| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
31 | P51178 | 756 | PLCD1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 132 | 1e-20 | 100 | 41 | 58 | GO:0005737; C:cytoplasm; IDA:MGI. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0032794; F:GTPase activating protein binding; IPI:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0006644; P:phospholipid metabolic process; TAS:ProtInc. | 32 | P10687 | 1216 | PLCB1_RAT 1-phosphatidylinositol 4,5-bisphosp... | 109 | 0.000000000000002 | 84.3 | 39 | 61 | GO:0005829; C:cytosol; IDA:RGD.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005624; C:membrane fraction; IDA:RGD.::GO:0016607; C:nuclear speck; ISS:BHF-UCL. | | | | | | | | | | GO:0005509; F:calcium ion binding; IDA:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:RGD.::GO:0042803; F:protein homodimerization activity; IDA:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0060466; P:activation of meiosis involved in egg activation; ISS:BHF-UCL.::GO:0021987; P:cerebral cortex development; ISS:BHF-UCL.::GO:0051318; P:G1 phase; ISS:BHF-UCL.::GO:0007215; P:glutamate receptor signaling pathway; ISS:BHF-UCL.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0007612; P:learning; IEP:RGD.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007613; P:memory; IEP:RGD.::GO:2000438; P:negative regulation of monocyte extravasation; ISS:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:BHF-UCL.::GO:0046488; P:phosphatidylinositol metabolic process; IEP:RGD.::GO:2000560; P:positive regulation of CD24 biosynthetic process; ISS:BHF-UCL.::GO:0048639; P:positive regulation of developmental growth; ISS:BHF-UCL.::GO:0032735; P:positive regulation of interleukin-12 production; ISS:BHF-UCL.::GO:0045663; P:positive regulation of myoblast differentiation; ISS:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:BHF-UCL.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; ISS:BHF-UCL.::GO:0034284; P:response to monosaccharide stimulus; IDA:BHF-UCL.::GO:0010243; P:response to organic nitrogen; IEP:RGD.::GO:0043434; P:response to peptide hormone stimulus; IDA:BHF-UCL. | 33 | Q9Z1B3 | 1216 | PLCB1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 109 | 0.000000000000002 | 84.3 | 39 | 61 | GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.::GO:0016607; C:nuclear speck; IDA:BHF-UCL.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0005516; F:calmodulin binding; ISS:BHF-UCL.::GO:0019899; F:enzyme binding; ISS:BHF-UCL.::GO:0005521; F:lamin binding; IPI:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:BHF-UCL.::GO:0005546; F:phosphatidylinositol-4,5-bisphosphate binding; ISS:BHF-UCL.::GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0060466; P:activation of meiosis involved in egg activation; IDA:BHF-UCL.::GO:0007155; P:cell adhesion; IC:BHF-UCL.::GO:0021987; P:cerebral cortex development; IMP:BHF-UCL.::GO:0030218; P:erythrocyte differentiation; TAS:BHF-UCL.::GO:0045444; P:fat cell differentiation; IDA:BHF-UCL.::GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IMP:BHF-UCL.::GO:0051318; P:G1 phase; IDA:BHF-UCL.::GO:0000086; P:G2/M transition of mitotic cell cycle; IDA:BHF-UCL.::GO:0007215; P:glutamate receptor signaling pathway; IMP:BHF-UCL.::GO:0008286; P:insulin receptor signaling pathway; TAS:BHF-UCL.::GO:0048009; P:insulin-like growth factor receptor signaling pathway; IDA:BHF-UCL.::GO:0035722; P:interleukin-12-mediated signaling pathway; ISS:BHF-UCL.::GO:0035723; P:interleukin-15-mediated signaling pathway; ISS:BHF-UCL.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0030225; P:macrophage differentiation; NAS:BHF-UCL.::GO:0007613; P:memory; IMP:BHF-UCL.::GO:0006397; P:mRNA processing; TAS:BHF-UCL.::GO:2000438; P:negative regulation of monocyte extravasation; IDA:BHF-UCL.::GO:0045892; P:negative regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0001556; P:oocyte maturation; NAS:BHF-UCL.::GO:0046488; P:phosphatidylinositol metabolic process; ISS:BHF-UCL.::GO:2000344; P:positive regulation of acrosome reaction; IMP:BHF-UCL.::GO:2000560; P:positive regulation of CD24 biosynthetic process; IDA:BHF-UCL.::GO:0048639; P:positive regulation of developmental growth; IMP:BHF-UCL.::GO:0040019; P:positive regulation of embryonic development; IMP:BHF-UCL.::GO:0032735; P:positive regulation of interleukin-12 production; IMP:BHF-UCL.::GO:0046330; P:positive regulation of JNK cascade; ISS:BHF-UCL.::GO:0045663; P:positive regulation of myoblast differentiation; IDA:BHF-UCL.::GO:0032417; P:positive regulation of sodium:hydrogen antiporter activity; NAS:BHF-UCL.::GO:0045893; P:positive regulation of transcription, DNA-dependent; IDA:BHF-UCL.::GO:0080154; P:regulation of fertilization; IMP:BHF-UCL.::GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; IMP:BHF-UCL. | 34 | Q07722 | 1023 | PLCB4_BOVIN 1-phosphatidylinositol 4,5-bispho... | 53 | 0.0000000000002 | 77.4 | 57 | 75 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 35 | Q1RML2 | 634 | PLCZ1_BOVIN 1-phosphatidylinositol 4,5-bispho... | 52 | 0.0000000001 | 68.2 | 54 | 71 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 36 | Q2VRL0 | 637 | PLCZ1_CHICK 1-phosphatidylinositol 4,5-bispho... | 134 | 0.0000000000003 | 76.6 | 31 | 49 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.::GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 37 | Q00722 | 1185 | PLCB2_HUMAN 1-phosphatidylinositol 4,5-bispho... | 95 | 0.00000000000006 | 79.3 | 38 | 61 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007202; P:activation of phospholipase C activity; TAS:ProtInc.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0006644; P:phospholipid metabolic process; TAS:ProtInc.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 38 | O89040 | 1183 | PLCB2_RAT 1-phosphatidylinositol 4,5-bisphosp... | 95 | 0.00000000000005 | 79.7 | 38 | 60 | GO:0005829; C:cytosol; IDA:RGD.::GO:0031680; C:G-protein beta/gamma-subunit complex; IDA:RGD.::GO:0005794; C:Golgi apparatus; IDA:RGD.::GO:0005886; C:plasma membrane; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0031683; F:G-protein beta/gamma-subunit complex binding; IDA:RGD.::GO:0004435; F:phosphatidylinositol phospholipase C activity; NAS:UniProtKB.::GO:0005543; F:phospholipid binding; IDA:RGD.::GO:0004871; F:signal transducer activity; IDA:UniProtKB. | | | | | | | | | | GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IDA:UniProtKB.::GO:0035556; P:intracellular signal transduction; IDA:UniProtKB.::GO:0009395; P:phospholipid catabolic process; NAS:UniProtKB. | 39 | A3KGF7 | 1181 | PLCB2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 95 | 0.00000000000006 | 79.3 | 38 | 60 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 40 | Q9LY51 | 584 | PLCD7_ARATH Phosphoinositide phospholipase C ... | 644 | 2e-27 | 120 | 24 | 39 | GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 41 | Q4R6L3 | 799 | PLCD4_MACFA 1-phosphatidylinositol 4,5-bispho... | 78 | 0.000000000000004 | 82.8 | 49 | 63 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 42 | P25455 | 1318 | PIP1_DROME 1-phosphatidylinositol 4,5-bisphos... | 86 | 0.000000005 | 63.2 | 36 | 55 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007629; P:flight behavior; IGI:FlyBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 43 | Q39032 | 561 | PLCD1_ARATH Phosphoinositide phospholipase C ... | 70 | 0.00000001 | 61.6 | 39 | 66 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0009738; P:abscisic acid mediated signaling pathway; TAS:TAIR.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0009409; P:response to cold; IEP:TAIR.::GO:0009651; P:response to salt stress; IEP:TAIR.::GO:0009414; P:response to water deprivation; IEP:TAIR. | 44 | Q8K3R3 | 807 | PLCD4_MOUSE 1-phosphatidylinositol 4,5-bispho... | 89 | 0.000000000001 | 75.1 | 48 | 61 | GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.::GO:0016020; C:membrane; IEA:UniProtKB-SubCell.::GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0007340; P:acrosome reaction; IMP:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0046488; P:phosphatidylinositol metabolic process; TAS:MGI. | 45 | Q944C1 | 597 | PLCD4_ARATH Phosphoinositide phospholipase C ... | 74 | 0.00000001 | 62 | 42 | 59 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 46 | Q39033 | 581 | PLCD2_ARATH Phosphoinositide phospholipase C ... | 124 | 0.0000000006 | 65.9 | 31 | 50 | GO:0005886; C:plasma membrane; IDA:TAIR. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 47 | Q01970 | 1234 | PLCB3_HUMAN 1-phosphatidylinositol 4,5-bispho... | 105 | 0.00000000005 | 69.7 | 41 | 53 | GO:0005829; C:cytosol; TAS:Reactome. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005516; F:calmodulin binding; IPI:BHF-UCL.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0007268; P:synaptic transmission; TAS:Reactome. | 48 | P51432 | 1234 | PLCB3_MOUSE 1-phosphatidylinositol 4,5-bispho... | 93 | 0.000000002 | 64.3 | 43 | 56 | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 49 | Q944C2 | 578 | PLCD5_ARATH Phosphoinositide phospholipase C ... | 74 | 0.00000002 | 60.8 | 38 | 62 | GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 50 | Q99JE6 | 1234 | PLCB3_RAT 1-phosphatidylinositol 4,5-bisphosp... | 93 | 0.0000000002 | 67.8 | 43 | 56 | GO:0005829; C:cytosol; IDA:UniProtKB.::GO:0005626; C:insoluble fraction; IDA:UniProtKB.::GO:0042383; C:sarcolemma; IDA:RGD. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0004871; F:signal transducer activity; NAS:UniProtKB. | | | | | | | | | | GO:0007186; P:G-protein coupled receptor signaling pathway; IMP:RGD.::GO:0035556; P:intracellular signal transduction; NAS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IDA:UniProtKB.::GO:0006892; P:post-Golgi vesicle-mediated transport; IDA:RGD. | 51 | Q56W08 | 564 | PLCD3_ARATH Phosphoinositide phospholipase C ... | 129 | 0.0000001 | 58.5 | 27 | 50 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 52 | Q8GV43 | 613 | PLCD6_ARATH Phosphoinositide phospholipase C ... | 50 | 0.00000004 | 60.1 | 52 | 72 | GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 53 | P13217 | 1095 | PIPA_DROME 1-phosphatidylinositol 4,5-bisphos... | 52 | 0.00000000003 | 70.5 | 50 | 75 | GO:0016027; C:inaD signaling complex; IPI:FlyBase.::GO:0005624; C:membrane fraction; IDA:FlyBase. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0005096; F:GTPase activator activity; NAS:FlyBase.::GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:FlyBase.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0008344; P:adult locomotory behavior; IMP:FlyBase.::GO:0019722; P:calcium-mediated signaling; TAS:FlyBase.::GO:0016059; P:deactivation of rhodopsin mediated signaling; IDA:FlyBase.::GO:0001580; P:detection of chemical stimulus involved in sensory perception of bitter taste; IMP:FlyBase.::GO:0006651; P:diacylglycerol biosynthetic process; TAS:FlyBase.::GO:0051482; P:elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger; TAS:FlyBase.::GO:0009649; P:entrainment of circadian clock; IMP:FlyBase.::GO:0008377; P:light-induced release of internally sequestered calcium ion; TAS:FlyBase.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0002385; P:mucosal immune response; IMP:FlyBase.::GO:0046673; P:negative regulation of compound eye retinal cell programmed cell death; IMP:FlyBase.::GO:0046488; P:phosphatidylinositol metabolic process; IMP:FlyBase.::GO:0008654; P:phospholipid biosynthetic process; TAS:FlyBase.::GO:0045494; P:photoreceptor cell maintenance; IMP:FlyBase.::GO:0043052; P:thermotaxis; IMP:FlyBase. | 54 | Q4KWH5 | 1682 | PLCH1_MOUSE 1-phosphatidylinositol 4,5-bispho... | 127 | 0.00000000004 | 70.1 | 35 | 54 | GO:0005829; C:cytosol; IDA:MGI.::GO:0005624; C:membrane fraction; IDA:MGI. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 55 | Q4KWH8 | 1693 | PLCH1_HUMAN 1-phosphatidylinositol 4,5-bispho... | 127 | 0.000000000003 | 73.9 | 35 | 56 | GO:0031965; C:nuclear membrane; IDA:HPA. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0050429; F:calcium-dependent phospholipase C activity; IDA:MGI.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0048015; P:phosphatidylinositol-mediated signaling; IDA:MGI. | 56 | O75038 | 1416 | PLCH2_HUMAN 1-phosphatidylinositol 4,5-bispho... | 133 | 0.00000000000005 | 79.3 | 35 | 50 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW. | 57 | A2AP18 | 1501 | PLCH2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 332 | 0.00000000000002 | 80.9 | 27 | 41 | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IDA:MGI. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.::GO:0046488; P:phosphatidylinositol metabolic process; IDA:MGI. | 58 | P16885 | 1265 | PLCG2_HUMAN 1-phosphatidylinositol 4,5-bispho... | 75 | 0.00000000000005 | 79.3 | 51 | 67 | GO:0005829; C:cytosol; TAS:Reactome.::GO:0005886; C:plasma membrane; IDA:UniProtKB. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0050853; P:B cell receptor signaling pathway; ISS:UniProtKB.::GO:0019722; P:calcium-mediated signaling; NAS:UniProtKB.::GO:0006661; P:phosphatidylinositol biosynthetic process; IDA:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0030168; P:platelet activation; TAS:Reactome.::GO:0051209; P:release of sequestered calcium ion into cytosol; IDA:UniProtKB.::GO:0050852; P:T cell receptor signaling pathway; ISS:UniProtKB.::GO:0016055; P:Wnt receptor signaling pathway; TAS:UniProtKB. | 59 | Q8CIH5 | 1265 | PLCG2_MOUSE 1-phosphatidylinositol 4,5-bispho... | 112 | 0.00000000000001 | 81.3 | 38 | 61 | GO:0005829; C:cytosol; IMP:UniProtKB.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; ISS:UniProtKB.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:IntAct.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0032237; P:activation of store-operated calcium channel activity; IMP:MGI.::GO:0050853; P:B cell receptor signaling pathway; IMP:UniProtKB.::GO:0002316; P:follicular B cell differentiation; IMP:MGI.::GO:0032959; P:inositol trisphosphate biosynthetic process; IDA:MGI.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0043069; P:negative regulation of programmed cell death; IMP:MGI.::GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0010468; P:regulation of gene expression; IMP:MGI.::GO:0051209; P:release of sequestered calcium ion into cytosol; IMP:UniProtKB.::GO:0032496; P:response to lipopolysaccharide; IDA:MGI.::GO:0050852; P:T cell receptor signaling pathway; IDA:MGI. | 60 | P24135 | 1265 | PLCG2_RAT 1-phosphatidylinositol 4,5-bisphosp... | 112 | 0.000000000000009 | 82 | 38 | 61 | GO:0005624; C:membrane fraction; IDA:RGD.::GO:0005886; C:plasma membrane; ISS:UniProtKB. | | | | | | | | | | GO:0004435; F:phosphatidylinositol phospholipase C activity; IDA:RGD.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0005515; F:protein binding; IPI:RGD.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0051209; P:release of sequestered calcium ion into cytosol; ISS:UniProtKB.::GO:0033198; P:response to ATP; IDA:RGD.::GO:0032026; P:response to magnesium ion; IDA:RGD. | 61 | P08487 | 1291 | PLCG1_BOVIN 1-phosphatidylinositol 4,5-bispho... | 117 | 0.000000000001 | 74.7 | 35 | 55 | GO:0030027; C:lamellipodium; ISS:UniProtKB.::GO:0001726; C:ruffle; ISS:UniProtKB. | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro.::GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:EC.::GO:0005543; F:phospholipid binding; IEA:InterPro.::GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW. | | | | | | | | | | GO:0071364; P:cellular response to epidermal growth factor stimulus; ISS:UniProtKB.::GO:0001701; P:in utero embryonic development; ISS:AgBase.::GO:0035556; P:intracellular signal transduction; IEA:InterPro.::GO:0009395; P:phospholipid catabolic process; IEA:InterPro.::GO:0010634; P:positive regulation of epithelial cell migration; ISS:UniProtKB. |
