| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | Q15147 | 1175 | PLCB4_HUMAN 1-phosphatidylinositol 4,5-bispho... | 416 | 6e-33 | 138 | 27 | 42 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 32 | P13217 | 1095 | PIPA_DROME 1-phosphatidylinositol 4,5-bisphos... | 396 | 5e-32 | 135 | 28 | 42 | GO:0016027; C:inaD signaling complex; IPI:FlyBase.::GO:0005624; C:membrane fraction; IDA:FlyBase. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005096; F:GTPase activator activity; NAS:FlyBase.::GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:FlyBase.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008344; P:adult locomotory behavior; IMP:FlyBase.::GO:0019722; P:calcium-mediated signaling; TAS:FlyBase.::GO:0016059; P:deactivation of rhodopsin mediated signaling; IDA:FlyBase.::GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IMP:FlyBase.::GO:0006651; P:diacylglycerol biosynthetic process; TAS:FlyBase.::GO:0051482; P:elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger; TAS:FlyBase.::GO:0009649; P:entrainment of circadian clock; IMP:FlyBase.::GO:0008377; P:light-induced release of internally sequestered calcium ion; TAS:FlyBase.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0002385; P:mucosal immune response; IMP:FlyBase.::GO:0046673; P:negative regulation of compound eye retinal cell programmed cell death; IMP:FlyBase.::GO:0046488; P:phosphatidylinositol metabolic process; IMP:FlyBase.::GO:0008654; P:phospholipid biosynthetic process; TAS:FlyBase.::GO:0045494; P:photoreceptor cell maintenance; IMP:FlyBase.::GO:0043052; P:thermotaxis; IMP:FlyBase. | 33 | Q15111 | 1095 | PLCL1_HUMAN Inactive phospholipase C-like pro... | 469 | 4e-31 | 132 | 27 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; TAS:ProtInc.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 34 | Q62688 | 1096 | PLCL1_RAT Inactive phospholipase C-like prote... | 469 | 4e-30 | 129 | 27 | 45 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 35 | Q3USB7 | 1096 | PLCL1_MOUSE Inactive phospholipase C-like pro... | 471 | 2e-29 | 127 | 27 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0050811; F:GABA receptor binding; TAS:MGI.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:InterPro.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007610; P:behavior; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006629; P:lipid metabolic process; IEA:InterPro. | 36 | Q8GV43 | 613 | PLCD6_ARATH Phosphoinositide phospholipase C ... | 554 | 2e-25 | 114 | 23 | 38 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 37 | Q01970 | 1234 | PLCB3_HUMAN 1-phosphatidylinositol 4,5-bispho... | 141 | 0.0000000000002 | 77.4 | 33 | 49 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IPI:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 38 | Q99JE6 | 1234 | PLCB3_RAT 1-phosphatidylinositol 4,5-bisphosp... | 141 | 0.0000000000004 | 76.3 | 32 | 49 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005626; C:insoluble fraction; IDA:UniProtKB.::GO:0042383; C:sarcolemma; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; NAS:UniProtKB. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IDA:UniProtKB.::GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:RGD. | 39 | P51432 | 1234 | PLCB3_MOUSE 1-phosphatidylinositol 4,5-bispho... | 141 | 0.0000000000002 | 77.4 | 33 | 49 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 40 | P25455 | 1318 | PIP1_DROME 1-phosphatidylinositol 4,5-bisphos... | 240 | 0.0000000003 | 67.4 | 26 | 41 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007629; P:flight behavior; IGI:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 41 | Q4KWH8 | 1693 | PLCH1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 285 | 0.000000000000008 | 82 | 26 | 43 | GO:0031965; C:nuclear membrane; IDA:HPA. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0050429; F:calcium-dependent phospholipase C activity; IDA:MGI.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:MGI. | 42 | Q95JS1 | 641 | PLCZ1_MACFA 1-phosphatidylinositol 4,5-bispho... | 147 | 6e-22 | 103 | 41 | 52 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007338; P:single fertilization; IEA:UniProtKB-KW. | 43 | O89040 | 1183 | PLCB2_RAT 1-phosphatidylinositol 4,5-bisphosp... | 185 | 0.000000000004 | 73.2 | 30 | 46 | GO:0005829; C:cytosol; IDA:RGD.::GO:0031680; C:G-protein beta/gamma-subunit complex; IDA:RGD.::GO:0005794; C:Golgi apparatus; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0031683; F:G-protein beta/gamma-subunit complex binding; IDA:RGD.::GO:0004435; F:phosphatidylinositol phospholipase C activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IDA:RGD.::GO:0004871; F:signal transducer activity; IDA:UniProtKB. | | | | | | | | | | GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.::GO:0009395; P:phospholipid catabolic process; NAS:UniProtKB. | 44 | Q7YRU3 | 636 | PLCZ1_PIG 1-phosphatidylinositol 4,5-bisphosp... | 147 | 9e-22 | 103 | 39 | 53 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0007338; P:single fertilization; IEA:UniProtKB-KW. | 45 | A3KGF7 | 1181 | PLCB2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 190 | 0.000000000002 | 73.9 | 30 | 46 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 46 | Q4KWH5 | 1682 | PLCH1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 285 | 0.000000000000003 | 83.2 | 26 | 43 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 47 | O75038 | 1416 | PLCH2_HUMAN 1-phosphatidylinositol 4,5-bispho... | 217 | 0.0000000002 | 67.8 | 26 | 42 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 48 | Q07722 | 1023 | PLCB4_BOVIN 1-phosphatidylinositol 4,5-bispho... | 193 | 0.00000000007 | 68.9 | 30 | 47 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 49 | A2AP18 | 1501 | PLCH2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 214 | 0.00000000005 | 69.7 | 27 | 43 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0046488; P:phosphatidylinositol metabolic process; IDA:MGI. | 50 | Q944C2 | 578 | PLCD5_ARATH Phosphoinositide phospholipase C ... | 527 | 1e-19 | 96.7 | 24 | 39 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 51 | Q99P84 | 2281 | PLCE1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 207 | 0.000000000003 | 73.9 | 29 | 44 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0017016; F:Ras GTPase binding; IDA:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; ISS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007265; P:Ras protein signal transduction; IDA:RGD.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB. | 52 | Q9P212 | 2302 | PLCE1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 207 | 0.000000000002 | 74.3 | 29 | 44 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:UniProtKB.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005085; F:guanyl-nucleotide exchange factor activity; TAS:UniProtKB.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0017016; F:Ras GTPase binding; TAS:UniProtKB.::GO:0005057; F:receptor signaling protein activity; TAS:UniProtKB. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; IDA:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; IDA:UniProtKB.::GO:0007205; P:activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway; NAS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; NAS:UniProtKB.::GO:0008283; P:cell proliferation; NAS:UniProtKB.::GO:0007010; P:cytoskeleton organization; NAS:UniProtKB.::GO:0006651; P:diacylglycerol biosynthetic process; TAS:UniProtKB.::GO:0007204; P:elevation of cytosolic calcium ion concentration; TAS:UniProtKB.::GO:0007173; P:epidermal growth factor receptor signaling pathway; NAS:UniProtKB.::GO:0032835; P:glomerulus development; IMP:HGNC.::GO:0007507; P:heart development; TAS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0006644; P:phospholipid metabolic process; IC:UniProtKB.::GO:0007265; P:Ras protein signal transduction; TAS:UniProtKB.::GO:0001558; P:regulation of cell growth; TAS:UniProtKB.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IDA:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; IDA:UniProtKB.::GO:0006940; P:regulation of smooth muscle contraction; TAS:UniProtKB. | 53 | Q944C1 | 597 | PLCD4_ARATH Phosphoinositide phospholipase C ... | 374 | 1e-19 | 96.3 | 24 | 40 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 54 | Q8K4S1 | 2282 | PLCE1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 207 | 0.000000000002 | 74.3 | 29 | 44 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; ISS:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0019899; F:enzyme binding; ISS:UniProtKB.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.::GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.::GO:0007200; P:activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger; ISS:UniProtKB.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:UniProtKB.::GO:0046578; P:regulation of Ras protein signal transduction; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 55 | Q39032 | 561 | PLCD1_ARATH Phosphoinositide phospholipase C ... | 514 | 2e-19 | 95.9 | 24 | 38 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.::GO:0009414; P:response to water deprivation; IEP:TAIR. | 56 | Q8CIH5 | 1265 | PLCG2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 184 | 0.0000000000003 | 76.6 | 33 | 46 | GO:0005829; C:cytosol; IMP:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0032237; P:activation of store-operated calcium channel activity; IMP:MGI.::GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.::GO:0002316; P:follicular B cell differentiation; IMP:MGI.::GO:0032959; P:inositol trisphosphate biosynthetic process; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043069; P:negative regulation of programmed cell death; IMP:MGI.::GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0010468; P:regulation of gene expression; IMP:MGI.::GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; IDA:MGI.::GO:0050852; P:T cell receptor signaling pathway; IDA:MGI. | 57 | P24135 | 1265 | PLCG2_RAT 1-phosphatidylinositol 4,5-bisphosp... | 184 | 0.00000000000002 | 80.9 | 34 | 46 | GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:RGD.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.::GO:0033198; P:response to ATP; IDA:RGD.::GO:0032026; P:response to magnesium ion; IDA:RGD. | 58 | Q8K3R3 | 807 | PLCD4_MOUSE 1-phosphatidylinositol 4,5-bispho... | 275 | 0.000000000000003 | 82.8 | 27 | 43 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007340; P:acrosome reaction; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0046488; P:phosphatidylinositol metabolic process; TAS:MGI. | 59 | P16885 | 1265 | PLCG2_HUMAN 1-phosphatidylinositol 4,5-bispho... | 200 | 0.00000000000002 | 80.5 | 32 | 46 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; NAS:UniProtKB.::GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; TAS:UniProtKB. | 60 | Q62077 | 1302 | PLCG1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 299 | 0.000000000000004 | 82.8 | 28 | 43 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0035254; F:glutamate receptor binding; IPI:MGI.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0030971; F:receptor tyrosine kinase binding; IPI:UniProtKB.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0001701; P:in utero embryonic development; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; IDA:MGI. | 61 | P10686 | 1290 | PLCG1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 299 | 0.000000000000004 | 82.8 | 28 | 43 | GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0005886; C:plasma membrane; TAS:Reactome.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005158; F:insulin receptor binding; IDA:RGD.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0051219; F:phosphoprotein binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0006816; P:calcium ion transport; IMP:RGD.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0032959; P:inositol trisphosphate biosynthetic process; IMP:RGD.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0032236; P:positive regulation of calcium ion transport via store-operated calcium channel activity; IMP:RGD.::GO:0010634; P:positive regulation of epithelial cell migration; IMP:RGD.::GO:0009306; P:protein secretion; IMP:RGD.::GO:0009629; P:response to gravity; IEP:RGD.::GO:0042542; P:response to hydrogen peroxide; IEP:RGD.::GO:0043278; P:response to morphine; IEP:RGD.::GO:0010243; P:response to organic nitrogen; IEP:RGD. |
