Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCR026C
Length:
742
Number of sequences:
5887
Description:
YCR026C NPP1 SGDID:S000000621, Chr III from 166339-164111, Genome Release 64-1-1, reverse complement, Verified ORF, "Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P25353    742   NPP1_YEAST Ectonucleotide pyrophosphatase/pho...7420     1526     100     100GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0017111; F:nucleoside-triphosphatase activity; IMP:SGD.::GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IDA:SGD.::GO:0004528; F:phosphodiesterase I activity; ISS:SGD.
GO:0016036; P:cellular response to phosphate starvation; IEP:SGD.::GO:0009141; P:nucleoside triphosphate metabolic process; IMP:SGD.::GO:0006796; P:phosphate-containing compound metabolic process; ISS:SGD.
2P39997    493   NPP2_YEAST Ectonucleotide pyrophosphatase/pho...5299e-112     354     38     57GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0017111; F:nucleoside-triphosphatase activity; IMP:SGD.::GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IMP:SGD.::GO:0004528; F:phosphodiesterase I activity; ISS:SGD.
GO:0009141; P:nucleoside triphosphate metabolic process; IMP:SGD.
3O94323    485   YGK5_SCHPO Uncharacterized pyrophosphatase/ph...5201e-54     200     31     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0047429; F:nucleoside-triphosphate diphosphatase activity; ISS:PomBase.::GO:0004551; F:nucleotide diphosphatase activity; ISS:PomBase.
GO:0009141; P:nucleoside triphosphate metabolic process; ISS:PomBase.
4P97675    875   ENPP3_RAT Ectonucleotide pyrophosphatase/phos...4571e-36     151     27     46GO:0009986; C:cell surface; TAS:RGD.::GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0004528; F:phosphodiesterase I activity; TAS:RGD.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO:0006955; P:immune response; IEA:InterPro.::GO:0051150; P:regulation of smooth muscle cell differentiation; NAS:RGD.
5P15396    874   ENPP3_BOVIN Ectonucleotide pyrophosphatase/ph...4612e-36     150     27     44GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0004528; F:phosphodiesterase I activity; IEA:EC.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO:0006955; P:immune response; IEA:InterPro.
6Q6DYE8    874   ENPP3_MOUSE Ectonucleotide pyrophosphatase/ph...4665e-36     149     26     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0004528; F:phosphodiesterase I activity; IEA:EC.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO:0006955; P:immune response; IEA:InterPro.
7O14638    875   ENPP3_HUMAN Ectonucleotide pyrophosphatase/ph...4583e-35     147     26     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IDA:BHF-UCL.::GO:0004528; F:phosphodiesterase I activity; TAS:ProtInc.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO:0006955; P:immune response; IEA:InterPro.::GO:0009143; P:nucleoside triphosphate catabolic process; IDA:BHF-UCL.::GO:0006796; P:phosphate-containing compound metabolic process; IDA:BHF-UCL.
8P06802    906   ENPP1_MOUSE Ectonucleotide pyrophosphatase/ph...4485e-35     146     27     44GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.::GO:0009986; C:cell surface; IDA:BHF-UCL.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0004528; F:phosphodiesterase I activity; IEA:EC.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.::GO:0046849; P:bone remodeling; IMP:MGI.::GO:0006955; P:immune response; IEA:InterPro.::GO:0045599; P:negative regulation of fat cell differentiation; IMP:BHF-UCL.::GO:0030279; P:negative regulation of ossification; IMP:MGI.
9P22413    925   ENPP1_HUMAN Ectonucleotide pyrophosphatase/ph...4571e-34     145     27     43GO:0016323; C:basolateral plasma membrane; NAS:BHF-UCL.::GO:0009986; C:cell surface; IDA:BHF-UCL.::GO:0005615; C:extracellular space; IDA:BHF-UCL.::GO:0016021; C:integral to membrane; TAS:ProtInc.
GO:0050656; F:3'-phosphoadenosine 5'-phosphosulfate binding; IC:BHF-UCL.::GO:0005524; F:ATP binding; IDA:BHF-UCL.::GO:0005158; F:insulin receptor binding; IDA:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0047429; F:nucleoside-triphosphate diphosphatase activity; IDA:BHF-UCL.::GO:0004528; F:phosphodiesterase I activity; IEA:EC.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO:0050427; P:3'-phosphoadenosine 5'-phosphosulfate metabolic process; IDA:BHF-UCL.::GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.::GO:0030643; P:cellular phosphate ion homeostasis; IDA:BHF-UCL.::GO:0032869; P:cellular response to insulin stimulus; IDA:BHF-UCL.::GO:0006091; P:generation of precursor metabolites and energy; IDA:BHF-UCL.::GO:0006955; P:immune response; IEA:InterPro.::GO:0030505; P:inorganic diphosphate transport; IDA:BHF-UCL.::GO:0030308; P:negative regulation of cell growth; IDA:BHF-UCL.::GO:0045599; P:negative regulation of fat cell differentiation; IDA:BHF-UCL.::GO:0046325; P:negative regulation of glucose import; IDA:BHF-UCL.::GO:0045719; P:negative regulation of glycogen biosynthetic process; IDA:BHF-UCL.::GO:0046627; P:negative regulation of insulin receptor signaling pathway; IDA:BHF-UCL.::GO:0031953; P:negative regulation of protein autophosphorylation; IDA:BHF-UCL.::GO:0009143; P:nucleoside triphosphate catabolic process; IDA:BHF-UCL.::GO:0006796; P:phosphate-containing compound metabolic process; IDA:BHF-UCL.::GO:0030500; P:regulation of bone mineralization; IC:BHF-UCL.::GO:0006771; P:riboflavin metabolic process; TAS:Reactome.::GO:0030730; P:sequestering of triglyceride; IDA:BHF-UCL.
10Q924C3    906   ENPP1_RAT Ectonucleotide pyrophosphatase/phos...4481e-34     145     27     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:MGI.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0004528; F:phosphodiesterase I activity; IEA:EC.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO:0031214; P:biomineral tissue development; IEA:UniProtKB-KW.::GO:0006955; P:immune response; IEA:InterPro.
11Q8BGN3    440   ENPP6_MOUSE Ectonucleotide pyrophosphatase/ph...4284e-34     140     27     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IDA:MGI.
GO:0008889; F:glycerophosphodiester phosphodiesterase activity; IDA:MGI.
GO:0019695; P:choline metabolic process; IDA:MGI.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
12Q9UJA9    477   ENPP5_HUMAN Ectonucleotide pyrophosphatase/ph...4286e-34     139     29     45GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
13Q5R5M5    873   ENPP3_PONAB Ectonucleotide pyrophosphatase/ph...4588e-34     142     26     44GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035529; F:NADH pyrophosphatase activity; IEA:EC.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0004528; F:phosphodiesterase I activity; IEA:EC.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.
GO:0006955; P:immune response; IEA:InterPro.
14B0BND0    440   ENPP6_RAT Ectonucleotide pyrophosphatase/phos...4291e-33     138     27     46GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
15Q6UWR7    440   ENPP6_HUMAN Ectonucleotide pyrophosphatase/ph...4391e-32     135     27     44GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
16Q9R1E6    862   ENPP2_MOUSE Ectonucleotide pyrophosphatase/ph...4752e-32     138     25     42GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0047391; F:alkylglycerophosphoethanolamine phosphodiesterase activity; IEA:EC.::GO:0005509; F:calcium ion binding; IDA:UniProtKB.::GO:0004622; F:lysophospholipase activity; IDA:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.::GO:0006955; P:immune response; IEA:InterPro.::GO:0034638; P:phosphatidylcholine catabolic process; IDA:UniProtKB.
17Q64610    887   ENPP2_RAT Ectonucleotide pyrophosphatase/phos...4527e-32     136     26     42GO:0005615; C:extracellular space; IDA:UniProtKB.
GO:0047391; F:alkylglycerophosphoethanolamine phosphodiesterase activity; IEA:EC.::GO:0005509; F:calcium ion binding; IDA:UniProtKB.::GO:0004622; F:lysophospholipase activity; IDA:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IDA:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.::GO:0006955; P:immune response; IEA:InterPro.::GO:0034638; P:phosphatidylcholine catabolic process; IDA:UniProtKB.
18Q13822    863   ENPP2_HUMAN Ectonucleotide pyrophosphatase/ph...4751e-31     136     25     41GO:0005615; C:extracellular space; ISS:UniProtKB.::GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
GO:0047391; F:alkylglycerophosphoethanolamine phosphodiesterase activity; IEA:EC.::GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; IDA:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0004551; F:nucleotide diphosphatase activity; TAS:ProtInc.::GO:0004528; F:phosphodiesterase I activity; TAS:ProtInc.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.::GO:0008134; F:transcription factor binding; TAS:ProtInc.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0006928; P:cellular component movement; TAS:ProtInc.::GO:0006935; P:chemotaxis; NAS:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.::GO:0006955; P:immune response; IEA:InterPro.::GO:0006796; P:phosphate-containing compound metabolic process; TAS:ProtInc.::GO:0034638; P:phosphatidylcholine catabolic process; IDA:UniProtKB.::GO:0030334; P:regulation of cell migration; IDA:UniProtKB.
19Q58D68    440   ENPP6_BOVIN Ectonucleotide pyrophosphatase/ph...4491e-31     132     27     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
20Q9EQG7    477   ENPP5_MOUSE Ectonucleotide pyrophosphatase/ph...4282e-31     132     28     44GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
21P84039    477   ENPP5_RAT Ectonucleotide pyrophosphatase/phos...4281e-30     129     27     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:UniProtKB.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO:0007154; P:cell communication; IDA:UniProtKB.
22A1A4K5    888   ENPP2_BOVIN Ectonucleotide pyrophosphatase/ph...4632e-30     132     25     43GO:0005615; C:extracellular space; ISS:UniProtKB.
GO:0047391; F:alkylglycerophosphoethanolamine phosphodiesterase activity; IEA:EC.::GO:0005509; F:calcium ion binding; ISS:UniProtKB.::GO:0004622; F:lysophospholipase activity; ISS:UniProtKB.::GO:0003676; F:nucleic acid binding; IEA:InterPro.::GO:0030247; F:polysaccharide binding; IEA:InterPro.::GO:0005044; F:scavenger receptor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO:0006935; P:chemotaxis; IEA:UniProtKB-KW.::GO:0006955; P:immune response; IEA:InterPro.::GO:0034638; P:phosphatidylcholine catabolic process; ISS:UniProtKB.
23Q6DDP3    441   ENPP6_XENLA Ectonucleotide pyrophosphatase/ph...4273e-30     128     26     45GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
24P90755    743   ENPP2_CAEEL Ectonucleotide pyrophosphatase/ph...5377e-29     126     25     41GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
25Q5BKW7    438   ENPP6_DANRE Ectonucleotide pyrophosphatase/ph...4224e-28     121     25     43GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
26Q6AX80    452   ENPP4_XENLA Ectonucleotide pyrophosphatase/ph...4617e-28     121     25     41GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
27Q5RB45    435   ENPP6_PONAB Ectonucleotide pyrophosphatase/ph...4038e-28     120     27     43GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
28Q5EZ72    439   ENPP7_RAT Ectonucleotide pyrophosphatase/phos...4391e-27     120     25     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC.
29Q6UWV6    458   ENPP7_HUMAN Ectonucleotide pyrophosphatase/ph...4332e-27     120     26     44GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005902; C:microvillus; IDA:UniProtKB.::GO:0005886; C:plasma membrane; TAS:Reactome.
GO:0004767; F:sphingomyelin phosphodiesterase activity; IDA:UniProtKB.
GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0008156; P:negative regulation of DNA replication; IDA:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006684; P:sphingomyelin metabolic process; IDA:UniProtKB.
30Q566N0    459   ENPP4_DANRE Ectonucleotide pyrophosphatase/ph...4289e-27     117     26     44GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
31A2VDP5    453   ENPP4_BOVIN Ectonucleotide pyrophosphatase/ph...4312e-24     110     28     42GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
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