| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q9VZF4 | 1326 | FBXW7_DROME F-box/WD repeat-containing protei... | 211 | 0.00000000002 | 70.9 | 25 | 42 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; NAS:FlyBase. | | | | | | | | | | GO:0030332; F:cyclin binding; TAS:FlyBase. | | | | | | | | | | GO:0007411; P:axon guidance; IMP:FlyBase.::GO:0008054; P:cyclin catabolic process; TAS:FlyBase.::GO:0042023; P:DNA endoreduplication; IMP:FlyBase.::GO:0060253; P:negative regulation of glial cell proliferation; IGI:FlyBase.::GO:0045926; P:negative regulation of growth; IMP:FlyBase.::GO:0007096; P:regulation of exit from mitosis; TAS:FlyBase.::GO:0007088; P:regulation of mitosis; IMP:FlyBase.::GO:0030162; P:regulation of proteolysis; TAS:FlyBase. | 32 | Q969H0 | 707 | FBXW7_HUMAN F-box/WD repeat-containing protei... | 267 | 6e-17 | 88.2 | 25 | 40 | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0034644; P:cellular response to UV; IDA:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0055088; P:lipid homeostasis; ISS:BHF-UCL.::GO:0032876; P:negative regulation of DNA endoreduplication; IMP:BHF-UCL.::GO:2000346; P:negative regulation of hepatocyte proliferation; ISS:BHF-UCL.::GO:0045746; P:negative regulation of Notch signaling pathway; ISS:BHF-UCL.::GO:2000639; P:negative regulation of SREBP-mediated signaling pathway; ISS:BHF-UCL.::GO:0010868; P:negative regulation of triglyceride biosynthetic process; ISS:BHF-UCL.::GO:0007219; P:Notch signaling pathway; TAS:Reactome.::GO:0045741; P:positive regulation of epidermal growth factor-activated receptor activity; IDA:BHF-UCL.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:BHF-UCL.::GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.::GO:0050821; P:protein stabilization; IDA:BHF-UCL.::GO:0016567; P:protein ubiquitination; IDA:UniProtKB.::GO:0010883; P:regulation of lipid storage; ISS:BHF-UCL.::GO:0032880; P:regulation of protein localization; ISS:BHF-UCL.::GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0007062; P:sister chromatid cohesion; IMP:BHF-UCL.::GO:0001944; P:vasculature development; TAS:BHF-UCL. | 33 | Q8VBV4 | 629 | FBXW7_MOUSE F-box/WD repeat-containing protei... | 267 | 1e-16 | 87.4 | 25 | 41 | GO:0005783; C:endoplasmic reticulum; IDA:MGI.::GO:0005794; C:Golgi apparatus; IDA:MGI.::GO:0005634; C:nucleus; IDA:BHF-UCL.::GO:0048471; C:perinuclear region of cytoplasm; IDA:BHF-UCL.::GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; IDA:MGI. | | | | | | | | | | GO:0007219; P:Notch signaling pathway; IDA:MGI.::GO:0016567; P:protein ubiquitination; ISS:UniProtKB.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; ISS:UniProtKB. | 34 | Q8YTC2 | 1258 | Y2800_NOSS1 Uncharacterized WD repeat-contain... | 179 | 0.00000000000009 | 79 | 30 | 45 | | | | | | | | | | | GO:0043531; F:ADP binding; IEA:InterPro. | | | | | | | | | | GO:0006952; P:defense response; IEA:InterPro. | 35 | Q8I0F4 | 419 | LIS1_DICDI Lissencephaly-1 homolog OS=Dictyos... | 312 | 0.00001 | 51.6 | 20 | 35 | GO:0031592; C:centrosomal corona; IDA:dictyBase.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0045504; F:dynein heavy chain binding; IPI:dictyBase.::GO:0017048; F:Rho GTPase binding; IPI:dictyBase. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0051642; P:centrosome localization; IMP:dictyBase.::GO:0051645; P:Golgi localization; IMP:dictyBase.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 36 | Q9UKB1 | 542 | FBW1B_HUMAN F-box/WD repeat-containing protei... | 256 | 0.000000000002 | 73.6 | 24 | 39 | GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB. | | | | | | | | | | GO:0046983; F:protein dimerization activity; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0042753; P:positive regulation of circadian rhythm; ISS:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; IMP:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0006470; P:protein dephosphorylation; ISS:UniProtKB.::GO:0031648; P:protein destabilization; IMP:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.::GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 37 | Q5SRY7 | 542 | FBW1B_MOUSE F-box/WD repeat-containing protei... | 178 | 0.000000000001 | 73.9 | 26 | 46 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:UniProtKB.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB. | | | | | | | | | | GO:0046983; F:protein dimerization activity; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0042347; P:negative regulation of NF-kappaB import into nucleus; IMP:UniProtKB.::GO:0042753; P:positive regulation of circadian rhythm; IMP:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0006470; P:protein dephosphorylation; IDA:UniProtKB.::GO:0031648; P:protein destabilization; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:UniProtKB.::GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.::GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IMP:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 38 | Q00808 | 1356 | HETE1_PODAS Vegetative incompatibility protei... | 258 | 0.00000000000001 | 81.6 | 26 | 40 | | | | | | | | | | | GO:0005525; F:GTP binding; IEA:UniProtKB-KW. | | | | | | | | | | | 39 | P39014 | 640 | MET30_YEAST F-box protein MET30 OS=Saccharomy... | 140 | 0.68 | 37 | 30 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0043224; C:nuclear SCF ubiquitin ligase complex; IDA:SGD. | | | | | | | | | | GO:0042802; F:identical protein binding; IPI:IntAct.::GO:0043130; F:ubiquitin binding; IDA:SGD. | | | | | | | | | | GO:0019344; P:cysteine biosynthetic process; IEA:UniProtKB-KW.::GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:SGD.::GO:0000087; P:M phase of mitotic cell cycle; IMP:SGD.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0000209; P:protein polyubiquitination; IMP:SGD.::GO:0030174; P:regulation of DNA-dependent DNA replication initiation; IMP:SGD.::GO:0000114; P:regulation of transcription involved in G1 phase of mitotic cell cycle; IMP:SGD.::GO:0046685; P:response to arsenic-containing substance; IDA:SGD.::GO:0046686; P:response to cadmium ion; IDA:SGD.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 40 | O14170 | 703 | POP2_SCHPO WD repeat-containing protein pop2 ... | 81 | 0.00000000004 | 69.7 | 41 | 59 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005635; C:nuclear envelope; IDA:PomBase.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:PomBase. | | | | | | | | | | GO:0030674; F:protein binding, bridging; IPI:PomBase. | | | | | | | | | | GO:0032876; P:negative regulation of DNA endoreduplication; IMP:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IC:PomBase.::GO:0006511; P:ubiquitin-dependent protein catabolic process; TAS:PomBase. | 41 | Q91854 | 518 | TRCB_XENLA Beta-TrCP OS=Xenopus laevis (Afric... | 156 | 0.0000000001 | 68.2 | 28 | 45 | | | | | | | | | | | GO:0046983; F:protein dimerization activity; IEA:InterPro. | | | | | | | | | | GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 42 | D3BUN1 | 417 | LIS1_POLPA Lissencephaly-1 homolog OS=Polysph... | 311 | 0.00002 | 51.2 | 21 | 34 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 43 | Q9Y297 | 605 | FBW1A_HUMAN F-box/WD repeat-containing protei... | 156 | 0.0000000001 | 67.8 | 28 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB. | | | | | | | | | | GO:0046983; F:protein dimerization activity; IEA:InterPro. | | | | | | | | | | GO:0031145; P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; TAS:Reactome.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0043433; P:negative regulation of sequence-specific DNA binding transcription factor activity; TAS:BHF-UCL.::GO:0045879; P:negative regulation of smoothened signaling pathway; TAS:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; IMP:UniProtKB.::GO:0051437; P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle; TAS:Reactome.::GO:0031648; P:protein destabilization; IMP:UniProtKB.::GO:0016032; P:viral reproduction; TAS:Reactome.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 44 | P90648 | 732 | MHCKB_DICDI Myosin heavy chain kinase B OS=Di... | 337 | 0.00000000000002 | 80.9 | 21 | 42 | GO:0005826; C:actomyosin contractile ring; IDA:dictyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IC:dictyBase.::GO:0016905; F:myosin heavy chain kinase activity; IDA:dictyBase.::GO:0045159; F:myosin II binding; IPI:dictyBase. | | | | | | | | | | GO:0000910; P:cytokinesis; IMP:dictyBase.::GO:0031037; P:myosin II filament disassembly; IMP:dictyBase.::GO:0018107; P:peptidyl-threonine phosphorylation; IDA:dictyBase.::GO:0046777; P:protein autophosphorylation; IDA:dictyBase. | 45 | Q3ULA2 | 605 | FBW1A_MOUSE F-box/WD repeat-containing protei... | 156 | 0.0000000001 | 67.8 | 28 | 45 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0019005; C:SCF ubiquitin ligase complex; ISS:UniProtKB. | | | | | | | | | | GO:0008013; F:beta-catenin binding; IDA:BHF-UCL.::GO:0046983; F:protein dimerization activity; IEA:InterPro.::GO:0045309; F:protein phosphorylated amino acid binding; IDA:BHF-UCL.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:BHF-UCL. | | | | | | | | | | GO:0060444; P:branching involved in mammary gland duct morphogenesis; IMP:MGI.::GO:0071407; P:cellular response to organic cyclic compound; IDA:MGI.::GO:0033598; P:mammary gland epithelial cell proliferation; IMP:MGI.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.::GO:0042753; P:positive regulation of circadian rhythm; IMP:UniProtKB.::GO:0045862; P:positive regulation of proteolysis; ISS:UniProtKB.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IMP:UniProtKB.::GO:0006470; P:protein dephosphorylation; IDA:UniProtKB.::GO:0031648; P:protein destabilization; ISS:UniProtKB.::GO:0000209; P:protein polyubiquitination; IDA:BHF-UCL.::GO:0051726; P:regulation of cell cycle; IMP:MGI.::GO:0043122; P:regulation of I-kappaB kinase/NF-kappaB cascade; IMP:MGI.::GO:0061136; P:regulation of proteasomal protein catabolic process; IDA:MGI.::GO:0006511; P:ubiquitin-dependent protein catabolic process; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. | 46 | P87053 | 605 | POF1_SCHPO F-box/WD repeat-containing protein... | 157 | 0.00000000000002 | 80.5 | 32 | 48 | GO:0000152; C:nuclear ubiquitin ligase complex; ISS:PomBase.::GO:0019005; C:SCF ubiquitin ligase complex; IDA:PomBase. | | | | | | | | | | GO:0030674; F:protein binding, bridging; IPI:PomBase. | | | | | | | | | | GO:0071276; P:cellular response to cadmium ion; IEP:PomBase.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IPI:PomBase.::GO:0007346; P:regulation of mitotic cell cycle; IC:PomBase. | 47 | B6Q4Z5 | 660 | SCONB_PENMQ Probable E3 ubiquitin ligase comp... | 190 | 0.0000000000003 | 76.6 | 26 | 46 | | | | | | | | | | | | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 48 | Q0P593 | 415 | WDR69_BOVIN Outer row dynein assembly protein... | 143 | 0.00002 | 51.2 | 24 | 43 | GO:0005929; C:cilium; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 49 | Q09990 | 665 | LIN23_CAEEL F-box/WD repeat-containing protei... | 92 | 0.000003 | 53.9 | 34 | 48 | GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0005634; C:nucleus; IDA:WormBase. | | | | | | | | | | GO:0046983; F:protein dimerization activity; IEA:InterPro. | | | | | | | | | | GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0040035; P:hermaphrodite genitalia development; IMP:WormBase.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0008285; P:negative regulation of cell proliferation; IMP:UniProtKB.::GO:0040015; P:negative regulation of multicellular organism growth; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0048812; P:neuron projection morphogenesis; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase. | 50 | Q3Y8L7 | 446 | WDR69_CHLRE Outer row dynein assembly protein... | 102 | 0.00009 | 48.9 | 27 | 54 | GO:0005929; C:cilium; IEA:UniProtKB-KW.::GO:0035086; C:flagellar axoneme; IEA:UniProtKB-SubCell.::GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 51 | Q00659 | 678 | SCONB_EMENI Probable E3 ubiquitin ligase comp... | 184 | 0.0000000000003 | 77 | 27 | 45 | | | | | | | | | | | | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 52 | Q5FWQ6 | 415 | WDR69_XENLA Outer row dynein assembly protein... | 148 | 0.000003 | 53.5 | 24 | 45 | GO:0005929; C:cilium; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 53 | Q8N136 | 415 | WDR69_HUMAN Outer row dynein assembly protein... | 96 | 0.00002 | 51.2 | 28 | 51 | GO:0005929; C:cilium; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 54 | B8M7Q5 | 667 | SCONB_TALSN Probable E3 ubiquitin ligase comp... | 190 | 0.0000000000002 | 77 | 26 | 46 | | | | | | | | | | | | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 55 | Q6P2Y2 | 415 | WDR69_XENTR Outer row dynein assembly protein... | 148 | 0.000005 | 53.1 | 24 | 44 | GO:0005929; C:cilium; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 56 | A1DHW6 | 689 | SCONB_NEOFI Probable E3 ubiquitin ligase comp... | 183 | 0.00003 | 50.8 | 24 | 45 | | | | | | | | | | | | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 57 | A2QCU8 | 670 | SCONB_ASPNC Probable E3 ubiquitin ligase comp... | 184 | 0.00000000001 | 71.2 | 26 | 43 | | | | | | | | | | | | | | | | | | | | | GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 58 | Q5BK30 | 415 | WDR69_RAT Outer row dynein assembly protein 1... | 96 | 0.00007 | 49.3 | 28 | 50 | GO:0005929; C:cilium; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 59 | D3TLL6 | 411 | LIS1_GLOMM Lissencephaly-1 homolog OS=Glossin... | 387 | 0.000000000000002 | 82.4 | 23 | 41 | GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 60 | Q61FW2 | 589 | SEL10_CAEBR F-box/WD repeat-containing protei... | 319 | 0.000000000000002 | 83.6 | 26 | 38 | | | | | | | | | | | | | | | | | | | | | | 61 | Q93794 | 587 | SEL10_CAEEL F-box/WD repeat-containing protei... | 213 | 0.0000000002 | 67.4 | 24 | 42 | GO:0030424; C:axon; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IDA:WormBase. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0046660; P:female sex differentiation; IMP:UniProtKB.::GO:0045746; P:negative regulation of Notch signaling pathway; IGI:UniProtKB. |
