| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P0CS88 | 354 | HST22_EMENI NAD-dependent protein deacetylase... | 331 | 7e-126 | 371 | 53 | 72 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 2 | Q5AW69 | 361 | HST21_EMENI NAD-dependent protein deacetylase... | 319 | 6e-106 | 321 | 50 | 67 | | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 3 | Q9USN7 | 332 | HST2_SCHPO NAD-dependent protein deacetylase ... | 268 | 2e-86 | 270 | 49 | 65 | GO:0005721; C:centromeric heterochromatin; IDA:PomBase.::GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.::GO:0000790; C:nuclear chromatin; IDA:PomBase.::GO:0033553; C:rDNA heterochromatin; IDA:PomBase.::GO:0031933; C:telomeric heterochromatin; IDA:PomBase. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; TAS:PomBase.::GO:0003714; F:transcription corepressor activity; IMP:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0000183; P:chromatin silencing at rDNA; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 4 | Q5RBF1 | 352 | SIR2_PONAB NAD-dependent protein deacetylase ... | 293 | 9e-77 | 245 | 44 | 61 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro. | 5 | Q9NTG7 | 399 | SIR3_HUMAN NAD-dependent protein deacetylase ... | 265 | 2e-76 | 246 | 46 | 65 | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0003950; F:NAD+ ADP-ribosyltransferase activity; TAS:ProtInc.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0009060; P:aerobic respiration; IMP:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IMP:UniProtKB.::GO:0006471; P:protein ADP-ribosylation; TAS:ProtInc. | 6 | Q8IXJ6 | 389 | SIR2_HUMAN NAD-dependent protein deacetylase ... | 293 | 3e-76 | 245 | 44 | 61 | GO:0005677; C:chromatin silencing complex; NAS:UniProtKB.::GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0005874; C:microtubule; IDA:UniProtKB. | | | | | | | | | | GO:0035035; F:histone acetyltransferase binding; IPI:UniProtKB.::GO:0042826; F:histone deacetylase binding; IPI:UniProtKB.::GO:0070403; F:NAD+ binding; IDA:UniProtKB.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008134; F:transcription factor binding; IPI:UniProtKB.::GO:0042903; F:tubulin deacetylase activity; IDA:UniProtKB.::GO:0043130; F:ubiquitin binding; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IDA:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000183; P:chromatin silencing at rDNA; NAS:UniProtKB.::GO:0006348; P:chromatin silencing at telomere; NAS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045843; P:negative regulation of striated muscle tissue development; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0006471; P:protein ADP-ribosylation; NAS:UniProtKB.::GO:0007096; P:regulation of exit from mitosis; NAS:UniProtKB.::GO:0042325; P:regulation of phosphorylation; NAS:UniProtKB.::GO:0051775; P:response to redox state; NAS:UniProtKB. | 7 | Q4R834 | 389 | SIR2_MACFA NAD-dependent protein deacetylase ... | 293 | 1e-75 | 244 | 44 | 61 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro. | 8 | Q7ZVK3 | 379 | SIR2_DANRE NAD-dependent protein deacetylase ... | 316 | 6e-75 | 241 | 41 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 9 | Q8R104 | 257 | SIR3_MOUSE NAD-dependent protein deacetylase ... | 248 | 2e-73 | 234 | 46 | 65 | GO:0016020; C:membrane; IDA:MGI.::GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; ISS:UniProtKB. | | | | | | | | | | GO:0009060; P:aerobic respiration; ISS:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; ISS:UniProtKB. | 10 | Q8VDQ8 | 389 | SIR2_MOUSE NAD-dependent protein deacetylase ... | 283 | 1e-71 | 233 | 43 | 60 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; ISS:UniProtKB. | | | | | | | | | | GO:0035035; F:histone acetyltransferase binding; ISS:UniProtKB.::GO:0042826; F:histone deacetylase binding; ISS:UniProtKB.::GO:0017136; F:NAD-dependent histone deacetylase activity; ISS:UniProtKB.::GO:0008134; F:transcription factor binding; ISS:UniProtKB.::GO:0042903; F:tubulin deacetylase activity; ISS:UniProtKB.::GO:0043130; F:ubiquitin binding; ISS:UniProtKB. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0045843; P:negative regulation of striated muscle tissue development; ISS:UniProtKB.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. | 11 | Q54QE6 | 512 | SIR2A_DICDI NAD-dependent deacetylase sir2A O... | 275 | 2e-71 | 236 | 45 | 61 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 12 | Q9I7I7 | 355 | SIRT2_DROME NAD-dependent protein deacetylase... | 266 | 5e-71 | 231 | 45 | 60 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:FlyBase. | 13 | Q5RJQ4 | 350 | SIR2_RAT NAD-dependent protein deacetylase si... | 278 | 1e-69 | 227 | 42 | 59 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0005874; C:microtubule; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0006476; P:protein deacetylation; IEA:InterPro. | 14 | Q5A985 | 331 | HST2_CANAL NAD-dependent protein deacetylase ... | 320 | 7e-63 | 209 | 38 | 55 | | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048869; P:cellular developmental process; IMP:CGD.::GO:0006476; P:protein deacetylation; IEA:InterPro. | 15 | P53686 | 357 | HST2_YEAST NAD-dependent protein deacetylase ... | 279 | 2e-62 | 208 | 40 | 57 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:SGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0000183; P:chromatin silencing at rDNA; IMP:SGD.::GO:0001300; P:chronological cell aging; IMP:SGD.::GO:0031939; P:negative regulation of chromatin silencing at telomere; IMP:SGD.::GO:0045950; P:negative regulation of mitotic recombination; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 16 | Q54P49 | 456 | SIR2C_DICDI NAD-dependent deacetylase sir2C O... | 276 | 5e-58 | 199 | 40 | 58 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 17 | Q57V41 | 351 | SIR2_TRYB2 NAD-dependent protein deacetylase ... | 229 | 3e-57 | 194 | 45 | 58 | | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 18 | Q54GV7 | 542 | SIR2D_DICDI NAD-dependent deacetylase sir2D O... | 261 | 7e-55 | 193 | 39 | 61 | | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 19 | Q25337 | 373 | SIR2_LEIMA NAD-dependent protein deacetylase ... | 251 | 9e-53 | 183 | 41 | 59 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:InterPro.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0016757; F:transferase activity, transferring glycosyl groups; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 20 | Q21921 | 607 | SIR2_CAEEL NAD-dependent protein deacetylase ... | 289 | 3e-50 | 181 | 35 | 57 | GO:0000784; C:nuclear chromosome, telomeric region; IDA:WormBase. | | | | | | | | | | GO:0019213; F:deacetylase activity; IDA:WormBase.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0040024; P:dauer larval development; IGI:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0070932; P:histone H3 deacetylation; IDA:WormBase. | 21 | Q60L58 | 602 | SIR2_CAEBR NAD-dependent protein deacetylase ... | 264 | 4e-48 | 175 | 38 | 55 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 22 | O59923 | 519 | SIR2_CANAL NAD-dependent histone deacetylase ... | 254 | 3e-47 | 172 | 37 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0000183; P:chromatin silencing at rDNA; IMP:CGD.::GO:0001319; P:inheritance of oxidatively modified proteins involved in replicative cell aging; IMP:CGD.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0045595; P:regulation of cell differentiation; IMP:CGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 23 | O94640 | 475 | SIR2_SCHPO NAD-dependent histone deacetylase ... | 299 | 8e-47 | 170 | 36 | 51 | GO:0016585; C:chromatin remodeling complex; ISS:PomBase.::GO:0000775; C:chromosome, centromeric region; IDA:PomBase.::GO:0000781; C:chromosome, telomeric region; IDA:PomBase.::GO:0031934; C:mating-type region heterochromatin; IDA:PomBase.::GO:0000790; C:nuclear chromatin; IC:PomBase. | | | | | | | | | | GO:0070403; F:NAD+ binding; IDA:PomBase.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:PomBase.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IDA:PomBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006338; P:chromatin remodeling; ISS:PomBase.::GO:0030702; P:chromatin silencing at centromere; IMP:PomBase.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:PomBase.::GO:0006348; P:chromatin silencing at telomere; IMP:PomBase.::GO:0006281; P:DNA repair; IEA:UniProtKB-KW.::GO:0000070; P:mitotic sister chromatid segregation; IMP:PomBase.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEP:PomBase.::GO:0070198; P:protein localization to chromosome, telomeric region; IGI:PomBase.::GO:0051570; P:regulation of histone H3-K9 methylation; IMP:PomBase.::GO:0060303; P:regulation of nucleosome density; IEP:PomBase.::GO:0001302; P:replicative cell aging; ISS:PomBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 24 | Q923E4 | 737 | SIR1_MOUSE NAD-dependent protein deacetylase ... | 264 | 7e-46 | 169 | 39 | 57 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005719; C:nuclear euchromatin; ISS:UniProtKB.::GO:0005720; C:nuclear heterochromatin; IDA:UniProtKB.::GO:0005637; C:nuclear inner membrane; ISS:UniProtKB.::GO:0016605; C:PML body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0043425; F:bHLH transcription factor binding; ISS:UniProtKB.::GO:0019899; F:enzyme binding; IPI:UniProtKB.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:UniProtKB.::GO:0002039; F:p53 binding; IPI:BHF-UCL.::GO:0019904; F:protein domain specific binding; IPI:BHF-UCL.::GO:0003714; F:transcription corepressor activity; IMP:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; ISS:UniProtKB.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0001678; P:cellular glucose homeostasis; IMP:UniProtKB.::GO:0071456; P:cellular response to hypoxia; ISS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; IMP:UniProtKB.::GO:0009267; P:cellular response to starvation; IMP:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; ISS:UniProtKB.::GO:0035356; P:cellular triglyceride homeostasis; IMP:UniProtKB.::GO:0042632; P:cholesterol homeostasis; IMP:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; ISS:UniProtKB.::GO:0000731; P:DNA synthesis involved in DNA repair; IMP:UniProtKB.::GO:0055089; P:fatty acid homeostasis; IMP:UniProtKB.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; ISS:UniProtKB.::GO:2000773; P:negative regulation of cellular senescence; ISS:UniProtKB.::GO:0045599; P:negative regulation of fat cell differentiation; IMP:BHF-UCL.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:2000757; P:negative regulation of peptidyl-lysine acetylation; ISS:UniProtKB.::GO:0042326; P:negative regulation of phosphorylation; IMP:UniProtKB.::GO:0031393; P:negative regulation of prostaglandin biosynthetic process; IMP:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IDA:UniProtKB.::GO:0001542; P:ovulation from ovarian follicle; IMP:MGI.::GO:0002821; P:positive regulation of adaptive immune response; ISS:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.::GO:2000774; P:positive regulation of cellular senescence; ISS:UniProtKB.::GO:0010875; P:positive regulation of cholesterol efflux; IMP:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; ISS:UniProtKB.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; ISS:UniProtKB.::GO:0016239; P:positive regulation of macroautophagy; IDA:UniProtKB.::GO:2000111; P:positive regulation of macrophage apoptotic process; IMP:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; IMP:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0031648; P:protein destabilization; IDA:UniProtKB.::GO:0016567; P:protein ubiquitination; ISS:UniProtKB.::GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IMP:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; IMP:UniProtKB.::GO:0032071; P:regulation of endodeoxyribonuclease activity; ISS:UniProtKB.::GO:0010906; P:regulation of glucose metabolic process; IMP:UniProtKB.::GO:0007346; P:regulation of mitotic cell cycle; ISS:UniProtKB.::GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; IMP:BHF-UCL.::GO:0034391; P:regulation of smooth muscle cell apoptotic process; IDA:UniProtKB.::GO:0032868; P:response to insulin stimulus; IDA:UniProtKB.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.::GO:0000012; P:single strand break repair; ISS:UniProtKB.::GO:0007283; P:spermatogenesis; IMP:MGI.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006642; P:triglyceride mobilization; IMP:BHF-UCL.::GO:0050872; P:white fat cell differentiation; IMP:BHF-UCL. | 25 | P06700 | 562 | SIR2_YEAST NAD-dependent histone deacetylase ... | 277 | 1e-45 | 168 | 36 | 52 | GO:0000783; C:nuclear telomere cap complex; IDA:SGD.::GO:0005724; C:nuclear telomeric heterochromatin; IDA:SGD.::GO:0030869; C:RENT complex; IDA:SGD. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0032041; F:NAD-dependent histone deacetylase activity (H3-K14 specific); IDA:SGD.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); IDA:SGD.::GO:0046970; F:NAD-dependent histone deacetylase activity (H4-K16 specific); IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006333; P:chromatin assembly or disassembly; IDA:SGD.::GO:0000183; P:chromatin silencing at rDNA; IMP:SGD.::GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD.::GO:0006348; P:chromatin silencing at telomere; IMP:SGD.::GO:0001300; P:chronological cell aging; IMP:SGD.::GO:0006303; P:double-strand break repair via nonhomologous end joining; IDA:SGD.::GO:0001308; P:negative regulation of chromatin silencing involved in replicative cell aging; TAS:SGD.::GO:0045910; P:negative regulation of DNA recombination; IGI:SGD.::GO:0008156; P:negative regulation of DNA replication; IMP:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 26 | Q96EB6 | 747 | SIR1_HUMAN NAD-dependent protein deacetylase ... | 264 | 3e-45 | 167 | 39 | 57 | GO:0005677; C:chromatin silencing complex; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0005719; C:nuclear euchromatin; IDA:UniProtKB.::GO:0005720; C:nuclear heterochromatin; IDA:UniProtKB.::GO:0005637; C:nuclear inner membrane; IDA:UniProtKB.::GO:0005730; C:nucleolus; IDA:BHF-UCL.::GO:0016605; C:PML body; IDA:BHF-UCL.::GO:0033553; C:rDNA heterochromatin; IDA:UniProtKB. | | | | | | | | | | GO:0043425; F:bHLH transcription factor binding; IPI:UniProtKB.::GO:0042393; F:histone binding; IPI:BHF-UCL.::GO:0043398; F:HLH domain binding; IPI:BHF-UCL.::GO:0042802; F:identical protein binding; IPI:BHF-UCL.::GO:0051019; F:mitogen-activated protein kinase binding; IPI:BHF-UCL.::GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0046969; F:NAD-dependent histone deacetylase activity (H3-K9 specific); ISS:UniProtKB.::GO:0002039; F:p53 binding; IPI:BHF-UCL.::GO:0008022; F:protein C-terminus binding; IPI:UniProtKB.::GO:0003714; F:transcription corepressor activity; IDA:BHF-UCL.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IDA:UniProtKB.::GO:0007569; P:cell aging; TAS:BHF-UCL.::GO:0001678; P:cellular glucose homeostasis; ISS:UniProtKB.::GO:0070301; P:cellular response to hydrogen peroxide; IDA:BHF-UCL.::GO:0071456; P:cellular response to hypoxia; IMP:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; ISS:UniProtKB.::GO:0009267; P:cellular response to starvation; ISS:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:UniProtKB.::GO:0035356; P:cellular triglyceride homeostasis; ISS:UniProtKB.::GO:0042632; P:cholesterol homeostasis; ISS:UniProtKB.::GO:0000183; P:chromatin silencing at rDNA; IDA:UniProtKB.::GO:0042771; P:DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; IMP:UniProtKB.::GO:0006260; P:DNA replication; TAS:BHF-UCL.::GO:0000731; P:DNA synthesis involved in DNA repair; ISS:UniProtKB.::GO:0006343; P:establishment of chromatin silencing; IDA:BHF-UCL.::GO:0055089; P:fatty acid homeostasis; ISS:UniProtKB.::GO:0070932; P:histone H3 deacetylation; IDA:BHF-UCL.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0006344; P:maintenance of chromatin silencing; IMP:BHF-UCL.::GO:0006346; P:methylation-dependent chromatin silencing; TAS:UniProtKB.::GO:0007517; P:muscle organ development; IEA:UniProtKB-KW.::GO:0060766; P:negative regulation of androgen receptor signaling pathway; IMP:BHF-UCL.::GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:2000480; P:negative regulation of cAMP-dependent protein kinase activity; IDA:UniProtKB.::GO:0030308; P:negative regulation of cell growth; IMP:BHF-UCL.::GO:2000655; P:negative regulation of cellular response to testosterone stimulus; IMP:BHF-UCL.::GO:2000773; P:negative regulation of cellular senescence; IDA:UniProtKB.::GO:0043518; P:negative regulation of DNA damage response, signal transduction by p53 class mediator; IDA:BHF-UCL.::GO:0045599; P:negative regulation of fat cell differentiation; ISS:BHF-UCL.::GO:0051097; P:negative regulation of helicase activity; IDA:UniProtKB.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:UniProtKB.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IDA:UniProtKB.::GO:2000757; P:negative regulation of peptidyl-lysine acetylation; IDA:UniProtKB.::GO:0042326; P:negative regulation of phosphorylation; IMP:UniProtKB.::GO:0031393; P:negative regulation of prostaglandin biosynthetic process; ISS:UniProtKB.::GO:0051898; P:negative regulation of protein kinase B signaling cascade; IMP:UniProtKB.::GO:0032007; P:negative regulation of TOR signaling cascade; IMP:UniProtKB.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.::GO:0018394; P:peptidyl-lysine acetylation; IMP:UniProtKB.::GO:0034983; P:peptidyl-lysine deacetylation; IDA:BHF-UCL.::GO:0002821; P:positive regulation of adaptive immune response; IDA:UniProtKB.::GO:0045768; P:positive regulation of anti-apoptosis; IMP:UniProtKB.::GO:2000481; P:positive regulation of cAMP-dependent protein kinase activity; IMP:UniProtKB.::GO:0008284; P:positive regulation of cell proliferation; IMP:UniProtKB.::GO:2000774; P:positive regulation of cellular senescence; IDA:UniProtKB.::GO:0010875; P:positive regulation of cholesterol efflux; ISS:UniProtKB.::GO:0031937; P:positive regulation of chromatin silencing; IMP:BHF-UCL.::GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.::GO:0045739; P:positive regulation of DNA repair; IMP:UniProtKB.::GO:0046628; P:positive regulation of insulin receptor signaling pathway; IDA:UniProtKB.::GO:0016239; P:positive regulation of macroautophagy; IDA:UniProtKB.::GO:2000111; P:positive regulation of macrophage apoptotic process; ISS:UniProtKB.::GO:0045348; P:positive regulation of MHC class II biosynthetic process; IDA:UniProtKB.::GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:UniProtKB.::GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0031648; P:protein destabilization; ISS:UniProtKB.::GO:0016567; P:protein ubiquitination; IDA:UniProtKB.::GO:0000720; P:pyrimidine dimer repair by nucleotide-excision repair; IMP:UniProtKB.::GO:0070857; P:regulation of bile acid biosynthetic process; ISS:UniProtKB.::GO:0032071; P:regulation of endodeoxyribonuclease activity; IMP:UniProtKB.::GO:0010906; P:regulation of glucose metabolic process; ISS:UniProtKB.::GO:0007346; P:regulation of mitotic cell cycle; IDA:UniProtKB.::GO:0035358; P:regulation of peroxisome proliferator activated receptor signaling pathway; ISS:BHF-UCL.::GO:0033158; P:regulation of protein import into nucleus, translocation; IMP:UniProtKB.::GO:0034391; P:regulation of smooth muscle cell apoptotic process; ISS:UniProtKB.::GO:0032868; P:response to insulin stimulus; ISS:UniProtKB.::GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.::GO:0000012; P:single strand break repair; IMP:UniProtKB.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006642; P:triglyceride mobilization; ISS:BHF-UCL.::GO:0050872; P:white fat cell differentiation; ISS:BHF-UCL. | 27 | Q9VK34 | 823 | SIR2_DROME NAD-dependent histone deacetylase ... | 294 | 4e-45 | 168 | 35 | 53 | GO:0005737; C:cytoplasm; IDA:FlyBase.::GO:0005654; C:nucleoplasm; IDA:FlyBase. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:FlyBase.::GO:0008134; F:transcription factor binding; IPI:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0048149; P:behavioral response to ethanol; IMP:FlyBase.::GO:0006342; P:chromatin silencing; IMP:FlyBase.::GO:0008340; P:determination of adult lifespan; IMP:FlyBase.::GO:0006476; P:protein deacetylation; IEA:InterPro.::GO:0042981; P:regulation of apoptotic process; IMP:FlyBase.::GO:0035065; P:regulation of histone acetylation; IMP:FlyBase. | 28 | C8V3W5 | 489 | HST1_EMENI NAD-dependent protein deacetylase ... | 300 | 6e-44 | 162 | 33 | 50 | | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006476; P:protein deacetylation; IEA:InterPro. | 29 | Q757M7 | 559 | SIR2_ASHGO NAD-dependent histone deacetylase ... | 277 | 2e-42 | 159 | 35 | 51 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 30 | P53685 | 503 | HST1_YEAST NAD-dependent protein deacetylase ... | 273 | 4e-42 | 157 | 35 | 52 | GO:0034967; C:Set3 complex; IDA:SGD. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IDA:SGD.::GO:0045129; F:NAD-independent histone deacetylase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IMP:SGD.::GO:0045950; P:negative regulation of mitotic recombination; IMP:SGD.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 31 | P33294 | 670 | SIR2_KLULA NAD-dependent histone deacetylase ... | 297 | 5e-42 | 158 | 34 | 51 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0070403; F:NAD+ binding; IEA:InterPro.::GO:0017136; F:NAD-dependent histone deacetylase activity; IEA:InterPro.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006342; P:chromatin silencing; IEA:InterPro.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
