rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q5RE95 | 330 | WDR5B_PONAB WD repeat-containing protein 5B O... | 164 | 2e-24 | 110 | 35 | 59 | | | | | | | | | | | | | | | | | | | | | | 32 | Q9GL51 | 410 | LIS1_PIG Platelet-activating factor acetylhyd... | 169 | 6e-30 | 129 | 41 | 57 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 33 | C4Q0P6 | 417 | LIS1_SCHMA Lissencephaly-1 homolog OS=Schisto... | 163 | 1e-23 | 108 | 37 | 53 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 34 | Q5JTN6 | 314 | WDR38_HUMAN WD repeat-containing protein 38 O... | 94 | 0.000000001 | 65.1 | 39 | 53 | | | | | | | | | | | | | | | | | | | | | | 35 | P63004 | 410 | LIS1_RAT Platelet-activating factor acetylhyd... | 169 | 1e-29 | 127 | 40 | 57 | GO:0033267; C:axon part; IDA:RGD.::GO:0005829; C:cytosol; IDA:RGD.::GO:0030426; C:growth cone; IDA:RGD.::GO:0005871; C:kinesin complex; IDA:RGD.::GO:0043025; C:neuronal cell body; IDA:RGD.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; IDA:RGD.::GO:0042598; C:vesicular fraction; IDA:RGD. | | | | | | | | | | GO:0045505; F:dynein intermediate chain binding; IDA:RGD.::GO:0047179; F:platelet-activating factor acetyltransferase activity; TAS:RGD. | | | | | | | | | | GO:0021895; P:cerebral cortex neuron differentiation; IMP:RGD.::GO:0051660; P:establishment of centrosome localization; IMP:RGD.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0010977; P:negative regulation of neuron projection development; IMP:RGD.::GO:0001764; P:neuron migration; IMP:RGD.::GO:0007097; P:nuclear migration; IMP:RGD.::GO:0045773; P:positive regulation of axon extension; IMP:RGD.::GO:0045931; P:positive regulation of mitotic cell cycle; IMP:RGD.::GO:0017145; P:stem cell division; IMP:RGD. | 36 | P63005 | 410 | LIS1_MOUSE Platelet-activating factor acetylh... | 169 | 1e-29 | 127 | 40 | 57 | GO:0005813; C:centrosome; IDA:MGI.::GO:0031512; C:motile primary cilium; IDA:MGI.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IDA:MGI. | | | | | | | | | | GO:0008017; F:microtubule binding; IDA:MGI.::GO:0051219; F:phosphoprotein binding; IPI:MGI.::GO:0042803; F:protein homodimerization activity; IPI:MGI. | | | | | | | | | | GO:0001675; P:acrosome assembly; IMP:MGI.::GO:0030036; P:actin cytoskeleton organization; IMP:MGI.::GO:0008344; P:adult locomotory behavior; IMP:MGI.::GO:0021766; P:hippocampus development; IMP:MGI.::GO:0021819; P:layer formation in cerebral cortex; IGI:MGI.::GO:0007611; P:learning or memory; IMP:MGI.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007405; P:neuroblast proliferation; IMP:MGI.::GO:0050885; P:neuromuscular process controlling balance; IMP:MGI.::GO:0001764; P:neuron migration; IMP:MGI.::GO:0051081; P:nuclear envelope disassembly; IMP:MGI.::GO:0032319; P:regulation of Rho GTPase activity; IMP:MGI.::GO:0008090; P:retrograde axon cargo transport; IDA:MGI.::GO:0007268; P:synaptic transmission; IMP:MGI. | 37 | B0LSW3 | 410 | LIS1_FELCA Platelet-activating factor acetylh... | 169 | 1e-29 | 127 | 40 | 57 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 38 | P43034 | 410 | LIS1_HUMAN Platelet-activating factor acetylh... | 169 | 1e-29 | 127 | 40 | 57 | GO:0000235; C:astral microtubule; IDA:UniProtKB.::GO:0005938; C:cell cortex; IDA:UniProtKB.::GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005829; C:cytosol; ISS:BHF-UCL.::GO:0000776; C:kinetochore; IDA:UniProtKB.::GO:0031512; C:motile primary cilium; ISS:BHF-UCL.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; ISS:BHF-UCL. | | | | | | | | | | GO:0034452; F:dynactin binding; ISS:BHF-UCL.::GO:0008201; F:heparin binding; ISS:BHF-UCL.::GO:0008017; F:microtubule binding; ISS:BHF-UCL.::GO:0043274; F:phospholipase binding; ISS:BHF-UCL.::GO:0051219; F:phosphoprotein binding; ISS:BHF-UCL.::GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL. | | | | | | | | | | GO:0001675; P:acrosome assembly; ISS:BHF-UCL.::GO:0030036; P:actin cytoskeleton organization; ISS:BHF-UCL.::GO:0008344; P:adult locomotory behavior; IMP:BHF-UCL.::GO:0048854; P:brain morphogenesis; IMP:BHF-UCL.::GO:0021540; P:corpus callosum morphogenesis; IMP:BHF-UCL.::GO:0000132; P:establishment of mitotic spindle orientation; IMP:UniProtKB.::GO:0000086; P:G2/M transition of mitotic cell cycle; TAS:Reactome.::GO:0021766; P:hippocampus development; ISS:BHF-UCL.::GO:0021819; P:layer formation in cerebral cortex; ISS:BHF-UCL.::GO:0007611; P:learning or memory; ISS:BHF-UCL.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0031023; P:microtubule organizing center organization; IMP:UniProtKB.::GO:0000236; P:mitotic prometaphase; TAS:Reactome.::GO:0007405; P:neuroblast proliferation; ISS:BHF-UCL.::GO:0050885; P:neuromuscular process controlling balance; IMP:BHF-UCL.::GO:0001764; P:neuron migration; IMP:UniProtKB.::GO:0046469; P:platelet activating factor metabolic process; ISS:BHF-UCL.::GO:0032319; P:regulation of Rho GTPase activity; ISS:BHF-UCL.::GO:0008090; P:retrograde axon cargo transport; ISS:BHF-UCL.::GO:0007268; P:synaptic transmission; ISS:BHF-UCL.::GO:0047496; P:vesicle transport along microtubule; ISS:BHF-UCL. | 39 | P74442 | 1191 | Y143_SYNY3 Uncharacterized WD repeat-containi... | 407 | 0.000000000000009 | 83.6 | 22 | 42 | | | | | | | | | | | | | | | | | | | | | | 40 | P43033 | 410 | LIS1_BOVIN Platelet-activating factor acetylh... | 169 | 6e-30 | 129 | 41 | 57 | GO:0005829; C:cytosol; IDA:BHF-UCL.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0034452; F:dynactin binding; IDA:BHF-UCL.::GO:0045502; F:dynein binding; IDA:BHF-UCL.::GO:0008201; F:heparin binding; IDA:BHF-UCL.::GO:0008017; F:microtubule binding; IDA:MGI.::GO:0043274; F:phospholipase binding; IDA:BHF-UCL. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0046469; P:platelet activating factor metabolic process; IDA:BHF-UCL.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 41 | Q5IS43 | 410 | LIS1_PANTR Platelet-activating factor acetylh... | 169 | 1e-29 | 128 | 40 | 57 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 42 | Q5REG7 | 410 | LIS1_PONAB Platelet-activating factor acetylh... | 169 | 3e-29 | 127 | 40 | 56 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 43 | Q4RJN5 | 410 | LIS1_TETNG Lissencephaly-1 homolog OS=nigrovi... | 169 | 7e-30 | 129 | 40 | 58 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 44 | Q9PTR5 | 410 | LIS1_CHICK Lissencephaly-1 homolog OS=Gallus ... | 169 | 2e-29 | 127 | 40 | 57 | | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 45 | Q90ZL4 | 410 | LIS1_XENLA Lissencephaly-1 homolog OS=Xenopus... | 169 | 2e-29 | 127 | 40 | 57 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 46 | Q7T394 | 410 | LIS1A_DANRE Lissencephaly-1 homolog A OS=Dani... | 169 | 2e-30 | 130 | 41 | 58 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0048854; P:brain morphogenesis; IMP:ZFIN.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 47 | Q6NZH4 | 410 | LIS1_XENTR Lissencephaly-1 homolog OS=Xenopus... | 169 | 3e-29 | 127 | 40 | 57 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 48 | Q8HXX0 | 410 | LIS1_MACFA Platelet-activating factor acetylh... | 169 | 1e-28 | 125 | 39 | 56 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.::GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 49 | Q54KL5 | 335 | WDR5_DICDI WD repeat-containing protein 5 hom... | 213 | 8e-17 | 87 | 30 | 46 | GO:0035097; C:histone methyltransferase complex; ISS:dictyBase. | | | | | | | | | | GO:0042393; F:histone binding; ISS:dictyBase. | | | | | | | | | | GO:0051568; P:histone H3-K4 methylation; ISS:dictyBase. | 50 | Q8I0F4 | 419 | LIS1_DICDI Lissencephaly-1 homolog OS=Dictyos... | 182 | 8e-33 | 138 | 40 | 55 | GO:0031592; C:centrosomal corona; IDA:dictyBase.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0045504; F:dynein heavy chain binding; IPI:dictyBase.::GO:0017048; F:Rho GTPase binding; IPI:dictyBase. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051642; P:centrosome localization; IMP:dictyBase.::GO:0051645; P:Golgi localization; IMP:dictyBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 51 | Q9D994 | 303 | WDR38_MOUSE WD repeat-containing protein 38 O... | 199 | 5e-27 | 118 | 33 | 53 | | | | | | | | | | | | | | | | | | | | | | 52 | Q803D2 | 410 | LIS1B_DANRE Lissencephaly-1 homolog B OS=Dani... | 169 | 1e-28 | 124 | 39 | 57 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0045176; P:apical protein localization; IMP:ZFIN.::GO:0048854; P:brain morphogenesis; IMP:ZFIN.::GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0040023; P:establishment of nucleus localization; IMP:ZFIN.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045494; P:photoreceptor cell maintenance; IMP:ZFIN.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 53 | B3S4I5 | 409 | LIS1_TRIAD Lissencephaly-1 homolog OS=Trichop... | 53 | 4.2 | 35.4 | 26 | 55 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 54 | O14727 | 1248 | APAF_HUMAN Apoptotic protease-activating fact... | 126 | 0.000000001 | 67 | 28 | 48 | GO:0043293; C:apoptosome; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IDA:HPA.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0043531; F:ADP binding; IEA:InterPro.::GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008656; F:cysteine-type endopeptidase activator activity involved in apoptotic process; NAS:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0008635; P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; IDA:UniProtKB.::GO:0006952; P:defense response; IEA:InterPro.::GO:0008629; P:induction of apoptosis by intracellular signals; TAS:Reactome.::GO:0097193; P:intrinsic apoptotic signaling pathway; TAS:UniProtKB.::GO:0007399; P:nervous system development; TAS:ProtInc. | 55 | Q9USN3 | 777 | UTP13_SCHPO Probable U3 small nucleolar RNA-a... | 575 | 1e-53 | 206 | 26 | 46 | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005732; C:small nucleolar ribonucleoprotein complex; ISS:PomBase.::GO:0032040; C:small-subunit processome; IEA:InterPro. | | | | | | | | | | GO:0030515; F:snoRNA binding; ISS:PomBase. | | | | | | | | | | GO:0030490; P:maturation of SSU-rRNA; ISS:PomBase. | 56 | B5X3Z6 | 410 | LIS1A_SALSA Lissencephaly-1 homolog A OS=Salm... | 169 | 1e-29 | 128 | 40 | 57 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007399; P:nervous system development; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 57 | Q4P9P9 | 453 | LIS1_USTMA Nuclear distribution protein PAC1 ... | 309 | 4e-32 | 136 | 28 | 48 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 58 | D3BUN1 | 417 | LIS1_POLPA Lissencephaly-1 homolog OS=Polysph... | 40 | 0.73 | 37.7 | 40 | 58 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 59 | Q9FLX9 | 473 | NLE1_ARATH Notchless protein homolog OS=Arabi... | 256 | 1e-19 | 97.4 | 30 | 47 | GO:0080008; C:CUL4 RING ubiquitin ligase complex; ISS:TAIR.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 60 | A7S338 | 409 | LIS1_NEMVE Lissencephaly-1 homolog OS=Nematos... | 169 | 2e-29 | 127 | 40 | 59 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 61 | Q7ZVF0 | 416 | POC1A_DANRE POC1 centriolar protein homolog A... | 194 | 4e-28 | 123 | 35 | 55 | | | | | | | | | | | | | | | | | | | | | |