Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YBL085W
Length:
980
Number of sequences:
5887
Description:
YBL085W BOI1 SGDID:S000000181, Chr II from 63876-66818, Genome Release 64-1-1, Verified ORF, "Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
91Q5EAD0    521   BAIP2_BOVIN Brain-specific angiogenesis inhib...720.05     41.2     35     53GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0001726; C:ruffle; IEA:UniProtKB-SubCell.
GO:0008093; F:cytoskeletal adaptor activity; IEA:InterPro.::GO:0070064; F:proline-rich region binding; ISS:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:InterPro.
GO:0046847; P:filopodium assembly; IEA:InterPro.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0009617; P:response to bacterium; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
92Q3U5C8    713   ARHGG_MOUSE Rho guanine nucleotide exchange f...590.063     40.8     32     53GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; ISS:UniProtKB.
GO:0032863; P:activation of Rac GTPase activity; ISS:UniProtKB.::GO:0060326; P:cell chemotaxis; ISS:UniProtKB.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; ISS:UniProtKB.
93Q2KI41    410   CYH2_BOVIN Cytohesin-2 OS=Bos taurus (Bovine)...560.075     40.4     36     50GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB.
GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; ISS:RefGenome.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.::GO:0030155; P:regulation of cell adhesion; ISS:RefGenome.
94Q80XI6    850   M3K11_MOUSE Mitogen-activated protein kinase ...730.079     40.4     26     56
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
95P39769    1589   PHP_DROME Polyhomeotic-proximal chromatin pro...1010.083     40.8     24     50GO:0035102; C:PRC1 complex; IDA:FlyBase.
GO:0051087; F:chaperone binding; IDA:FlyBase.::GO:0003682; F:chromatin binding; IDA:FlyBase.::GO:0003677; F:DNA binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0021954; P:central nervous system neuron development; IMP:FlyBase.::GO:0016458; P:gene silencing; IGI:FlyBase.::GO:0030708; P:germarium-derived female germ-line cyst encapsulation; IMP:FlyBase.::GO:0030713; P:ovarian follicle cell stalk formation; IMP:FlyBase.::GO:0035075; P:response to ecdysone; IMP:FlyBase.::GO:0035186; P:syncytial blastoderm mitotic cell cycle; IMP:FlyBase.
96Q66HA1    850   M3K11_RAT Mitogen-activated protein kinase ki...730.085     40.4     26     56GO:0005625; C:soluble fraction; IDA:RGD.
GO:0005524; F:ATP binding; IDA:RGD.::GO:0004706; F:JUN kinase kinase kinase activity; IDA:RGD.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:RGD.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; IPI:RGD.
GO:0008219; P:cell death; IMP:RGD.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.
97Q3U1V8    1077   M3K9_MOUSE Mitogen-activated protein kinase k...620.085     40.4     31     60
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004709; F:MAP kinase kinase kinase activity; IEA:EC.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006950; P:response to stress; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
98P42683    508   LCK_CHICK Proto-oncogene tyrosine-protein kin...650.1     40     31     55GO:0045121; C:membrane raft; ISS:UniProtKB.::GO:0000242; C:pericentriolar material; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0004722; F:protein serine/threonine phosphatase activity; ISS:UniProtKB.::GO:0042169; F:SH2 domain binding; ISS:UniProtKB.
GO:0006919; P:activation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.::GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.::GO:0006917; P:induction of apoptosis; ISS:UniProtKB.::GO:0050870; P:positive regulation of T cell activation; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0030217; P:T cell differentiation; ISS:UniProtKB.
99Q5VV41    709   ARHGG_HUMAN Rho guanine nucleotide exchange f...530.11     40     36     53GO:0005829; C:cytosol; TAS:Reactome.
GO:0030165; F:PDZ domain binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0017048; F:Rho GTPase binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:UniProtKB.
GO:0032864; P:activation of Cdc42 GTPase activity; IDA:BHF-UCL.::GO:0032863; P:activation of Rac GTPase activity; IMP:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0060326; P:cell chemotaxis; IMP:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0090004; P:positive regulation of establishment of protein localization in plasma membrane; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
100Q8N157    1196   AHI1_HUMAN Jouberin OS=Homo sapiens (Human). ...690.12     40     30     51GO:0005912; C:adherens junction; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; IDA:UniProtKB.::GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035844; P:cloaca development; ISS:UniProtKB.::GO:0001947; P:heart looping; ISS:UniProtKB.::GO:0030902; P:hindbrain development; ISS:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0071599; P:otic vesicle development; ISS:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.::GO:0050795; P:regulation of behavior; ISS:UniProtKB.::GO:0010842; P:retina layer formation; ISS:UniProtKB.::GO:0065001; P:specification of axis polarity; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
101Q9UQF2    711   JIP1_HUMAN C-Jun-amino-terminal kinase-intera...640.12     40     31     55GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0019894; F:kinesin binding; IPI:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; IPI:UniProtKB.::GO:0004860; F:protein kinase inhibitor activity; TAS:ProtInc.
GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB.
102Q9R237    708   JIP1_RAT C-Jun-amino-terminal kinase-interact...640.13     40     31     55GO:0044295; C:axonal growth cone; IDA:MGI.::GO:0005829; C:cytosol; IDA:RGD.::GO:0044294; C:dendritic growth cone; IDA:MGI.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
GO:0008432; F:JUN kinase binding; IPI:RGD.::GO:0019894; F:kinesin binding; ISS:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; IMP:RGD.::GO:0031434; F:mitogen-activated protein kinase kinase binding; IPI:RGD.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:RGD.
GO:0006916; P:anti-apoptosis; IDA:RGD.::GO:0046329; P:negative regulation of JNK cascade; IMP:RGD.::GO:0043508; P:negative regulation of JUN kinase activity; IMP:RGD.
103Q9D0I6    474   WSDU1_MOUSE WD repeat, SAM and U-box domain-c...740.13     39.7     30     55GO:0000151; C:ubiquitin ligase complex; IEA:InterPro.
GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
104Q8K1N2    1249   PHLB2_MOUSE Pleckstrin homology-like domain f...1180.13     40     25     42GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.
105P80192    1104   M3K9_HUMAN Mitogen-activated protein kinase k...610.13     40     31     59
GO:0005524; F:ATP binding; NAS:UniProtKB.::GO:0004706; F:JUN kinase kinase kinase activity; ISS:UniProtKB.::GO:0004708; F:MAP kinase kinase activity; NAS:UniProtKB.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0004713; F:protein tyrosine kinase activity; IEA:InterPro.
GO:0007257; P:activation of JUN kinase activity; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
106Q9WVI9    707   JIP1_MOUSE C-Jun-amino-terminal kinase-intera...640.16     39.7     31     55GO:0044297; C:cell body; IDA:MGI.::GO:0005829; C:cytosol; IDA:MGI.::GO:0044302; C:dentate gyrus mossy fiber; IDA:MGI.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:MGI.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0045202; C:synapse; IDA:MGI.
GO:0019894; F:kinesin binding; IPI:UniProtKB.::GO:0005078; F:MAP-kinase scaffold activity; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.
GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0007258; P:JUN phosphorylation; IDA:MGI.::GO:0006355; P:regulation of transcription, DNA-dependent; IDA:MGI.::GO:0016192; P:vesicle-mediated transport; IDA:MGI.
107Q8BUR4    1865   DOCK1_MOUSE Dedicator of cytokinesis protein ...520.18     39.7     37     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IDA:MGI.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.
108P57075    661   UBS3A_HUMAN Ubiquitin-associated and SH3 doma...560.19     39.3     39     52GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
109Q1ZXH8    1632   GXCDD_DICDI Guanine exchange factor for Rac 3...990.19     39.3     28     41GO:0005938; C:cell cortex; IMP:dictyBase.::GO:0032009; C:early phagosome; IMP:dictyBase.::GO:0005626; C:insoluble fraction; IDA:dictyBase.::GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:dictyBase.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0048365; F:Rac GTPase binding; IDA:dictyBase.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0031152; P:aggregation involved in sorocarp development; IMP:dictyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IPI:dictyBase.
110Q14185    1865   DOCK1_HUMAN Dedicator of cytokinesis protein ...520.2     39.3     37     60GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
GO:0005525; F:GTP binding; IEA:InterPro.::GO:0005096; F:GTPase activator activity; TAS:ProtInc.::GO:0051020; F:GTPase binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
GO:0006915; P:apoptotic process; TAS:ProtInc.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007596; P:blood coagulation; TAS:Reactome.::GO:0007229; P:integrin-mediated signaling pathway; TAS:ProtInc.::GO:0006911; P:phagocytosis, engulfment; TAS:ProtInc.::GO:0007264; P:small GTPase mediated signal transduction; TAS:ProtInc.
111P97306    403   STAC_MOUSE SH3 and cysteine-rich domain-conta...580.21     38.9     29     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0034605; P:cellular response to heat; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.
112Q95M30    504   HCK_MACFA Tyrosine-protein kinase HCK OS=Maca...680.22     38.9     26     59GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0071801; P:regulation of podosome assembly; ISS:UniProtKB.
113Q9WVE8    486   PACN2_MOUSE Protein kinase C and casein kinas...560.22     38.9     39     57GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IDA:MGI.
GO:0008092; F:cytoskeletal protein binding; IDA:MGI.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045806; P:negative regulation of endocytosis; IDA:MGI.::GO:0007165; P:signal transduction; TAS:MGI.
114Q9QY17    488   PACN2_RAT Protein kinase C and casein kinase ...560.23     38.9     39     57GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
115Q9H4E7    631   DEFI6_HUMAN Differentially expressed in FDCP ...710.24     38.9     31     52GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005543; F:phospholipid binding; IEA:InterPro.
116Q8BYW1    648   RHG25_MOUSE Rho GTPase-activating protein 25 ...760.24     38.9     28     49GO:0005622; C:intracellular; IEA:InterPro.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.
GO:0007165; P:signal transduction; IEA:InterPro.
117A0JNJ1    403   STAC_BOVIN SH3 and cysteine-rich domain-conta...580.25     38.5     29     57GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
118P07948    512   LYN_HUMAN Tyrosine-protein kinase Lyn OS=Homo...750.31     38.5     29     56GO:0005829; C:cytosol; TAS:Reactome.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0044325; F:ion channel binding; IPI:BHF-UCL.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; TAS:Reactome.::GO:0004716; F:receptor signaling protein tyrosine kinase activity; TAS:ProtInc.
GO:0001782; P:B cell homeostasis; ISS:UniProtKB.::GO:0071300; P:cellular response to retinoic acid; IMP:BHF-UCL.::GO:0097028; P:dendritic cell differentiation; ISS:UniProtKB.::GO:0030218; P:erythrocyte differentiation; ISS:UniProtKB.::GO:0002774; P:Fc receptor mediated inhibitory signaling pathway; ISS:UniProtKB.::GO:0002431; P:Fc receptor mediated stimulatory signaling pathway; ISS:UniProtKB.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0060397; P:JAK-STAT cascade involved in growth hormone signaling pathway; TAS:Reactome.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0050777; P:negative regulation of immune response; TAS:UniProtKB.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:UniProtKB.::GO:0070667; P:negative regulation of mast cell proliferation; ISS:UniProtKB.::GO:0001933; P:negative regulation of protein phosphorylation; ISS:UniProtKB.::GO:0034136; P:negative regulation of toll-like receptor 2 signaling pathway; ISS:UniProtKB.::GO:0034144; P:negative regulation of toll-like receptor 4 signaling pathway; ISS:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0002576; P:platelet degranulation; ISS:UniProtKB.::GO:2000670; P:positive regulation of dendritic cell apoptotic process; ISS:UniProtKB.::GO:0070668; P:positive regulation of mast cell proliferation; IMP:UniProtKB.::GO:0010976; P:positive regulation of neuron projection development; IMP:BHF-UCL.::GO:0070304; P:positive regulation of stress-activated protein kinase signaling cascade; IDA:UniProtKB.::GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; IDA:UniProtKB.::GO:0050855; P:regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0033628; P:regulation of cell adhesion mediated by integrin; IMP:UniProtKB.::GO:0045646; P:regulation of erythrocyte differentiation; ISS:UniProtKB.::GO:0043304; P:regulation of mast cell degranulation; ISS:UniProtKB.::GO:0090025; P:regulation of monocyte chemotaxis; IMP:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.::GO:0031295; P:T cell costimulation; TAS:Reactome.::GO:0002513; P:tolerance induction to self antigen; ISS:UniProtKB.
119P50545    524   HCK_RAT Tyrosine-protein kinase HCK OS=Rattus...590.36     38.1     29     58GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0071801; P:regulation of podosome assembly; ISS:UniProtKB.
120Q8N5V2    710   NGEF_HUMAN Ephexin-1 OS=Homo sapiens (Human)....600.37     38.5     28     52GO:0005829; C:cytosol; TAS:Reactome.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:HPA.
GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0061002; P:negative regulation of dendritic spine morphogenesis; ISS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043087; P:regulation of GTPase activity; ISS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
121Q63788    722   P85B_RAT Phosphatidylinositol 3-kinase regula...780.37     38.5     29     49GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:InterPro.
GO:0035014; F:phosphatidylinositol 3-kinase regulator activity; IEA:InterPro.
GO:0019987; P:negative regulation of anti-apoptosis; ISS:UniProtKB.::GO:0007165; P:signal transduction; IEA:InterPro.
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