F:transcription activator activity; IBA:RefGenome.::GO:0008134; F:transcription factor binding; IBA:RefGenome.
GO:0009653; P:anatomical structure morphogenesis; IBA:RefGenome.::GO:0009790; P:embryo development; IBA:RefGenome.::GO:0048513; P:organ development; IBA:RefGenome.::GO:0007389; P:pattern specification process; IBA:RefGenome.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IBA:RefGenome.::GO:0009888; P:tissue development; IBA:RefGenome.
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