UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YCL018W

Length:

364

Number of sequences:

5887

Description:

YCL018W LEU2 SGDID:S000000523, Chr III from 91324-92418, Genome Release 64-1-1, Verified ORF, "Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
361	Q9ZN36	425	IDH_HELPJ Isocitrate dehydrogenase [NADP] OS=...	306	0.000000001	62.8	25	39
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
362	Q4QQT5	395	IDHG2_RAT Probable isocitrate dehydrogenase [...	364	0.000000001	62.8	25	43	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
363	P39126	423	IDH_BACSU Isocitrate dehydrogenase [NADP] OS=...	393	0.000000002	62.4	23	41
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
364	Q9ZH99	427	IDH_COXBU Isocitrate dehydrogenase [NADP] OS=...	361	0.000000002	62.4	24	40
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
365	Q59940	393	IDH_STRMU Isocitrate dehydrogenase [NADP] OS=...	385	0.000000005	61.2	25	40
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
366	Q8BPC6	396	IDHG2_MOUSE Probable isocitrate dehydrogenase...	362	0.00000001	59.7	24	43	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
367	Q8NW61	422	IDH_STAAW Isocitrate dehydrogenase [NADP] OS=...	137	0.01	41.2	31	46
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
368	Q6G8N2	422	IDH_STAAS Isocitrate dehydrogenase [NADP] OS=...	137	0.01	41.2	31	46
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
369	P99167	422	IDH_STAAN Isocitrate dehydrogenase [NADP] OS=...	137	0.01	41.2	31	46
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
370	P65099	422	IDH_STAAM Isocitrate dehydrogenase [NADP] OS=...	137	0.01	41.2	31	46
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
371	Q5HF79	422	IDH_STAAC Isocitrate dehydrogenase [NADP] OS=...	137	0.01	41.2	31	46
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
372	P41560	415	IDH1_COLMA Isocitrate dehydrogenase [NADP] 1 ...	74	0.000008	51.2	41	57
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
373	P50214	473	IDH_NOSS1 Isocitrate dehydrogenase [NADP] OS=...	143	3.1	33.5	26	41
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
374	P80046	475	IDH_SYNY3 Isocitrate dehydrogenase [NADP] OS=...	97	0.00006	48.5	31	53	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
375	O14254	439	IDHP_SCHPO Probable isocitrate dehydrogenase ...	235	0.0009	44.7	27	42	GO:0005739; C:mitochondrion; IDA:PomBase.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006537; P:glutamate biosynthetic process; ISS:PomBase.::GO:0006102; P:isocitrate metabolic process; ISS:PomBase.::GO:0006740; P:NADPH regeneration; ISS:PomBase.::GO:0006099; P:tricarboxylic acid cycle; IC:PomBase.
376	O88844	414	IDHC_MOUSE Isocitrate dehydrogenase [NADP] cy...	157	0.002	43.5	28	45	GO:0005829; C:cytosol; IDA:MGI.::GO:0005739; C:mitochondrion; IDA:MGI.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; IMP:MGI.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; IDA:MGI.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
377	Q9Z2K9	414	IDHC_MICME Isocitrate dehydrogenase [NADP] cy...	157	0.009	41.6	25	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
378	Q9Z2K8	414	IDHC_MICOH Isocitrate dehydrogenase [NADP] cy...	157	0.009	41.6	25	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
379	P41562	414	IDHC_RAT Isocitrate dehydrogenase [NADP] cyto...	157	0.031	39.7	27	45	GO:0005777; C:peroxisome; IDA:HGNC.::GO:0005625; C:soluble fraction; IDA:RGD.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050661; F:NADP binding; IDA:RGD.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0008585; P:female gonad development; IEP:RGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0014070; P:response to organic cyclic compound; IDA:RGD.::GO:0048545; P:response to steroid hormone stimulus; IDA:RGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
380	Q9XSG3	414	IDHC_BOVIN Isocitrate dehydrogenase [NADP] cy...	157	0.038	39.3	27	44	GO:0005829; C:cytosol; ISS:AgBase.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006749; P:glutathione metabolic process; ISS:AgBase.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:AgBase.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
381	Q6XUZ5	414	IDHC_SHEEP Isocitrate dehydrogenase [NADP] cy...	160	0.048	39.3	26	43	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
382	Q5R9C5	414	IDHC_PONAB Isocitrate dehydrogenase [NADP] cy...	157	0.055	38.9	27	44
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; ISS:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
383	O75874	414	IDHC_HUMAN Isocitrate dehydrogenase [NADP] cy...	157	0.072	38.5	27	44	GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005782; C:peroxisomal matrix; TAS:Reactome.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
									GO:0006103; P:2-oxoglutarate metabolic process; IDA:UniProtKB.::GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IDA:UniProtKB.::GO:0006740; P:NADPH regeneration; TAS:Reactome.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
384	Q9LQK9	294	IDH4_ARATH Putative isocitrate dehydrogenase ...	320	0.1	37.7	26	42
									GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IEA:InterPro.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006099; P:tricarboxylic acid cycle; IEA:InterPro.
385	P41939	412	IDHC_YEAST Isocitrate dehydrogenase [NADP] cy...	217	0.11	38.1	29	43	GO:0005829; C:cytosol; IDA:SGD.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006537; P:glutamate biosynthetic process; TAS:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IMP:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
386	P79089	498	IDHP_ASPNG Isocitrate dehydrogenase [NADP], m...	214	0.66	35.8	26	41	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
387	O13285	430	IDH1_CANTR Isocitrate dehydrogenase [NADP], m...	207	0.9	35	25	39	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; IEA:InterPro.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
388	P62576	1035	NANA_STRR6 Sialidase A OS=Streptococcus pneum...	94	1	35	27	40	GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-KW.::GO:0016020; C:membrane; IEA:InterPro.
									GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:EC.::GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:EC.::GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:EC.
									GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
389	P62575	1035	NANA_STRPN Sialidase A OS=Streptococcus pneum...	94	1	35	27	40	GO:0005618; C:cell wall; IEA:UniProtKB-SubCell.::GO:0005576; C:extracellular region; IEA:UniProtKB-KW.::GO:0016020; C:membrane; IEA:InterPro.
									GO:0052794; F:exo-alpha-(2->3)-sialidase activity; IEA:EC.::GO:0052795; F:exo-alpha-(2->6)-sialidase activity; IEA:EC.::GO:0052796; F:exo-alpha-(2->8)-sialidase activity; IEA:EC.
									GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
390	P53982	420	IDHH_YEAST Isocitrate dehydrogenase [NADP] OS...	113	1.7	34.3	28	47	GO:0005739; C:mitochondrion; IDA:SGD.::GO:0005777; C:peroxisome; IDA:SGD.
									GO:0004450; F:isocitrate dehydrogenase (NADP+) activity; TAS:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
									GO:0006635; P:fatty acid beta-oxidation; IMP:SGD.::GO:0006097; P:glyoxylate cycle; IEA:UniProtKB-KW.::GO:0006102; P:isocitrate metabolic process; TAS:SGD.::GO:0006740; P:NADPH regeneration; TAS:SGD.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
391	B3PKV6	270	APAH_CELJU Bis(5'-nucleosyl)-tetraphosphatase...	68	4.5	32.7	37	46
									GO:0008803; F:bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity; IEA:EC.

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