| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q96PE2 | 2063 | ARHGH_HUMAN Rho guanine nucleotide exchange f... | 203 | 0.0000004 | 56.6 | 24 | 48 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IDA:MGI.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 2 | Q80U35 | 2057 | ARHGH_MOUSE Rho guanine nucleotide exchange f... | 203 | 0.000001 | 55.1 | 24 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 3 | O15085 | 1522 | ARHGB_HUMAN Rho guanine nucleotide exchange f... | 296 | 0.003 | 44.3 | 21 | 40 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0001664; F:G-protein coupled receptor binding; IDA:MGI.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0006928; P:cellular component movement; NAS:UniProtKB.::GO:0000910; P:cytokinesis; NAS:UniProtKB.::GO:0030010; P:establishment of cell polarity; NAS:UniProtKB.::GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:UniProtKB.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:UniProtKB.::GO:0001558; P:regulation of cell growth; NAS:UniProtKB.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; IDA:UniProtKB.::GO:0006941; P:striated muscle contraction; NAS:UniProtKB.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 4 | Q15811 | 1721 | ITSN1_HUMAN Intersectin-1 OS=Homo sapiens (Hu... | 201 | 0.003 | 43.9 | 27 | 43 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005905; C:coated pit; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:UniProtKB.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0070064; F:proline-rich region binding; IPI:UniProtKB.::GO:0032947; F:protein complex scaffold; IDA:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0048488; P:synaptic vesicle endocytosis; TAS:ProtInc. | 5 | Q9Z0R4 | 1714 | ITSN1_MOUSE Intersectin-1 OS=Mus musculus (Mo... | 198 | 0.005 | 43.5 | 26 | 44 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-KW.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019209; F:kinase activator activity; IDA:MGI.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:MGI.::GO:0051897; P:positive regulation of protein kinase B signaling cascade; IDA:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IDA:MGI. | 6 | Q9NHV9 | 793 | VAV_DROME Protein vav OS=Drosophila melanogas... | 218 | 0.006 | 42.7 | 22 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IDA:FlyBase.::GO:0007015; P:actin filament organization; IMP:FlyBase.::GO:0007155; P:cell adhesion; IMP:FlyBase.::GO:0016477; P:cell migration; IMP:FlyBase.::GO:0007417; P:central nervous system development; IGI:FlyBase.::GO:0007391; P:dorsal closure; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007520; P:myoblast fusion; IMP:FlyBase.::GO:0007424; P:open tracheal system development; IMP:FlyBase.::GO:0072499; P:photoreceptor cell axon guidance; IMP:FlyBase.::GO:0008360; P:regulation of cell shape; IMP:FlyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 7 | Q9ES67 | 1527 | ARHGB_RAT Rho guanine nucleotide exchange fac... | 284 | 0.024 | 41.2 | 20 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0001505; P:regulation of neurotransmitter levels; TAS:RGD.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 8 | Q8R4H2 | 1543 | ARHGC_MOUSE Rho guanine nucleotide exchange f... | 211 | 0.42 | 37 | 22 | 39 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 9 | Q8C033 | 1345 | ARHGA_MOUSE Rho guanine nucleotide exchange f... | 238 | 0.47 | 37 | 23 | 44 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 10 | Q9TW28 | 1737 | MYOM_DICDI Myosin-M heavy chain OS=Dictyostel... | 208 | 0.83 | 36.2 | 22 | 41 | GO:0042995; C:cell projection; IDA:dictyBase.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016461; C:unconventional myosin complex; ISS:dictyBase. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:dictyBase.::GO:0005524; F:ATP binding; ISS:dictyBase.::GO:0016887; F:ATPase activity; ISS:dictyBase.::GO:0000146; F:microfilament motor activity; ISS:dictyBase.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:dictyBase. | | | | | | | | | | GO:0006972; P:hyperosmotic response; IMP:dictyBase.::GO:0006971; P:hypotonic response; IMP:dictyBase.::GO:0031268; P:pseudopodium organization; IMP:dictyBase.::GO:0035020; P:regulation of Rac protein signal transduction; IDA:dictyBase.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 11 | Q9NZM3 | 1697 | ITSN2_HUMAN Intersectin-2 OS=Homo sapiens (Hu... | 202 | 0.96 | 35.8 | 26 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 12 | Q9NZN5 | 1544 | ARHGC_HUMAN Rho guanine nucleotide exchange f... | 225 | 1.2 | 35.8 | 21 | 39 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0001664; F:G-protein coupled receptor binding; IDA:MGI.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007186; P:G-protein coupled receptor signaling pathway; IDA:MGI.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 13 | Q92888 | 912 | ARHG1_HUMAN Rho guanine nucleotide exchange f... | 216 | 1.2 | 35.4 | 23 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0008283; P:cell proliferation; TAS:ProtInc.::GO:0050771; P:negative regulation of axonogenesis; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007266; P:Rho protein signal transduction; TAS:ProtInc.::GO:0038032; P:termination of G-protein coupled receptor signaling pathway; IEA:InterPro. | 14 | Q5F479 | 1073 | S11IP_CHICK Serine/threonine-protein kinase 1... | 47 | 1.4 | 35.4 | 40 | 60 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 15 | Q22639 | 1058 | VPS54_CAEEL Vacuolar protein sorting-associat... | 185 | 1.8 | 35 | 23 | 45 | GO:0000938; C:GARP complex; IPI:WormBase. | | | | | | | | | | GO:0019905; F:syntaxin binding; IPI:WormBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0019915; P:lipid storage; IMP:WormBase.::GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro. | 16 | Q9H7P9 | 1386 | PKHG2_HUMAN Pleckstrin homology domain-contai... | 201 | 2.4 | 34.7 | 23 | 39 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 17 | Q8IVF5 | 1701 | TIAM2_HUMAN T-lymphoma invasion and metastasi... | 208 | 2.5 | 34.7 | 19 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005057; F:receptor signaling protein activity; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0044255; P:cellular lipid metabolic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 18 | Q9Z0R6 | 1659 | ITSN2_MOUSE Intersectin-2 OS=Mus musculus (Mo... | 54 | 2.8 | 34.3 | 39 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 19 | O15013 | 1369 | ARHGA_HUMAN Rho guanine nucleotide exchange f... | 250 | 4.3 | 33.9 | 21 | 40 | GO:0005813; C:centrosome; IDA:BHF-UCL.::GO:0005829; C:cytosol; NAS:BHF-UCL.::GO:0005625; C:soluble fraction; IDA:BHF-UCL. | | | | | | | | | | GO:0019894; F:kinesin binding; IPI:BHF-UCL.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IDA:BHF-UCL. | | | | | | | | | | GO:0051298; P:centrosome duplication; IMP:BHF-UCL.::GO:0022011; P:myelination in peripheral nervous system; IMP:BHF-UCL.::GO:0033126; P:positive regulation of GTP catabolic process; IDA:BHF-UCL.::GO:0051496; P:positive regulation of stress fiber assembly; IMP:BHF-UCL.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0090307; P:spindle assembly involved in mitosis; IMP:BHF-UCL. | 20 | Q61JT8 | 1055 | VPS54_CAEBR Vacuolar protein sorting-associat... | 185 | 4.9 | 33.5 | 23 | 45 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0015031; P:protein transport; IEA:UniProtKB-KW.::GO:0042147; P:retrograde transport, endosome to Golgi; IEA:InterPro. | 21 | Q4VCS5 | 1084 | AMOT_HUMAN Angiomotin OS=Homo sapiens (Human)... | 73 | 8 | 32.7 | 26 | 48 | GO:0005884; C:actin filament; IDA:UniProtKB.::GO:0009986; C:cell surface; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030139; C:endocytic vesicle; IDA:MGI.::GO:0009897; C:external side of plasma membrane; IDA:MGI.::GO:0016021; C:integral to membrane; IDA:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:MGI.::GO:0001725; C:stress fiber; IDA:UniProtKB.::GO:0005923; C:tight junction; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0043532; F:angiostatin binding; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004872; F:receptor activity; IDA:MGI. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; TAS:UniProtKB.::GO:0007043; P:cell-cell junction assembly; TAS:UniProtKB.::GO:0034613; P:cellular protein localization; IDA:MGI.::GO:0035329; P:hippo signaling cascade; IGI:MGI.::GO:0016525; P:negative regulation of angiogenesis; IDA:MGI.::GO:0043116; P:negative regulation of vascular permeability; IDA:UniProtKB.::GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:UniProtKB.::GO:0045793; P:positive regulation of cell size; TAS:UniProtKB.::GO:0051496; P:positive regulation of stress fiber assembly; TAS:UniProtKB.::GO:0030334; P:regulation of cell migration; IDA:MGI. |
