Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YCL018W
Length:
364
Number of sequences:
5887
Description:
YCL018W LEU2 SGDID:S000000523, Chr III from 91324-92418, Genome Release 64-1-1, Verified ORF, "Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
271P42958    354   TTUC_BACSU Probable tartrate dehydrogenase/de...3652e-41     154     32     50
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
272C4LJH3    342   LEU3_CORK4 3-isopropylmalate dehydrogenase OS...3472e-41     154     34     54GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
273Q47SB4    354   LEU3_THEFY 3-isopropylmalate dehydrogenase OS...3621e-40     152     34     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
274Q6NHM7    339   LEU3_CORDI 3-isopropylmalate dehydrogenase OS...3665e-40     149     34     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
275Q82JN6    347   LEU3_STRAW 3-isopropylmalate dehydrogenase OS...3232e-39     148     35     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
276A5CPZ4    355   LEU3_CLAM3 3-isopropylmalate dehydrogenase OS...3614e-39     147     34     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
277Q51945    365   TTUC_PSEPU Tartrate dehydrogenase/decarboxyla...3804e-39     147     31     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
278P40495    371   LYS12_YEAST Homoisocitrate dehydrogenase, mit...3642e-37     143     33     52GO:0005739; C:mitochondrion; IDA:SGD.
GO:0047046; F:homoisocitrate dehydrogenase activity; IDA:SGD.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009085; P:lysine biosynthetic process; IEA:UniProtKB-KW.
279Q1BAR4    336   LEU3_MYCSS 3-isopropylmalate dehydrogenase OS...3136e-37     141     35     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
280A1UE98    336   LEU3_MYCSK 3-isopropylmalate dehydrogenase OS...3136e-37     141     35     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
281A3PXQ2    336   LEU3_MYCSJ 3-isopropylmalate dehydrogenase OS...3136e-37     141     35     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
282B0RIP4    355   LEU3_CLAMS 3-isopropylmalate dehydrogenase OS...3611e-36     140     35     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
283C1B2M3    336   LEU3_RHOOB 3-isopropylmalate dehydrogenase OS...3612e-36     140     33     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
284Q0S2H1    336   LEU3_RHOSR 3-isopropylmalate dehydrogenase OS...3612e-36     139     33     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
285C0ZXM4    337   LEU3_RHOE4 3-isopropylmalate dehydrogenase OS...2983e-36     139     33     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
286A4TE12    336   LEU3_MYCGI 3-isopropylmalate dehydrogenase OS...3597e-36     138     33     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
287O14104    362   LYS12_SCHPO Probable homoisocitrate dehydroge...3798e-36     139     31     51GO:0005739; C:mitochondrion; ISS:PomBase.
GO:0047046; F:homoisocitrate dehydrogenase activity; ISS:PomBase.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006091; P:generation of precursor metabolites and energy; NAS:PomBase.::GO:0009085; P:lysine biosynthetic process; IMP:PomBase.
288Q55BI2    354   IDHA_DICDI Isocitrate dehydrogenase [NAD] reg...3662e-35     137     34     52GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; ISS:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0006102; P:isocitrate metabolic process; ISS:UniProtKB.::GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
289A0PPY6    339   LEU3_MYCUA 3-isopropylmalate dehydrogenase OS...3352e-35     137     33     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
290Q945K7    374   IDH5_ARATH Isocitrate dehydrogenase [NAD] cat...3682e-35     138     31     47GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005739; C:mitochondrion; IDA:TAIR.
GO:0005524; F:ATP binding; IDA:TAIR.::GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IMP:TAIR.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IDA:TAIR.
GO:0006102; P:isocitrate metabolic process; IMP:TAIR.::GO:0006099; P:tricarboxylic acid cycle; TAS:TAIR.
291B2HIH1    339   LEU3_MYCMM 3-isopropylmalate dehydrogenase OS...3352e-35     137     33     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
292P70792    358   TTUC4_AGRVI Probable tartrate dehydrogenase/d...3676e-35     136     31     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
293P70787    364   TTUC2_AGRVI Probable tartrate dehydrogenase/d...3679e-35     135     31     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
294O34296    358   TTUC3_AGRVI Probable tartrate dehydrogenase/d...3678e-34     133     31     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
295O34295    358   TTUC5_AGRVI Probable tartrate dehydrogenase/d...3679e-34     132     31     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
296Q44471    364   TTUC1_AGRVI Probable tartrate dehydrogenase/d...3671e-33     132     31     47GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046553; F:D-malate dehydrogenase (decarboxylating) activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0050319; F:tartrate decarboxylase activity; IEA:EC.::GO:0009027; F:tartrate dehydrogenase activity; IEA:EC.
297A0QJC2    336   LEU3_MYCA1 3-isopropylmalate dehydrogenase OS...3602e-33     131     34     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
298Q73VI1    336   LEU3_MYCPA 3-isopropylmalate dehydrogenase OS...3603e-33     131     33     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
299A8L554    342   LEU3_FRASN 3-isopropylmalate dehydrogenase OS...3274e-33     130     34     51GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
300Q9UXB2    336   LEU3_SULSO 3-isopropylmalate dehydrogenase OS...3595e-33     130     31     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:EC.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.
GO:0009098; P:leucine biosynthetic process; IEA:UniProtKB-KW.
301Q48806    615   DLPA_LEGPH Protein dlpA OS=ATCC 33152 / DSM 7...3917e-33     133     29     46
GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0051287; F:NAD binding; IEA:InterPro.::GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
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