rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P48508 | 274 | GSH0_RAT Glutamate--cysteine ligase regulator... | 222 | 4e-17 | 83.2 | 26 | 49 | GO:0017109; C:glutamate-cysteine ligase complex; IDA:RGD.::GO:0005625; C:soluble fraction; ISS:UniProtKB. | | | | | | | | | | GO:0004357; F:glutamate-cysteine ligase activity; IDA:RGD.::GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; ISS:UniProtKB.::GO:0046982; F:protein heterodimerization activity; IDA:RGD. | | | | | | | | | | GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.::GO:0006750; P:glutathione biosynthetic process; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; IMP:RGD.::GO:0035229; P:positive regulation of glutamate-cysteine ligase activity; IDA:RGD.::GO:0050880; P:regulation of blood vessel size; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0051409; P:response to nitrosative stress; IMP:RGD.::GO:0006979; P:response to oxidative stress; ISS:UniProtKB. | 2 | Q2T9Y6 | 274 | GSH0_BOVIN Glutamate--cysteine ligase regulat... | 225 | 7e-17 | 82.8 | 25 | 48 | GO:0005625; C:soluble fraction; ISS:UniProtKB. | | | | | | | | | | GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; ISS:UniProtKB. | | | | | | | | | | GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.::GO:0006750; P:glutathione biosynthetic process; ISS:UniProtKB.::GO:0050880; P:regulation of blood vessel size; ISS:UniProtKB.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:UniProtKB. | 3 | O94246 | 287 | GSH0_SCHPO Putative glutamate--cysteine ligas... | 240 | 9e-16 | 79.7 | 28 | 43 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0017109; C:glutamate-cysteine ligase complex; ISS:PomBase. | | | | | | | | | | GO:0030234; F:enzyme regulator activity; ISS:PomBase.::GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; ISS:PomBase. | | | | | | | | | | GO:0006750; P:glutathione biosynthetic process; IEA:UniProtKB-KW.::GO:0035229; P:positive regulation of glutamate-cysteine ligase activity; ISS:PomBase. | 4 | P48507 | 274 | GSH0_HUMAN Glutamate--cysteine ligase regulat... | 224 | 0.000000000000001 | 79.3 | 26 | 50 | GO:0005829; C:cytosol; NAS:UniProtKB.::GO:0005625; C:soluble fraction; IDA:UniProtKB. | | | | | | | | | | GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; IPI:UniProtKB. | | | | | | | | | | GO:0006536; P:glutamate metabolic process; IDA:UniProtKB.::GO:0006750; P:glutathione biosynthetic process; IDA:UniProtKB.::GO:0050880; P:regulation of blood vessel size; IMP:UniProtKB.::GO:0042493; P:response to drug; IDA:UniProtKB.::GO:0006979; P:response to oxidative stress; IDA:UniProtKB.::GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. | 5 | O09172 | 274 | GSH0_MOUSE Glutamate--cysteine ligase regulat... | 224 | 0.000000000000007 | 77 | 25 | 48 | GO:0017109; C:glutamate-cysteine ligase complex; IDA:MGI.::GO:0005625; C:soluble fraction; ISS:UniProtKB. | | | | | | | | | | GO:0035226; F:glutamate-cysteine ligase catalytic subunit binding; ISS:UniProtKB.::GO:0046982; F:protein heterodimerization activity; IPI:MGI. | | | | | | | | | | GO:0006534; P:cysteine metabolic process; IMP:MGI.::GO:0006536; P:glutamate metabolic process; ISS:UniProtKB.::GO:0006750; P:glutathione biosynthetic process; ISS:UniProtKB.::GO:0035229; P:positive regulation of glutamate-cysteine ligase activity; IDA:MGI.::GO:0050880; P:regulation of blood vessel size; ISS:UniProtKB.::GO:0051900; P:regulation of mitochondrial depolarization; IGI:MGI.::GO:0042493; P:response to drug; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:UniProtKB. | 6 | Q7G765 | 322 | NADO2_ORYSJ Probable NAD(P)H-dependent oxidor... | 91 | 0.000005 | 51.2 | 33 | 54 | | | | | | | | | | | GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 7 | Q7G764 | 321 | NADO1_ORYSJ Probable NAD(P)H-dependent oxidor... | 90 | 0.000007 | 50.8 | 36 | 57 | | | | | | | | | | | GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 8 | P82125 | 301 | AKCL2_PIG 1,5-anhydro-D-fructose reductase OS... | 106 | 0.00001 | 50.1 | 30 | 52 | | | | | | | | | | | GO:0050571; F:1,5-anhydro-D-fructose reductase activity; IEA:EC. | | | | | | | | | | | 9 | Q6IMN8 | 297 | ALRA_DICDI Aldose reductase A OS=Dictyosteliu... | 142 | 0.00003 | 48.5 | 29 | 47 | GO:0005829; C:cytosol; IDA:dictyBase.::GO:0005615; C:extracellular space; IDA:dictyBase.::GO:0045335; C:phagocytic vesicle; IDA:dictyBase. | | | | | | | | | | GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:dictyBase. | | | | | | | | | | GO:0006928; P:cellular component movement; IMP:dictyBase.::GO:0042593; P:glucose homeostasis; IMP:dictyBase.::GO:0031158; P:negative regulation of aggregate size involved in sorocarp development; IMP:dictyBase.::GO:0009617; P:response to bacterium; IEP:dictyBase.::GO:0006979; P:response to oxidative stress; IMP:dictyBase. | 10 | Q9TV64 | 326 | AK1D1_RABIT 3-oxo-5-beta-steroid 4-dehydrogen... | 138 | 0.00005 | 48.5 | 28 | 46 | | | | | | | | | | | GO:0047787; F:delta4-3-oxosteroid 5beta-reductase activity; IEA:EC. | | | | | | | | | | GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-KW. | 11 | Q3ZCJ2 | 325 | AK1A1_BOVIN Alcohol dehydrogenase [NADP(+)] O... | 93 | 0.0002 | 46.6 | 32 | 51 | | | | | | | | | | | | | | | | | | | | | | 12 | Q8VCX1 | 325 | AK1D1_MOUSE 3-oxo-5-beta-steroid 4-dehydrogen... | 135 | 0.0003 | 45.8 | 30 | 46 | | | | | | | | | | | GO:0047787; F:delta4-3-oxosteroid 5beta-reductase activity; IEA:EC. | | | | | | | | | | GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-KW. | 13 | P14550 | 325 | AK1A1_HUMAN Alcohol dehydrogenase [NADP(+)] O... | 93 | 0.0004 | 45.4 | 32 | 49 | | | | | | | | | | | GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; TAS:ProtInc.::GO:0009055; F:electron carrier activity; TAS:UniProtKB. | | | | | | | | | | GO:0006006; P:glucose metabolic process; TAS:ProtInc. | 14 | O70473 | 228 | AK1A1_CRIGR Alcohol dehydrogenase [NADP(+)] O... | 93 | 0.0004 | 44.7 | 31 | 51 | | | | | | | | | | | GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | | 15 | O42888 | 325 | YBN4_SCHPO Uncharacterized oxidoreductase C8E... | 163 | 0.0005 | 45.1 | 25 | 45 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0004033; F:aldo-keto reductase (NADP) activity; ISS:PomBase. | | | | | | | | | | GO:0019568; P:arabinose catabolic process; ISS:PomBase.::GO:0042843; P:D-xylose catabolic process; ISS:PomBase. | 16 | Q8VC28 | 323 | AK1CD_MOUSE Aldo-keto reductase family 1 memb... | 117 | 0.0007 | 44.7 | 28 | 47 | | | | | | | | | | | GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006805; P:xenobiotic metabolic process; TAS:MGI. | 17 | Q9JII6 | 325 | AK1A1_MOUSE Alcohol dehydrogenase [NADP(+)] O... | 93 | 0.0007 | 44.7 | 31 | 51 | GO:0016324; C:apical plasma membrane; IDA:MGI.::GO:0005829; C:cytosol; IDA:MGI. | | | | | | | | | | GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:MGI.::GO:0047939; F:L-glucuronate reductase activity; IDA:MGI. | | | | | | | | | | GO:0046185; P:aldehyde catabolic process; IDA:MGI.::GO:0042840; P:D-glucuronate catabolic process; IDA:MGI.::GO:0019853; P:L-ascorbic acid biosynthetic process; IDA:MGI. | 18 | P51857 | 326 | AK1D1_HUMAN 3-oxo-5-beta-steroid 4-dehydrogen... | 151 | 0.001 | 44.3 | 28 | 43 | GO:0005829; C:cytosol; IDA:UniProtKB. | | | | | | | | | | GO:0047787; F:delta4-3-oxosteroid 5beta-reductase activity; IEA:EC.::GO:0005496; F:steroid binding; TAS:UniProtKB. | | | | | | | | | | GO:0008209; P:androgen metabolic process; IDA:UniProtKB.::GO:0006699; P:bile acid biosynthetic process; IDA:UniProtKB.::GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-KW.::GO:0008207; P:C21-steroid hormone metabolic process; IDA:UniProtKB.::GO:0006707; P:cholesterol catabolic process; IDA:UniProtKB.::GO:0007586; P:digestion; IDA:UniProtKB. | 19 | Q10494 | 321 | YDG7_SCHPO Uncharacterized oxidoreductase C26... | 117 | 0.001 | 44.3 | 27 | 48 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0047935; F:glucose 1-dehydrogenase (NADP+) activity; ISS:PomBase. | | | | | | | | | | GO:0019568; P:arabinose catabolic process; ISS:PomBase.::GO:0033554; P:cellular response to stress; IEP:PomBase.::GO:0042843; P:D-xylose catabolic process; ISS:PomBase. | 20 | Q6AYQ2 | 318 | AK1CL_RAT Aldo-keto reductase family 1 member... | 98 | 0.001 | 44.3 | 28 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008202; P:steroid metabolic process; IEA:UniProtKB-KW. | 21 | Q5R5D5 | 325 | AK1A1_PONAB Alcohol dehydrogenase [NADP(+)] O... | 93 | 0.001 | 44.3 | 31 | 49 | | | | | | | | | | | GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | | 22 | P51635 | 325 | AK1A1_RAT Alcohol dehydrogenase [NADP(+)] OS=... | 93 | 0.001 | 43.9 | 30 | 51 | | | | | | | | | | | | | | | | | | | | | | 23 | P50578 | 325 | AK1A1_PIG Alcohol dehydrogenase [NADP(+)] OS=... | 93 | 0.001 | 43.9 | 31 | 51 | | | | | | | | | | | GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | | 24 | P82809 | 322 | AK1CD_MESAU Aldo-keto reductase family 1 memb... | 117 | 0.001 | 43.9 | 29 | 45 | | | | | | | | | | | GO:0050109; F:morphine 6-dehydrogenase activity; IEA:EC. | | | | | | | | | | GO:0009820; P:alkaloid metabolic process; IEA:UniProtKB-KW. | 25 | O60218 | 316 | AK1BA_HUMAN Aldo-keto reductase family 1 memb... | 129 | 0.001 | 43.5 | 27 | 47 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.::GO:0005764; C:lysosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004033; F:aldo-keto reductase (NADP) activity; TAS:UniProtKB.::GO:0045550; F:geranylgeranyl reductase activity; IDA:UniProtKB.::GO:0047718; F:indanol dehydrogenase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0001758; F:retinal dehydrogenase activity; IDA:UniProtKB. | | | | | | | | | | GO:0016999; P:antibiotic metabolic process; IMP:UniProtKB.::GO:0006081; P:cellular aldehyde metabolic process; TAS:ProtInc.::GO:0007586; P:digestion; TAS:ProtInc.::GO:0016488; P:farnesol catabolic process; IDA:UniProtKB.::GO:0008202; P:steroid metabolic process; TAS:ProtInc. | 26 | Q07551 | 312 | KAR_YEAST NADPH-dependent alpha-keto amide re... | 122 | 0.002 | 43.5 | 29 | 47 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD.::GO:0001950; C:plasma membrane enriched fraction; IDA:SGD. | | | | | | | | | | GO:0004032; F:alditol:NADP+ 1-oxidoreductase activity; IDA:SGD.::GO:0051268; F:alpha-keto amide reductase activity; IDA:SGD.::GO:0051269; F:alpha-keto ester reductase activity; IDA:SGD. | | | | | | | | | | GO:0043603; P:cellular amide metabolic process; IDA:SGD.::GO:0006725; P:cellular aromatic compound metabolic process; IDA:SGD.::GO:0042180; P:cellular ketone metabolic process; IDA:SGD. | 27 | Q0PGJ6 | 315 | AKRC9_ARATH Aldo-keto reductase family 4 memb... | 102 | 0.002 | 43.1 | 32 | 49 | GO:0009507; C:chloroplast; IDA:TAIR. | | | | | | | | | | GO:0008106; F:alcohol dehydrogenase (NADP+) activity; IDA:TAIR.::GO:0070401; F:NADP+ binding; IDA:UniProtKB.::GO:0016229; F:steroid dehydrogenase activity; IDA:UniProtKB. | | | | | | | | | | GO:0009409; P:response to cold; IEP:UniProtKB.::GO:0009651; P:response to salt stress; IEP:UniProtKB.::GO:0009636; P:response to toxin; IEA:UniProtKB-KW.::GO:0009414; P:response to water deprivation; IEP:UniProtKB. | 28 | Q84TF0 | 314 | AKRCA_ARATH Aldo-keto reductase family 4 memb... | 123 | 0.003 | 42.7 | 31 | 46 | GO:0005829; C:cytosol; IDA:TAIR.::GO:0005634; C:nucleus; IDA:TAIR. | | | | | | | | | | GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 29 | Q8X195 | 321 | XYL1_CANBO NADPH-dependent D-xylose reductase... | 160 | 0.004 | 42.4 | 28 | 42 | | | | | | | | | | | GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0042732; P:D-xylose metabolic process; IEA:UniProtKB-KW. | 30 | P31210 | 326 | AK1D1_RAT 3-oxo-5-beta-steroid 4-dehydrogenas... | 99 | 0.005 | 42 | 31 | 49 | | | | | | | | | | | GO:0047568; F:3-oxo-5-beta-steroid 4-dehydrogenase activity; IDA:MGI.::GO:0047787; F:delta4-3-oxosteroid 5beta-reductase activity; IEA:EC. | | | | | | | | | | GO:0030573; P:bile acid catabolic process; IEA:UniProtKB-KW. | 31 | C9JRZ8 | 344 | AK1BF_HUMAN Aldo-keto reductase family 1 memb... | 106 | 0.006 | 42 | 27 | 45 | | | | | | | | | | | GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW. | | | | | | | | | | |