| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | Q8WZJ7 | 937 | C1TC_SCHPO C-1-tetrahydrofolate synthase, cyt... | 937 | 0 | 1197 | 65 | 80 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:PomBase.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IDA:PomBase.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IDA:PomBase.::GO:0003697; F:single-stranded DNA binding; IDA:PomBase. | | | | | | | | | | GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; IDA:PomBase.::GO:0046656; P:folic acid biosynthetic process; IDA:PomBase.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IDA:PomBase.::GO:0009113; P:purine base biosynthetic process; IDA:PomBase.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 2 | P09440 | 975 | C1TM_YEAST C-1-tetrahydrofolate synthase, mit... | 940 | 0 | 1173 | 64 | 77 | GO:0005739; C:mitochondrion; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:SGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IDA:SGD.::GO:0004479; F:methionyl-tRNA formyltransferase activity; IMP:SGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IDA:SGD. | | | | | | | | | | GO:0046656; P:folic acid biosynthetic process; IDA:SGD.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 3 | P07245 | 946 | C1TC_YEAST C-1-tetrahydrofolate synthase, cyt... | 950 | 0 | 1148 | 63 | 77 | GO:0005737; C:cytoplasm; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IMP:SGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IMP:SGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IMP:SGD. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; IMP:SGD.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 4 | O43007 | 969 | C1TM_SCHPO C-1-tetrahydrofolate synthase, mit... | 982 | 0 | 1103 | 57 | 74 | GO:0005739; C:mitochondrion; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; ISS:PomBase.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; ISS:PomBase.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; ISS:PomBase. | | | | | | | | | | GO:0009257; P:10-formyltetrahydrofolate biosynthetic process; ISS:PomBase.::GO:0046656; P:folic acid biosynthetic process; ISS:PomBase.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0009113; P:purine base biosynthetic process; ISS:PomBase.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 5 | P27653 | 935 | C1TC_RAT C-1-tetrahydrofolate synthase, cytop... | 939 | 0 | 1098 | 59 | 75 | GO:0005737; C:cytoplasm; TAS:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:RGD.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:RGD.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.::GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity; TAS:RGD. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEP:RGD.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; TAS:RGD.] | 6 | Q922D8 | 935 | C1TC_MOUSE C-1-tetrahydrofolate synthase, cyt... | 939 | 0 | 1084 | 60 | 75 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0016155; F:formyltetrahydrofolate dehydrogenase activity; IMP:MGI.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0006548; P:histidine catabolic process; IMP:MGI.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 7 | P11586 | 935 | C1TC_HUMAN C-1-tetrahydrofolate synthase, cyt... | 939 | 0 | 1078 | 59 | 74 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005739; C:mitochondrion; TAS:ProtInc. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; TAS:Reactome.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; TAS:Reactome.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC.::GO:0004486; F:methylenetetrahydrofolate dehydrogenase [NAD(P)+ activity; TAS:Reactome. | | | | | | | | | | GO:0046655; P:folic acid metabolic process; TAS:Reactome.::GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW.] | 8 | Q5R8P0 | 935 | C1TC_PONAB C-1-tetrahydrofolate synthase, cyt... | 939 | 0 | 1069 | 59 | 74 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 9 | O96553 | 968 | C1TC_DROME C-1-tetrahydrofolate synthase, cyt... | 952 | 0 | 1033 | 56 | 72 | GO:0005737; C:cytoplasm; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; NAS:UniProtKB.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; NAS:UniProtKB.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; NAS:UniProtKB. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 10 | Q27772 | 933 | C1TC_SPOFR C-1-tetrahydrofolate synthase, cyt... | 938 | 0 | 1008 | 56 | 71 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004477; F:methenyltetrahydrofolate cyclohydrolase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0000105; P:histidine biosynthetic process; IEA:UniProtKB-KW.::GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0006164; P:purine nucleotide biosynthetic process; IEA:UniProtKB-KW. | 11 | Q6UB35 | 978 | C1TM_HUMAN Monofunctional C1-tetrahydrofolate... | 916 | 0 | 879 | 52 | 68 | GO:0005739; C:mitochondrion; IDA:BHF-UCL. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:BHF-UCL.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IDA:BHF-UCL.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IDA:BHF-UCL. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0015942; P:formate metabolic process; IDA:BHF-UCL.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046653; P:tetrahydrofolate metabolic process; IDA:BHF-UCL. | 12 | Q0VCR7 | 975 | C1TM_BOVIN Monofunctional C1-tetrahydrofolate... | 919 | 0 | 875 | 52 | 68 | GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 13 | Q3V3R1 | 977 | C1TM_MOUSE Monofunctional C1-tetrahydrofolate... | 916 | 0 | 866 | 52 | 68 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC.::GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 14 | Q9SPK5 | 634 | FTHS_ARATH Formate--tetrahydrofolate ligase O... | 636 | 0 | 778 | 62 | 75 | GO:0048046; C:apoplast; IDA:TAIR.::GO:0009507; C:chloroplast; IDA:TAIR.::GO:0005829; C:cytosol; IDA:TAIR.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005507; F:copper ion binding; IDA:TAIR.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.::GO:0046686; P:response to cadmium ion; IEP:TAIR. | 15 | P28723 | 637 | FTHS_SPIOL Formate--tetrahydrofolate ligase O... | 636 | 0 | 769 | 61 | 75 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 16 | A5UPV2 | 564 | FTHS_ROSS1 Formate--tetrahydrofolate ligase O... | 618 | 0 | 568 | 50 | 66 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 17 | A7NGQ9 | 564 | FTHS_ROSCS Formate--tetrahydrofolate ligase O... | 627 | 0 | 554 | 49 | 64 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 18 | A4J0S6 | 567 | FTHS_DESRM Formate--tetrahydrofolate ligase O... | 633 | 0 | 553 | 47 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 19 | A4FL80 | 565 | FTHS_SACEN Formate--tetrahydrofolate ligase O... | 629 | 2e-173 | 527 | 49 | 63 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 20 | A8MIN1 | 556 | FTHS_ALKOO Formate--tetrahydrofolate ligase O... | 628 | 2e-172 | 524 | 46 | 62 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 21 | Q2RM91 | 559 | FTHS_MOOTA Formate--tetrahydrofolate ligase O... | 633 | 5e-171 | 521 | 45 | 62 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 22 | P13419 | 556 | FTHS_CLOAC Formate--tetrahydrofolate ligase O... | 631 | 9e-171 | 520 | 47 | 62 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 23 | Q3Z8K3 | 597 | FTHS_DEHE1 Formate--tetrahydrofolate ligase O... | 650 | 4e-170 | 520 | 46 | 60 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 24 | Q6ABS5 | 563 | FTHS_PROAC Formate--tetrahydrofolate ligase O... | 628 | 1e-169 | 517 | 45 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 25 | Q3ZX40 | 597 | FTHS_DEHSC Formate--tetrahydrofolate ligase O... | 641 | 3e-168 | 515 | 45 | 60 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 26 | P21164 | 559 | FTHS_MOOTH Formate--tetrahydrofolate ligase O... | 633 | 3e-168 | 513 | 45 | 62 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 27 | Q1AT39 | 573 | FTHS3_RUBXD Formate--tetrahydrofolate ligase ... | 623 | 6e-167 | 511 | 46 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 28 | A0PXN0 | 556 | FTHS_CLONN Formate--tetrahydrofolate ligase O... | 630 | 7e-167 | 509 | 44 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 29 | Q1AXZ4 | 576 | FTHS1_RUBXD Formate--tetrahydrofolate ligase ... | 637 | 8e-167 | 510 | 45 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 30 | Q1AVP8 | 576 | FTHS2_RUBXD Formate--tetrahydrofolate ligase ... | 637 | 1e-166 | 510 | 45 | 61 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. | 31 | B7VSJ2 | 582 | FTHS_VIBSL Formate--tetrahydrofolate ligase O... | 631 | 9e-166 | 508 | 45 | 62 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004329; F:formate-tetrahydrofolate ligase activity; IEA:EC. | | | | | | | | | | GO:0009396; P:folic acid-containing compound biosynthetic process; IEA:InterPro.::GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW. |
