Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YBR103W
Length:
535
Number of sequences:
5887
Description:
YBR103W SIF2 SGDID:S000000307, Chr II from 447709-449316, Genome Release 64-1-1, Verified ORF, "WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
1P38262    535   SIF2_YEAST SIR4-interacting protein SIF2 OS=S...5350     1096     100     100GO:0070210; C:Rpd3L-Expanded complex; IDA:SGD.::GO:0034967; C:Set3 complex; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0016575; P:histone deacetylation; IDA:SGD.::GO:0031939; P:negative regulation of chromatin silencing at telomere; IMP:SGD.::GO:0045835; P:negative regulation of meiosis; IPI:SGD.::GO:0032874; P:positive regulation of stress-activated MAPK cascade; IMP:SGD.
2Q8BHJ5    514   TBL1R_MOUSE F-box-like/WD repeat-containing p...5611e-44     169     25     44
GO:0003714; F:transcription corepressor activity; IMP:MGI.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
3Q9BZK7    514   TBL1R_HUMAN F-box-like/WD repeat-containing p...5611e-43     167     25     44GO:0005876; C:spindle microtubule; IDA:UniProtKB.::GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0047485; F:protein N-terminus binding; IPI:UniProtKB.::GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:UniProtKB.::GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
4Q9BQ87    522   TBL1Y_HUMAN F-box-like/WD repeat-containing p...5714e-42     162     25     42GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
5Q6GPC6    522   TB1RB_XENLA F-box-like/WD repeat-containing p...5692e-41     160     25     44GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
6Q7SZM9    519   TB1RA_XENLA F-box-like/WD repeat-containing p...5673e-41     159     25     43GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
7Q9QXE7    527   TBL1X_MOUSE F-box-like/WD repeat-containing p...5763e-40     157     24     43GO:0005667; C:transcription factor complex; IDA:MGI.
GO:0003682; F:chromatin binding; IDA:MGI.::GO:0005515; F:protein binding; IPI:MGI.::GO:0003714; F:transcription corepressor activity; IMP:MGI.::GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
GO:0045444; P:fat cell differentiation; IMP:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.::GO:0043627; P:response to estrogen stimulus; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
8Q4R8H1    569   TBL1X_MACFA F-box-like/WD repeat-containing p...5652e-39     155     24     42GO:0005876; C:spindle microtubule; ISS:UniProtKB.::GO:0017053; C:transcriptional repressor complex; ISS:UniProtKB.
GO:0008013; F:beta-catenin binding; ISS:UniProtKB.::GO:0042393; F:histone binding; ISS:UniProtKB.::GO:0003714; F:transcription corepressor activity; ISS:UniProtKB.
GO:0060070; P:canonical Wnt receptor signaling pathway; ISS:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0006508; P:proteolysis; ISS:UniProtKB.::GO:0007605; P:sensory perception of sound; ISS:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
9O60907    577   TBL1X_HUMAN F-box-like/WD repeat-containing p...5731e-38     152     24     42GO:0005876; C:spindle microtubule; IDA:UniProtKB.::GO:0017053; C:transcriptional repressor complex; IDA:UniProtKB.
GO:0008013; F:beta-catenin binding; IPI:UniProtKB.::GO:0042393; F:histone binding; IDA:UniProtKB.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:UniProtKB.::GO:0003714; F:transcription corepressor activity; IDA:UniProtKB.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.::GO:0044212; F:transcription regulatory region DNA binding; IDA:UniProtKB.
GO:0060070; P:canonical Wnt receptor signaling pathway; IMP:UniProtKB.::GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0007605; P:sensory perception of sound; IMP:UniProtKB.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
10Q95RJ9    700   EBI_DROME F-box-like/WD repeat-containing pro...1300.76     36.2     27     40GO:0005700; C:polytene chromosome; IDA:FlyBase.::GO:0017053; C:transcriptional repressor complex; IGI:FlyBase.
GO:0003682; F:chromatin binding; IDA:FlyBase.::GO:0070491; F:repressing transcription factor binding; IPI:FlyBase.
GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0022416; P:chaeta development; IMP:FlyBase.::GO:0042676; P:compound eye cone cell fate commitment; TAS:FlyBase.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:FlyBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IPI:GOC.::GO:0007219; P:Notch signaling pathway; TAS:FlyBase.::GO:0042461; P:photoreceptor cell development; IMP:FlyBase.::GO:0031065; P:positive regulation of histone deacetylation; IDA:FlyBase.::GO:0045572; P:positive regulation of imaginal disc growth; IMP:FlyBase.::GO:0045747; P:positive regulation of Notch signaling pathway; IDA:FlyBase.::GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; IMP:UniProtKB.::GO:0030162; P:regulation of proteolysis; TAS:FlyBase.::GO:0007601; P:visual perception; IEA:UniProtKB-KW.::GO:0035220; P:wing disc development; IMP:FlyBase.
11Q00808    1356   HETE1_PODAS Vegetative incompatibility protei...840.019     41.6     26     48
GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
12Q3Y8L7    446   WDR69_CHLRE Outer row dynein assembly protein...1381.9     34.7     20     41GO:0005929; C:cilium; IEA:UniProtKB-KW.::GO:0035086; C:flagellar axoneme; IEA:UniProtKB-SubCell.::GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell.
13Q55563    1693   Y163_SYNY3 Uncharacterized WD repeat-containi...1410.016     42     27     40
GO:0005488; F:binding; IEA:InterPro.
14O74845    564   YCY9_SCHPO Uncharacterized WD repeat-containi...600.00002     50.8     33     62GO:0005829; C:cytosol; IDA:PomBase.::GO:0070210; C:Rpd3L-Expanded complex; IDA:PomBase.::GO:0034967; C:Set3 complex; IDA:PomBase.
GO:0006338; P:chromatin remodeling; IC:PomBase.::GO:0006342; P:chromatin silencing; ISS:PomBase.::GO:0016575; P:histone deacetylation; ISS:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:PomBase.
15Q8YV57    1683   Y2124_NOSS1 Uncharacterized WD repeat-contain...2370.0001     48.5     22     41
GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
GO:0006508; P:proteolysis; IEA:InterPro.
16Q9BRX9    315   WDR83_HUMAN WD repeat domain-containing prote...1034.6     33.5     23     41GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0000398; P:nuclear mRNA splicing, via spliceosome; IDA:UniProtKB.
17Q6DH44    315   WDR83_DANRE WD repeat domain-containing prote...2810.00003     49.7     23     40GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
18Q9Y297    605   FBW1A_HUMAN F-box/WD repeat-containing protei...1580.0008     45.8     22     44GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; TAS:BHF-UCL.::GO:0045879; P:negative regulation of smoothened signaling pathway; TAS:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; IMP:UniProtKB.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0031648; P:protein destabilization; IMP:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
19Q3ULA2    605   FBW1A_MOUSE F-box/WD repeat-containing protei...2070.0008     45.8     21     43GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB.
GO:0008013; F:beta-catenin binding; IDA:BHF-UCL.::GO:0046983; F:protein dimerization activity; IEA:InterPro.::GO:0045309; F:protein phosphorylated amino acid binding; IDA:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:BHF-UCL.
GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.::GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.::GO:0033598; P:mammary gland epithelial cell proliferation; IMP:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0042753; P:positive regulation of circadian rhythm; IMP:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0006470; P:protein dephosphorylation; IDA:UniProtKB.::GO:0031648; P:protein destabilization; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:BHF-UCL.::GO:0051726; P:regulation of cell cycle; IMP:MGI.::GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB cascade; IMP:MGI.::GO:0061136; P:regulation of proteasomal protein catabolic process; IDA:MGI.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
20P49695    742   PKWA_THECU Probable serine/threonine-protein ...2330.00008     49.3     21     41
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
21B0WYR6    1033   WDY_CULQU WD repeat-containing protein on Y c...3440.000000000009     71.6     24     43
22Q91854    518   TRCB_XENLA Beta-TrCP OS=Xenopus laevis (Afric...1870.0003     47.4     23     43
GO:0046983; F:protein dimerization activity; IEA:InterPro.
GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW.
23Q8YTC2    1258   Y2800_NOSS1 Uncharacterized WD repeat-contain...850.7     36.6     27     48
GO:0043531; F:ADP binding; IEA:InterPro.
GO:0006952; P:defense response; IEA:InterPro.
24Q8YRI1    1526   YY46_NOSS1 Uncharacterized WD repeat-containi...2710.00001     52     23     41
25Q4R8E7    415   WDR69_MACFA Outer row dynein assembly protein...2080.0000006     55.5     24     39GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
26Q5BLX8    315   WDR83_RAT WD repeat domain-containing protein...2450.000002     53.1     23     37GO:0005737; C:cytoplasm; IDA:UniProtKB.
GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
27Q9UUG8    598   TUP12_SCHPO Transcriptional repressor tup12 O...2330.001     45.1     22     45GO:0005829; C:cytosol; IDA:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase.::GO:0043234; C:protein complex; NAS:PomBase.
GO:0042393; F:histone binding; IDA:PomBase.::GO:0003714; F:transcription corepressor activity; IDA:PomBase.
GO:0043156; P:chromatin remodeling in response to cation stress; IMP:PomBase.::GO:0006342; P:chromatin silencing; IMP:PomBase.::GO:0045014; P:negative regulation of transcription by glucose; IMP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
28Q99973    2627   TEP1_HUMAN Telomerase protein component 1 OS=...363     34.7     39     67GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IDA:MGI.::GO:0016363; C:nuclear matrix; IDA:MGI.::GO:0005625; C:soluble fraction; ISS:UniProtKB.::GO:0005697; C:telomerase holoenzyme complex; IDA:UniProtKB.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003723; F:RNA binding; ISS:UniProtKB.
GO:0000722; P:telomere maintenance via recombination; IDA:UniProtKB.
29O43017    380   SWD3_SCHPO Set1 complex component swd3 OS=Sch...1890.093     38.9     19     40GO:0005829; C:cytosol; IDA:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase.::GO:0048188; C:Set1C/COMPASS complex; IDA:PomBase.
GO:0006338; P:chromatin remodeling; IC:PomBase.::GO:0051568; P:histone H3-K4 methylation; IMP:PomBase.
30P25635    923   PWP2_YEAST Periodic tryptophan protein 2 OS=S...3180.91     36.2     18     37GO:0005737; C:cytoplasm; IDA:SGD.::GO:0034388; C:Pwp2p-containing subcomplex of 90S preribosome; IDA:SGD.::GO:0032040; C:small-subunit processome; IDA:SGD.
GO:0005515; F:protein binding; IPI:IntAct.::GO:0030515; F:snoRNA binding; IPI:SGD.
GO:0000910; P:cytokinesis; IMP:SGD.::GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0000472; P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:SGD.::GO:0030010; P:establishment of cell polarity; IMP:SGD.
31Q0P593    415   WDR69_BOVIN Outer row dynein assembly protein...781.5     35     23     49GO:0005929; C:cilium; IEA:UniProtKB-SubCell.
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