UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YBR218C

Length:

1180

Number of sequences:

5887

Description:

YBR218C PYC2 SGDID:S000000422, Chr II from 662249-658707, Genome Release 64-1-1, reverse complement, Verified ORF, "Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
61	P11497	2345	ACACA_RAT Acetyl-CoA carboxylase 1 OS=Rattus ...	496	2e-62	238	32	50	GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:RGD.
									GO:0003989; F:acetyl-CoA carboxylase activity; IDA:RGD.::GO:0005524; F:ATP binding; IDA:RGD.::GO:0009374; F:biotin binding; IMP:RGD.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0019900; F:kinase binding; IPI:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006084; P:acetyl-CoA metabolic process; IDA:RGD.::GO:0006633; P:fatty acid biosynthetic process; IDA:RGD.::GO:0051289; P:protein homotetramerization; ISS:UniProtKB.::GO:0042493; P:response to drug; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IMP:RGD.
62	O00763	2458	ACACB_HUMAN Acetyl-CoA carboxylase 2 OS=Homo ...	510	4e-61	234	32	49	GO:0005829; C:cytosol; TAS:Reactome.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0016020; C:membrane; IEA:UniProtKB-KW.
									GO:0003989; F:acetyl-CoA carboxylase activity; IDA:UniProtKB.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.
									GO:0006084; P:acetyl-CoA metabolic process; IDA:UniProtKB.::GO:0006853; P:carnitine shuttle; TAS:Reactome.::GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0031325; P:positive regulation of cellular metabolic process; TAS:Reactome.::GO:0051289; P:protein homotetramerization; IDA:UniProtKB.::GO:0046320; P:regulation of fatty acid oxidation; TAS:Reactome.
63	Q00955	2233	ACAC_YEAST Acetyl-CoA carboxylase OS=Saccharo...	71	3.2	35.8	27	55	GO:0005789; C:endoplasmic reticulum membrane; IDA:SGD.::GO:0005739; C:mitochondrion; IDA:SGD.
									GO:0003989; F:acetyl-CoA carboxylase activity; IMP:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IMP:SGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.::GO:0006998; P:nuclear envelope organization; TAS:SGD.::GO:0006606; P:protein import into nucleus; IMP:SGD.
64	A6ZMR9	2273	HFA1_YEAS7 Acetyl-CoA carboxylase, mitochondr...	626	3e-60	231	29	48	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:InterPro.
									GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
65	C8ZF72	2273	HFA1_YEAS8 Acetyl-CoA carboxylase, mitochondr...	518	1e-59	229	31	50	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:InterPro.
									GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
66	C7GRE4	2273	HFA1_YEAS2 Acetyl-CoA carboxylase, mitochondr...	518	2e-59	229	31	50	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:InterPro.
									GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
67	P32874	2273	HFA1_YEAST Acetyl-CoA carboxylase, mitochondr...	518	2e-59	228	31	50	GO:0005739; C:mitochondrion; IDA:SGD.
									GO:0003989; F:acetyl-CoA carboxylase activity; IGI:SGD.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:InterPro.
									GO:0006633; P:fatty acid biosynthetic process; IGI:SGD.
68	B3LM95	2273	HFA1_YEAS1 Acetyl-CoA carboxylase, mitochondr...	626	3e-59	228	29	48	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:InterPro.
									GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
69	P78820	2280	ACAC_SCHPO Acetyl-CoA carboxylase OS=Schizosa...	71	0.091	40.8	34	55	GO:0005829; C:cytosol; IDA:PomBase.::GO:0000329; C:fungal-type vacuole membrane; IDA:PomBase.
									GO:0003989; F:acetyl-CoA carboxylase activity; ISS:PomBase.::GO:0005524; F:ATP binding; ISS:PomBase.::GO:0004075; F:biotin carboxylase activity; ISS:PomBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0042759; P:long-chain fatty acid biosynthetic process; IMP:PomBase.::GO:0007088; P:regulation of mitosis; IMP:PomBase.
70	Q54J08	2282	ACAC_DICDI Acetyl-CoA carboxylase OS=Dictyost...	532	2e-58	225	31	51	GO:0005829; C:cytosol; ISS:dictyBase.::GO:0005789; C:endoplasmic reticulum membrane; ISS:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0005739; C:mitochondrion; ISS:dictyBase.
									GO:0003989; F:acetyl-CoA carboxylase activity; ISS:dictyBase.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; ISS:dictyBase.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006633; P:fatty acid biosynthetic process; ISS:dictyBase.::GO:0006998; P:nuclear envelope organization; ISS:dictyBase.::GO:0006606; P:protein import into nucleus; ISS:dictyBase.
71	B9FK36	2327	ACC2_ORYSJ Acetyl-CoA carboxylase 2 OS=Oryza ...	511	2e-58	225	30	47	GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
									GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
72	Q8S6N5	2267	ACC1_ORYSJ Acetyl-CoA carboxylase 1 OS=Oryza ...	535	3e-58	224	29	47	GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
									GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
73	F4I1L3	2355	ACC2_ARATH Acetyl-CoA carboxylase 2 OS=Arabid...	534	2e-57	222	28	48	GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
									GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
74	Q38970	2254	ACC1_ARATH Acetyl-CoA carboxylase 1 OS=Arabid...	536	2e-57	222	29	47	GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR.
									GO:0003989; F:acetyl-CoA carboxylase activity; IEA:EC.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004075; F:biotin carboxylase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0030497; P:fatty acid elongation; IMP:TAIR.::GO:0010072; P:primary shoot apical meristem specification; IMP:TAIR.::GO:0009735; P:response to cytokinin stimulus; IMP:TAIR.::GO:0048364; P:root development; IMP:TAIR.
75	Q97FT3	1065	CARB_CLOAB Carbamoyl-phosphate synthase large...	320	0.00000001	63.2	24	44
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
76	A2BJL3	1073	CARB_HYPBU Carbamoyl-phosphate synthase large...	226	0.002	46.6	20	40
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
77	Q1WVA9	1061	CARB_LACS1 Carbamoyl-phosphate synthase large...	196	0.002	46.6	24	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
78	Q8Z9L7	1075	CARB_SALTI Carbamoyl-phosphate synthase large...	234	0.00000001	63.5	24	44
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
79	P14846	1075	CARB_SALTY Carbamoyl-phosphate synthase large...	234	0.00000001	63.2	24	44
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
80	Q8U085	1056	CARB_PYRFU Carbamoyl-phosphate synthase large...	224	0.07	41.2	19	38
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
81	Q03HB0	1057	CARB_PEDPA Carbamoyl-phosphate synthase large...	350	0.00000008	60.5	21	41
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
82	C1EPQ0	1072	CARB_BACC3 Carbamoyl-phosphate synthase large...	236	0.0000004	58.2	21	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
83	A0RHQ8	1072	CARB_BACAH Carbamoyl-phosphate synthase large...	236	0.0000004	58.2	21	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
84	B7JJX3	1072	CARB_BACC0 Carbamoyl-phosphate synthase large...	236	0.0000004	58.2	21	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
85	Q81WF2	1072	CARB_BACAN Carbamoyl-phosphate synthase large...	353	0.0000004	58.2	20	42
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
86	C3L740	1072	CARB_BACAC Carbamoyl-phosphate synthase large...	353	0.0000004	58.2	20	42
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
87	C3P656	1072	CARB_BACAA Carbamoyl-phosphate synthase large...	353	0.0000004	58.2	20	42
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
88	Q732I3	1072	CARB_BACC1 Carbamoyl-phosphate synthase large...	236	0.00000009	60.5	22	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
89	Q8FLB0	1073	CARB_ECOL6 Carbamoyl-phosphate synthase large...	236	0.00000001	63.2	25	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
90	Q8ZIL4	1077	CARB_YERPE Carbamoyl-phosphate synthase large...	234	0.00000006	61.2	24	44
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
91	B7H6M2	1072	CARB_BACC4 Carbamoyl-phosphate synthase large...	236	0.0000004	58.2	21	43
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
									GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.

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