Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YBR223C
Length:
544
Number of sequences:
5887
Description:
YBR223C TDP1 SGDID:S000000427, Chr II from 670297-668663, Genome Release 64-1-1, reverse complement, Verified ORF, "Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P38319    544   TYDP1_YEAST Tyrosyl-DNA phosphodiesterase 1 O...5440     1143     100     100GO:0005634; C:nucleus; IDA:SGD.
GO:0017005; F:3'-tyrosyl-DNA phosphodiesterase activity; IDA:SGD.::GO:0070260; F:5'-tyrosyl-DNA phosphodiesterase activity; IDA:SGD.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0006281; P:DNA repair; IMP:SGD.
2Q9NUW8    608   TYDP1_HUMAN Tyrosyl-DNA phosphodiesterase 1 O...5290.000000000000002     82.8     24     42GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0017005; F:3'-tyrosyl-DNA phosphodiesterase activity; IDA:UniProtKB.::GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003697; F:single-stranded DNA binding; IDA:UniProtKB.
GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0006302; P:double-strand break repair; IDA:UniProtKB.::GO:0000012; P:single strand break repair; IDA:UniProtKB.
3Q8BJ37    609   TYDP1_MOUSE Tyrosyl-DNA phosphodiesterase 1 O...4370.0000000000007     74.7     24     41GO:0005634; C:nucleus; IDA:MGI.
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
GO:0000012; P:single strand break repair; IMP:MGI.
4Q4G056    609   TYDP1_RAT Tyrosyl-DNA phosphodiesterase 1 OS=...4390.00000000001     70.9     23     41GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
5Q9VQM4    580   TYDP1_DROME Probable tyrosyl-DNA phosphodiest...3980.00000004     59.7     22     38GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.
GO:0017005; F:3'-tyrosyl-DNA phosphodiesterase activity; ISS:UniProtKB.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0007417; P:central nervous system development; IMP:FlyBase.::GO:0006281; P:DNA repair; ISS:UniProtKB.::GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; IMP:FlyBase.
6Q9TXV7    451   TYDP1_CAEEL Probable tyrosyl-DNA phosphodiest...4600.0000006     55.5     23     38GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.::GO:0008081; F:phosphoric diester hydrolase activity; IEA:InterPro.
GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
7Q9USG9    536   TYDP1_SCHPO Probable tyrosyl-DNA phosphodiest...1220.000005     52.8     26     52GO:0005634; C:nucleus; IDA:PomBase.
GO:0017005; F:3'-tyrosyl-DNA phosphodiesterase activity; IMP:PomBase.::GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
GO:0000012; P:single strand break repair; IMP:PomBase.
8Q9Y823    418   HOSM_SCHPO Homocitrate synthase, mitochondria...1030.94     35.8     26     46GO:0005829; C:cytosol; IDA:PomBase.::GO:0005739; C:mitochondrion; ISS:PomBase.::GO:0005634; C:nucleus; ISS:PomBase.
GO:0004410; F:homocitrate synthase activity; IMP:PomBase.
GO:0006091; P:generation of precursor metabolites and energy; NAS:PomBase.::GO:0019878; P:lysine biosynthetic process via aminoadipic acid; IMP:PomBase.
9Q5LNK0    117   RPOZ_SILPO DNA-directed RNA polymerase subuni...665.7     31.6     35     50GO:0030880; C:RNA polymerase complex; IEA:InterPro.
GO:0003677; F:DNA binding; IEA:InterPro.::GO:0003899; F:DNA-directed RNA polymerase activity; IEA:UniProtKB-KW.
10Q6LA43    535   APRR2_ARATH Two-component response regulator-...1207.5     33.1     23     46GO:0005634; C:nucleus; IDA:TAIR.
GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:TAIR.::GO:0000156; F:two-component response regulator activity; IEA:InterPro.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
records
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