Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YBR140C
Length:
3092
Number of sequences:
5887
Description:
YBR140C IRA1 SGDID:S000000344, Chr II from 526628-517350, Genome Release 64-1-1, reverse complement, Verified ORF, "GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
31Q9QUH6    1308   SYGP1_RAT Ras GTPase-activating protein SynGA...2260.00001     55.1     26     46GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:UniProtKB.
32Q96PV0    1343   SYGP1_HUMAN Ras GTPase-activating protein Syn...2260.00001     55.1     26     46GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.
33F6SEU4    1340   SYGP1_MOUSE Ras GTPase-activating protein Syn...2260.00001     55.1     26     46GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0043198; C:dendritic shaft; IDA:MGI.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005097; F:Rab GTPase activator activity; IDA:MGI.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0016358; P:dendrite development; IMP:MGI.::GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.::GO:0050771; P:negative regulation of axonogenesis; IDA:MGI.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007389; P:pattern specification process; IMP:MGI.::GO:0007265; P:Ras protein signal transduction; IDA:MGI.::GO:0043113; P:receptor clustering; IMP:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.::GO:0043408; P:regulation of MAPK cascade; IMP:MGI.::GO:0050803; P:regulation of synapse structure and activity; IMP:MGI.::GO:0008542; P:visual learning; IMP:MGI.
34Q86VI3    1631   IQGA3_HUMAN Ras GTPase-activating-like protei...2620.00001     55.1     21     42
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
35A6QQ91    1012   RASL3_BOVIN RAS protein activator like-3 OS=B...2350.00002     54.3     26     44GO:0005737; C:cytoplasm; ISS:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; ISS:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; ISS:RefGenome.
GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro.
36Q8C2K5    1041   RASL3_MOUSE RAS protein activator like-3 OS=M...2310.00002     54.3     26     42GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro.
37Q86YV0    1011   RASL3_HUMAN RAS protein activator like-3 OS=H...1890.00003     53.9     29     44GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro.
38P09851    1044   RASA1_BOVIN Ras GTPase-activating protein 1 O...3400.00009     52     21     43GO:0005737; C:cytoplasm; ISS:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; ISS:RefGenome.
GO:0051020; F:GTPase binding; ISS:AgBase.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; ISS:RefGenome.::GO:0005102; F:receptor binding; ISS:AgBase.
GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:AgBase.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:AgBase.::GO:0030833; P:regulation of actin filament polymerization; ISS:AgBase.::GO:0007165; P:signal transduction; ISS:AgBase.::GO:0001570; P:vasculogenesis; ISS:UniProtKB.
39Q8MLZ5    1207   GAP2_CAEEL Ras GTPase-activating protein gap-...1790.0001     52     26     50GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; NAS:UniProtKB.
GO:0046580; P:negative regulation of Ras protein signal transduction; IEP:UniProtKB.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0007165; P:signal transduction; IEA:InterPro.
40P46940    1657   IQGA1_HUMAN Ras GTPase-activating-like protei...2560.0001     52     23     42GO:0005884; C:actin filament; TAS:ProtInc.::GO:0005737; C:cytoplasm; IDA:HPA.::GO:0030496; C:midbody; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0036057; C:slit diaphragm; ISS:UniProtKB.
GO:0005516; F:calmodulin binding; TAS:ProtInc.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.
41Q9UJF2    1139   NGAP_HUMAN Ras GTPase-activating protein nGAP...3110.0002     51.2     23     44GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; TAS:ProtInc.
42Q9JKF1    1657   IQGA1_MOUSE Ras GTPase-activating-like protei...2560.0002     51.2     23     42GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0036057; C:slit diaphragm; ISS:UniProtKB.
GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
43Q8T498    1580   GAP2_DROME Probable Ras GTPase-activating pro...2040.001     48.5     23     43GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0002121; P:inter-male aggressive behavior; IMP:FlyBase.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
44P33314    1104   BUD2_YEAST Inhibitory regulator protein BUD2/...1330.002     48.1     23     51GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.
GO:0007120; P:axial cellular bud site selection; TAS:SGD.::GO:0007121; P:bipolar cellular bud site selection; TAS:SGD.::GO:0030447; P:filamentous growth; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:SGD.
45Q22720    629   GAP1_CAEEL Ras GTPase-activating protein gap-...1270.13     41.6     25     46GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; NAS:UniProtKB.
GO:0046580; P:negative regulation of Ras protein signal transduction; IEP:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
46Q3U515    929   VWCE_MOUSE von Willebrand factor C and EGF do...1190.39     40     31     40GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.
47O14188    1489   RNG2_SCHPO Ras GTPase-activating-like protein...844.2     37     26     50GO:0005826; C:actomyosin contractile ring; IDA:PomBase.::GO:0030428; C:cell septum; IDA:UniProtKB.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IDA:UniProtKB.
GO:0003779; F:actin binding; IDA:PomBase.::GO:0005516; F:calmodulin binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro.
GO:0071519; P:actin filament bundle assembly involved in actomyosin contractile ring formation; IDA:PomBase.::GO:0071520; P:actin filament bundle convergence involved in actomyosin contractile ring formation; IDA:PomBase.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
48Q6P9X9    296   PARM1_RAT Prostate androgen-regulated mucin-l...995     35.8     30     49GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005770; C:late endosome; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0006915; P:apoptotic process; NAS:RGD.::GO:0051973; P:positive regulation of telomerase activity; IMP:UniProtKB.
records
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