Fungal Genome Collection
University of Nebraska Lincoln
School of Biological Sciences and Center for Plant Science Innovation
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UniProt_SwissProt BLAST: Single locus
Species:
Saccharomyces cerevisiae S288C
Locus:
YBL007C
Length:
1244
Number of sequences:
5887
Description:
YBL007C SLA1 SGDID:S000000103, Chr II from 216366-212632, Genome Release 64-1-1, reverse complement, Verified ORF, "Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains"
rec.SubjectHit LengthDescriptionAlign.LenE valueBit score% ident.  % pos.GO associations
211O67453    180   Y1476_AQUAE Uncharacterized protein aq_1476 O...490.072     39.7     45     65
212P31007    970   DLG1_DROME Disks large 1 tumor suppressor pro...740.074     41.2     30     55GO:0045179; C:apical cortex; IDA:FlyBase.::GO:0016323; C:basolateral plasma membrane; TAS:FlyBase.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016328; C:lateral plasma membrane; IDA:FlyBase.::GO:0031594; C:neuromuscular junction; IDA:FlyBase.::GO:0048471; C:perinuclear region of cytoplasm; IDA:FlyBase.::GO:0045211; C:postsynaptic membrane; IDA:FlyBase.::GO:0005918; C:septate junction; NAS:FlyBase.::GO:0043195; C:terminal button; IDA:FlyBase.
GO:0005154; F:epidermal growth factor receptor binding; TAS:FlyBase.::GO:0004385; F:guanylate kinase activity; TAS:FlyBase.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.::GO:0005198; F:structural molecule activity; TAS:FlyBase.
GO:0030714; P:anterior/posterior axis specification, follicular epithelium; IMP:BHF-UCL.::GO:0045167; P:asymmetric protein localization involved in cell fate determination; TAS:FlyBase.::GO:0045175; P:basal protein localization; IMP:FlyBase.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0060581; P:cell fate commitment involved in pattern specification; IMP:BHF-UCL.::GO:0001708; P:cell fate specification; IMP:BHF-UCL.::GO:0008283; P:cell proliferation; TAS:FlyBase.::GO:0007391; P:dorsal closure; NAS:FlyBase.::GO:0051294; P:establishment of spindle orientation; IMP:FlyBase.::GO:0045197; P:establishment or maintenance of epithelial cell apical/basal polarity; NAS:FlyBase.::GO:0045196; P:establishment or maintenance of neuroblast polarity; TAS:FlyBase.::GO:0016332; P:establishment or maintenance of polarity of embryonic epithelium; TAS:FlyBase.::GO:0016336; P:establishment or maintenance of polarity of larval imaginal disc epithelium; NAS:FlyBase.::GO:0045475; P:locomotor rhythm; IMP:FlyBase.::GO:0008049; P:male courtship behavior; IMP:FlyBase.::GO:0001738; P:morphogenesis of a polarized epithelium; TAS:FlyBase.::GO:0008285; P:negative regulation of cell proliferation; TAS:FlyBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.::GO:0007318; P:pole plasm protein localization; IMP:BHF-UCL.::GO:0046956; P:positive phototaxis; IMP:FlyBase.::GO:0030710; P:regulation of border follicle cell delamination; TAS:FlyBase.::GO:0051726; P:regulation of cell cycle; NAS:FlyBase.::GO:0042058; P:regulation of epidermal growth factor receptor signaling pathway; IMP:BHF-UCL.::GO:0046425; P:regulation of JAK-STAT cascade; IMP:BHF-UCL.::GO:0008593; P:regulation of Notch signaling pathway; IMP:BHF-UCL.::GO:0019991; P:septate junction assembly; TAS:FlyBase.::GO:0051124; P:synaptic growth at neuromuscular junction; IMP:FlyBase.::GO:0007268; P:synaptic transmission; IMP:FlyBase.
213P08631    526   HCK_HUMAN Tyrosine-protein kinase HCK OS=Homo...540.12     40.4     35     59GO:0005901; C:caveola; IDA:UniProtKB.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0031234; C:extrinsic to internal side of plasma membrane; IMP:UniProtKB.::GO:0005925; C:focal adhesion; IMP:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007155; P:cell adhesion; TAS:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0002758; P:innate immune response-activating signal transduction; TAS:UniProtKB.::GO:0007229; P:integrin-mediated signaling pathway; TAS:UniProtKB.::GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0043299; P:leukocyte degranulation; TAS:UniProtKB.::GO:0002522; P:leukocyte migration involved in immune response; TAS:UniProtKB.::GO:0031663; P:lipopolysaccharide-mediated signaling pathway; TAS:UniProtKB.::GO:0007498; P:mesoderm development; TAS:ProtInc.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IMP:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; IDA:UniProtKB.::GO:0030838; P:positive regulation of actin filament polymerization; TAS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:0046777; P:protein autophosphorylation; IMP:UniProtKB.::GO:0008360; P:regulation of cell shape; IMP:UniProtKB.::GO:0050690; P:regulation of defense response to virus by virus; TAS:Reactome.::GO:0050727; P:regulation of inflammatory response; TAS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; IMP:UniProtKB.::GO:0071801; P:regulation of podosome assembly; IDA:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; IMP:UniProtKB.::GO:0045728; P:respiratory burst after phagocytosis; TAS:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome.
214Q0CEX5    1246   MYO1_ASPTN Myosin-1 OS=Aspergillus terreus (s...520.075     41.2     35     56GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
215Q7TSG5    549   SH321_MOUSE SH3 domain-containing protein 21 ...770.078     40.8     29     53
216Q8TE68    723   ES8L1_HUMAN Epidermal growth factor receptor ...711.6     36.6     34     49GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
217Q2US45    1261   MYO1_ASPOR Myosin-1 OS=Aspergillus oryzae (st...500.077     41.2     34     56GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
218Q5TCZ1    1133   SPD2A_HUMAN SH3 and PX domain-containing prot...640.077     41.2     28     59GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0002102; C:podosome; IDA:UniProtKB.
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007154; P:cell communication; IEA:InterPro.::GO:0006801; P:superoxide metabolic process; IDA:UniProtKB.
219Q7Z6J0    888   SH3R1_HUMAN E3 ubiquitin-protein ligase SH3RF...800.15     40     29     44GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.::GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
220A1C4A5    1253   MYO1_ASPCL Myosin-1 OS=3887 / NRRL 1). GN=myo...500.082     41.2     34     60GO:0030479; C:actin cortical patch; IEA:UniProtKB-SubCell.::GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro.
221O89032    1124   SPD2A_MOUSE SH3 and PX domain-containing prot...640.083     40.8     28     59GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0042995; C:cell projection; IEA:UniProtKB-KW.::GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0002102; C:podosome; ISS:UniProtKB.
GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0007154; P:cell communication; IEA:InterPro.
222Q71F54    894   SH3R1_RAT E3 ubiquitin-protein ligase SH3RF1 ...800.24     39.3     29     44GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0006917; P:induction of apoptosis; IMP:RGD.
223Q08EC4    804   CASS4_MOUSE Cas scaffolding protein family me...560.088     40.8     36     55GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.
GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
224Q69ZI1    892   SH3R1_MOUSE E3 ubiquitin-protein ligase SH3RF...800.2     39.7     29     44GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005078; F:MAP-kinase scaffold activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0046328; P:regulation of JNK cascade; IDA:MGI.
225A4FU49    640   SH321_HUMAN SH3 domain-containing protein 21 ...560.13     40     36     54
226Q92968    403   PEX13_HUMAN Peroxisomal membrane protein PEX1...770.097     40.4     26     61GO:0005779; C:integral to peroxisomal membrane; IDA:UniProtKB.::GO:0005624; C:membrane fraction; IDA:UniProtKB.
GO:0005515; F:protein binding; IPI:UniProtKB.
GO:0021795; P:cerebral cortex cell migration; ISS:UniProtKB.::GO:0001561; P:fatty acid alpha-oxidation; ISS:UniProtKB.::GO:0007626; P:locomotory behavior; ISS:UniProtKB.::GO:0060152; P:microtubule-based peroxisome localization; ISS:UniProtKB.::GO:0001764; P:neuron migration; ISS:UniProtKB.::GO:0016560; P:protein import into peroxisome matrix, docking; IMP:UniProtKB.::GO:0001967; P:suckling behavior; ISS:UniProtKB.
227Q7SIG6    958   ASAP2_MOUSE Arf-GAP with SH3 domain, ANK repe...670.1     40.8     34     58GO:0032580; C:Golgi cisterna membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008060; F:ARF GTPase activator activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro.
GO:0032312; P:regulation of ARF GTPase activity; IEA:InterPro.
228O77775    527   NCF2_BOVIN Neutrophil cytosol factor 2 OS=Bos...591.6     36.6     34     59GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005488; F:binding; IEA:InterPro.
229P42686    505   SRK1_SPOLA Tyrosine-protein kinase isoform SR...516.5     34.7     31     55GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
230Q9QY53    687   NPHP1_MOUSE Nephrocystin-1 OS=Mus musculus (M...561.6     36.6     38     48GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.::GO:0035085; C:cilium axoneme; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-KW.::GO:0031514; C:motile cilium; ISS:UniProtKB.::GO:0032391; C:photoreceptor connecting cilium; IDA:UniProtKB.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0030030; P:cell projection organization; IMP:UniProtKB.::GO:0034613; P:cellular protein localization; IGI:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; IGI:UniProtKB.::GO:0060041; P:retina development in camera-type eye; IMP:UniProtKB.::GO:0048515; P:spermatid differentiation; IMP:UniProtKB.
231Q0U6X7    618   HSE1_PHANO Class E vacuolar protein-sorting m...900.11     40.4     28     49GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
GO:0006886; P:intracellular protein transport; IEA:InterPro.
232P15891    592   ABP1_YEAST Actin-binding protein OS=Saccharom...521.3     37     40     48GO:0030479; C:actin cortical patch; IDA:SGD.::GO:0043332; C:mating projection tip; IDA:SGD.
GO:0051015; F:actin filament binding; IDA:SGD.
GO:0000147; P:actin cortical patch assembly; IMP:SGD.::GO:0008104; P:protein localization; IMP:SGD.
233Q12163    236   NBP2_YEAST NAP1-binding protein 2 OS=Saccharo...590.11     39.7     32     56GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; TAS:SGD.
GO:0005515; F:protein binding; IPI:IntAct.
GO:0006972; P:hyperosmotic response; IPI:SGD.::GO:0006469; P:negative regulation of protein kinase activity; IDA:SGD.::GO:0009408; P:response to heat; IMP:SGD.
234Q0P5B1    403   PEX13_BOVIN Peroxisomal membrane protein PEX1...790.12     40     24     62GO:0005779; C:integral to peroxisomal membrane; ISS:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.
GO:0016560; P:protein import into peroxisome matrix, docking; ISS:UniProtKB.
235Q9UKS6    424   PACN3_HUMAN Protein kinase C and casein kinas...530.12     40     32     62GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0008092; F:cytoskeletal protein binding; ISS:UniProtKB.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045806; P:negative regulation of endocytosis; ISS:UniProtKB.::GO:0051044; P:positive regulation of membrane protein ectodomain proteolysis; IMP:BHF-UCL.
236Q99469    402   STAC_HUMAN SH3 and cysteine-rich domain-conta...530.82     37.4     28     60GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; TAS:ProtInc.
GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO:0035556; P:intracellular signal transduction; IEA:InterPro.
237P51451    505   BLK_HUMAN Tyrosine-protein kinase Blk OS=Homo...650.13     40     29     55GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IDA:UniProtKB.
GO:0050853; P:B cell receptor signaling pathway; IDA:UniProtKB.::GO:0007243; P:intracellular protein kinase cascade; TAS:ProtInc.::GO:0032024; P:positive regulation of insulin secretion; IMP:UniProtKB.
238Q95M30    504   HCK_MACFA Tyrosine-protein kinase HCK OS=Maca...680.4     38.5     25     54GO:0005901; C:caveola; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; ISS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0030133; C:transport vesicle; IEA:UniProtKB-SubCell.
GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.
GO:0006887; P:exocytosis; IEA:UniProtKB-KW.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0045087; P:innate immune response; IEA:UniProtKB-KW.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:UniProtKB.::GO:0006909; P:phagocytosis; IEA:UniProtKB-KW.::GO:2000251; P:positive regulation of actin cytoskeleton reorganization; ISS:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.::GO:0008360; P:regulation of cell shape; ISS:UniProtKB.::GO:0050764; P:regulation of phagocytosis; ISS:UniProtKB.::GO:0071801; P:regulation of podosome assembly; ISS:UniProtKB.
239P05433    440   GAGC_AVISC P47(GAG-CRK) protein OS=Avian sarc...640.14     39.7     31     52GO:0019028; C:viral capsid; IEA:InterPro.
GO:0005198; F:structural molecule activity; IEA:InterPro.
GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.
240O43295    1099   SRGP3_HUMAN SLIT-ROBO Rho GTPase-activating p...530.14     40     36     58GO:0005829; C:cytosol; TAS:Reactome.
GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
GO:0051056; P:regulation of small GTPase mediated signal transduction; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.
241Q9Z0R6    1659   ITSN2_MOUSE Intersectin-2 OS=Mus musculus (Mo...1023.8     35.4     29     50GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.
GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
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