UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YCR038C

Length:

642

Number of sequences:

5887

Description:

YCR038C BUD5 SGDID:S000000634, Chr III from 199549-197621, Genome Release 64-1-1, reverse complement, Verified ORF, "GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
61	Q3UYI5	709	RGL3_MOUSE Ral guanine nucleotide dissociatio...	219	0.00004	50.4	24	43	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; IDA:MGI.::GO:0017016; F:Ras GTPase binding; IDA:MGI.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:MGI.
62	Q5ZJK0	584	RGPS1_CHICK Ras-specific guanine nucleotide-r...	210	0.00005	50.1	23	46	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
									GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
63	B0M0P8	2356	GEFL_DICDI Ras guanine nucleotide exchange fa...	202	0.00005	50.4	23	45	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0003779; F:actin binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017048; F:Rho GTPase binding; IEA:InterPro.
									GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.::GO:0046956; P:positive phototaxis; IMP:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase.::GO:0043052; P:thermotaxis; IMP:dictyBase.
64	Q54FF3	1557	GEFK_DICDI Ras guanine nucleotide exchange fa...	201	0.00006	50.1	24	45	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
65	Q8SSQ0	1721	GEFR_DICDI Ras guanine nucleotide exchange fa...	247	0.0002	48.5	24	44	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005488; F:binding; IEA:InterPro.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase.
									GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
66	Q8IS21	1529	GEFB_DICDI Ras guanine nucleotide exchange fa...	252	0.0002	48.5	25	42	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005488; F:binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IGI:dictyBase.
									GO:0007015; P:actin filament organization; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0030866; P:cortical actin cytoskeleton organization; IMP:dictyBase.::GO:0051271; P:negative regulation of cellular component movement; IMP:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:dictyBase.::GO:0050766; P:positive regulation of phagocytosis; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; ISS:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0019953; P:sexual reproduction; IEP:dictyBase.
67	Q552M5	1508	GEFY_DICDI Ras guanine nucleotide exchange fa...	188	0.0002	48.1	27	47	GO:0005813; C:centrosome; IDA:dictyBase.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
68	Q86G47	1298	GEFQ_DICDI Ras guanine nucleotide exchange fa...	206	0.0002	48.1	25	45	GO:0005938; C:cell cortex; IDA:dictyBase.::GO:0005829; C:cytosol; IDA:dictyBase.
									GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0045159; F:myosin II binding; IPI:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase.
									GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0043520; P:regulation of myosin II filament assembly; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0030587; P:sorocarp development; IMP:dictyBase.
69	Q8IS14	812	GEFJ_DICDI Ras guanine nucleotide exchange fa...	212	0.0003	47.8	20	45	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
70	P34578	1038	RPGF1_CAEEL Rap guanine nucleotide exchange f...	147	0.0003	47.8	27	47	GO:0005952; C:cAMP-dependent protein kinase complex; IEA:InterPro.
									GO:0008603; F:cAMP-dependent protein kinase regulator activity; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0001932; P:regulation of protein phosphorylation; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
71	Q13905	1077	RPGF1_HUMAN Rap guanine nucleotide exchange f...	203	0.0003	47.8	23	43	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; TAS:Reactome.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
									GO:0000186; P:activation of MAPKK activity; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
72	Q8SSW7	1043	GEFS_DICDI Ras guanine nucleotide exchange fa...	170	0.0006	47	26	42	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
73	Q8IV61	690	GRP3_HUMAN Ras guanyl-releasing protein 3 OS=...	191	0.0006	46.6	24	46	GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
									GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0046582; F:Rap GTPase activator activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; TAS:UniProtKB.
									GO:0000165; P:MAPK cascade; NAS:UniProtKB.
74	Q03386	895	GNDS_RAT Ral guanine nucleotide dissociation ...	106	0.0007	46.6	27	52	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; TAS:RGD.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:RGD.
75	Q07890	1332	SOS2_HUMAN Son of sevenless homolog 2 OS=Homo...	239	0.0007	46.6	23	41	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.
76	Q03385	852	GNDS_MOUSE Ral guanine nucleotide dissociatio...	106	0.0008	46.2	27	52	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
77	A6N9I4	608	GRP2_BOVIN RAS guanyl-releasing protein 2 OS=...	248	0.001	45.8	23	42	GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
78	Q02384	1333	SOS2_MOUSE Son of sevenless homolog 2 OS=Mus ...	239	0.001	45.8	23	40	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI.
79	Q55GH9	1172	GEFW_DICDI Ras guanine nucleotide exchange fa...	195	0.002	45.4	22	44	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
80	Q8IS15	824	GEFI_DICDI Ras guanine nucleotide exchange fa...	193	0.002	45.4	19	45	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
81	Q54PQ4	605	GEFA_DICDI Ras guanine nucleotide exchange fa...	200	0.002	44.7	22	45	GO:0005829; C:cytosol; IDA:dictyBase.
									GO:0030250; F:guanylate cyclase activator activity; IMP:dictyBase.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase.
									GO:0007190; P:activation of adenylate cyclase activity; IMP:dictyBase.::GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0006935; P:chemotaxis; IMP:dictyBase.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007265; P:Ras protein signal transduction; IDA:dictyBase.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
82	Q7LDG7	609	GRP2_HUMAN RAS guanyl-releasing protein 2 OS=...	248	0.003	44.7	23	42	GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0019992; F:diacylglycerol binding; NAS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:UniProtKB.
									GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; NAS:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
83	Q8MVR1	2631	GBPC_DICDI Cyclic GMP-binding protein C OS=Di...	152	0.004	44.3	24	43	GO:0005737; C:cytoplasm; IDA:dictyBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0030553; F:cGMP binding; IDA:dictyBase.::GO:0005525; F:GTP binding; IDA:dictyBase.::GO:0005543; F:phospholipid binding; IDA:dictyBase.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005088; F:Ras guanyl-nucleotide exchange factor activity; IDA:dictyBase.
									GO:0031589; P:cell-substrate adhesion; IMP:dictyBase.::GO:0019934; P:cGMP-mediated signaling; IDA:dictyBase.::GO:0007163; P:establishment or maintenance of cell polarity; IMP:dictyBase.::GO:0051272; P:positive regulation of cellular component movement; TAS:dictyBase.::GO:0045860; P:positive regulation of protein kinase activity; IMP:dictyBase.::GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:dictyBase.::GO:0050920; P:regulation of chemotaxis; IMP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
84	P0C643	608	GRP2_RAT RAS guanyl-releasing protein 2 OS=Ra...	251	0.005	43.9	23	42	GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
85	Q60695	768	RGL1_MOUSE Ral guanine nucleotide dissociatio...	197	0.007	43.5	24	41	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
86	Q9QUG9	608	GRP2_MOUSE RAS guanyl-releasing protein 2 OS=...	251	0.01	42.7	23	42	GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0032587; C:ruffle membrane; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell.
									GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
87	Q61193	778	RGL2_MOUSE Ral guanine nucleotide dissociatio...	194	0.01	42.7	24	41	GO:0005622; C:intracellular; IEA:InterPro.
									GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
									GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
88	P26675	1596	SOS_DROME Protein son of sevenless OS=Drosoph...	214	0.011	42.7	21	41	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0008595; P:anterior/posterior axis specification, embryo; TAS:FlyBase.::GO:0045749; P:negative regulation of S phase of mitotic cell cycle; IMP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0045500; P:sevenless signaling pathway; TAS:FlyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0008293; P:torso signaling pathway; TAS:FlyBase.::GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase.
89	Q9NZL6	768	RGL1_HUMAN Ral guanine nucleotide dissociatio...	197	0.015	42	24	41	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0008321; F:Ral guanyl-nucleotide exchange factor activity; NAS:UniProtKB.
									GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; NAS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
90	Q07889	1333	SOS1_HUMAN Son of sevenless homolog 1 OS=Homo...	226	0.018	42	21	42	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005100; F:Rho GTPase activator activity; TAS:ProtInc.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc.
									GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0007265; P:Ras protein signal transduction; TAS:Reactome.
91	Q62245	1319	SOS1_MOUSE Son of sevenless homolog 1 OS=Mus ...	226	0.021	42	21	42	GO:0005829; C:cytosol; TAS:Reactome.
									GO:0003677; F:DNA binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
									GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI.

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