| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | O14159 | 458 | LCB4_SCHPO Sphingoid long chain base kinase 4... | 79 | 0.57 | 36.6 | 30 | 48 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017050; F:D-erythro-sphingosine kinase activity; ISS:PomBase.::GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro. | | | | | | | | | | GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; IEA:InterPro.::GO:0019722; P:calcium-mediated signaling; ISS:PomBase.::GO:0046520; P:sphingoid biosynthetic process; ISS:PomBase. | 2 | Q9NYA1 | 384 | SPHK1_HUMAN Sphingosine kinase 1 OS=Homo sapi... | 93 | 1.2 | 35.4 | 32 | 49 | GO:0005829; C:cytosol; TAS:UniProtKB.::GO:0005624; C:membrane fraction; TAS:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:BHF-UCL.::GO:0005625; C:soluble fraction; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005516; F:calmodulin binding; IDA:UniProtKB.::GO:0017050; F:D-erythro-sphingosine kinase activity; IDA:UniProtKB.::GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro.::GO:0003677; F:DNA binding; IDA:MGI.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0051721; F:protein phosphatase 2A binding; IPI:BHF-UCL.::GO:0008481; F:sphinganine kinase activity; IDA:MGI. | | | | | | | | | | GO:0051084; P:'de novo' posttranslational protein folding; TAS:Reactome.::GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; IEA:InterPro.::GO:0006916; P:anti-apoptosis; TAS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; IDA:UniProtKB.::GO:0045766; P:positive regulation of angiogenesis; IDA:UniProtKB.::GO:0030307; P:positive regulation of cell growth; IDA:UniProtKB.::GO:0030335; P:positive regulation of cell migration; IDA:UniProtKB.::GO:0048146; P:positive regulation of fibroblast proliferation; IDA:MGI.::GO:0045931; P:positive regulation of mitotic cell cycle; IDA:UniProtKB.::GO:0042346; P:positive regulation of NF-kappaB import into nucleus; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:0031398; P:positive regulation of protein ubiquitination; IDA:UniProtKB.::GO:0045987; P:positive regulation of smooth muscle contraction; IDA:UniProtKB.::GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway; IDA:UniProtKB.::GO:0046521; P:sphingoid catabolic process; NAS:UniProtKB.::GO:0030148; P:sphingolipid biosynthetic process; TAS:Reactome.::GO:0006670; P:sphingosine metabolic process; IDA:UniProtKB. | 3 | Q12246 | 624 | LCB4_YEAST Sphingoid long chain base kinase 4... | 105 | 4.5 | 33.9 | 26 | 46 | GO:0032541; C:cortical endoplasmic reticulum; IDA:SGD.::GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:SGD.::GO:0005886; C:plasma membrane; IDA:SGD.::GO:0005625; C:soluble fraction; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0017050; F:D-erythro-sphingosine kinase activity; IDA:SGD.::GO:0004143; F:diacylglycerol kinase activity; IEA:InterPro.::GO:0008481; F:sphinganine kinase activity; IEA:EC. | | | | | | | | | | GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; IEA:InterPro.::GO:0019722; P:calcium-mediated signaling; IMP:SGD.::GO:0006665; P:sphingolipid metabolic process; IDA:SGD. | 4 | Q6B516 | 760 | SPHKB_DICDI Sphingosine kinase B OS=Dictyoste... | 49 | 5 | 33.9 | 37 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IDA:dictyBase.::GO:0017050; F:D-erythro-sphingosine kinase activity; IDA:dictyBase.::GO:0008481; F:sphinganine kinase activity; IEA:EC. | | | | | | | | | | GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; IEA:InterPro.::GO:0006648; P:dihydrosphingosine-1-P pathway; IDA:dictyBase.::GO:0008284; P:positive regulation of cell proliferation; IMP:dictyBase.::GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-KW. | 5 | Q49YU2 | 305 | DAGK_STAS1 Diacylglycerol kinase OS=DSM 20229... | 67 | 7.5 | 32.7 | 31 | 51 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004143; F:diacylglycerol kinase activity; IEA:EC.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0003951; F:NAD+ kinase activity; IEA:InterPro. | | | | | | | | | | GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; IEA:InterPro.::GO:0008654; P:phospholipid biosynthetic process; IEA:UniProtKB-KW. | 6 | Q9CF80 | 357 | CARA_LACLA Carbamoyl-phosphate synthase small... | 84 | 8 | 32.7 | 35 | 50 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004088; F:carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity; IEA:EC. | | | | | | | | | | GO:0006526; P:arginine biosynthetic process; IEA:UniProtKB-KW.::GO:0070409; P:carbamoyl phosphate biosynthetic process; IEA:InterPro.::GO:0006543; P:glutamine catabolic process; IEA:InterPro.::GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW. |
