| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q96Q42 | 1657 | ALS2_HUMAN Alsin OS=Homo sapiens (Human). GN=... | 248 | 0.023 | 41.6 | 25 | 39 | GO:0005813; C:centrosome; IDA:MGI.::GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005769; C:early endosome; IDA:UniProtKB.::GO:0030426; C:growth cone; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0043234; C:protein complex; IDA:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.::GO:0043539; F:protein serine/threonine kinase activator activity; IDA:UniProtKB.::GO:0017137; F:Rab GTPase binding; IDA:UniProtKB.::GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IDA:UniProtKB.::GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0008219; P:cell death; IEA:UniProtKB-KW.::GO:0007032; P:endosome organization; NAS:UniProtKB.::GO:0032855; P:positive regulation of Rac GTPase activity; IDA:UniProtKB.::GO:0035022; P:positive regulation of Rac protein signal transduction; IC:UniProtKB.::GO:0051036; P:regulation of endosome size; IEP:UniProtKB. | 32 | Q8NDN9 | 531 | RCBT1_HUMAN RCC1 and BTB domain-containing pr... | 261 | 0.00005 | 49.7 | 24 | 38 | GO:0005737; C:cytoplasm; IDA:LIFEdb.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 33 | Q5DX34 | 1392 | RPGRH_CAEEL X-linked retinitis pigmentosa GTP... | 325 | 0.00003 | 50.8 | 25 | 36 | GO:0030424; C:axon; IDA:WormBase.::GO:0045202; C:synapse; IDA:WormBase. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0019915; P:lipid storage; IMP:WormBase. | 34 | Q5BIW4 | 1657 | ALS2_PANTR Alsin OS=Pan troglodytes (Chimpanz... | 248 | 0.016 | 42 | 25 | 39 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005769; C:early endosome; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0014069; C:postsynaptic density; ISS:UniProtKB.::GO:0043234; C:protein complex; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.::GO:0042598; C:vesicular fraction; ISS:UniProtKB. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.::GO:0043539; F:protein serine/threonine kinase activator activity; ISS:UniProtKB.::GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.::GO:0017112; F:Rab guanyl-nucleotide exchange factor activity; ISS:UniProtKB.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0001662; P:behavioral fear response; ISS:UniProtKB.::GO:0016197; P:endosome transport; ISS:UniProtKB.::GO:0007626; P:locomotory behavior; ISS:UniProtKB.::GO:0007528; P:neuromuscular junction development; ISS:UniProtKB.::GO:0048812; P:neuron projection morphogenesis; ISS:UniProtKB.::GO:0032855; P:positive regulation of Rac GTPase activity; ISS:UniProtKB.::GO:0008104; P:protein localization; ISS:UniProtKB.::GO:0001881; P:receptor recycling; ISS:UniProtKB.::GO:0051036; P:regulation of endosome size; ISS:UniProtKB.::GO:0032313; P:regulation of Rab GTPase activity; ISS:UniProtKB.::GO:0006979; P:response to oxidative stress; ISS:UniProtKB.::GO:0035249; P:synaptic transmission, glutamatergic; ISS:UniProtKB.::GO:0016050; P:vesicle organization; ISS:UniProtKB. | 35 | O42645 | 351 | YF94_SCHPO RCC1 repeat-containing protein C10... | 56 | 5.5 | 33.5 | 34 | 52 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | | | | | | | | | | | GO:0007017; P:microtubule-based process; ISS:PomBase.::GO:0006400; P:tRNA modification; ISS:PomBase. | 36 | Q9UGK8 | 458 | SRGEF_HUMAN Secretion-regulating guanine nucl... | 214 | 0.00005 | 49.7 | 26 | 41 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.::GO:0005730; C:nucleolus; IDA:HPA. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0050709; P:negative regulation of protein secretion; IDA:HGNC.::GO:0007165; P:signal transduction; TAS:UniProtKB. | 37 | Q9VR91 | 4912 | HERC2_DROME Probable E3 ubiquitin-protein lig... | 113 | 4.2 | 34.3 | 27 | 43 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0020037; F:heme binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 38 | P21827 | 482 | RCC1_YEAST Guanine nucleotide exchange factor... | 56 | 1.3 | 35.4 | 41 | 52 | GO:0000790; C:nuclear chromatin; IDA:SGD. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004871; F:signal transducer activity; IMP:SGD. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.::GO:0000054; P:ribosomal subunit export from nucleus; IMP:SGD.::GO:0006407; P:rRNA export from nucleus; IMP:SGD. | 39 | Q96I51 | 464 | WBS16_HUMAN Williams-Beuren syndrome chromoso... | 265 | 0.013 | 42 | 25 | 36 | | | | | | | | | | | | | | | | | | | | | | 40 | Q9N1T2 | 1003 | RPGR_CANFA X-linked retinitis pigmentosa GTPa... | 94 | 1.5 | 35.4 | 28 | 49 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0005929; C:cilium; IEA:UniProtKB-KW.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.::GO:0007601; P:visual perception; ISS:UniProtKB. | 41 | Q8BTU7 | 377 | RCCD1_MOUSE RCC1 domain-containing protein 1 ... | 151 | 0.0002 | 47.8 | 26 | 44 | | | | | | | | | | | | | | | | | | | | | | 42 | Q9P258 | 522 | RCC2_HUMAN Protein RCC2 OS=Homo sapiens (Huma... | 100 | 2 | 35 | 29 | 45 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000236; P:mitotic prometaphase; TAS:Reactome. | 43 | Q9R0X5 | 1001 | RPGR_MOUSE X-linked retinitis pigmentosa GTPa... | 112 | 3.2 | 34.7 | 25 | 45 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0005929; C:cilium; IDA:MGI.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.::GO:0042462; P:eye photoreceptor cell development; IMP:MGI.::GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.::GO:0007601; P:visual perception; ISS:UniProtKB. | 44 | Q91ZR4 | 698 | NEK8_MOUSE Serine/threonine-protein kinase Ne... | 258 | 0.5 | 37 | 24 | 37 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0072372; C:primary cilium; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 45 | Q54Q89 | 487 | RCCDC_DICDI RCC1 repeat-containing protein DD... | 173 | 0.0008 | 45.8 | 24 | 42 | | | | | | | | | | | | | | | | | | | | | | 46 | Q52KW8 | 513 | RCC2_XENLA Protein RCC2 homolog OS=Xenopus la... | 260 | 0.02 | 41.2 | 22 | 37 | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 47 | A6NED2 | 376 | RCCD1_HUMAN RCC1 domain-containing protein 1 ... | 114 | 0.002 | 44.3 | 27 | 46 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005886; C:plasma membrane; IDA:HPA. | | | | | | | | | | | | | | | | | | | | | 48 | Q4R828 | 376 | RCCD1_MACFA RCC1 domain-containing protein 1 ... | 114 | 0.002 | 44.3 | 27 | 46 | | | | | | | | | | | | | | | | | | | | | | 49 | P52499 | 464 | RCC1_CANAX Protein RCC1 OS=Candida albicans (... | 64 | 3.5 | 34.3 | 30 | 48 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 50 | Q92834 | 1020 | RPGR_HUMAN X-linked retinitis pigmentosa GTPa... | 222 | 0.16 | 38.9 | 22 | 42 | GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell.::GO:0001750; C:photoreceptor outer segment; IDA:UniProtKB. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0006886; P:intracellular protein transport; TAS:ProtInc.::GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.::GO:0007601; P:visual perception; IMP:UniProtKB. | 51 | Q9NB71 | 5233 | HIW_DROME E3 ubiquitin-protein ligase highwir... | 53 | 2.3 | 35 | 34 | 49 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:FlyBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:FlyBase. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007628; P:adult walking behavior; NAS:FlyBase.::GO:0006914; P:autophagy; IDA:FlyBase.::GO:0030509; P:BMP signaling pathway; IPI:UniProtKB.::GO:0040011; P:locomotion; NAS:FlyBase.::GO:0030514; P:negative regulation of BMP signaling pathway; IGI:UniProtKB.::GO:0045886; P:negative regulation of synaptic growth at neuromuscular junction; IMP:UniProtKB.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0050808; P:synapse organization; IDA:FlyBase.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 52 | Q8IS20 | 1457 | GEFC_DICDI Ras guanine nucleotide exchange fa... | 46 | 0.005 | 43.5 | 41 | 63 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 53 | Q54HT1 | 1336 | TIRA_DICDI Protein tirA OS=Dictyostelium disc... | 118 | 0.007 | 43.1 | 29 | 48 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | | | | | | | | | | | GO:0008283; P:cell proliferation; IMP:dictyBase.::GO:0006952; P:defense response; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 54 | Q8BK67 | 520 | RCC2_MOUSE Protein RCC2 OS=Mus musculus (Mous... | 100 | 3.4 | 34.3 | 29 | 45 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 55 | Q6NYE2 | 495 | RCC2_DANRE Protein RCC2 homolog OS=Danio reri... | 112 | 2.9 | 34.3 | 30 | 45 | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 56 | Q54VW7 | 1203 | GACGG_DICDI Rho GTPase-activating protein gac... | 125 | 3.4 | 34.3 | 22 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007165; P:signal transduction; IEA:InterPro. | 57 | Q90XC2 | 697 | NEK8_DANRE Serine/threonine-protein kinase Ne... | 98 | 0.21 | 38.1 | 29 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 58 | P25171 | 547 | RCC1_DROME Regulator of chromosome condensati... | 168 | 0.036 | 40.4 | 29 | 44 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0003682; F:chromatin binding; IDA:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007417; P:central nervous system development; IDA:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0007346; P:regulation of mitotic cell cycle; IDA:UniProtKB.::GO:0050767; P:regulation of neurogenesis; IMP:FlyBase.::GO:0046822; P:regulation of nucleocytoplasmic transport; IMP:FlyBase. | 59 | O74881 | 1347 | BTB1_SCHPO BTB/POZ domain-containing protein ... | 123 | 0.039 | 40.8 | 28 | 46 | GO:0000151; C:ubiquitin ligase complex; IPI:PomBase. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0006511; P:ubiquitin-dependent protein catabolic process; IC:PomBase. | 60 | Q54X24 | 512 | RCCDA_DICDI RCC1 domain-containing protein DD... | 47 | 0.98 | 35.8 | 40 | 53 | | | | | | | | | | | | | | | | | | | | | | 61 | Q17551 | 3766 | RPM1_CAEEL E3 ubiquitin-protein ligase rpm-1 ... | 301 | 0.21 | 38.5 | 23 | 39 | GO:0030424; C:axon; IDA:WormBase.::GO:0031594; C:neuromuscular junction; IDA:WormBase.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:WormBase.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:WormBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006915; P:apoptotic process; IMP:WormBase.::GO:0010171; P:body morphogenesis; IMP:WormBase.::GO:0040011; P:locomotion; IGI:WormBase.::GO:0043409; P:negative regulation of MAPK cascade; IGI:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0031647; P:regulation of protein stability; IMP:WormBase.::GO:0050807; P:regulation of synapse organization; IMP:WormBase.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
