| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P54874 | 447 | HMCS_SCHPO Hydroxymethylglutaryl-CoA synthase... | 455 | 0 | 595 | 62 | 76 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005783; C:endoplasmic reticulum; IC:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IMP:PomBase. | | | | | | | | | | GO:0006084; P:acetyl-CoA metabolic process; IMP:PomBase.::GO:0006696; P:ergosterol biosynthetic process; IMP:PomBase.::GO:0010142; P:farnesyl diphosphate biosynthetic process, mevalonate pathway; IMP:PomBase.::GO:0070317; P:negative regulation of G0 to G1 transition; IMP:PomBase. | 2 | P54839 | 491 | HMCS_YEAST Hydroxymethylglutaryl-CoA synthase... | 453 | 0 | 568 | 61 | 74 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IMP:SGD. | | | | | | | | | | GO:0006696; P:ergosterol biosynthetic process; IMP:SGD.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 3 | P54872 | 482 | HMCSA_DICDI Hydroxymethylglutaryl-CoA synthas... | 460 | 9e-160 | 468 | 51 | 68 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 4 | P54869 | 508 | HMCS2_MOUSE Hydroxymethylglutaryl-CoA synthas... | 460 | 3e-159 | 467 | 50 | 70 | GO:0005743; C:mitochondrial inner membrane; IDA:MGI. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 5 | P54961 | 453 | HMCS1_BLAGE Hydroxymethylglutaryl-CoA synthas... | 458 | 2e-158 | 463 | 50 | 67 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 6 | P22791 | 508 | HMCS2_RAT Hydroxymethylglutaryl-CoA synthase,... | 462 | 2e-157 | 463 | 49 | 69 | GO:0005759; C:mitochondrial matrix; IDA:RGD. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IDA:RGD. | | | | | | | | | | GO:0060612; P:adipose tissue development; IEP:RGD.::GO:0007420; P:brain development; IEP:RGD.::GO:0071230; P:cellular response to amino acid stimulus; IEP:RGD.::GO:0071398; P:cellular response to fatty acid; IEP:RGD.::GO:0071385; P:cellular response to glucocorticoid stimulus; IEP:RGD.::GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.::GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.::GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0046951; P:ketone body biosynthetic process; IEP:RGD.::GO:0001822; P:kidney development; IEP:RGD.::GO:0001889; P:liver development; IEP:RGD.::GO:0030324; P:lung development; IEP:RGD.::GO:0007494; P:midgut development; IEP:RGD.::GO:0033555; P:multicellular organismal response to stress; IEP:RGD.::GO:0051591; P:response to cAMP; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0045471; P:response to ethanol; IEP:RGD.::GO:0033762; P:response to glucagon stimulus; IEP:RGD.::GO:0060416; P:response to growth hormone stimulus; IEP:RGD.::GO:0070543; P:response to linoleic acid; IEP:RGD.::GO:0010038; P:response to metal ion; IEP:RGD.::GO:0034284; P:response to monosaccharide stimulus; IEP:RGD.::GO:0007584; P:response to nutrient; IEP:RGD.::GO:0034696; P:response to prostaglandin F stimulus; IEP:RGD.::GO:0042594; P:response to starvation; IEP:RGD.::GO:0009266; P:response to temperature stimulus; IEP:RGD.::GO:0033574; P:response to testosterone stimulus; IEP:RGD.::GO:0034014; P:response to triglyceride; IEP:RGD. | 7 | Q01581 | 520 | HMCS1_HUMAN Hydroxymethylglutaryl-CoA synthas... | 463 | 2e-157 | 463 | 50 | 67 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005625; C:soluble fraction; TAS:ProtInc. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; TAS:ProtInc. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; TAS:Reactome.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 8 | Q5R7Z9 | 520 | HMCS1_PONAB Hydroxymethylglutaryl-CoA synthas... | 464 | 6e-157 | 462 | 51 | 68 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 9 | P23228 | 522 | HMCS1_CHICK Hydroxymethylglutaryl-CoA synthas... | 462 | 3e-156 | 460 | 51 | 68 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 10 | Q8JZK9 | 520 | HMCS1_MOUSE Hydroxymethylglutaryl-CoA synthas... | 464 | 7e-155 | 456 | 49 | 67 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 11 | P17425 | 520 | HMCS1_RAT Hydroxymethylglutaryl-CoA synthase,... | 464 | 1e-154 | 456 | 49 | 67 | GO:0005829; C:cytosol; IDA:RGD. | | | | | | | | | | GO:0008144; F:drug binding; IDA:RGD.::GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IDA:RGD.::GO:0016853; F:isomerase activity; IDA:RGD.::GO:0043177; F:organic acid binding; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD. | | | | | | | | | | GO:0007420; P:brain development; IEP:RGD.::GO:0071397; P:cellular response to cholesterol; IEP:RGD.::GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEP:RGD.::GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.::GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0001889; P:liver development; IEP:RGD.::GO:0008584; P:male gonad development; IEP:RGD.::GO:0001101; P:response to acid; IEP:RGD.::GO:0042493; P:response to drug; IEP:RGD.::GO:0055094; P:response to lipoprotein stimulus; IEP:RGD.::GO:0009645; P:response to low light intensity stimulus; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IDA:RGD.::GO:0014074; P:response to purine-containing compound; IEP:RGD.::GO:0046690; P:response to tellurium ion; IEP:RGD.::GO:0033197; P:response to vitamin E; IEP:RGD. | 12 | P13704 | 520 | HMCS1_CRIGR Hydroxymethylglutaryl-CoA synthas... | 466 | 1e-154 | 456 | 50 | 68 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 13 | P54868 | 508 | HMCS2_HUMAN Hydroxymethylglutaryl-CoA synthas... | 462 | 1e-154 | 455 | 48 | 69 | GO:0005759; C:mitochondrial matrix; TAS:Reactome. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0046951; P:ketone body biosynthetic process; TAS:Reactome. | 14 | Q2KIE6 | 508 | HMCS2_BOVIN Hydroxymethylglutaryl-CoA synthas... | 461 | 1e-154 | 455 | 49 | 69 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 15 | O02734 | 508 | HMCS2_PIG Hydroxymethylglutaryl-CoA synthase,... | 461 | 4e-152 | 449 | 48 | 68 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0006695; P:cholesterol biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 16 | Q86HL5 | 468 | HMCSB_DICDI Hydroxymethylglutaryl-CoA synthas... | 472 | 8e-151 | 444 | 48 | 66 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 17 | P54870 | 455 | HMCS2_BLAGE Hydroxymethylglutaryl-CoA synthas... | 462 | 9e-146 | 431 | 48 | 66 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 18 | P54873 | 461 | HMCS_ARATH Hydroxymethylglutaryl-CoA synthase... | 461 | 4e-133 | 399 | 45 | 62 | GO:0005829; C:cytosol; IDA:TAIR.::GO:0009506; C:plasmodesma; IDA:TAIR. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IGI:TAIR. | | | | | | | | | | GO:0019287; P:isopentenyl diphosphate biosynthetic process, mevalonate pathway; TAS:TAIR.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 19 | P54871 | 462 | HMCS_CAEEL Hydroxymethylglutaryl-CoA synthase... | 455 | 8e-94 | 298 | 38 | 58 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:EC. | | | | | | | | | | GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0040007; P:growth; IMP:WormBase.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro.::GO:0040011; P:locomotion; IMP:WormBase.::GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IMP:WormBase.::GO:0002009; P:morphogenesis of an epithelium; IMP:WormBase.::GO:0002119; P:nematode larval development; IMP:WormBase.::GO:0040010; P:positive regulation of growth rate; IMP:WormBase.::GO:0006898; P:receptor-mediated endocytosis; IMP:WormBase.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0016126; P:sterol biosynthetic process; IEA:UniProtKB-KW. | 20 | P40830 | 420 | PKSG_BACSU Polyketide biosynthesis 3-hydroxy-... | 417 | 7e-22 | 100 | 25 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro. | | | | | | | | | | GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.::GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 21 | A1RSQ5 | 350 | Y811_PYRIL UPF0219 protein Pisl_0811 OS=Pyrob... | 427 | 0.0000000001 | 66.2 | 24 | 38 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 22 | Q8TVL0 | 350 | Y1379_METKA UPF0219 protein MK1379 OS=100938)... | 416 | 0.000000003 | 62 | 24 | 37 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 23 | Q8ZVP4 | 350 | Y2185_PYRAE UPF0219 protein PAE2185 OS=/ NBRC... | 341 | 0.00000002 | 59.7 | 24 | 40 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 24 | A3MV40 | 350 | Y1082_PYRCJ UPF0219 protein Pcal_1082 OS=Pyro... | 425 | 0.00000005 | 58.2 | 22 | 37 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 25 | O26883 | 346 | Y792_METTH UPF0219 protein MTH_792 OS=thermoa... | 376 | 0.0000002 | 56.6 | 22 | 36 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 26 | Q4J933 | 348 | Y1362_SULAC UPF0219 protein Saci_1362 OS=NBRC... | 289 | 0.0000003 | 55.8 | 25 | 40 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 27 | Q0W7K1 | 347 | Y2538_UNCMA UPF0219 protein UNCMA_25380 OS=Un... | 405 | 0.0000008 | 54.7 | 21 | 38 | | | | | | | | | | | GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro. | | | | | | | | | | GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.] | 28 | Q46F10 | 349 | Y551_METBF UPF0219 protein Mbar_A0551 OS=Meth... | 386 | 0.000001 | 53.5 | 22 | 35 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 29 | Q6L233 | 351 | Y384_PICTO UPF0219 protein PTO0384 OS=100828)... | 375 | 0.000002 | 53.5 | 21 | 35 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 30 | A8ME61 | 349 | Y1240_CALMQ UPF0219 protein Cmaq_1240 OS=/ IC... | 320 | 0.000002 | 53.5 | 23 | 38 | | | | | | | | | | | GO:0004421; F:hydroxymethylglutaryl-CoA synthase activity; IEA:InterPro.::GO:0016747; F:transferase activity, transferring acyl groups other than amino-acyl groups; IEA:InterPro. | | | | | | | | | | GO:0008299; P:isoprenoid biosynthetic process; IEA:InterPro. | 31 | Q51798 | 350 | Y972_PYRFU UPF0219 protein PF0972 OS=Pyrococc... | 167 | 0.000003 | 52.8 | 27 | 45 | | | | | | | | | | | GO:0004315; F:3-oxoacyl-[acyl-carrier-protein synthase activity; IEA:InterPro. | | | | | | | | | | GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.] |
