| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
241 | P14085 | 557 | SRC_AVIST Tyrosine-protein kinase transformin... | 105 | 0.000004 | 54.7 | 29 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 242 | P14084 | 568 | SRC_AVISS Tyrosine-protein kinase transformin... | 105 | 0.000004 | 54.7 | 29 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 243 | Q60992 | 868 | VAV2_MOUSE Guanine nucleotide exchange factor... | 64 | 0.000004 | 55.1 | 41 | 58 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005154; F:epidermal growth factor receptor binding; IPI:MGI.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0016477; P:cell migration; IGI:MGI.::GO:0030032; P:lamellipodium assembly; IGI:MGI.::GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity; IGI:MGI.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; IMP:MGI. | 244 | Q09014 | 390 | NCF1_MOUSE Neutrophil cytosol factor 1 OS=Mus... | 55 | 0.16 | 39.7 | 36 | 53 | GO:0005829; C:cytosol; TAS:MGI. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB.::GO:0005515; F:protein binding; IPI:MGI.::GO:0016175; F:superoxide-generating NADPH oxidase activity; IDA:MGI. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro.::GO:0008283; P:cell proliferation; IMP:MGI.::GO:0006968; P:cellular defense response; IMP:MGI.::GO:0050665; P:hydrogen peroxide biosynthetic process; IMP:MGI.::GO:0006954; P:inflammatory response; IMP:MGI.::GO:0006691; P:leukotriene metabolic process; IMP:MGI.::GO:0045986; P:negative regulation of smooth muscle contraction; IMP:MGI.::GO:0070947; P:neutrophil mediated killing of fungus; IMP:MGI.::GO:0070946; P:neutrophil mediated killing of gram-positive bacterium; IMP:MGI.::GO:0006612; P:protein targeting to membrane; ISS:UniProtKB.::GO:0002679; P:respiratory burst involved in defense response; IMP:MGI.::GO:0001878; P:response to yeast; IMP:MGI.::GO:0042554; P:superoxide anion generation; IMP:MGI. | 245 | A6H7G2 | 423 | DBNL_BOVIN Drebrin-like protein OS=Bos taurus... | 83 | 0.000004 | 54.3 | 37 | 54 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW. | 246 | P52735 | 878 | VAV2_HUMAN Guanine nucleotide exchange factor... | 64 | 0.000004 | 55.1 | 41 | 58 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005089; F:Rho guanyl-nucleotide exchange factor activity; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; TAS:Reactome.::GO:0007411; P:axon guidance; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.::GO:0007264; P:small GTPase mediated signal transduction; TAS:Reactome. | 247 | Q8IVI9 | 506 | NOSTN_HUMAN Nostrin OS=Homo sapiens (Human). ... | 60 | 0.000004 | 54.3 | 35 | 57 | GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0046209; P:nitric oxide metabolic process; TAS:Reactome.::GO:0050999; P:regulation of nitric-oxide synthase activity; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 248 | P0CR79 | 660 | HSE1_CRYNB Class E vacuolar protein-sorting m... | 74 | 0.000005 | 54.7 | 36 | 50 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006886; P:intracellular protein transport; IEA:InterPro. | 249 | P0CR78 | 660 | HSE1_CRYNJ Class E vacuolar protein-sorting m... | 74 | 0.000005 | 54.7 | 36 | 50 | GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | | | | | | | | | | | GO:0006886; P:intracellular protein transport; IEA:InterPro. | 250 | P14598 | 390 | NCF1_HUMAN Neutrophil cytosol factor 1 OS=Hom... | 55 | 0.14 | 39.7 | 38 | 56 | GO:0005829; C:cytosol; TAS:ProtInc.::GO:0043020; C:NADPH oxidase complex; TAS:BHF-UCL.::GO:0032010; C:phagolysosome; TAS:Reactome.::GO:0005625; C:soluble fraction; TAS:ProtInc. | | | | | | | | | | GO:0009055; F:electron carrier activity; TAS:UniProtKB.::GO:0005525; F:GTP binding; TAS:ProtInc.::GO:0003924; F:GTPase activity; TAS:ProtInc.::GO:0035091; F:phosphatidylinositol binding; IDA:UniProtKB.::GO:0017124; F:SH3 domain binding; IPI:BHF-UCL. | | | | | | | | | | GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.::GO:0007154; P:cell communication; IEA:InterPro.::GO:0006968; P:cellular defense response; TAS:ProtInc.::GO:0045087; P:innate immune response; TAS:BHF-UCL.::GO:0006612; P:protein targeting to membrane; IDA:UniProtKB.::GO:0042554; P:superoxide anion generation; TAS:BHF-UCL. | 251 | A6NI72 | 391 | NCF1B_HUMAN Putative neutrophil cytosol facto... | 55 | 0.14 | 39.7 | 38 | 56 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IEA:InterPro. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro. | 252 | Q8I7C3 | 657 | LASP1_DROME LIM and SH3 domain protein Lasp O... | 57 | 0.000006 | 54.3 | 49 | 61 | GO:0005925; C:focal adhesion; IDA:FlyBase.::GO:0070864; C:sperm individualization complex; IDA:FlyBase. | | | | | | | | | | GO:0003779; F:actin binding; IDA:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007279; P:pole cell formation; IMP:FlyBase.::GO:0045856; P:positive regulation of pole plasm oskar mRNA localization; IMP:FlyBase.::GO:0007291; P:sperm individualization; IMP:FlyBase. | 253 | Q15080 | 339 | NCF4_HUMAN Neutrophil cytosol factor 4 OS=Hom... | 71 | 0.000006 | 53.5 | 32 | 56 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0043020; C:NADPH oxidase complex; IDA:UniProtKB.::GO:0032010; C:phagolysosome; TAS:Reactome. | | | | | | | | | | GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0046983; F:protein dimerization activity; TAS:UniProtKB. | | | | | | | | | | GO:0002479; P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; TAS:Reactome.::GO:0007154; P:cell communication; IEA:InterPro.::GO:0006955; P:immune response; TAS:UniProtKB.::GO:0055114; P:oxidation-reduction process; TAS:UniProtKB. | 254 | P15054 | 587 | SRC_AVIS2 Tyrosine-protein kinase transformin... | 105 | 0.000006 | 54.3 | 29 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 255 | Q8I1A6 | 366 | SH3G3_DROWI Endophilin-A OS=Drosophila willis... | 57 | 0.000006 | 53.5 | 35 | 65 | GO:0005737; C:cytoplasm; ISS:UniProtKB.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0042171; F:lysophosphatidic acid acyltransferase activity; ISS:UniProtKB. | | | | | | | | | | GO:0050803; P:regulation of synapse structure and activity; ISS:UniProtKB.::GO:0048488; P:synaptic vesicle endocytosis; ISS:UniProtKB. | 256 | A0JNB0 | 537 | FYN_BOVIN Tyrosine-protein kinase Fyn OS=Bos ... | 113 | 0.000007 | 53.9 | 28 | 45 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 257 | P63185 | 526 | SRC_RSVSE Tyrosine-protein kinase transformin... | 105 | 0.000007 | 53.9 | 30 | 46 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 258 | Q05876 | 534 | FYN_CHICK Tyrosine-protein kinase Fyn OS=Gall... | 113 | 0.000008 | 53.5 | 28 | 45 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC.::GO:0015631; F:tubulin binding; ISS:AgBase. | | | | | | | | | | GO:0030900; P:forebrain development; ISS:AgBase.::GO:0001764; P:neuron migration; ISS:AgBase.::GO:0018108; P:peptidyl-tyrosine phosphorylation; ISS:AgBase.::GO:0008360; P:regulation of cell shape; ISS:AgBase. | 259 | P62994 | 217 | GRB2_RAT Growth factor receptor-bound protein... | 51 | 0.032 | 40.8 | 35 | 59 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0043234; C:protein complex; IDA:RGD. | | | | | | | | | | GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:RGD.::GO:0001784; F:phosphotyrosine binding; IPI:RGD.::GO:0019904; F:protein domain specific binding; IPI:RGD. | | | | | | | | | | GO:0007568; P:aging; IPI:RGD.::GO:0051291; P:protein heterooligomerization; IDA:RGD.::GO:0007265; P:Ras protein signal transduction; TAS:RGD. | 260 | Q5R4J7 | 217 | GRB2_PONAB Growth factor receptor-bound prote... | 51 | 0.032 | 40.8 | 35 | 59 | GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | | | | | | | | | | | | 261 | P62993 | 217 | GRB2_HUMAN Growth factor receptor-bound prote... | 51 | 0.032 | 40.8 | 35 | 59 | GO:0005829; C:cytosol; TAS:HGNC.::GO:0005768; C:endosome; IDA:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0070436; C:Grb2-EGFR complex; IDA:BHF-UCL.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0005154; F:epidermal growth factor receptor binding; IPI:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; IPI:UniProtKB.::GO:0005168; F:neurotrophin TRKA receptor binding; IPI:UniProtKB.::GO:0019901; F:protein kinase binding; IPI:BHF-UCL.::GO:0005070; F:SH3/SH2 adaptor activity; TAS:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0007267; P:cell-cell signaling; TAS:UniProtKB.::GO:0071479; P:cellular response to ionizing radiation; IMP:BHF-UCL.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:UniProtKB.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0008286; P:insulin receptor signaling pathway; IPI:UniProtKB.::GO:0044419; P:interspecies interaction between organisms; IEA:UniProtKB-KW.::GO:0050900; P:leukocyte migration; TAS:Reactome.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IMP:BHF-UCL.::GO:0007265; P:Ras protein signal transduction; TAS:UniProtKB.::GO:0031623; P:receptor internalization; IMP:BHF-UCL.::GO:0042770; P:signal transduction in response to DNA damage; IMP:BHF-UCL.::GO:0031295; P:T cell costimulation; TAS:Reactome. | 262 | Q60631 | 217 | GRB2_MOUSE Growth factor receptor-bound prote... | 51 | 0.031 | 41.2 | 35 | 59 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IDA:MGI.::GO:0012506; C:vesicle membrane; IDA:MGI. | | | | | | | | | | GO:0046875; F:ephrin receptor binding; IPI:UniProtKB.::GO:0019904; F:protein domain specific binding; IPI:MGI.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0005070; F:SH3/SH2 adaptor activity; IDA:MGI. | | | | | | | | | | GO:0048646; P:anatomical structure formation involved in morphogenesis; IMP:MGI.::GO:0060670; P:branching involved in embryonic placenta morphogenesis; IMP:MGI.::GO:0030154; P:cell differentiation; IMP:MGI.::GO:0030838; P:positive regulation of actin filament polymerization; IGI:MGI.::GO:0007265; P:Ras protein signal transduction; TAS:MGI.::GO:0043408; P:regulation of MAPK cascade; IGI:MGI. | 263 | Q60598 | 546 | SRC8_MOUSE Src substrate cortactin OS=Mus mus... | 50 | 0.000009 | 53.5 | 46 | 60 | GO:0005938; C:cell cortex; IDA:MGI.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | | 264 | Q14247 | 550 | SRC8_HUMAN Src substrate cortactin OS=Homo sa... | 50 | 0.000009 | 53.5 | 46 | 60 | GO:0005938; C:cell cortex; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; TAS:ProtInc.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB.::GO:0005625; C:soluble fraction; TAS:ProtInc. | | | | | | | | | | GO:0005515; F:protein binding; IPI:UniProtKB. | | | | | | | | | | | 265 | P97814 | 415 | PPIP1_MOUSE Proline-serine-threonine phosphat... | 71 | 0.000009 | 53.1 | 37 | 49 | GO:0005826; C:actomyosin contractile ring; IDA:MGI.::GO:0032154; C:cleavage furrow; IDA:MGI.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.::GO:0001725; C:stress fiber; IDA:MGI. | | | | | | | | | | GO:0003779; F:actin binding; IDA:MGI.::GO:0016491; F:oxidoreductase activity; IEA:InterPro.::GO:0019903; F:protein phosphatase binding; IDA:MGI. | | | | | | | | | | GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0000910; P:cytokinesis; IC:MGI. | 266 | Q9JHL4 | 436 | DBNL_RAT Drebrin-like protein OS=Rattus norve... | 57 | 0.000009 | 53.1 | 44 | 61 | GO:0005938; C:cell cortex; ISS:UniProtKB.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0014069; C:postsynaptic density; IDA:RGD. | | | | | | | | | | | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0016601; P:Rac protein signal transduction; ISS:UniProtKB. | 267 | Q62418 | 436 | DBNL_MOUSE Drebrin-like protein OS=Mus muscul... | 57 | 0.000009 | 53.1 | 44 | 61 | GO:0005938; C:cell cortex; IDA:MGI.::GO:0030027; C:lamellipodium; IDA:UniProtKB.::GO:0001726; C:ruffle; IDA:UniProtKB. | | | | | | | | | | GO:0051015; F:actin filament binding; IDA:UniProtKB.::GO:0019904; F:protein domain specific binding; IDA:MGI. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0016601; P:Rac protein signal transduction; IDA:MGI. | 268 | Q9UJU6 | 430 | DBNL_HUMAN Drebrin-like protein OS=Homo sapie... | 82 | 0.000009 | 53.1 | 37 | 54 | GO:0005938; C:cell cortex; ISS:UniProtKB.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; ISS:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; ISS:UniProtKB.::GO:0008047; F:enzyme activator activity; TAS:ProtInc. | | | | | | | | | | GO:0007257; P:activation of JUN kinase activity; TAS:ProtInc.::GO:0006921; P:cellular component disassembly involved in apoptotic process; TAS:Reactome.::GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0016601; P:Rac protein signal transduction; ISS:UniProtKB. | 269 | Q66II3 | 229 | GRB2_XENTR Growth factor receptor-bound prote... | 55 | 0.029 | 41.2 | 35 | 56 | GO:0005768; C:endosome; ISS:UniProtKB.::GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; ISS:UniProtKB. | | | | | | | | | | GO:0005154; F:epidermal growth factor receptor binding; ISS:UniProtKB.::GO:0043560; F:insulin receptor substrate binding; ISS:UniProtKB. | | | | | | | | | | GO:0008286; P:insulin receptor signaling pathway; ISS:UniProtKB.::GO:0007126; P:meiosis; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 270 | P25020 | 526 | SRC_RSVH1 Tyrosine-protein kinase transformin... | 105 | 0.00001 | 53.1 | 29 | 47 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004715; F:non-membrane spanning protein tyrosine kinase activity; IEA:EC. | | | | | | | | | | | 271 | Q7ZXQ9 | 447 | DBNLA_XENLA Drebrin-like protein A OS=Xenopus... | 57 | 0.00001 | 53.1 | 44 | 60 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0030027; C:lamellipodium; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0003779; F:actin binding; IEA:UniProtKB-KW. | | | | | | | | | | |
