| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q9UII4 | 1024 | HERC5_HUMAN E3 ISG15--protein ligase HERC5 OS... | 173 | 0.00001 | 51.2 | 28 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042296; F:ISG15 ligase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0032020; P:ISG15-protein conjugation; IDA:UniProtKB.::GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0000079; P:regulation of cyclin-dependent protein kinase activity; TAS:ProtInc.::GO:0050688; P:regulation of defense response to virus; IDA:UniProtKB.::GO:0009615; P:response to virus; IEA:UniProtKB-KW. | 32 | Q4R828 | 376 | RCCD1_MACFA RCC1 domain-containing protein 1 ... | 231 | 0.024 | 40.4 | 23 | 35 | | | | | | | | | | | | | | | | | | | | | | 33 | Q52KW8 | 513 | RCC2_XENLA Protein RCC2 homolog OS=Xenopus la... | 370 | 0.0001 | 47.8 | 24 | 38 | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 34 | A6NED2 | 376 | RCCD1_HUMAN RCC1 domain-containing protein 1 ... | 128 | 0.7 | 35.8 | 25 | 44 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA. | | | | | | | | | | | | | | | | | | | | | 35 | Q9P258 | 522 | RCC2_HUMAN Protein RCC2 OS=Homo sapiens (Huma... | 321 | 0.0000003 | 56.2 | 26 | 39 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000236; P:mitotic prometaphase; TAS:Reactome. | 36 | Q80YD6 | 464 | SRGEF_MOUSE Secretion-regulating guanine nucl... | 376 | 0.00000000003 | 68.6 | 25 | 38 | GO:0005737; C:cytoplasm; ISS:UniProtKB. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 37 | Q8BK67 | 520 | RCC2_MOUSE Protein RCC2 OS=Mus musculus (Mous... | 321 | 0.0000002 | 57 | 26 | 39 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 38 | Q96I51 | 464 | WBS16_HUMAN Williams-Beuren syndrome chromoso... | 320 | 0.000000001 | 63.5 | 24 | 39 | | | | | | | | | | | | | | | | | | | | | | 39 | Q9CYF5 | 461 | WBS16_MOUSE Williams-Beuren syndrome chromoso... | 332 | 0.000000002 | 62.8 | 24 | 38 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | | 40 | Q3MHW0 | 464 | SRGEF_BOVIN Secretion-regulating guanine nucl... | 380 | 0.000000002 | 63.2 | 25 | 38 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 41 | Q8IS20 | 1457 | GEFC_DICDI Ras guanine nucleotide exchange fa... | 48 | 0.98 | 35.8 | 38 | 50 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 42 | Q8K1R7 | 984 | NEK9_MOUSE Serine/threonine-protein kinase Ne... | 264 | 0.00003 | 50.1 | 24 | 40 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 43 | Q8TD19 | 979 | NEK9_HUMAN Serine/threonine-protein kinase Ne... | 264 | 0.00004 | 50.1 | 23 | 40 | GO:0005739; C:mitochondrion; IDA:HPA.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 44 | Q9UGK8 | 458 | SRGEF_HUMAN Secretion-regulating guanine nucl... | 211 | 0.00009 | 48.1 | 28 | 39 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.::GO:0005730; C:nucleolus; IDA:HPA. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0050709; P:negative regulation of protein secretion; IDA:HGNC.::GO:0007165; P:signal transduction; TAS:UniProtKB. | 45 | Q8BTU7 | 377 | RCCD1_MOUSE RCC1 domain-containing protein 1 ... | 290 | 0.26 | 37 | 21 | 35 | | | | | | | | | | | | | | | | | | | | | | 46 | Q91ZR4 | 698 | NEK8_MOUSE Serine/threonine-protein kinase Ne... | 221 | 0.0008 | 45.4 | 26 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0072372; C:primary cilium; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 47 | Q86SG6 | 692 | NEK8_HUMAN Serine/threonine-protein kinase Ne... | 282 | 0.00003 | 50.1 | 22 | 38 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0072372; C:primary cilium; ISS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 48 | Q54Q89 | 487 | RCCDC_DICDI RCC1 repeat-containing protein DD... | 165 | 6.9 | 32.7 | 24 | 42 | | | | | | | | | | | | | | | | | | | | | | 49 | P0C5Y8 | 1651 | ALS2_RAT Alsin OS=Rattus norvegicus (Rat). GN... | 116 | 0.65 | 36.2 | 27 | 36 | GO:0030424; C:axon; IDA:RGD.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0030426; C:growth cone; IDA:UniProtKB.::GO:0016020; C:membrane; IDA:UniProtKB.::GO:0005792; C:microsome; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0043234; C:protein complex; ISS:UniProtKB.::GO:0019717; C:synaptosome; IDA:RGD. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043539; F:protein serine/threonine kinase activator activity; ISS:UniProtKB.::GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0007409; P:axonogenesis; IMP:RGD.::GO:0008219; P:cell death; IMP:RGD.::GO:0001701; P:in utero embryonic development; IEP:RGD.::GO:0032855; P:positive regulation of Rac GTPase activity; ISS:UniProtKB.::GO:0016601; P:Rac protein signal transduction; IDA:RGD.::GO:0051036; P:regulation of endosome size; ISS:UniProtKB. | 50 | Q54VW7 | 1203 | GACGG_DICDI Rho GTPase-activating protein gac... | 172 | 0.002 | 44.3 | 26 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 51 | Q7ZZC8 | 944 | NEK9_XENLA Serine/threonine-protein kinase Ne... | 176 | 0.0001 | 48.5 | 24 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0019901; F:protein kinase binding; ISS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 52 | Q920R0 | 1651 | ALS2_MOUSE Alsin OS=Mus musculus (Mouse). GN=... | 116 | 0.63 | 36.2 | 27 | 36 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0030426; C:growth cone; ISS:UniProtKB.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0014069; C:postsynaptic density; IDA:MGI.::GO:0043234; C:protein complex; ISS:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB.::GO:0042598; C:vesicular fraction; ISS:UniProtKB. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043539; F:protein serine/threonine kinase activator activity; ISS:UniProtKB.::GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0001662; P:behavioral fear response; IMP:MGI.::GO:0016197; P:endosome transport; IMP:MGI.::GO:0007626; P:locomotory behavior; IMP:MGI.::GO:0007528; P:neuromuscular junction development; IMP:MGI.::GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.::GO:0032855; P:positive regulation of Rac GTPase activity; ISS:UniProtKB.::GO:0008104; P:protein localization; IMP:MGI.::GO:0001881; P:receptor recycling; IMP:MGI.::GO:0051036; P:regulation of endosome size; ISS:UniProtKB.::GO:0032313; P:regulation of Rab GTPase activity; IDA:MGI.::GO:0006979; P:response to oxidative stress; IMP:MGI.::GO:0035249; P:synaptic transmission, glutamatergic; IMP:MGI.::GO:0016050; P:vesicle organization; IDA:MGI. | 53 | Q5BIW4 | 1657 | ALS2_PANTR Alsin OS=Pan troglodytes (Chimpanz... | 233 | 0.092 | 38.9 | 25 | 39 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0014069; C:postsynaptic density; ISS:UniProtKB.::GO:0043234; C:protein complex; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.::GO:0042598; C:vesicular fraction; ISS:UniProtKB. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043539; F:protein serine/threonine kinase activator activity; ISS:UniProtKB.::GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0001662; P:behavioral fear response; ISS:UniProtKB.::GO:0016197; P:endosome transport; ISS:UniProtKB.::GO:0007626; P:locomotory behavior; ISS:UniProtKB.::GO:0007528; P:neuromuscular junction development; ISS:UniProtKB.::GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.::GO:0032855; P:positive regulation of Rac GTPase activity; ISS:UniProtKB.::GO:0008104; P:protein localization; ISS:UniProtKB.::GO:0001881; P:receptor recycling; ISS:UniProtKB.::GO:0051036; P:regulation of endosome size; ISS:UniProtKB.::GO:0032313; P:regulation of Rab GTPase activity; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:UniProtKB.::GO:0035249; P:synaptic transmission, glutamatergic; ISS:UniProtKB.::GO:0016050; P:vesicle organization; ISS:UniProtKB. | 54 | Q96Q42 | 1657 | ALS2_HUMAN Alsin OS=Homo sapiens (Human). GN=... | 233 | 0.13 | 38.5 | 24 | 39 | GO:0005813; C:centrosome; IDA:MGI.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0030426; C:growth cone; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0043539; F:protein serine/threonine kinase activator activity; IDA:UniProtKB.::GO:0017137; F:Rab GTPase binding; IDA:UniProtKB.::GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0007032; P:endosome organization; NAS:UniProtKB.::GO:0032855; P:positive regulation of Rac GTPase activity; IDA:UniProtKB.::GO:0035022; P:positive regulation of Rac protein signal transduction; IC:UniProtKB.::GO:0051036; P:regulation of endosome size; IEP:UniProtKB. | 55 | Q90XC2 | 697 | NEK8_DANRE Serine/threonine-protein kinase Ne... | 295 | 0.00002 | 50.8 | 22 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 56 | Q6NRS1 | 1339 | IBTK_XENLA Inhibitor of Bruton tyrosine kinas... | 184 | 0.0002 | 47.8 | 26 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 57 | Q9NB71 | 5233 | HIW_DROME E3 ubiquitin-protein ligase highwir... | 197 | 0.078 | 39.3 | 23 | 38 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:FlyBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007628; P:adult walking behavior; NAS:FlyBase.::GO:0006914; P:autophagy; IDA:FlyBase.::GO:0030509; P:BMP signaling pathway; IPI:UniProtKB.::GO:0040011; P:locomotion; NAS:FlyBase.::GO:0030514; P:negative regulation of BMP signaling pathway; IGI:UniProtKB.::GO:0045886; P:negative regulation of synaptic growth at neuromuscular junction; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0050808; P:synapse organization; IDA:FlyBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 58 | Q9P2D0 | 1353 | IBTK_HUMAN Inhibitor of Bruton tyrosine kinas... | 230 | 0.00008 | 48.9 | 27 | 42 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0019901; F:protein kinase binding; IDA:MGI.::GO:0030292; F:protein tyrosine kinase inhibitor activity; IDA:MGI. | | | | | | | | | | GO:0001933; P:negative regulation of protein phosphorylation; IDA:MGI.::GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:MGI. | 59 | Q54X24 | 512 | RCCDA_DICDI RCC1 domain-containing protein DD... | 40 | 1 | 35.4 | 40 | 65 | | | | | | | | | | | | | | | | | | | | | | 60 | Q54HT1 | 1336 | TIRA_DICDI Protein tirA OS=Dictyostelium disc... | 74 | 0.069 | 39.3 | 31 | 50 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | | | | | | | | | | | GO:0008283; P:cell proliferation; IMP:dictyBase.::GO:0006952; P:defense response; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 61 | Q6ZPR6 | 1352 | IBTK_MOUSE Inhibitor of Bruton tyrosine kinas... | 145 | 8.8 | 32.7 | 26 | 39 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | |
