| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
181 | Q14511 | 834 | CASL_HUMAN Enhancer of filamentation 1 OS=Hom... | 58 | 0.000002 | 54.7 | 47 | 59 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005925; C:focal adhesion; IEA:UniProtKB-SubCell.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; TAS:ProtInc. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | GO:0051017; P:actin filament bundle assembly; NAS:UniProtKB.::GO:0007155; P:cell adhesion; NAS:ProtInc.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007229; P:integrin-mediated signaling pathway; NAS:UniProtKB.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. | 182 | O35177 | 833 | CASL_MOUSE Enhancer of filamentation 1 OS=Mus... | 59 | 0.000002 | 54.7 | 46 | 58 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IDA:MGI.::GO:0000922; C:spindle pole; IDA:MGI. | | | | | | | | | | | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0007067; P:mitosis; IEA:UniProtKB-KW.::GO:0040008; P:regulation of growth; IEA:UniProtKB-KW. | 183 | Q28E95 | 861 | SH3R1_XENTR E3 ubiquitin-protein ligase SH3RF... | 50 | 0.0004 | 47.4 | 38 | 62 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 184 | P10569 | 1168 | MYSC_ACACA Myosin IC heavy chain OS=Acanthamo... | 52 | 0.000003 | 54.7 | 46 | 60 | GO:0016459; C:myosin complex; IEA:UniProtKB-KW. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0003774; F:motor activity; IEA:InterPro. | | | | | | | | | | | 185 | Q3UTH8 | 516 | ARHG9_MOUSE Rho guanine nucleotide exchange f... | 112 | 0.000003 | 54.3 | 31 | 44 | GO:0005938; C:cell cortex; TAS:MGI. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:MGI. | 186 | P46109 | 303 | CRKL_HUMAN Crk-like protein OS=Homo sapiens (... | 84 | 0.041 | 40.4 | 35 | 44 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005070; F:SH3/SH2 adaptor activity; TAS:ProtInc.::GO:0004871; F:signal transducer activity; TAS:ProtInc. | | | | | | | | | | GO:0007254; P:JNK cascade; TAS:ProtInc.::GO:0007265; P:Ras protein signal transduction; TAS:ProtInc. | 187 | Q04929 | 305 | CRK_CHICK Adapter molecule crk OS=Gallus gall... | 67 | 0.000003 | 53.5 | 39 | 58 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0048013; P:ephrin receptor signaling pathway; ISS:UniProtKB.::GO:0032956; P:regulation of actin cytoskeleton organization; ISS:UniProtKB.::GO:0032319; P:regulation of Rho GTPase activity; ISS:UniProtKB. | 188 | Q9Z0W5 | 441 | PACN1_RAT Protein kinase C and casein kinase ... | 97 | 0.000003 | 53.9 | 38 | 53 | | | | | | | | | | | | | | | | | | | | | GO:0007010; P:cytoskeleton organization; IDA:RGD.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 189 | Q61644 | 441 | PACN1_MOUSE Protein kinase C and casein kinas... | 97 | 0.000003 | 53.9 | 38 | 53 | GO:0030137; C:COPI-coated vesicle; IDA:MGI. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; IDA:MGI. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0045806; P:negative regulation of endocytosis; IDA:MGI.::GO:0007165; P:signal transduction; TAS:MGI. | 190 | Q555L8 | 389 | Y4695_DICDI SH3 and FCH domain-containing pro... | 50 | 0.000003 | 53.5 | 44 | 66 | | | | | | | | | | | | | | | | | | | | | | 191 | P16086 | 2472 | SPTA2_RAT Spectrin alpha chain, brain OS=Ratt... | 134 | 0.000004 | 54.3 | 30 | 47 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.::GO:0008091; C:spectrin; TAS:RGD. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0032403; F:protein complex binding; IPI:RGD.::GO:0047485; F:protein N-terminus binding; IPI:RGD.::GO:0019905; F:syntaxin binding; IPI:RGD. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IMP:RGD.::GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. | 192 | P16546 | 2472 | SPTA2_MOUSE Spectrin alpha chain, brain OS=Mu... | 134 | 0.000004 | 54.3 | 30 | 47 | GO:0032437; C:cuticular plate; IDA:MGI.::GO:0005916; C:fascia adherens; IDA:MGI.::GO:0016328; C:lateral plasma membrane; IDA:MGI.::GO:0033270; C:paranode region of axon; IDA:BHF-UCL.::GO:0030018; C:Z disc; IDA:MGI. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0046982; F:protein heterodimerization activity; IDA:MGI.::GO:0030507; F:spectrin binding; IDA:MGI. | | | | | | | | | | GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. | 193 | Q69ZI1 | 892 | SH3R1_MOUSE E3 ubiquitin-protein ligase SH3RF... | 67 | 0.0006 | 47 | 31 | 52 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:MGI.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0005078; F:MAP-kinase scaffold activity; IDA:MGI.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0046328; P:regulation of JNK cascade; IDA:MGI. | 194 | Q15052 | 776 | ARHG6_HUMAN Rho guanine nucleotide exchange f... | 105 | 0.000004 | 53.9 | 29 | 47 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005096; F:GTPase activator activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; NAS:UniProtKB. | | | | | | | | | | GO:0006915; P:apoptotic process; NAS:UniProtKB.::GO:0034329; P:cell junction assembly; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0007254; P:JNK cascade; NAS:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 195 | A5D7F8 | 840 | SH3R1_BOVIN E3 ubiquitin-protein ligase SH3RF... | 50 | 0.0008 | 46.6 | 38 | 60 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 196 | P07751 | 2477 | SPTA2_CHICK Spectrin alpha chain, brain OS=Ga... | 133 | 0.000004 | 54.3 | 29 | 47 | GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW.::GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0051693; P:actin filament capping; IEA:UniProtKB-KW. | 197 | Q5U2U2 | 303 | CRKL_RAT Crk-like protein OS=Rattus norvegicu... | 84 | 0.25 | 37.7 | 33 | 44 | | | | | | | | | | | | | | | | | | | | | | 198 | P47941 | 303 | CRKL_MOUSE Crk-like protein OS=Mus musculus (... | 84 | 0.27 | 37.7 | 33 | 44 | | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI. | | | | | | | | | | GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.::GO:0001568; P:blood vessel development; IGI:MGI.::GO:0007507; P:heart development; IGI:MGI.::GO:0009887; P:organ morphogenesis; IMP:MGI.::GO:0060017; P:parathyroid gland development; IGI:MGI.::GO:0048538; P:thymus development; IGI:MGI. | 199 | P15498 | 845 | VAV_HUMAN Proto-oncogene vav OS=Homo sapiens ... | 52 | 0.000005 | 53.9 | 44 | 62 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0003700; F:sequence-specific DNA binding transcription factor activity; TAS:ProtInc. | | | | | | | | | | GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome.::GO:0031295; P:T cell costimulation; TAS:Reactome. | 200 | Q5RBR0 | 888 | SH3R1_PONAB E3 ubiquitin-protein ligase SH3RF... | 50 | 0.001 | 46.2 | 38 | 60 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 201 | Q71F54 | 894 | SH3R1_RAT E3 ubiquitin-protein ligase SH3RF1 ... | 50 | 0.001 | 46.2 | 38 | 60 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0006917; P:induction of apoptosis; IMP:RGD. | 202 | O70145 | 525 | NCF2_MOUSE Neutrophil cytosol factor 2 OS=Mus... | 50 | 0.3 | 38.1 | 34 | 54 | GO:0001669; C:acrosomal vesicle; IDA:MGI. | | | | | | | | | | GO:0048365; F:Rac GTPase binding; IPI:MGI. | | | | | | | | | | GO:0042554; P:superoxide anion generation; IDA:MGI. | 203 | Q9BY11 | 444 | PACN1_HUMAN Protein kinase C and casein kinas... | 97 | 0.000005 | 53.1 | 37 | 53 | | | | | | | | | | | GO:0004672; F:protein kinase activity; NAS:UniProtKB. | | | | | | | | | | GO:0006897; P:endocytosis; NAS:UniProtKB. | 204 | A5D8S5 | 867 | SH3R1_DANRE E3 ubiquitin-protein ligase SH3RF... | 50 | 0.0005 | 47 | 38 | 64 | GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | | 205 | Q7Z6J0 | 888 | SH3R1_HUMAN E3 ubiquitin-protein ligase SH3RF... | 50 | 0.001 | 45.8 | 38 | 60 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0016874; F:ligase activity; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.::GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB. | 206 | Q5ZLR6 | 764 | ARHG6_CHICK Rho guanine nucleotide exchange f... | 53 | 0.000006 | 53.5 | 43 | 60 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 207 | P54100 | 843 | VAV_RAT Proto-oncogene vav OS=Rattus norvegic... | 52 | 0.000006 | 53.5 | 44 | 62 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0048468; P:cell development; TAS:RGD.::GO:0002768; P:immune response-regulating cell surface receptor signaling pathway; IEP:RGD.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro. | 208 | Q8IZP0 | 508 | ABI1_HUMAN Abl interactor 1 OS=Homo sapiens (... | 60 | 0.000006 | 53.1 | 37 | 57 | GO:0030054; C:cell junction; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:ProtInc.::GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.::GO:0030175; C:filopodium; IDA:UniProtKB.::GO:0030426; C:growth cone; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005625; C:soluble fraction; TAS:ProtInc.::GO:0045202; C:synapse; IEA:UniProtKB-KW.::GO:0019717; C:synaptosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0008092; F:cytoskeletal protein binding; TAS:ProtInc. | | | | | | | | | | GO:0008154; P:actin polymerization or depolymerization; NAS:UniProtKB.::GO:0006928; P:cellular component movement; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; TAS:ProtInc.::GO:0018108; P:peptidyl-tyrosine phosphorylation; IDA:MGI.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; TAS:ProtInc. | 209 | P27870 | 845 | VAV_MOUSE Proto-oncogene vav OS=Mus musculus ... | 52 | 0.000006 | 53.5 | 44 | 62 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0030676; F:Rac guanyl-nucleotide exchange factor activity; IGI:MGI. | | | | | | | | | | GO:0006955; P:immune response; IMP:MGI.::GO:0007229; P:integrin-mediated signaling pathway; IGI:MGI.::GO:0035556; P:intracellular signal transduction; IMP:MGI.::GO:0006909; P:phagocytosis; IGI:MGI.::GO:0045785; P:positive regulation of cell adhesion; IGI:MGI.::GO:0043087; P:regulation of GTPase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0030217; P:T cell differentiation; TAS:MGI. | 210 | Q6DTM3 | 1047 | AHI1_RAT Jouberin OS=Rattus norvegicus (Rat).... | 51 | 0.000007 | 53.5 | 49 | 61 | GO:0005912; C:adherens junction; ISS:UniProtKB.::GO:0005911; C:cell-cell junction; ISS:UniProtKB.::GO:0005814; C:centriole; ISS:UniProtKB.::GO:0005932; C:microtubule basal body; ISS:UniProtKB.::GO:0036038; C:TCTN-B9D complex; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | GO:0042384; P:cilium assembly; ISS:UniProtKB.::GO:0035844; P:cloaca development; ISS:UniProtKB.::GO:0001947; P:heart looping; ISS:UniProtKB.::GO:0030902; P:hindbrain development; ISS:UniProtKB.::GO:0070121; P:Kupffer's vesicle development; ISS:UniProtKB.::GO:0070986; P:left/right axis specification; ISS:UniProtKB.::GO:0001738; P:morphogenesis of a polarized epithelium; ISS:UniProtKB.::GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.::GO:0071599; P:otic vesicle development; ISS:UniProtKB.::GO:0035845; P:photoreceptor cell outer segment organization; ISS:UniProtKB.::GO:0030862; P:positive regulation of polarized epithelial cell differentiation; ISS:UniProtKB.::GO:0002092; P:positive regulation of receptor internalization; ISS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; ISS:UniProtKB.::GO:0039023; P:pronephric duct morphogenesis; ISS:UniProtKB.::GO:0039008; P:pronephric nephron tubule morphogenesis; ISS:UniProtKB.::GO:0050795; P:regulation of behavior; ISS:UniProtKB.::GO:0010842; P:retina layer formation; ISS:UniProtKB.::GO:0065001; P:specification of axis polarity; ISS:UniProtKB.::GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; ISS:UniProtKB.::GO:0016192; P:vesicle-mediated transport; ISS:UniProtKB. | 211 | Q9QY17 | 488 | PACN2_RAT Protein kinase C and casein kinase ... | 68 | 0.000009 | 52.4 | 43 | 57 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. |
