| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
121 | P47197 | 481 | AKT2_RAT RAC-beta serine/threonine-protein ki... | 142 | 2e-19 | 97.8 | 36 | 55 | GO:0005829; C:cytosol; IDA:RGD.::GO:0032593; C:insulin-responsive compartment; IDA:RGD.::GO:0005792; C:microsome; IDA:RGD.::GO:0005739; C:mitochondrion; IDA:RGD.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0005625; C:soluble fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:RGD.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005080; F:protein kinase C binding; IPI:RGD.::GO:0004674; F:protein serine/threonine kinase activity; IDA:RGD. | | | | | | | | | | GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0043066; P:negative regulation of apoptotic process; IMP:RGD.::GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:RGD.::GO:0033119; P:negative regulation of RNA splicing; IMP:RGD.::GO:0030335; P:positive regulation of cell migration; IMP:RGD.::GO:0046326; P:positive regulation of glucose import; IMP:RGD.::GO:0045429; P:positive regulation of nitric oxide biosynthetic process; IMP:RGD.::GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IMP:RGD.::GO:0050927; P:positive regulation of positive chemotaxis; IDA:RGD.::GO:0009967; P:positive regulation of signal transduction; IMP:RGD.::GO:0010765; P:positive regulation of sodium ion transport; IMP:MGI.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:RGD.::GO:0043491; P:protein kinase B signaling cascade; IMP:RGD.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.::GO:0014850; P:response to muscle activity; IEP:RGD.::GO:0006970; P:response to osmotic stress; IEP:RGD. | 122 | O54874 | 1732 | MRCKA_RAT Serine/threonine-protein kinase MRC... | 164 | 4e-21 | 105 | 35 | 54 | GO:0042641; C:actomyosin; IDA:UniProtKB.::GO:0031252; C:cell leading edge; IDA:UniProtKB.::GO:0005911; C:cell-cell junction; IDA:UniProtKB.::GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0042802; F:identical protein binding; IPI:UniProtKB.::GO:0000287; F:magnesium ion binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0031532; P:actin cytoskeleton reorganization; IDA:UniProtKB.::GO:0031032; P:actomyosin structure organization; IMP:UniProtKB.::GO:0016477; P:cell migration; IMP:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IDA:UniProtKB. | 123 | Q5R7A7 | 496 | SGK3_PONAB Serine/threonine-protein kinase Sg... | 174 | 4e-22 | 106 | 37 | 54 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro. | 124 | Q96BR1 | 496 | SGK3_HUMAN Serine/threonine-protein kinase Sg... | 174 | 4e-22 | 106 | 37 | 54 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.::GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005246; F:calcium channel regulator activity; TAS:UniProtKB.::GO:0017081; F:chloride channel regulator activity; TAS:UniProtKB.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0015459; F:potassium channel regulator activity; TAS:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc.::GO:0017080; F:sodium channel regulator activity; TAS:UniProtKB. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro.::GO:0001558; P:regulation of cell growth; TAS:UniProtKB.::GO:0030334; P:regulation of cell migration; TAS:UniProtKB.::GO:0042127; P:regulation of cell proliferation; TAS:UniProtKB.::GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity; TAS:UniProtKB.::GO:0006950; P:response to stress; TAS:ProtInc. | 125 | P10102 | 672 | KPCA_RABIT Protein kinase C alpha type OS=Ory... | 147 | 1e-17 | 93.2 | 33 | 54 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.::GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.::GO:0045785; P:positive regulation of cell adhesion; ISS:UniProtKB.::GO:2000707; P:positive regulation of dense core granule biogenesis; ISS:UniProtKB.::GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0045651; P:positive regulation of macrophage differentiation; ISS:UniProtKB.::GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB. | 126 | Q3UU96 | 1719 | MRCKA_MOUSE Serine/threonine-protein kinase M... | 164 | 5e-21 | 105 | 35 | 54 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0000226; P:microtubule cytoskeleton organization; IMP:MGI.::GO:0007097; P:nuclear migration; IMP:MGI. | 127 | P40376 | 512 | KAPB_SCHPO cAMP-dependent protein kinase cata... | 142 | 7e-21 | 102 | 38 | 57 | GO:0005952; C:cAMP-dependent protein kinase complex; TAS:PomBase.::GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IGI:PomBase.::GO:0005515; F:protein binding; IPI:PomBase. | | | | | | | | | | GO:0051519; P:activation of bipolar cell growth; IMP:PomBase.::GO:0001315; P:age-dependent response to reactive oxygen species; IMP:PomBase.::GO:0019933; P:cAMP-mediated signaling; IC:PomBase.::GO:0001300; P:chronological cell aging; IGI:PomBase.::GO:0031142; P:induction of conjugation upon nitrogen starvation; IMP:PomBase.::GO:0031138; P:negative regulation of conjugation with cellular fusion; IMP:PomBase.::GO:0045014; P:negative regulation of transcription by glucose; IMP:PomBase.::GO:0006110; P:regulation of glycolysis; NAS:PomBase. | 128 | Q9ERE3 | 496 | SGK3_MOUSE Serine/threonine-protein kinase Sg... | 174 | 3e-23 | 109 | 38 | 54 | GO:0016023; C:cytoplasmic membrane-bounded vesicle; IDA:MGI.::GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.::GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:MGI. | | | | | | | | | | GO:0006916; P:anti-apoptosis; IDA:MGI.::GO:0007154; P:cell communication; IEA:InterPro. | 129 | P04409 | 672 | KPCA_BOVIN Protein kinase C alpha type OS=Bos... | 147 | 1e-17 | 92.8 | 33 | 54 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.::GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.::GO:0045785; P:positive regulation of cell adhesion; ISS:UniProtKB.::GO:2000707; P:positive regulation of dense core granule biogenesis; ISS:UniProtKB.::GO:0010595; P:positive regulation of endothelial cell migration; ISS:UniProtKB.::GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0045651; P:positive regulation of macrophage differentiation; ISS:UniProtKB.::GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB. | 130 | Q16974 | 649 | KPC1_APLCA Calcium-dependent protein kinase C... | 146 | 2e-16 | 89 | 31 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 131 | Q64617 | 683 | KPCL_RAT Protein kinase C eta type OS=Rattus ... | 141 | 0.000000000000003 | 85.5 | 35 | 53 | GO:0005829; C:cytosol; IDA:RGD.::GO:0005624; C:membrane fraction; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004699; F:calcium-independent protein kinase C activity; IDA:RGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0050861; P:positive regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0060252; P:positive regulation of glial cell proliferation; ISS:UniProtKB.::GO:0045618; P:positive regulation of keratinocyte differentiation; ISS:UniProtKB.::GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:0070528; P:protein kinase C signaling cascade; IMP:RGD.::GO:2000810; P:regulation of tight junction assembly; ISS:UniProtKB. | 132 | P23298 | 683 | KPCL_MOUSE Protein kinase C eta type OS=Mus m... | 141 | 0.000000000000002 | 85.9 | 35 | 53 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; IEA:EC.::GO:0017160; F:Ral GTPase binding; IPI:UniProtKB. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0050861; P:positive regulation of B cell receptor signaling pathway; ISS:UniProtKB.::GO:0060252; P:positive regulation of glial cell proliferation; ISS:UniProtKB.::GO:0045618; P:positive regulation of keratinocyte differentiation; IMP:UniProtKB.::GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; IMP:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; ISS:UniProtKB.::GO:2000810; P:regulation of tight junction assembly; ISS:UniProtKB. | 133 | Q2PJ68 | 463 | SGK1_CAEEL Serine/threonine-protein kinase sg... | 175 | 1e-20 | 101 | 33 | 51 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007154; P:cell communication; IEA:InterPro.::GO:0043053; P:dauer entry; IMP:WormBase.::GO:0008340; P:determination of adult lifespan; IMP:WormBase.::GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.::GO:0019915; P:lipid storage; IMP:WormBase.::GO:0018991; P:oviposition; IMP:WormBase.::GO:0040018; P:positive regulation of multicellular organism growth; IMP:WormBase.::GO:0006950; P:response to stress; IEA:UniProtKB-KW. | 134 | P05696 | 672 | KPCA_RAT Protein kinase C alpha type OS=Rattu... | 147 | 1e-17 | 93.2 | 33 | 54 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0045121; C:membrane raft; IDA:RGD.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.::GO:0019717; C:synaptosome; IDA:RGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004698; F:calcium-dependent protein kinase C activity; IDA:RGD.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007568; P:aging; IEP:RGD.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0021955; P:central nervous system neuron axonogenesis; IMP:RGD.::GO:0045184; P:establishment of protein localization; TAS:UniProtKB.::GO:0035556; P:intracellular signal transduction; IDA:RGD.::GO:0007611; P:learning or memory; IMP:RGD.::GO:0034351; P:negative regulation of glial cell apoptotic process; ISS:UniProtKB.::GO:0045822; P:negative regulation of heart contraction; IMP:RGD.::GO:0017148; P:negative regulation of translation; IMP:RGD.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:RGD.::GO:0045766; P:positive regulation of angiogenesis; ISS:UniProtKB.::GO:0010613; P:positive regulation of cardiac muscle hypertrophy; IDA:UniProtKB.::GO:0045785; P:positive regulation of cell adhesion; ISS:UniProtKB.::GO:2000707; P:positive regulation of dense core granule biogenesis; ISS:UniProtKB.::GO:0001938; P:positive regulation of endothelial cell proliferation; ISS:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:UniProtKB.::GO:0045921; P:positive regulation of exocytosis; IMP:RGD.::GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; ISS:UniProtKB.::GO:0045651; P:positive regulation of macrophage differentiation; ISS:UniProtKB.::GO:0045931; P:positive regulation of mitotic cell cycle; ISS:UniProtKB.::GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.::GO:0051965; P:positive regulation of synapse assembly; IMP:RGD.::GO:0046777; P:protein autophosphorylation; IDA:RGD.::GO:0090330; P:regulation of platelet aggregation; ISS:UniProtKB.::GO:0048259; P:regulation of receptor-mediated endocytosis; IMP:RGD.::GO:0046677; P:response to antibiotic; IEP:RGD.::GO:0051412; P:response to corticosterone stimulus; IEP:RGD.::GO:0032355; P:response to estradiol stimulus; IMP:RGD.::GO:0045471; P:response to ethanol; IMP:RGD.::GO:0009612; P:response to mechanical stimulus; IEP:RGD.::GO:0014070; P:response to organic cyclic compound; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IEP:RGD.::GO:0000302; P:response to reactive oxygen species; IMP:RGD.::GO:0009636; P:response to toxin; IEP:RGD. | 135 | P17252 | 672 | KPCA_HUMAN Protein kinase C alpha type OS=Hom... | 147 | 2e-17 | 92.4 | 33 | 54 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005783; C:endoplasmic reticulum; IDA:BHF-UCL.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.::GO:0005654; C:nucleoplasm; TAS:Reactome.::GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0019899; F:enzyme binding; IPI:BHF-UCL.::GO:0035403; F:histone kinase activity (H3-T6 specific); IDA:UniProtKB.::GO:0004697; F:protein kinase C activity; TAS:ProtInc.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; TAS:Reactome.::GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.::GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.::GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.::GO:0008543; P:fibroblast growth factor receptor signaling pathway; TAS:Reactome.::GO:0010467; P:gene expression; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:ProtInc.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016071; P:mRNA metabolic process; TAS:Reactome.::GO:0034351; P:negative regulation of glial cell apoptotic process; IMP:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0045766; P:positive regulation of angiogenesis; IMP:UniProtKB.::GO:0043536; P:positive regulation of blood vessel endothelial cell migration; IDA:DFLAT.::GO:0010613; P:positive regulation of cardiac muscle hypertrophy; ISS:UniProtKB.::GO:0045785; P:positive regulation of cell adhesion; IMP:UniProtKB.::GO:2000707; P:positive regulation of dense core granule biogenesis; ISS:UniProtKB.::GO:0001938; P:positive regulation of endothelial cell proliferation; IMP:UniProtKB.::GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.::GO:0031666; P:positive regulation of lipopolysaccharide-mediated signaling pathway; IMP:UniProtKB.::GO:0045651; P:positive regulation of macrophage differentiation; ISS:UniProtKB.::GO:0045931; P:positive regulation of mitotic cell cycle; IMP:UniProtKB.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0090330; P:regulation of platelet aggregation; IDA:UniProtKB.::GO:0070555; P:response to interleukin-1; IMP:BHF-UCL.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 136 | Q9W1B0 | 1637 | GEK_DROME Serine/threonine-protein kinase Gen... | 148 | 6e-19 | 98.2 | 36 | 54 | GO:0030424; C:axon; IDA:FlyBase.::GO:0030426; C:growth cone; IDA:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0008154; P:actin polymerization or depolymerization; IMP:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0030833; P:regulation of actin filament polymerization; IMP:UniProtKB.::GO:0008039; P:synaptic target recognition; IMP:FlyBase. | 137 | Q15349 | 733 | KS6A2_HUMAN Ribosomal protein S6 kinase alpha... | 109 | 0.000007 | 55.1 | 31 | 50 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005654; C:nucleoplasm; TAS:Reactome. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; TAS:ProtInc. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0045087; P:innate immune response; TAS:Reactome.::GO:0002755; P:MyD88-dependent toll-like receptor signaling pathway; TAS:Reactome.::GO:0045786; P:negative regulation of cell cycle; IDA:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; IDA:UniProtKB.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0043065; P:positive regulation of apoptotic process; IDA:UniProtKB.::GO:0051403; P:stress-activated MAPK cascade; TAS:Reactome.::GO:0007268; P:synaptic transmission; TAS:Reactome.::GO:0008063; P:Toll signaling pathway; TAS:Reactome.::GO:0034130; P:toll-like receptor 1 signaling pathway; TAS:Reactome.::GO:0034134; P:toll-like receptor 2 signaling pathway; TAS:Reactome.::GO:0034138; P:toll-like receptor 3 signaling pathway; TAS:Reactome.::GO:0034142; P:toll-like receptor 4 signaling pathway; TAS:Reactome.::GO:0035666; P:TRIF-dependent toll-like receptor signaling pathway; TAS:Reactome. | 138 | P49025 | 2055 | CTRO_MOUSE Citron Rho-interacting kinase OS=M... | 145 | 0.000000002 | 67.4 | 34 | 52 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB.::GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.::GO:0005083; F:small GTPase regulator activity; IEA:InterPro. | | | | | | | | | | GO:0033205; P:cell cycle cytokinesis; ISS:UniProtKB.::GO:0048699; P:generation of neurons; IDA:UniProtKB.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007067; P:mitosis; IDA:UniProtKB. | 139 | P24723 | 683 | KPCL_HUMAN Protein kinase C eta type OS=Homo ... | 141 | 0.000000000000005 | 84.3 | 35 | 52 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; TAS:ProtInc. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0034351; P:negative regulation of glial cell apoptotic process; IMP:UniProtKB.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0050861; P:positive regulation of B cell receptor signaling pathway; IMP:UniProtKB.::GO:0060252; P:positive regulation of glial cell proliferation; IMP:UniProtKB.::GO:0045618; P:positive regulation of keratinocyte differentiation; ISS:UniProtKB.::GO:0010744; P:positive regulation of macrophage derived foam cell differentiation; ISS:UniProtKB.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.::GO:2000810; P:regulation of tight junction assembly; IMP:UniProtKB. | 140 | P10666 | 629 | KS6AB_XENLA Ribosomal protein S6 kinase 2 bet... | 53 | 0.13 | 40.8 | 42 | 57 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | | 141 | P31751 | 481 | AKT2_HUMAN RAC-beta serine/threonine-protein ... | 142 | 8e-20 | 98.6 | 37 | 56 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; TAS:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB. | | | | | | | | | | GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.::GO:0045444; P:fat cell differentiation; TAS:UniProtKB.::GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.::GO:0005978; P:glycogen biosynthetic process; IEA:UniProtKB-KW.::GO:0008286; P:insulin receptor signaling pathway; TAS:UniProtKB.::GO:0060644; P:mammary gland epithelial cell differentiation; TAS:UniProtKB.::GO:0010748; P:negative regulation of plasma membrane long-chain fatty acid transport; IMP:BHF-UCL.::GO:0032000; P:positive regulation of fatty acid beta-oxidation; IMP:BHF-UCL.::GO:0046326; P:positive regulation of glucose import; IMP:BHF-UCL.::GO:0045725; P:positive regulation of glycogen biosynthetic process; IMP:BHF-UCL.::GO:0071156; P:regulation of cell cycle arrest; TAS:UniProtKB.::GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. | 142 | P06245 | 380 | KAPB_YEAST cAMP-dependent protein kinase type... | 166 | 3e-18 | 92.4 | 32 | 51 | GO:0005952; C:cAMP-dependent protein kinase complex; IDA:SGD.::GO:0005634; C:nucleus; IDA:SGD. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004691; F:cAMP-dependent protein kinase activity; IDA:SGD.::GO:0005515; F:protein binding; IPI:IntAct. | | | | | | | | | | GO:0001403; P:invasive growth in response to glucose limitation; IMP:SGD.::GO:0007265; P:Ras protein signal transduction; ISS:SGD. | 143 | P28178 | 479 | PK2_DICDI Protein kinase 2 OS=Dictyostelium d... | 145 | 2e-18 | 94.4 | 34 | 54 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006935; P:chemotaxis; IEA:UniProtKB-KW. | 144 | Q12706 | 436 | PSK1_SCHPO Serine/threonine-protein kinase ps... | 141 | 6e-18 | 92.4 | 37 | 55 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004693; F:cyclin-dependent protein kinase activity; IEA:EC. | | | | | | | | | | GO:0007165; P:signal transduction; IC:PomBase. | 145 | P13677 | 700 | KPC2_DROME Protein kinase C, eye isozyme OS=D... | 159 | 3e-18 | 95.1 | 33 | 51 | GO:0016027; C:inaD signaling complex; TAS:FlyBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004697; F:protein kinase C activity; ISS:FlyBase.::GO:0008270; F:zinc ion binding; IEA:InterPro. | | | | | | | | | | GO:0016062; P:adaptation of rhodopsin mediated signaling; IMP:FlyBase.::GO:0019722; P:calcium-mediated signaling; TAS:FlyBase.::GO:0006928; P:cellular component movement; IMP:FlyBase.::GO:0016059; P:deactivation of rhodopsin mediated signaling; IMP:FlyBase.::GO:0008585; P:female gonad development; IMP:FlyBase.::GO:0030845; P:inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway; IMP:FlyBase.::GO:0006911; P:phagocytosis, engulfment; IMP:FlyBase.::GO:0045471; P:response to ethanol; IDA:FlyBase. | 146 | P83099 | 671 | KPC4_DROME Putative protein kinase C delta ty... | 140 | 5e-18 | 94.4 | 39 | 56 | | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 147 | P34885 | 707 | KPC1B_CAEEL Protein kinase C-like 1B OS=Caeno... | 142 | 1e-17 | 93.2 | 35 | 56 | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.::GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004697; F:protein kinase C activity; IEA:EC. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro. | 148 | Q9USX7 | 526 | PPK22_SCHPO Serine/threonine-protein kinase p... | 131 | 4e-16 | 87.4 | 32 | 51 | GO:0005829; C:cytosol; IDA:PomBase. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0004674; F:protein serine/threonine kinase activity; TAS:PomBase. | | | | | | | | | | GO:0019236; P:response to pheromone; ISS:PomBase.::GO:0007165; P:signal transduction; NAS:PomBase. | 149 | Q9WUT3 | 733 | KS6A2_MOUSE Ribosomal protein S6 kinase alpha... | 122 | 0.000007 | 54.7 | 30 | 51 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0005634; C:nucleus; ISS:UniProtKB.::GO:0005819; C:spindle; IDA:MGI. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:MGI.::GO:0004711; F:ribosomal protein S6 kinase activity; IDA:MGI. | | | | | | | | | | GO:0002035; P:brain renin-angiotensin system; IDA:MGI.::GO:0010659; P:cardiac muscle cell apoptotic process; IDA:MGI.::GO:0071322; P:cellular response to carbohydrate stimulus; IDA:MGI.::GO:0060047; P:heart contraction; IDA:MGI.::GO:0007507; P:heart development; IDA:MGI.::GO:0007243; P:intracellular protein kinase cascade; IEA:InterPro.::GO:0000089; P:mitotic metaphase; IDA:MGI.::GO:0045786; P:negative regulation of cell cycle; ISS:UniProtKB.::GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.::GO:0001556; P:oocyte maturation; IDA:MGI.::GO:0018105; P:peptidyl-serine phosphorylation; IDA:MGI.::GO:0043065; P:positive regulation of apoptotic process; ISS:UniProtKB.::GO:0010628; P:positive regulation of gene expression; IDA:MGI.::GO:0070613; P:regulation of protein processing; IDA:MGI. | 150 | Q9WVC6 | 431 | SGK1_MOUSE Serine/threonine-protein kinase Sg... | 140 | 4e-22 | 105 | 36 | 57 | GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.::GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005524; F:ATP binding; IEA:UniProtKB-KW.::GO:0005515; F:protein binding; IPI:UniProtKB.::GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.::GO:0006974; P:response to DNA damage stimulus; IDA:MGI. | 151 | O75676 | 772 | KS6A4_HUMAN Ribosomal protein S6 kinase alpha... | 147 | 0.002 | 47 | 28 | 49 | GO:0005737; C:cytoplasm; IDA:HPA.::GO:0005634; C:nucleus; IDA:UniProtKB. | | | | | | | | | | GO:0005524; F:ATP binding; IDA:UniProtKB.::GO:0000287; F:magnesium ion binding; IEA:InterPro.::GO:0048273; F:mitogen-activated protein kinase p38 binding; IGI:UniProtKB.::GO:0004711; F:ribosomal protein S6 kinase activity; NAS:UniProtKB. | | | | | | | | | | GO:0007411; P:axon guidance; TAS:Reactome.::GO:0043987; P:histone H3-S10 phosphorylation; IMP:UniProtKB.::GO:0043988; P:histone H3-S28 phosphorylation; IMP:UniProtKB.::GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.::GO:0070498; P:interleukin-1-mediated signaling pathway; IMP:BHF-UCL.::GO:0007243; P:intracellular protein kinase cascade; IDA:UniProtKB.::GO:0001818; P:negative regulation of cytokine production; TAS:UniProtKB.::GO:0032793; P:positive regulation of CREB transcription factor activity; TAS:UniProtKB.::GO:0035066; P:positive regulation of histone acetylation; IMP:BHF-UCL.::GO:0033129; P:positive regulation of histone phosphorylation; IMP:BHF-UCL.::GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; TAS:UniProtKB.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL. |
