| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | P33277 | 766 | GAP1_SCHPO GTPase-activating protein OS=Schiz... | 750 | 0 | 626 | 44 | 65 | GO:0005829; C:cytosol; IDA:PomBase.::GO:0005634; C:nucleus; IDA:PomBase. | | | | | | | | | | GO:0005099; F:Ras GTPase activator activity; IGI:PomBase. | | | | | | | | | | GO:0007265; P:Ras protein signal transduction; IC:PomBase.::GO:0032005; P:signal transduction involved in conjugation with cellular fusion; IMP:PomBase. | 2 | O00899 | 860 | GAPA_DICDI Ras GTPase-activating-like protein... | 676 | 2e-78 | 276 | 30 | 51 | GO:0005622; C:intracellular; IEA:InterPro. | | | | | | | | | | GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0051301; P:cell division; IEA:UniProtKB-KW.::GO:0006972; P:hyperosmotic response; IEP:dictyBase.::GO:0006979; P:response to oxidative stress; IEP:dictyBase.::GO:0019953; P:sexual reproduction; IEP:dictyBase.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 3 | Q54K32 | 822 | RGAA_DICDI Ras GTPase-activating-like protein... | 672 | 2e-77 | 272 | 28 | 53 | GO:0005938; C:cell cortex; TAS:dictyBase.::GO:0032154; C:cleavage furrow; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005516; F:calmodulin binding; ISS:dictyBase.::GO:0048365; F:Rac GTPase binding; IPI:dictyBase.::GO:0005099; F:Ras GTPase activator activity; IDA:dictyBase. | | | | | | | | | | GO:0000910; P:cytokinesis; IMP:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0031149; P:sorocarp stalk cell differentiation; IMP:dictyBase.::GO:0030435; P:sporulation resulting in formation of a cellular spore; IMP:dictyBase. | 4 | Q9JKF1 | 1657 | IQGA1_MOUSE Ras GTPase-activating-like protei... | 786 | 2e-56 | 215 | 24 | 47 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.::GO:0036057; C:slit diaphragm; ISS:UniProtKB. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 5 | P46940 | 1657 | IQGA1_HUMAN Ras GTPase-activating-like protei... | 780 | 2e-56 | 214 | 24 | 48 | GO:0005884; C:actin filament; TAS:ProtInc.::GO:0005737; C:cytoplasm; IDA:HPA.::GO:0030496; C:midbody; IDA:UniProtKB.::GO:0005634; C:nucleus; IDA:HPA.::GO:0036057; C:slit diaphragm; ISS:UniProtKB. | | | | | | | | | | GO:0005516; F:calmodulin binding; TAS:ProtInc.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0019903; F:protein phosphatase binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0006112; P:energy reserve metabolic process; TAS:Reactome.::GO:0072015; P:glomerular visceral epithelial cell development; ISS:UniProtKB.::GO:0050796; P:regulation of insulin secretion; TAS:Reactome.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.::GO:0044281; P:small molecule metabolic process; TAS:Reactome. | 6 | Q3UQ44 | 1575 | IQGA2_MOUSE Ras GTPase-activating-like protei... | 805 | 5e-55 | 210 | 24 | 47 | GO:0005622; C:intracellular; IEA:InterPro.::GO:0005902; C:microvillus; IDA:MGI. | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 7 | Q13576 | 1575 | IQGA2_HUMAN Ras GTPase-activating-like protei... | 805 | 5e-50 | 194 | 24 | 47 | GO:0015629; C:actin cytoskeleton; TAS:ProtInc. | | | | | | | | | | GO:0003779; F:actin binding; TAS:ProtInc.::GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005095; F:GTPase inhibitor activity; TAS:ProtInc.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 8 | Q86VI3 | 1631 | IQGA3_HUMAN Ras GTPase-activating-like protei... | 830 | 7e-50 | 194 | 24 | 47 | | | | | | | | | | | GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | | 9 | P50904 | 1038 | RASA1_RAT Ras GTPase-activating protein 1 OS=... | 318 | 2e-19 | 97.8 | 29 | 48 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; NAS:UniProtKB.::GO:0007155; P:cell adhesion; NAS:UniProtKB.::GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:UniProtKB.::GO:0030833; P:regulation of actin filament polymerization; ISS:UniProtKB.::GO:0007165; P:signal transduction; ISS:UniProtKB.::GO:0001570; P:vasculogenesis; ISS:UniProtKB. | 10 | P20936 | 1047 | RASA1_HUMAN Ras GTPase-activating protein 1 O... | 318 | 1e-18 | 95.1 | 28 | 46 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0001948; F:glycoprotein binding; IPI:UniProtKB.::GO:0051020; F:GTPase binding; IPI:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0019870; F:potassium channel inhibitor activity; NAS:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.::GO:0005102; F:receptor binding; IPI:UniProtKB. | | | | | | | | | | GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; IDA:UniProtKB.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; IDA:UniProtKB.::GO:0030833; P:regulation of actin filament polymerization; IDA:UniProtKB.::GO:0008360; P:regulation of cell shape; NAS:UniProtKB.::GO:0051252; P:regulation of RNA metabolic process; NAS:UniProtKB.::GO:0001570; P:vasculogenesis; ISS:UniProtKB. | 11 | Q55AR6 | 920 | NFAA_DICDI Neurofibromin-A OS=Dictyostelium d... | 307 | 4e-18 | 93.2 | 27 | 47 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005099; F:Ras GTPase activator activity; ISS:dictyBase. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0030833; P:regulation of actin filament polymerization; IMP:dictyBase.::GO:0050920; P:regulation of chemotaxis; IMP:dictyBase.::GO:0051896; P:regulation of protein kinase B signaling cascade; IMP:dictyBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 12 | P09851 | 1044 | RASA1_BOVIN Ras GTPase-activating protein 1 O... | 326 | 1e-17 | 91.7 | 27 | 46 | GO:0005737; C:cytoplasm; ISS:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; ISS:RefGenome. | | | | | | | | | | GO:0051020; F:GTPase binding; ISS:AgBase.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; ISS:RefGenome.::GO:0005102; F:receptor binding; ISS:AgBase. | | | | | | | | | | GO:0000910; P:cytokinesis; ISS:UniProtKB.::GO:0009790; P:embryo development; ISS:UniProtKB.::GO:0001953; P:negative regulation of cell-matrix adhesion; ISS:AgBase.::GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.::GO:0046580; P:negative regulation of Ras protein signal transduction; ISS:RefGenome.::GO:0045768; P:positive regulation of anti-apoptosis; ISS:AgBase.::GO:0030833; P:regulation of actin filament polymerization; ISS:AgBase.::GO:0007165; P:signal transduction; ISS:AgBase.::GO:0001570; P:vasculogenesis; ISS:UniProtKB. | 13 | O14188 | 1489 | RNG2_SCHPO Ras GTPase-activating-like protein... | 786 | 6e-17 | 89.7 | 20 | 41 | GO:0005826; C:actomyosin contractile ring; IDA:PomBase.::GO:0030428; C:cell septum; IDA:UniProtKB.::GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.::GO:0005816; C:spindle pole body; IDA:UniProtKB. | | | | | | | | | | GO:0003779; F:actin binding; IDA:PomBase.::GO:0005516; F:calmodulin binding; IPI:UniProtKB.::GO:0005099; F:Ras GTPase activator activity; IEA:InterPro. | | | | | | | | | | GO:0071519; P:actin filament bundle assembly involved in actomyosin contractile ring formation; IDA:PomBase.::GO:0071520; P:actin filament bundle convergence involved in actomyosin contractile ring formation; IDA:PomBase.::GO:0000917; P:barrier septum assembly; IEA:UniProtKB-KW.::GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. | 14 | P97526 | 2820 | NF1_RAT Neurofibromin OS=Rattus norvegicus (R... | 287 | 4e-16 | 87 | 25 | 45 | GO:0030424; C:axon; IDA:HGNC.::GO:0005737; C:cytoplasm; IDA:HGNC.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005634; C:nucleus; IDA:HGNC.::GO:0014069; C:postsynaptic density; IDA:RGD.::GO:0043234; C:protein complex; IDA:RGD.::GO:0019717; C:synaptosome; IDA:RGD. | | | | | | | | | | GO:0008017; F:microtubule binding; IDA:MGI.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome.::GO:0045545; F:syndecan binding; IPI:RGD. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:HGNC.::GO:0030325; P:adrenal gland development; ISS:HGNC.::GO:0048844; P:artery morphogenesis; ISS:HGNC.::GO:0048593; P:camera-type eye morphogenesis; ISS:HGNC.::GO:0021987; P:cerebral cortex development; ISS:HGNC.::GO:0030199; P:collagen fibril organization; ISS:HGNC.::GO:0021897; P:forebrain astrocyte development; ISS:HGNC.::GO:0048853; P:forebrain morphogenesis; ISS:HGNC.::GO:0007507; P:heart development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0000165; P:MAPK cascade; ISS:HGNC.::GO:0001656; P:metanephros development; ISS:HGNC.::GO:0022011; P:myelination in peripheral nervous system; ISS:HGNC.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:HGNC.::GO:0043409; P:negative regulation of MAPK cascade; ISS:HGNC.::GO:0007406; P:negative regulation of neuroblast proliferation; ISS:HGNC.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:HGNC.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:HGNC.::GO:0001649; P:osteoblast differentiation; ISS:HGNC.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:HGNC.::GO:0043473; P:pigmentation; ISS:HGNC.::GO:0045762; P:positive regulation of adenylate cyclase activity; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0007265; P:Ras protein signal transduction; ISS:HGNC.::GO:0045765; P:regulation of angiogenesis; ISS:HGNC.::GO:0045124; P:regulation of bone resorption; ISS:HGNC.::GO:0001952; P:regulation of cell-matrix adhesion; ISS:HGNC.::GO:0045664; P:regulation of neuron differentiation; IMP:RGD.::GO:0001666; P:response to hypoxia; ISS:HGNC.::GO:0048745; P:smooth muscle tissue development; ISS:HGNC.::GO:0021510; P:spinal cord development; ISS:HGNC.::GO:0048485; P:sympathetic nervous system development; ISS:HGNC.::GO:0008542; P:visual learning; ISS:HGNC.::GO:0042060; P:wound healing; ISS:HGNC. | 15 | Q9UJF2 | 1139 | NGAP_HUMAN Ras GTPase-activating protein nGAP... | 145 | 0.000000000000002 | 84.7 | 35 | 53 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; TAS:ProtInc. | 16 | O95294 | 804 | RASL1_HUMAN RasGAP-activating-like protein 1 ... | 234 | 0.00000000000001 | 81.6 | 31 | 47 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; TAS:ProtInc.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 17 | Q6PFQ7 | 802 | RASL2_MOUSE Ras GTPase-activating protein 4 O... | 259 | 0.00000000000003 | 80.5 | 27 | 46 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 18 | Q9Z268 | 799 | RASL1_MOUSE RasGAP-activating-like protein 1 ... | 235 | 0.0000000000002 | 77.8 | 29 | 46 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 19 | Q04690 | 2841 | NF1_MOUSE Neurofibromin OS=Mus musculus (Mous... | 308 | 0.0000000000002 | 78.2 | 24 | 43 | GO:0005737; C:cytoplasm; IDA:MGI.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005515; F:protein binding; IPI:MGI.::GO:0005099; F:Ras GTPase activator activity; IGI:MGI. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; IMP:MGI.::GO:0030325; P:adrenal gland development; IMP:MGI.::GO:0048844; P:artery morphogenesis; IMP:MGI.::GO:0048593; P:camera-type eye morphogenesis; IMP:MGI.::GO:0021987; P:cerebral cortex development; IMP:MGI.::GO:0030199; P:collagen fibril organization; IMP:MGI.::GO:0021897; P:forebrain astrocyte development; IMP:MGI.::GO:0048853; P:forebrain morphogenesis; IMP:MGI.::GO:0007507; P:heart development; IMP:MGI.::GO:0001889; P:liver development; IMP:MGI.::GO:0000165; P:MAPK cascade; IMP:MGI.::GO:0001656; P:metanephros development; IMP:MGI.::GO:0022011; P:myelination in peripheral nervous system; IMP:MGI.::GO:0016525; P:negative regulation of angiogenesis; IGI:MGI.::GO:0048712; P:negative regulation of astrocyte differentiation; IMP:MGI.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IMP:MGI.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0007406; P:negative regulation of neuroblast proliferation; IMP:MGI.::GO:0046929; P:negative regulation of neurotransmitter secretion; IMP:MGI.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; IMP:MGI.::GO:0035021; P:negative regulation of Rac protein signal transduction; IGI:MGI.::GO:0042992; P:negative regulation of transcription factor import into nucleus; IMP:MGI.::GO:0021915; P:neural tube development; IGI:MGI.::GO:0001649; P:osteoblast differentiation; IMP:MGI.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; IMP:MGI.::GO:0043473; P:pigmentation; IMP:MGI.::GO:0045762; P:positive regulation of adenylate cyclase activity; IMP:MGI.::GO:0001938; P:positive regulation of endothelial cell proliferation; IGI:MGI.::GO:0043525; P:positive regulation of neuron apoptotic process; IMP:MGI.::GO:0007265; P:Ras protein signal transduction; IMP:MGI.::GO:0045124; P:regulation of bone resorption; IMP:MGI.::GO:0001952; P:regulation of cell-matrix adhesion; IMP:MGI.::GO:0048169; P:regulation of long-term neuronal synaptic plasticity; IMP:MGI.::GO:0032228; P:regulation of synaptic transmission, GABAergic; IGI:MGI.::GO:0001666; P:response to hypoxia; IMP:MGI.::GO:0007519; P:skeletal muscle tissue development; IMP:MGI.::GO:0048745; P:smooth muscle tissue development; IMP:MGI.::GO:0021510; P:spinal cord development; IMP:MGI.::GO:0048485; P:sympathetic nervous system development; IMP:MGI.::GO:0008542; P:visual learning; IMP:MGI.::GO:0042060; P:wound healing; IMP:MGI. | 20 | P21359 | 2839 | NF1_HUMAN Neurofibromin OS=Homo sapiens (Huma... | 308 | 0.0000000000003 | 77.8 | 24 | 43 | GO:0030424; C:axon; IDA:HGNC.::GO:0005737; C:cytoplasm; ISS:HGNC.::GO:0030425; C:dendrite; IDA:HGNC.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005634; C:nucleus; ISS:HGNC. | | | | | | | | | | GO:0005515; F:protein binding; IPI:IntAct.::GO:0005099; F:Ras GTPase activator activity; IDA:HGNC. | | | | | | | | | | GO:0030036; P:actin cytoskeleton organization; ISS:HGNC.::GO:0030325; P:adrenal gland development; ISS:HGNC.::GO:0048844; P:artery morphogenesis; ISS:HGNC.::GO:0048593; P:camera-type eye morphogenesis; ISS:HGNC.::GO:0021987; P:cerebral cortex development; ISS:HGNC.::GO:0030199; P:collagen fibril organization; ISS:HGNC.::GO:0021897; P:forebrain astrocyte development; ISS:HGNC.::GO:0048853; P:forebrain morphogenesis; ISS:HGNC.::GO:0007507; P:heart development; ISS:HGNC.::GO:0001889; P:liver development; ISS:HGNC.::GO:0000165; P:MAPK cascade; ISS:HGNC.::GO:0001656; P:metanephros development; ISS:HGNC.::GO:0022011; P:myelination in peripheral nervous system; ISS:HGNC.::GO:0030336; P:negative regulation of cell migration; IMP:MGI.::GO:0001937; P:negative regulation of endothelial cell proliferation; IMP:MGI.::GO:0043407; P:negative regulation of MAP kinase activity; ISS:HGNC.::GO:0043409; P:negative regulation of MAPK cascade; IMP:MGI.::GO:0007406; P:negative regulation of neuroblast proliferation; ISS:HGNC.::GO:0048715; P:negative regulation of oligodendrocyte differentiation; ISS:HGNC.::GO:0042992; P:negative regulation of transcription factor import into nucleus; ISS:HGNC.::GO:0001649; P:osteoblast differentiation; ISS:HGNC.::GO:0014065; P:phosphatidylinositol 3-kinase cascade; ISS:HGNC.::GO:0043473; P:pigmentation; ISS:HGNC.::GO:0045762; P:positive regulation of adenylate cyclase activity; ISS:HGNC.::GO:0043525; P:positive regulation of neuron apoptotic process; ISS:HGNC.::GO:0007265; P:Ras protein signal transduction; ISS:HGNC.::GO:0043535; P:regulation of blood vessel endothelial cell migration; IMP:HGNC.::GO:0045124; P:regulation of bone resorption; ISS:HGNC.::GO:0001952; P:regulation of cell-matrix adhesion; ISS:HGNC.::GO:0001666; P:response to hypoxia; ISS:HGNC.::GO:0048745; P:smooth muscle tissue development; ISS:HGNC.::GO:0021510; P:spinal cord development; ISS:HGNC.::GO:0048485; P:sympathetic nervous system development; ISS:HGNC.::GO:0008542; P:visual learning; ISS:HGNC.::GO:0042060; P:wound healing; ISS:HGNC. | 21 | O43374 | 803 | RASL2_HUMAN Ras GTPase-activating protein 4 O... | 241 | 0.0000000000003 | 77 | 27 | 46 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome. | 22 | C9J798 | 803 | RAS4B_HUMAN Putative Ras GTPase-activating pr... | 241 | 0.000000000001 | 75.5 | 26 | 46 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0005543; F:phospholipid binding; IEA:InterPro. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro. | 23 | Q5VWQ8 | 1189 | DAB2P_HUMAN Disabled homolog 2-interacting pr... | 263 | 0.000000000002 | 75.1 | 26 | 44 | GO:0005737; C:cytoplasm; IDA:BHF-UCL.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0071889; F:14-3-3 protein binding; IDA:BHF-UCL.::GO:0005123; F:death receptor binding; IPI:BHF-UCL.::GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:BHF-UCL.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0042803; F:protein homodimerization activity; IPI:BHF-UCL.::GO:0051721; F:protein phosphatase 2A binding; IDA:BHF-UCL.::GO:0005099; F:Ras GTPase activator activity; ISS:BHF-UCL.::GO:0035591; F:signaling adaptor activity; IDA:BHF-UCL. | | | | | | | | | | GO:0007257; P:activation of JUN kinase activity; IDA:BHF-UCL.::GO:0070059; P:apoptosis in response to endoplasmic reticulum stress; ISS:BHF-UCL.::GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IDA:BHF-UCL.::GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IMP:BHF-UCL.::GO:0035414; P:negative regulation of catenin import into nucleus; ISS:BHF-UCL.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0010633; P:negative regulation of epithelial cell migration; TAS:BHF-UCL.::GO:0050680; P:negative regulation of epithelial cell proliferation; IMP:BHF-UCL.::GO:0010719; P:negative regulation of epithelial to mesenchymal transition; IMP:BHF-UCL.::GO:0048147; P:negative regulation of fibroblast proliferation; ISS:BHF-UCL.::GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; IDA:BHF-UCL.::GO:0043407; P:negative regulation of MAP kinase activity; IDA:BHF-UCL.::GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:BHF-UCL.::GO:0034261; P:negative regulation of Ras GTPase activity; IMP:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IC:BHF-UCL.::GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.::GO:0043065; P:positive regulation of apoptotic process; IDA:BHF-UCL.::GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL. | 24 | Q3UHC7 | 1189 | DAB2P_MOUSE Disabled homolog 2-interacting pr... | 263 | 0.000000000002 | 75.1 | 26 | 44 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0070059; P:apoptosis in response to endoplasmic reticulum stress; IMP:BHF-UCL.::GO:0071356; P:cellular response to tumor necrosis factor; IMP:BHF-UCL.::GO:0035414; P:negative regulation of catenin import into nucleus; IMP:BHF-UCL.::GO:0048147; P:negative regulation of fibroblast proliferation; IMP:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0043065; P:positive regulation of apoptotic process; IMP:BHF-UCL. | 25 | Q6P730 | 996 | DAB2P_RAT Disabled homolog 2-interacting prot... | 263 | 0.000000000002 | 74.7 | 26 | 44 | GO:0005737; C:cytoplasm; IBA:RefGenome.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0047485; F:protein N-terminus binding; IPI:RGD.::GO:0005099; F:Ras GTPase activator activity; IDA:RGD. | | | | | | | | | | GO:0071364; P:cellular response to epidermal growth factor stimulus; IDA:BHF-UCL.::GO:0030308; P:negative regulation of cell growth; IDA:RGD.::GO:0042059; P:negative regulation of epidermal growth factor receptor signaling pathway; IDA:BHF-UCL.::GO:0046580; P:negative regulation of Ras protein signal transduction; IDA:RGD. | 26 | P19158 | 3079 | IRA2_YEAST Inhibitory regulator protein IRA2 ... | 135 | 0.000000000007 | 73.2 | 30 | 56 | GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome.::GO:0005739; C:mitochondrion; IDA:SGD. | | | | | | | | | | GO:0005099; F:Ras GTPase activator activity; IDA:SGD. | | | | | | | | | | GO:0030818; P:negative regulation of cAMP biosynthetic process; IMP:SGD.::GO:0046580; P:negative regulation of Ras protein signal transduction; IMP:SGD.::GO:0006950; P:response to stress; IMP:SGD.::GO:0007165; P:signal transduction; IEA:InterPro. | 27 | A2RV61 | 1452 | GAPD1_XENLA GTPase-activating protein and VPS... | 301 | 0.00000000001 | 72.4 | 26 | 44 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro. | 28 | Q54Y08 | 877 | NGAP_DICDI Probable Ras GTPase-activating-lik... | 124 | 0.00000000003 | 70.9 | 35 | 53 | GO:0005813; C:centrosome; TAS:dictyBase.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005099; F:Ras GTPase activator activity; IBA:RefGenome. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IBA:RefGenome.::GO:0007165; P:signal transduction; IEA:InterPro. | 29 | Q8MLZ5 | 1207 | GAP2_CAEEL Ras GTPase-activating protein gap-... | 303 | 0.00000000003 | 70.9 | 24 | 45 | GO:0005737; C:cytoplasm; NAS:UniProtKB.::GO:0031235; C:intrinsic to internal side of plasma membrane; IBA:RefGenome. | | | | | | | | | | GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005099; F:Ras GTPase activator activity; NAS:UniProtKB. | | | | | | | | | | GO:0046580; P:negative regulation of Ras protein signal transduction; IEP:UniProtKB.::GO:0000003; P:reproduction; IMP:WormBase.::GO:0007165; P:signal transduction; IEA:InterPro. | 30 | Q14C86 | 1478 | GAPD1_HUMAN GTPase-activating protein and VPS... | 282 | 0.00000000008 | 69.7 | 24 | 44 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032794; F:GTPase activating protein binding; IMP:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; IMP:UniProtKB. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; IMP:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro. | 31 | A5D794 | 1413 | GAPD1_BOVIN GTPase-activating protein and VPS... | 282 | 0.0000000002 | 68.6 | 25 | 45 | GO:0005829; C:cytosol; ISS:UniProtKB.::GO:0005768; C:endosome; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0032794; F:GTPase activating protein binding; ISS:UniProtKB.::GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.::GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:UniProtKB. | | | | | | | | | | GO:0006897; P:endocytosis; IEA:UniProtKB-KW.::GO:0051223; P:regulation of protein transport; ISS:UniProtKB.::GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.::GO:0007165; P:signal transduction; IEA:InterPro. |
