UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YCR032W

Length:

2167

Number of sequences:

5887

Description:

YCR032W BPH1 SGDID:S000000628, Chr III from 179520-186023, Genome Release 64-1-1, Verified ORF, "PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P25356	2167	BPH1_YEAST Beige protein homolog 1 OS=Sacchar...	2167	0	4439	100	100	GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IDA:SGD.::GO:0000300; C:peripheral to membrane of membrane fraction; IDA:SGD.::GO:0005625; C:soluble fraction; IDA:SGD.
									GO:0031505; P:fungal-type cell wall organization; IMP:SGD.::GO:0006886; P:intracellular protein transport; IMP:SGD.::GO:0009268; P:response to pH; IMP:SGD.
2	Q7LKZ7	2609	BPH1_SCHPO Beige protein homolog 1 OS=Schizos...	958	1e-139	491	35	51	GO:0005829; C:cytosol; IDA:PomBase.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0043234; C:protein complex; NAS:PomBase.
									GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0009268; P:response to pH; ISS:PomBase.
3	Q8IZQ1	3526	WDFY3_HUMAN WD repeat and FYVE domain-contain...	488	1e-114	412	43	62	GO:0044444; C:cytoplasmic part; IDA:MGI.::GO:0019898; C:extrinsic to membrane; IDA:MGI.::GO:0005635; C:nuclear envelope; IDA:MGI.
									GO:0005545; F:1-phosphatidylinositol binding; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:IntAct.
4	Q6VNB8	3508	WDFY3_MOUSE WD repeat and FYVE domain-contain...	822	2e-114	412	33	51
									GO:0003831; F:beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity; IDA:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
5	Q55DM1	3619	LVSA_DICDI BEACH domain-containing protein lv...	760	1e-111	403	34	52	GO:0031164; C:contractile vacuolar membrane; IDA:dictyBase.::GO:0005624; C:membrane fraction; IDA:dictyBase.::GO:0005625; C:soluble fraction; IDA:dictyBase.
									GO:0005543; F:phospholipid binding; IDA:dictyBase.
									GO:0007155; P:cell adhesion; IMP:dictyBase.::GO:0006874; P:cellular calcium ion homeostasis; IMP:dictyBase.::GO:0033298; P:contractile vacuole organization; IMP:dictyBase.::GO:0000915; P:cytokinesis, actomyosin contractile ring assembly; IMP:dictyBase.::GO:0007032; P:endosome organization; IMP:dictyBase.::GO:0007041; P:lysosomal transport; ISS:dictyBase.::GO:0006909; P:phagocytosis; IMP:dictyBase.
6	Q6ZS81	3184	WDFY4_HUMAN WD repeat- and FYVE domain-contai...	792	1e-100	367	32	49	GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
									GO:0005488; F:binding; IEA:InterPro.
7	Q86JF2	4118	LVSB_DICDI BEACH domain-containing protein lv...	720	7e-97	355	33	50	GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005764; C:lysosome; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase.
									GO:0005488; F:binding; IEA:InterPro.
									GO:0009267; P:cellular response to starvation; IMP:dictyBase.::GO:0031154; P:culmination involved in sorocarp development; IMP:dictyBase.::GO:0006887; P:exocytosis; IMP:dictyBase.::GO:0007041; P:lysosomal transport; IMP:dictyBase.::GO:0007040; P:lysosome organization; IMP:dictyBase.::GO:0001845; P:phagolysosome assembly; IMP:dictyBase.::GO:0006970; P:response to osmotic stress; IMP:dictyBase.
8	Q54U63	2491	LVSC_DICDI BEACH domain-containing protein lv...	375	2e-88	326	47	62
									GO:0005488; F:binding; IEA:InterPro.
9	Q6ZQA0	2742	NBEL2_MOUSE Neurobeachin-like protein 2 OS=Mu...	290	7e-88	325	55	71	GO:0005783; C:endoplasmic reticulum; ISS:UniProtKB.
									GO:0005488; F:binding; IEA:InterPro.
									GO:0030220; P:platelet formation; ISS:UniProtKB.
10	P50851	2863	LRBA_HUMAN Lipopolysaccharide-responsive and ...	390	1e-87	324	44	60	GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
									GO:0005488; F:binding; IEA:InterPro.
11	Q9W4E2	3578	NBEA_DROME Neurobeachin OS=Drosophila melanog...	390	1e-87	324	42	59	GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IDA:UniProtKB.
									GO:0051018; F:protein kinase A binding; IDA:UniProtKB.
									GO:0042675; P:compound eye cone cell differentiation; IMP:FlyBase.::GO:0042462; P:eye photoreceptor cell development; IMP:UniProtKB.
12	Q9ESE1	2856	LRBA_MOUSE Lipopolysaccharide-responsive and ...	390	6e-87	322	44	60	GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.::GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005764; C:lysosome; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
									GO:0005488; F:binding; IEA:InterPro.
									GO:0016197; P:endosome transport; TAS:MGI.::GO:0007165; P:signal transduction; TAS:MGI.
13	Q6ZNJ1	2754	NBEL2_HUMAN Neurobeachin-like protein 2 OS=Ho...	289	1e-86	321	54	71	GO:0005783; C:endoplasmic reticulum; IDA:UniProtKB.
									GO:0005488; F:binding; IEA:InterPro.
									GO:0030220; P:platelet formation; IMP:UniProtKB.
14	E7FAW3	2801	NBEL2_DANRE Neurobeachin-like protein 2 OS=Da...	335	2e-85	317	48	66	GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
									GO:0005488; F:binding; IEA:InterPro.
15	Q9EPN1	2936	NBEA_MOUSE Neurobeachin OS=Mus musculus (Mous...	390	3e-85	317	43	59	GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0012505; C:endomembrane system; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0045211; C:postsynaptic membrane; NAS:UniProtKB.::GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
									GO:0051018; F:protein kinase A binding; NAS:UniProtKB.::GO:0019901; F:protein kinase binding; IDA:MGI.
									GO:0006892; P:post-Golgi vesicle-mediated transport; NAS:UniProtKB.::GO:0008104; P:protein localization; IDA:MGI.
16	Q8NFP9	2946	NBEA_HUMAN Neurobeachin OS=Homo sapiens (Huma...	390	3e-85	317	42	60	GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0012505; C:endomembrane system; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.::GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
									GO:0005488; F:binding; IEA:InterPro.
17	Q6ZS30	2694	NBEL1_HUMAN Neurobeachin-like protein 1 OS=Ho...	316	3e-84	313	51	66
									GO:0005488; F:binding; IEA:InterPro.
18	Q55AV3	2967	LVSD_DICDI BEACH domain-containing protein lv...	390	7e-80	299	42	60	GO:0005829; C:cytosol; IDA:dictyBase.
									GO:0033298; P:contractile vacuole organization; IGI:dictyBase.::GO:0030587; P:sorocarp development; IMP:dictyBase.
19	Q92636	917	FAN_HUMAN Protein FAN OS=Homo sapiens (Human)...	515	3e-79	289	37	55	GO:0005737; C:cytoplasm; TAS:ProtInc.::GO:0005625; C:soluble fraction; TAS:ProtInc.
									GO:0005515; F:protein binding; IPI:IntAct.::GO:0005057; F:receptor signaling protein activity; TAS:ProtInc.
									GO:0006672; P:ceramide metabolic process; TAS:ProtInc.
20	Q54RQ8	2192	LVSE_DICDI BEACH domain-containing protein lv...	499	2e-78	293	35	55
									GO:0003677; F:DNA binding; IEA:InterPro.
									GO:0019933; P:cAMP-mediated signaling; IMP:dictyBase.
21	Q9TTK4	3796	LYST_BOVIN Lysosomal-trafficking regulator OS...	405	7e-78	292	39	58	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB.
									GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; ISS:UniProtKB.::GO:0042267; P:natural killer cell mediated cytotoxicity; ISS:UniProtKB.::GO:0043473; P:pigmentation; ISS:UniProtKB.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.
22	O35242	920	FAN_MOUSE Protein FAN OS=Mus musculus (Mouse)...	325	1e-76	281	46	63
									GO:0005123; F:death receptor binding; TAS:MGI.
23	P97412	3788	LYST_MOUSE Lysosomal-trafficking regulator OS...	405	6e-76	286	38	58	GO:0005829; C:cytosol; IDA:MGI.
									GO:0007596; P:blood coagulation; IMP:MGI.::GO:0042742; P:defense response to bacterium; IMP:MGI.::GO:0042832; P:defense response to protozoan; IMP:MGI.::GO:0051607; P:defense response to virus; IMP:MGI.::GO:0030595; P:leukocyte chemotaxis; IMP:MGI.::GO:0007040; P:lysosome organization; IMP:MGI.::GO:0033364; P:mast cell secretory granule organization; IMP:MGI.::GO:0032438; P:melanosome organization; IMP:MGI.::GO:0007017; P:microtubule-based process; IMP:MGI.::GO:0002446; P:neutrophil mediated immunity; IMP:MGI.::GO:0055091; P:phospholipid homeostasis; IMP:MGI.::GO:0006644; P:phospholipid metabolic process; IMP:MGI.::GO:0032816; P:positive regulation of natural killer cell activation; IMP:MGI.::GO:0042493; P:response to drug; IMP:MGI.::GO:0033299; P:secretion of lysosomal enzymes; IMP:MGI.::GO:0002456; P:T cell mediated immunity; IMP:MGI.
24	Q99698	3801	LYST_HUMAN Lysosomal-trafficking regulator OS...	402	1e-75	285	39	58	GO:0015630; C:microtubule cytoskeleton; IDA:UniProtKB.
									GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0042742; P:defense response to bacterium; ISS:UniProtKB.::GO:0042832; P:defense response to protozoan; ISS:UniProtKB.::GO:0051607; P:defense response to virus; ISS:UniProtKB.::GO:0032510; P:endosome to lysosome transport via multivesicular body sorting pathway; IMP:UniProtKB.::GO:0030595; P:leukocyte chemotaxis; ISS:UniProtKB.::GO:0033364; P:mast cell secretory granule organization; ISS:UniProtKB.::GO:0032438; P:melanosome organization; ISS:UniProtKB.::GO:0042267; P:natural killer cell mediated cytotoxicity; IMP:UniProtKB.
25	A8XSV3	2531	NBEA_CAEBR Putative neurobeachin homolog OS=C...	390	2e-73	277	38	56	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
									GO:0005488; F:binding; IEA:InterPro.
26	Q19317	2507	NBEA_CAEEL Putative neurobeachin homolog OS=C...	390	3e-73	277	38	56	GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IDA:WormBase.
									GO:0005488; F:binding; IEA:InterPro.
									GO:0045176; P:apical protein localization; IMP:WormBase.::GO:0016197; P:endosome transport; IMP:WormBase.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:WormBase.::GO:0040027; P:negative regulation of vulval development; IMP:WormBase.::GO:0045807; P:positive regulation of endocytosis; IMP:WormBase.
27	Q54PP7	1154	LVSF_DICDI BEACH domain-containing protein lv...	423	2e-72	270	39	54
28	Q10122	1336	YSM1_CAEEL Uncharacterized WD repeat-containi...	292	0.000000009	64.7	24	42
29	Q55FJ0	2179	LVSG_DICDI Probable inactive serine/threonine...	131	0.00003	53.1	33	44
									GO:0005524; F:ATP binding; IEA:InterPro.::GO:0004672; F:protein kinase activity; IEA:InterPro.
30	Q9P2L0	1181	WDR35_HUMAN WD repeat-containing protein 35 O...	177	0.059	42.4	25	42	GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0035085; C:cilium axoneme; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; ISS:UniProtKB.
									GO:0042384; P:cilium assembly; IMP:UniProtKB.
31	Q32LN7	305	WDR61_BOVIN WD repeat-containing protein 61 O...	209	0.089	40.8	21	42	GO:0016593; C:Cdc73/Paf1 complex; ISS:UniProtKB.::GO:0055087; C:Ski complex; ISS:UniProtKB.::GO:0035327; C:transcriptionally active chromatin; ISS:UniProtKB.
									GO:0080182; P:histone H3-K4 trimethylation; ISS:UniProtKB.::GO:0045638; P:negative regulation of myeloid cell differentiation; ISS:UniProtKB.::GO:0051571; P:positive regulation of histone H3-K4 methylation; ISS:UniProtKB.::GO:2001162; P:positive regulation of histone H3-K79 methylation; ISS:UniProtKB.::GO:0032968; P:positive regulation of transcription elongation from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.

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