Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCL040W
Length:
500
Number of sequences:
5887
Description:
YCL040W GLK1 SGDID:S000000545, Chr III from 50838-52340, Genome Release 64-1-1, Verified ORF, "Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31A2PYL6    917   HXK2_HORSE Hexokinase-2 OS=Equus caballus (Ho...4952e-64     229     36     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
32A2PYL7    917   HXK2_EQUZE Hexokinase-2 OS=Equus zebra (Mount...4952e-64     229     36     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
33A2PYL8    917   HXK2_EQUGR Hexokinase-2 OS=Equus grevyi (Grev...4952e-64     229     36     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
34P05708    918   HXK1_RAT Hexokinase-1 OS=Rattus norvegicus (R...4939e-53     196     31     51GO:0005901; C:caveola; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0043234; C:protein complex; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0016887; F:ATPase activity; IC:RGD.::GO:0004340; F:glucokinase activity; IDA:RGD.::GO:0005536; F:glucose binding; IDA:RGD.::GO:0032403; F:protein complex binding; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0004672; F:protein kinase activity; IDA:RGD.
GO:0006096; P:glycolysis; IDA:RGD.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:RGD.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:RGD.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0010359; P:regulation of anion channel activity; IDA:RGD.
35P19367    917   HXK1_HUMAN Hexokinase-1 OS=Homo sapiens (Huma...4931e-54     201     32     51GO:0005829; C:cytosol; TAS:Reactome.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; TAS:ProtInc.
GO:0015758; P:glucose transport; TAS:Reactome.::GO:0006096; P:glycolysis; TAS:ProtInc.::GO:0055085; P:transmembrane transport; TAS:Reactome.
36Q5RC71    917   HXK1_PONAB Hexokinase-1 OS=Pongo abelii (Suma...4932e-54     201     32     51
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
37P27926    924   HXK3_RAT Hexokinase-3 OS=Rattus norvegicus (R...4892e-54     200     32     49GO:0043234; C:protein complex; IDA:RGD.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019899; F:enzyme binding; IPI:RGD.::GO:0004396; F:hexokinase activity; IDA:RGD.::GO:0042562; F:hormone binding; IPI:RGD.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
38Q9NFT7    486   HXK2_DROME Hexokinase type 2 OS=Drosophila me...4824e-63     219     33     48
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; NAS:UniProtKB.
GO:0006096; P:glycolysis; NAS:UniProtKB.
39Q42525    496   HXK1_ARATH Hexokinase-1 OS=Arabidopsis thalia...4955e-63     219     35     50GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:TAIR.::GO:0009536; C:plastid; IDA:TAIR.::GO:0005774; C:vacuolar membrane; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008865; F:fructokinase activity; IDA:TAIR.::GO:0004340; F:glucokinase activity; IDA:TAIR.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IDA:TAIR.
GO:0010255; P:glucose mediated signaling pathway; IMP:TAIR.::GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0012501; P:programmed cell death; IMP:TAIR.
40P27595    918   HXK1_BOVIN Hexokinase-1 OS=Bos taurus (Bovine...4911e-41     163     29     49GO:0005829; C:cytosol; ISS:AgBase.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; ISS:AgBase.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
41Q3TRM8    922   HXK3_MOUSE Hexokinase-3 OS=Mus musculus (Mous...4872e-46     177     32     48GO:0005739; C:mitochondrion; IDA:MGI.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
42Q2KNB9    494   HXK2_ORYSJ Hexokinase-2 OS=Oryza sativa subsp...4866e-62     216     36     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
43P93834    502   HXK2_ARATH Hexokinase-2 OS=Arabidopsis thalia...4912e-61     214     35     49GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0009536; C:plastid; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008865; F:fructokinase activity; IDA:TAIR.::GO:0004340; F:glucokinase activity; IDA:TAIR.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0009747; P:hexokinase-dependent signaling; IMP:TAIR.::GO:0012501; P:programmed cell death; IMP:TAIR.
44Q2KNB7    502   HXK9_ORYSJ Hexokinase-9 OS=Oryza sativa subsp...4983e-61     214     35     50GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
45Q5W676    507   HXK5_ORYSJ Hexokinase-5 OS=Oryza sativa subsp...4995e-60     211     34     49GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
46Q26609    451   HXK_SCHMA Hexokinase OS=Schistosoma mansoni (...4927e-59     207     32     50
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
47Q9LPS1    498   HXK3_ARATH Hexokinase-3 OS=Arabidopsis thalia...5021e-58     207     32     51GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.::GO:0009536; C:plastid; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.
48Q8LH82    498   HXK1_ORYSJ Hexokinase-1 OS=Oryza sativa subsp...4344e-58     206     36     52
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
49P35557    465   HXK4_HUMAN Glucokinase OS=Homo sapiens (Human...4976e-57     202     30     51GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome.
GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0004340; F:glucokinase activity; IDA:UniProtKB.::GO:0005536; F:glucose binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0032869; P:cellular response to insulin stimulus; ISS:BHF-UCL.::GO:0044320; P:cellular response to leptin stimulus; ISS:BHF-UCL.::GO:0051594; P:detection of glucose; IMP:UniProtKB.::GO:0031018; P:endocrine pancreas development; TAS:Reactome.::GO:0042593; P:glucose homeostasis; IMP:UniProtKB.::GO:0015758; P:glucose transport; TAS:Reactome.::GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0045721; P:negative regulation of gluconeogenesis; IMP:UniProtKB.::GO:0045725; P:positive regulation of glycogen biosynthetic process; IMP:UniProtKB.::GO:0032024; P:positive regulation of insulin secretion; IMP:UniProtKB.::GO:0010827; P:regulation of glucose transport; TAS:Reactome.::GO:0006110; P:regulation of glycolysis; NAS:BHF-UCL.::GO:0055085; P:transmembrane transport; TAS:Reactome.
50P52792    465   HXK4_MOUSE Glucokinase OS=Mus musculus (Mouse...4921e-56     201     30     51GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; IDA:MGI.::GO:0005625; C:soluble fraction; IDA:MGI.
GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004340; F:glucokinase activity; ISS:UniProtKB.::GO:0005536; F:glucose binding; ISS:UniProtKB.
GO:0070509; P:calcium ion import; IMP:UniProtKB.::GO:0001678; P:cellular glucose homeostasis; IMP:MGI.::GO:0051594; P:detection of glucose; ISS:UniProtKB.::GO:0031018; P:endocrine pancreas development; TAS:Reactome.::GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0006739; P:NADP metabolic process; IMP:MGI.::GO:0045721; P:negative regulation of gluconeogenesis; ISS:UniProtKB.::GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.::GO:0032024; P:positive regulation of insulin secretion; IMP:UniProtKB.::GO:0043266; P:regulation of potassium ion transport; IMP:MGI.
51P17712    465   HXK4_RAT Glucokinase OS=Rattus norvegicus (Ra...4921e-55     198     30     51GO:0044448; C:cell cortex part; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005654; C:nucleoplasm; IDA:RGD.::GO:0030141; C:secretory granule; IDA:RGD.
GO:0043531; F:ADP binding; IDA:RGD.::GO:0005524; F:ATP binding; ISS:UniProtKB.::GO:0004340; F:glucokinase activity; ISS:UniProtKB.::GO:0005536; F:glucose binding; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:RGD.::GO:0019903; F:protein phosphatase binding; IPI:RGD.
GO:0001678; P:cellular glucose homeostasis; IMP:RGD.::GO:0042149; P:cellular response to glucose starvation; IMP:RGD.::GO:0032869; P:cellular response to insulin stimulus; IDA:BHF-UCL.::GO:0044320; P:cellular response to leptin stimulus; IDA:BHF-UCL.::GO:0051594; P:detection of glucose; ISS:UniProtKB.::GO:0007204; P:elevation of cytosolic calcium ion concentration; IDA:RGD.::GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IDA:RGD.::GO:0005978; P:glycogen biosynthetic process; IDA:RGD.::GO:0006096; P:glycolysis; IDA:RGD.::GO:0032811; P:negative regulation of epinephrine secretion; IMP:RGD.::GO:0045721; P:negative regulation of gluconeogenesis; ISS:UniProtKB.::GO:0045725; P:positive regulation of glycogen biosynthetic process; ISS:UniProtKB.::GO:0045821; P:positive regulation of glycolysis; IDA:RGD.::GO:0032024; P:positive regulation of insulin secretion; ISS:UniProtKB.::GO:0042327; P:positive regulation of phosphorylation; IDA:RGD.::GO:0019932; P:second-messenger-mediated signaling; IDA:RGD.
52Q2KNB5    504   HXK10_ORYSJ Hexokinase-10 OS=Oryza sativa sub...4652e-53     193     34     48GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
53Q56XE8    502   HXK4_ARATH Hexokinase-4 OS=Arabidopsis thalia...4774e-52     189     32     51GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
54O64390    498   HXK1_SOLTU Hexokinase-1 OS=Solanum tuberosum ...4263e-48     179     34     47GO:0009707; C:chloroplast outer membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
55Q02155    493   HXK_PLAFA Hexokinase OS=Plasmodium falciparum...5028e-46     172     30     46
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
56Q969A8    468   HXK_TOXGO Hexokinase OS=Toxoplasma gondii. GN...4896e-34     137     29     44
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
57Q4U3Y2    549   HXK1_ASPFU Hexokinase-1 OS=A1100) (Aspergillu...4237e-34     137     25     47
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
58Q9NFT9    465   HXK1_DROME Hexokinase type 1 OS=Drosophila me...4861e-30     127     24     44
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
59Q9T071    493   HXKL2_ARATH Probable hexokinase-like 2 protei...4422e-27     118     26     47GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0006974; P:response to DNA damage stimulus; IEP:TAIR.::GO:0009408; P:response to heat; IEP:TAIR.::GO:0006979; P:response to oxidative stress; IEP:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.::GO:0010224; P:response to UV-B; IEP:TAIR.::GO:0009414; P:response to water deprivation; IEP:TAIR.
60Q06204    433   YL446_YEAST Putative hexokinase YLR446W OS=Sa...4060.0007     45.8     21     37
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004396; F:hexokinase activity; IEA:EC.
GO:0006096; P:glycolysis; IEA:UniProtKB-KW.
61Q6NIA1    311   ISPE_CORDI 4-diphosphocytidyl-2-C-methyl-D-er...922.5     34.3     28     42
GO:0050515; F:4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO:0016114; P:terpenoid biosynthetic process; IEA:InterPro.
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