UniProt_SwissProt BLAST: Single locus

Species:

Saccharomyces cerevisiae S288C

Locus:

YBR084W

Length:

975

Number of sequences:

5887

Description:

YBR084W MIS1 SGDID:S000000288, Chr II from 411054-413981, Genome Release 64-1-1, Verified ORF, "Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase"

rec.	Subject	Hit Length	Description	Align.Len	E value	Bit score	% ident.	% pos.	GO associations
1	P09440	975	C1TM_YEAST C-1-tetrahydrofolate synthase, mit...	975	0	2000	100	100	GO:0005739; C:mitochondrion; IDA:SGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:SGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IDA:SGD.::GO:0004479; F:methionyl-tRNA formyltransferase activity; IMP:SGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IDA:SGD.
									GO:0046656; P:folic acid biosynthetic process; IDA:SGD.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
2	P07245	946	C1TC_YEAST C-1-tetrahydrofolate synthase, cyt...	948	0	1321	71	82	GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IMP:SGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IMP:SGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IMP:SGD.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; IMP:SGD.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
3	Q8WZJ7	937	C1TC_SCHPO C-1-tetrahydrofolate synthase, cyt...	940	0	1033	57	75	GO:0005829; C:cytosol; IDA:PomBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:PomBase.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IDA:PomBase.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IDA:PomBase.::GO:0003697; F:single-stranded DNA binding; IDA:PomBase.
									GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IDA:PomBase.::GO:0046656; P:folic acid biosynthetic process; IDA:PomBase.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IDA:PomBase.::GO:0009113; P:purine base biosynthetic process; IDA:PomBase.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
4	P11586	935	C1TC_HUMAN C-1-tetrahydrofolate synthase, cyt...	946	0	1023	56	73	GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; TAS:ProtInc.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:Reactome.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:Reactome.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.::GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity; TAS:Reactome.
									GO:0046655; P:folic acid metabolic process; TAS:Reactome.::GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.]
5	P27653	935	C1TC_RAT C-1-tetrahydrofolate synthase, cytop...	945	0	1021	55	72	GO:0005737; C:cytoplasm; TAS:RGD.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:RGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:RGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.::GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity; TAS:RGD.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEP:RGD.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; TAS:RGD.]
6	O43007	969	C1TM_SCHPO C-1-tetrahydrofolate synthase, mit...	971	0	1021	54	71	GO:0005739; C:mitochondrion; IDA:PomBase.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; ISS:PomBase.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; ISS:PomBase.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; ISS:PomBase.
									GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; ISS:PomBase.::GO:0046656; P:folic acid biosynthetic process; ISS:PomBase.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; ISS:PomBase.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
7	Q5R8P0	935	C1TC_PONAB C-1-tetrahydrofolate synthase, cyt...	946	0	1015	56	72	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
8	Q922D8	935	C1TC_MOUSE C-1-tetrahydrofolate synthase, cyt...	945	0	1009	55	73	GO:0005739; C:mitochondrion; IDA:MGI.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IMP:MGI.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0006548; P:histidine catabolic process; IMP:MGI.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
9	O96553	968	C1TC_DROME C-1-tetrahydrofolate synthase, cyt...	953	0	989	54	71	GO:0005737; C:cytoplasm; IDA:UniProtKB.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; NAS:UniProtKB.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; NAS:UniProtKB.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; NAS:UniProtKB.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
10	Q27772	933	C1TC_SPOFR C-1-tetrahydrofolate synthase, cyt...	936	0	935	51	69	GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.
11	Q0VCR7	975	C1TM_BOVIN Monofunctional C1-tetrahydrofolate...	938	0	830	49	66	GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
12	Q3V3R1	977	C1TM_MOUSE Monofunctional C1-tetrahydrofolate...	938	0	826	49	66	GO:0005739; C:mitochondrion; IDA:MGI.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
13	Q6UB35	978	C1TM_HUMAN Monofunctional C1-tetrahydrofolate...	940	0	822	49	66	GO:0005739; C:mitochondrion; IDA:BHF-UCL.
									GO:0005524; F:ATP binding; IDA:BHF-UCL.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:BHF-UCL.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0015942; P:formate metabolic process; IDA:BHF-UCL.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:BHF-UCL.
14	Q9SPK5	634	FTHS_ARATH Formate--tetrahydrofolate ligase O...	639	0	691	54	72	GO:0048046; C:apoplast; IDA:TAIR.::GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005829; C:cytosol; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR.
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005507; F:copper ion binding; IDA:TAIR.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046686; P:response to cadmium ion; IEP:TAIR.
15	P28723	637	FTHS_SPIOL Formate--tetrahydrofolate ligase O...	639	0	690	55	71
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
16	A5UPV2	564	FTHS_ROSS1 Formate--tetrahydrofolate ligase O...	629	0	556	48	64
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
17	A7NGQ9	564	FTHS_ROSCS Formate--tetrahydrofolate ligase O...	629	0	554	47	63
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
18	A4FL80	565	FTHS_SACEN Formate--tetrahydrofolate ligase O...	631	4e-173	523	48	63
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
19	Q2RM91	559	FTHS_MOOTA Formate--tetrahydrofolate ligase O...	635	6e-171	518	45	61
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
20	A8MIN1	556	FTHS_ALKOO Formate--tetrahydrofolate ligase O...	631	7e-171	517	45	61
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
21	A4J0S6	567	FTHS_DESRM Formate--tetrahydrofolate ligase O...	632	1e-170	517	44	62
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
22	A9B4H8	570	FTHS_HERA2 Formate--tetrahydrofolate ligase O...	636	5e-170	516	44	61
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
23	Q6ABS5	563	FTHS_PROAC Formate--tetrahydrofolate ligase O...	630	2e-169	514	44	61
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
24	P21164	559	FTHS_MOOTH Formate--tetrahydrofolate ligase O...	635	3e-168	510	45	60
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
25	B0TBP1	556	FTHS_HELMI Formate--tetrahydrofolate ligase O...	631	5e-168	509	45	61
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
26	Q3A9K2	556	FTHS_CARHZ Formate--tetrahydrofolate ligase O...	631	7e-167	507	45	63
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
27	B0K5A5	555	FTHS_THEPX Formate--tetrahydrofolate ligase O...	630	9e-167	506	44	61
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
28	B0KC36	555	FTHS_THEP3 Formate--tetrahydrofolate ligase O...	631	1e-166	506	45	61
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
29	A4SPE5	580	FTHS_AERS4 Formate--tetrahydrofolate ligase O...	633	4e-166	506	47	63
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
30	A3DI22	556	FTHS_CLOTH Formate--tetrahydrofolate ligase O...	633	2e-164	500	45	61
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
31	A8H8Z4	570	FTHS_SHEPA Formate--tetrahydrofolate ligase O...	629	3e-164	501	45	62
									GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.
									GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.

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