rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | O74881 | 1347 | BTB1_SCHPO BTB/POZ domain-containing protein ... | 1496 | 7e-86 | 313 | 24 | 44 | GO:0000151; C:ubiquitin ligase complex; IPI:PomBase. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0006511; P:ubiquitin-dependent protein catabolic process; IC:PomBase. | 2 | Q9P2D0 | 1353 | IBTK_HUMAN Inhibitor of Bruton tyrosine kinas... | 1071 | 3e-39 | 164 | 23 | 38 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0019901; F:protein kinase binding; IDA:MGI.::GO:0030292; F:protein tyrosine kinase inhibitor activity; IDA:MGI. | | | | | | | | | | GO:0001933; P:negative regulation of protein phosphorylation; IDA:MGI.::GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:MGI. | 3 | Q6NRS1 | 1339 | IBTK_XENLA Inhibitor of Bruton tyrosine kinas... | 176 | 0.00000002 | 63.5 | 24 | 47 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 4 | Q6ZPR6 | 1352 | IBTK_MOUSE Inhibitor of Bruton tyrosine kinas... | 121 | 0.74 | 38.1 | 27 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | | 5 | Q5PQN1 | 1057 | HERC4_RAT Probable E3 ubiquitin-protein ligas... | 181 | 3.9 | 35.8 | 24 | 37 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; ISS:UniProtKB. | 6 | Q6PAV2 | 1057 | HERC4_MOUSE Probable E3 ubiquitin-protein lig... | 181 | 2.8 | 36.2 | 25 | 37 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; TAS:UniProtKB. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; IMP:UniProtKB. | 7 | Q5GLZ8 | 1057 | HERC4_HUMAN Probable E3 ubiquitin-protein lig... | 181 | 9.9 | 34.7 | 24 | 37 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; ISS:UniProtKB. | 8 | Q80YD6 | 464 | SRGEF_MOUSE Secretion-regulating guanine nucl... | 102 | 0.005 | 45.1 | 32 | 44 | GO:0005737; C:cytoplasm; ISS:UniProtKB. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 9 | Q15034 | 1050 | HERC3_HUMAN Probable E3 ubiquitin-protein lig... | 125 | 0.87 | 38.1 | 28 | 53 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 10 | Q9UGK8 | 458 | SRGEF_HUMAN Secretion-regulating guanine nucl... | 183 | 0.041 | 42 | 26 | 40 | GO:0005737; C:cytoplasm; IDA:UniProtKB.::GO:0045111; C:intermediate filament cytoskeleton; IDA:HPA.::GO:0005730; C:nucleolus; IDA:HPA. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; TAS:UniProtKB. | | | | | | | | | | GO:0050709; P:negative regulation of protein secretion; IDA:HGNC.::GO:0007165; P:signal transduction; TAS:UniProtKB. | 11 | Q8IVU3 | 1022 | HERC6_HUMAN Probable E3 ubiquitin-protein lig... | 134 | 0.023 | 43.1 | 30 | 46 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:HPA. | | | | | | | | | | GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 12 | Q3MHW0 | 464 | SRGEF_BOVIN Secretion-regulating guanine nucl... | 281 | 0.045 | 42 | 23 | 40 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | | 13 | Q15751 | 4861 | HERC1_HUMAN Probable E3 ubiquitin-protein lig... | 205 | 1.9 | 37 | 23 | 39 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; TAS:ProtInc.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016881; F:acid-amino acid ligase activity; IEA:InterPro.::GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006464; P:protein modification process; IEA:InterPro.::GO:0006810; P:transport; IEA:UniProtKB-KW. | 14 | Q5RCZ7 | 551 | RCBT2_PONAB RCC1 and BTB domain-containing pr... | 196 | 0.75 | 38.1 | 20 | 40 | | | | | | | | | | | | | | | | | | | | | | 15 | O95199 | 551 | RCBT2_HUMAN RCC1 and BTB domain-containing pr... | 196 | 0.75 | 38.1 | 20 | 40 | | | | | | | | | | | GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; TAS:ProtInc. | | | | | | | | | | | 16 | Q6NXM2 | 531 | RCBT1_MOUSE RCC1 and BTB domain-containing pr... | 255 | 0.0000005 | 58.2 | 27 | 40 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 17 | Q6P798 | 551 | RCBT2_RAT RCC1 and BTB domain-containing prot... | 196 | 0.91 | 37.7 | 20 | 40 | | | | | | | | | | | | | | | | | | | | | | 18 | Q99LJ7 | 551 | RCBT2_MOUSE RCC1 and BTB domain-containing pr... | 196 | 0.69 | 38.1 | 20 | 40 | | | | | | | | | | | | | | | | | | | | | | 19 | Q8NDN9 | 531 | RCBT1_HUMAN RCC1 and BTB domain-containing pr... | 246 | 0.000005 | 54.7 | 26 | 40 | GO:0005737; C:cytoplasm; IDA:LIFEdb.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.::GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.::GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. | 20 | Q9CYF5 | 461 | WBS16_MOUSE Williams-Beuren syndrome chromoso... | 33 | 3.9 | 35.8 | 45 | 64 | GO:0005739; C:mitochondrion; IDA:MGI. | | | | | | | | | | GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | | 21 | Q9N1T2 | 1003 | RPGR_CANFA X-linked retinitis pigmentosa GTPa... | 100 | 0.12 | 40.8 | 28 | 44 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0005929; C:cilium; IEA:UniProtKB-KW.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.::GO:0007601; P:visual perception; ISS:UniProtKB. | 22 | Q5DX34 | 1392 | RPGRH_CAEEL X-linked retinitis pigmentosa GTP... | 82 | 0.14 | 40.8 | 37 | 54 | GO:0030424; C:axon; IDA:WormBase.::GO:0045202; C:synapse; IDA:WormBase. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0019915; P:lipid storage; IMP:WormBase. | 23 | Q9P258 | 522 | RCC2_HUMAN Protein RCC2 OS=Homo sapiens (Huma... | 219 | 0.17 | 40 | 25 | 42 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0000236; P:mitotic prometaphase; TAS:Reactome. | 24 | Q4U2R1 | 4836 | HERC2_MOUSE E3 ubiquitin-protein ligase HERC2... | 210 | 0.81 | 38.1 | 25 | 41 | GO:0005743; C:mitochondrial inner membrane; IDA:MGI.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0020037; F:heme binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; ISS:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006281; P:DNA repair; ISS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0007283; P:spermatogenesis; IMP:MGI. | 25 | Q92834 | 1020 | RPGR_HUMAN X-linked retinitis pigmentosa GTPa... | 149 | 4.8 | 35.4 | 22 | 40 | GO:0005813; C:centrosome; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell.::GO:0001750; C:photoreceptor outer segment; IDA:UniProtKB. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0042384; P:cilium assembly; IMP:UniProtKB.::GO:0006886; P:intracellular protein transport; TAS:ProtInc.::GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.::GO:0007601; P:visual perception; IMP:UniProtKB. | 26 | O95714 | 4834 | HERC2_HUMAN E3 ubiquitin-protein ligase HERC2... | 209 | 1.1 | 37.7 | 24 | 41 | GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; NAS:UniProtKB.::GO:0020037; F:heme binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IDA:UniProtKB.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006281; P:DNA repair; IDA:UniProtKB.::GO:0006886; P:intracellular protein transport; NAS:UniProtKB.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 27 | Q9UII4 | 1024 | HERC5_HUMAN E3 ISG15--protein ligase HERC5 OS... | 112 | 0.00001 | 53.9 | 29 | 51 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042296; F:ISG15 ligase activity; IDA:UniProtKB.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0019221; P:cytokine-mediated signaling pathway; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0032020; P:ISG15-protein conjugation; IDA:UniProtKB.::GO:0032480; P:negative regulation of type I interferon production; TAS:Reactome.::GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome.::GO:0000079; P:regulation of cyclin-dependent protein kinase activity; TAS:ProtInc.::GO:0050688; P:regulation of defense response to virus; IDA:UniProtKB.::GO:0009615; P:response to virus; IEA:UniProtKB-KW. | 28 | Q8BK67 | 520 | RCC2_MOUSE Protein RCC2 OS=Mus musculus (Mous... | 331 | 0.00002 | 52.8 | 24 | 38 | GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.::GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005874; C:microtubule; IEA:UniProtKB-KW.::GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.::GO:0005819; C:spindle; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 29 | Q6NYE2 | 495 | RCC2_DANRE Protein RCC2 homolog OS=Danio reri... | 322 | 0.00003 | 52.4 | 23 | 39 | GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW. | 30 | Q9VR91 | 4912 | HERC2_DROME Probable E3 ubiquitin-protein lig... | 118 | 0.19 | 40.4 | 28 | 53 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0020037; F:heme binding; IEA:InterPro.::GO:0004842; F:ubiquitin-protein ligase activity; IBA:RefGenome. | | | | | | | | | | GO:0042787; P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IBA:RefGenome. | 31 | Q9R0X5 | 1001 | RPGR_MOUSE X-linked retinitis pigmentosa GTPa... | 180 | 0.31 | 39.7 | 26 | 42 | GO:0005813; C:centrosome; ISS:UniProtKB.::GO:0005929; C:cilium; IDA:MGI.::GO:0005794; C:Golgi apparatus; IDA:UniProtKB.::GO:0005932; C:microtubule basal body; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.::GO:0042462; P:eye photoreceptor cell development; IMP:MGI.::GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.::GO:0007601; P:visual perception; ISS:UniProtKB. |