Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YBR140C
Length:
3092
Number of sequences:
5887
Description:
YBR140C IRA1 SGDID:S000000344, Chr II from 526628-517350, Genome Release 64-1-1, reverse complement, Verified ORF, "GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P18963    3092   IRA1_YEAST Inhibitory regulator protein IRA1 ...30920     6338     100     100GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0005099; F:Ras GTPase activator activity; IMP:SGD.
GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:SGD.::GO:0045761; P:regulation of adenylate cyclase activity; IMP:SGD.::GO:0007165; P:signal transduction; IEA:InterPro.
2P19158    3079   IRA2_YEAST Inhibitory regulator protein IRA2 ...25890     2412     48     69GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005739; C:mitochondrion; IDA:SGD.
GO:0005099; F:Ras GTPase activator activity; IDA:SGD.
GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:SGD.::GO:0006950; P:response to stress; IMP:SGD.::GO:0007165; P:signal transduction; IEA:InterPro.
3P97526    2820   NF1_RAT Neurofibromin OS=Rattus norvegicus (R...15902e-61     239     22     42GO:0030424; C:axon; IDA:HGNC.::GO:0005737; C:cytoplasm; IDA:HGNC.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005634; C:nucleus; IDA:HGNC.::GO:0014069; C:postsynaptic density; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.::GO:0019717; C:synaptosome; IDA:RGD.
GO:0008017; F:microtubule binding; IDA:MGI.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.::GO:0045545; F:syndecan binding; IPI:RGD.
GO:0030036; P:actin cytoskeleton organization; ISS:HGNC.::GO:0030325; P:adrenal gland development; ISS:HGNC.::GO:0048844; P:artery morphogenesis; ISS:HGNC.::GO:0048593; P:camera-type eye morphogenesis; ISS:HGNC.::GO:0021987; P:cerebral cortex development; ISS:HGNC.::GO:0030199; P:collagen fibril organization; ISS:HGNC.::GO:0021897; P:forebrain astrocyte development; ISS:HGNC.::GO:0048853; P:forebrain morphogenesis; ISS:HGNC.::GO:0007507; P:heart development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0000165; P:MAPK cascade; ISS:HGNC.::GO:0001656; P:metanephros development; ISS:HGNC.::GO:0022011; P:myelination in peripheral nervous system; ISS:HGNC.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:HGNC.::GO:0043409; P:negative regulation of MAPK cascade; ISS:HGNC.::GO:0007406; P:negative regulation of neuroblast proliferation; ISS:HGNC.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:HGNC.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:HGNC.::GO:0001649; P:osteoblast differentiation; ISS:HGNC.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:HGNC.::GO:0043473; P:pigmentation; ISS:HGNC.::GO:0045762; P:positive regulation of adenylate cyclase activity; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0007265; P:Ras protein signal transduction; ISS:HGNC.::GO:0045765; P:regulation of angiogenesis; ISS:HGNC.::GO:0045124; P:regulation of bone resorption; ISS:HGNC.::GO:0001952; P:regulation of cell-matrix adhesion; ISS:HGNC.::GO:0045664; P:regulation of neuron differentiation; IMP:RGD.::GO:0001666; P:response to hypoxia; ISS:HGNC.::GO:0048745; P:smooth muscle tissue development; ISS:HGNC.::GO:0021510; P:spinal cord development; ISS:HGNC.::GO:0048485; P:sympathetic nervous system development; ISS:HGNC.::GO:0008542; P:visual learning; ISS:HGNC.::GO:0042060; P:wound healing; ISS:HGNC.
4Q04690    2841   NF1_MOUSE Neurofibromin OS=Mus musculus (Mous...16112e-58     229     22     41GO:0005737; C:cytoplasm; IDA:MGI.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005515; F:protein binding; IPI:MGI.::GO:0005099; F:Ras GTPase activator activity; IGI:MGI.
GO:0030036; P:actin cytoskeleton organization; IMP:MGI.::GO:0030325; P:adrenal gland development; IMP:MGI.::GO:0048844; P:artery morphogenesis; IMP:MGI.::GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.::GO:0021987; P:cerebral cortex development; IMP:MGI.::GO:0030199; P:collagen fibril organization; IMP:MGI.::GO:0021897; P:forebrain astrocyte development; IMP:MGI.::GO:0048853; P:forebrain morphogenesis; IMP:MGI.::GO:0007507; P:heart development; IMP:MGI.::GO:0001889; P:liver development; IMP:MGI.::GO:0000165; P:MAPK cascade; IMP:MGI.::GO:0001656; P:metanephros development; IMP:MGI.::GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.::GO:0016525; P:negative regulation of angiogenesis; IGI:MGI.::GO:0048712; P:negative regulation of astrocyte differentiation; IMP:MGI.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:MGI.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0007406; P:negative regulation of neuroblast proliferation; IMP:MGI.::GO:0046929; P:negative regulation of neurotransmitter secretion; IMP:MGI.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; IMP:MGI.::GO:0035021; P:negative regulation of Rac protein signal transduction; IGI:MGI.::GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:MGI.::GO:0021915; P:neural tube development; IGI:MGI.::GO:0001649; P:osteoblast differentiation; IMP:MGI.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; IMP:MGI.::GO:0043473; P:pigmentation; IMP:MGI.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:MGI.::GO:0001938; P:positive regulation of endothelial cell proliferation; IGI:MGI.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:MGI.::GO:0007265; P:Ras protein signal transduction; IMP:MGI.::GO:0045124; P:regulation of bone resorption; IMP:MGI.::GO:0001952; P:regulation of cell-matrix adhesion; IMP:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.::GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:MGI.::GO:0001666; P:response to hypoxia; IMP:MGI.::GO:0007519; P:skeletal muscle tissue development; IMP:MGI.::GO:0048745; P:smooth muscle tissue development; IMP:MGI.::GO:0021510; P:spinal cord development; IMP:MGI.::GO:0048485; P:sympathetic nervous system development; IMP:MGI.::GO:0008542; P:visual learning; IMP:MGI.::GO:0042060; P:wound healing; IMP:MGI.
5P21359    2839   NF1_HUMAN Neurofibromin OS=Homo sapiens (Huma...16116e-58     228     22     41GO:0030424; C:axon; IDA:HGNC.::GO:0005737; C:cytoplasm; ISS:HGNC.::GO:0030425; C:dendrite; IDA:HGNC.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005634; C:nucleus; ISS:HGNC.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0005099; F:Ras GTPase activator activity; IDA:HGNC.
GO:0030036; P:actin cytoskeleton organization; ISS:HGNC.::GO:0030325; P:adrenal gland development; ISS:HGNC.::GO:0048844; P:artery morphogenesis; ISS:HGNC.::GO:0048593; P:camera-type eye morphogenesis; ISS:HGNC.::GO:0021987; P:cerebral cortex development; ISS:HGNC.::GO:0030199; P:collagen fibril organization; ISS:HGNC.::GO:0021897; P:forebrain astrocyte development; ISS:HGNC.::GO:0048853; P:forebrain morphogenesis; ISS:HGNC.::GO:0007507; P:heart development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0000165; P:MAPK cascade; ISS:HGNC.::GO:0001656; P:metanephros development; ISS:HGNC.::GO:0022011; P:myelination in peripheral nervous system; ISS:HGNC.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:HGNC.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0007406; P:negative regulation of neuroblast proliferation; ISS:HGNC.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:HGNC.::GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:HGNC.::GO:0001649; P:osteoblast differentiation; ISS:HGNC.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:HGNC.::GO:0043473; P:pigmentation; ISS:HGNC.::GO:0045762; P:positive regulation of adenylate cyclase activity; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0007265; P:Ras protein signal transduction; ISS:HGNC.::GO:0043535; P:regulation of blood vessel endothelial cell migration; IMP:HGNC.::GO:0045124; P:regulation of bone resorption; ISS:HGNC.::GO:0001952; P:regulation of cell-matrix adhesion; ISS:HGNC.::GO:0001666; P:response to hypoxia; ISS:HGNC.::GO:0048745; P:smooth muscle tissue development; ISS:HGNC.::GO:0021510; P:spinal cord development; ISS:HGNC.::GO:0048485; P:sympathetic nervous system development; ISS:HGNC.::GO:0008542; P:visual learning; ISS:HGNC.::GO:0042060; P:wound healing; ISS:HGNC.
6O95294    804   RASL1_HUMAN RasGAP-activating-like protein 1 ...3990.000000000000002     87     24     42GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; TAS:ProtInc.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
7Q14644    834   RASA3_HUMAN Ras GTPase-activating protein 3 O...2120.000000000000004     85.9     31     50GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IDA:BHF-UCL.
GO:0015278; F:calcium-release channel activity; IDA:BHF-UCL.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
8Q9Z268    799   RASL1_MOUSE RasGAP-activating-like protein 1 ...3990.00000000000002     83.2     23     39GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
9Q54Y08    877   NGAP_DICDI Probable Ras GTPase-activating-lik...2280.00000000000002     83.6     27     52GO:0005813; C:centrosome; TAS:dictyBase.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro.
10Q9QYJ2    834   RASA3_RAT Ras GTPase-activating protein 3 OS=...2120.00000000000008     81.6     30     50GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
11Q60790    834   RASA3_MOUSE Ras GTPase-activating protein 3 O...2120.00000000000009     81.6     30     50GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
12P48423    1163   GAP1_DROME GTPase-activating protein OS=Droso...2080.0000000000008     78.6     31     44GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IMP:FlyBase.
GO:0008595; P:anterior/posterior axis specification, embryo; TAS:FlyBase.::GO:0016321; P:female meiosis chromosome segregation; IMP:FlyBase.::GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.::GO:0007067; P:mitosis; IMP:FlyBase.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0045678; P:positive regulation of R7 cell differentiation; IGI:FlyBase.::GO:0007265; P:Ras protein signal transduction; IMP:FlyBase.::GO:0007062; P:sister chromatid cohesion; IMP:FlyBase.::GO:0008293; P:torso signaling pathway; NAS:FlyBase.::GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase.
13Q63713    847   RASA2_RAT Ras GTPase-activating protein 2 OS=...2010.000000000002     77     33     50GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IDA:RGD.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
14Q15283    849   RASA2_HUMAN Ras GTPase-activating protein 2 O...1760.000000000002     77     34     49GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
15P58069    848   RASA2_MOUSE Ras GTPase-activating protein 2 O...2010.000000000003     76.6     31     51GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
16Q28013    834   RASA3_BOVIN Ras GTPase-activating protein 3 O...2120.000000000004     76.3     28     50GO:0005737; C:cytoplasm; ISS:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; ISS:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; ISS:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:RefGenome.
17P33277    766   GAP1_SCHPO GTPase-activating protein OS=Schiz...2570.000000000009     74.7     28     45GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase.
GO:0005099; F:Ras GTPase activator activity; IGI:PomBase.
GO:0007265; P:Ras protein signal transduction; IC:PomBase.::GO:0032005; P:signal transduction involved in conjugation with cellular fusion; IMP:PomBase.
18Q55AR6    920   NFAA_DICDI Neurofibromin-A OS=Dictyostelium d...2540.0000000005     69.3     24     44GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005099; F:Ras GTPase activator activity; ISS:dictyBase.
GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0030833; P:regulation of actin filament polymerization; IMP:dictyBase.::GO:0050920; P:regulation of chemotaxis; IMP:dictyBase.::GO:0051896; P:regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro.
19Q6PFQ7    802   RASL2_MOUSE Ras GTPase-activating protein 4 O...1990.00000006     62.4     24     44GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
20O43374    803   RASL2_HUMAN Ras GTPase-activating protein 4 O...1870.00000008     62     24     47GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.
21C9J798    803   RAS4B_HUMAN Putative Ras GTPase-activating pr...1870.0000001     61.6     24     47GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
22Q54K32    822   RGAA_DICDI Ras GTPase-activating-like protein...2020.0000008     58.9     24     46GO:0005938; C:cell cortex; TAS:dictyBase.::GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell.
GO:0005516; F:calmodulin binding; ISS:dictyBase.::GO:0048365; F:Rac GTPase binding; IPI:dictyBase.::GO:0005099; F:Ras GTPase activator activity; IDA:dictyBase.
GO:0000910; P:cytokinesis; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0031149; P:sorocarp stalk cell differentiation; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase.
23P20936    1047   RASA1_HUMAN Ras GTPase-activating protein 1 O...3650.000002     57.8     22     44GO:0005829; C:cytosol; TAS:Reactome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0001948; F:glycoprotein binding; IPI:UniProtKB.::GO:0051020; F:GTPase binding; IPI:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019870; F:potassium channel inhibitor activity; NAS:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.::GO:0005102; F:receptor binding; IPI:UniProtKB.
GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; IDA:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; IDA:UniProtKB.::GO:0030833; P:regulation of actin filament polymerization; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; NAS:UniProtKB.::GO:0051252; P:regulation of RNA metabolic process; NAS:UniProtKB.::GO:0001570; P:vasculogenesis; ISS:UniProtKB.
24Q3UQ44    1575   IQGA2_MOUSE Ras GTPase-activating-like protei...2440.000003     57.4     23     45GO:0005622; C:intracellular; IEA:InterPro.::GO:0005902; C:microvillus; IDA:MGI.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
25Q13576    1575   IQGA2_HUMAN Ras GTPase-activating-like protei...2440.000003     57     23     45GO:0015629; C:actin cytoskeleton; TAS:ProtInc.
GO:0003779; F:actin binding; TAS:ProtInc.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
26P50904    1038   RASA1_RAT Ras GTPase-activating protein 1 OS=...3650.000004     56.6     22     44GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0007155; P:cell adhesion; NAS:UniProtKB.::GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.::GO:0007165; P:signal transduction; ISS:UniProtKB.::GO:0001570; P:vasculogenesis; ISS:UniProtKB.
27Q3UHC7    1189   DAB2P_MOUSE Disabled homolog 2-interacting pr...1900.000006     55.8     28     49GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0070059; P:apoptosis in response to endoplasmic reticulum stress; IMP:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IMP:BHF-UCL.::GO:0035414; P:negative regulation of catenin import into nucleus; IMP:BHF-UCL.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL.
28Q6P730    996   DAB2P_RAT Disabled homolog 2-interacting prot...1960.000007     55.8     28     50GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0047485; F:protein N-terminus binding; IPI:RGD.::GO:0005099; F:Ras GTPase activator activity; IDA:RGD.
GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:BHF-UCL.::GO:0030308; P:negative regulation of cell growth; IDA:RGD.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IDA:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:RGD.
29Q5VWQ8    1189   DAB2P_HUMAN Disabled homolog 2-interacting pr...1960.00001     55.5     28     50GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0071889; F:14-3-3 protein binding; IDA:BHF-UCL.::GO:0005123; F:death receptor binding; IPI:BHF-UCL.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.::GO:0051721; F:protein phosphatase 2A binding; IDA:BHF-UCL.::GO:0005099; F:Ras GTPase activator activity; ISS:BHF-UCL.::GO:0035591; F:signaling adaptor activity; IDA:BHF-UCL.
GO:0007257; P:activation of JUN kinase activity; IDA:BHF-UCL.::GO:0070059; P:apoptosis in response to endoplasmic reticulum stress; ISS:BHF-UCL.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:BHF-UCL.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0035414; P:negative regulation of catenin import into nucleus; ISS:BHF-UCL.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0010633; P:negative regulation of epithelial cell migration; TAS:BHF-UCL.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:BHF-UCL.::GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.::GO:0048147; P:negative regulation of fibroblast proliferation; ISS:BHF-UCL.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0034261; P:negative regulation of Ras GTPase activity; IMP:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IC:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
30O00899    860   GAPA_DICDI Ras GTPase-activating-like protein...2030.00001     55.1     24     45GO:0005622; C:intracellular; IEA:InterPro.
GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006972; P:hyperosmotic response; IEP:dictyBase.::GO:0006979; P:response to oxidative stress; IEP:dictyBase.::GO:0019953; P:sexual reproduction; IEP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
31Q9QUH6    1308   SYGP1_RAT Ras GTPase-activating protein SynGA...2260.00001     55.1     26     46GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:UniProtKB.
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