| rec. | Subject | Hit Length | Description | Align.Len | E value | Bit score | % ident. | % pos. | GO associations |
1 | O74369 | 424 | CSS1_SCHPO Inositol phosphosphingolipids phos... | 183 | 3e-50 | 174 | 45 | 64 | GO:0005783; C:endoplasmic reticulum; IDA:PomBase.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005739; C:mitochondrion; ISS:PomBase.::GO:0005886; C:plasma membrane; IDA:PomBase. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004629; F:phospholipase C activity; ISS:PomBase.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | GO:0046513; P:ceramide biosynthetic process; ISS:PomBase.::GO:0051278; P:fungal-type cell wall polysaccharide biosynthetic process; IMP:PomBase.::GO:0030149; P:sphingolipid catabolic process; ISS:PomBase. | 2 | Q9VZS6 | 442 | NSMA_DROME Putative neutral sphingomyelinase ... | 191 | 1e-37 | 140 | 39 | 55 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | | 3 | P40015 | 477 | ISC1_YEAST Inositol phosphosphingolipids phos... | 203 | 3e-36 | 136 | 36 | 55 | GO:0005783; C:endoplasmic reticulum; IDA:SGD.::GO:0031307; C:integral to mitochondrial outer membrane; IDA:SGD. | | | | | | | | | | GO:0052712; F:inositol phosphosphingolipid phospholipase activity; IDA:SGD.::GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046513; P:ceramide biosynthetic process; IMP:SGD.::GO:0009651; P:response to salt stress; IMP:SGD.::GO:0030149; P:sphingolipid catabolic process; IDA:SGD. | 4 | O60906 | 423 | NSMA_HUMAN Sphingomyelin phosphodiesterase 2 ... | 191 | 1e-32 | 126 | 32 | 53 | GO:0005887; C:integral to plasma membrane; TAS:ProtInc. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; TAS:ProtInc. | | | | | | | | | | GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.::GO:0008624; P:induction of apoptosis by extracellular signals; TAS:Reactome.::GO:0048011; P:nerve growth factor receptor signaling pathway; TAS:Reactome.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006684; P:sphingomyelin metabolic process; TAS:ProtInc. | 5 | Q9ET64 | 422 | NSMA_RAT Sphingomyelin phosphodiesterase 2 OS... | 191 | 6e-32 | 124 | 32 | 52 | GO:0005901; C:caveola; IDA:RGD.::GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.::GO:0005624; C:membrane fraction; IDA:RGD. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IDA:RGD. | | | | | | | | | | GO:0046513; P:ceramide biosynthetic process; IDA:RGD.::GO:0007243; P:intracellular protein kinase cascade; IMP:RGD.::GO:0009612; P:response to mechanical stimulus; IMP:RGD. | 6 | O70572 | 419 | NSMA_MOUSE Sphingomyelin phosphodiesterase 2 ... | 191 | 4e-31 | 122 | 32 | 50 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IMP:MGI. | | | | | | | | | | | 7 | O45870 | 434 | NSMA_CAEEL Putative neutral sphingomyelinase ... | 185 | 5e-28 | 113 | 37 | 50 | GO:0016021; C:integral to membrane; IEA:UniProtKB-KW. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | | 8 | P59116 | 623 | PHL2_LEPIN Sphingomyelinase C 2 OS=(strain 56... | 195 | 0.00000002 | 57.4 | 24 | 39 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | | 9 | P17627 | 556 | PHL_LEPIR Sphingomyelinase C OS=Leptospira in... | 155 | 0.0005 | 43.9 | 28 | 39 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | | 10 | Q72P44 | 596 | PHL1_LEPIC Sphingomyelinase C 1 OS=copenhagen... | 125 | 0.038 | 38.1 | 24 | 39 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | | 11 | P59115 | 597 | PHL1_LEPIN Sphingomyelinase C 1 OS=(strain 56... | 125 | 0.038 | 38.1 | 24 | 39 | GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | | 12 | Q9NY59 | 655 | NSMA2_HUMAN Sphingomyelin phosphodiesterase 3... | 119 | 0.044 | 38.1 | 29 | 43 | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; TAS:Reactome. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0006687; P:glycosphingolipid metabolic process; TAS:Reactome.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0044281; P:small molecule metabolic process; TAS:Reactome.::GO:0006685; P:sphingomyelin catabolic process; TAS:ProtInc. | 13 | Q9JJY3 | 655 | NSMA2_MOUSE Sphingomyelin phosphodiesterase 3... | 119 | 0.058 | 37.7 | 29 | 43 | GO:0000137; C:Golgi cis cisterna; IDA:MGI.::GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IDA:MGI. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.::GO:0030072; P:peptide hormone secretion; IMP:MGI.::GO:0006950; P:response to stress; TAS:MGI.::GO:0007165; P:signal transduction; TAS:MGI.::GO:0006684; P:sphingomyelin metabolic process; IDA:MGI. | 14 | O35049 | 655 | NSMA2_RAT Sphingomyelin phosphodiesterase 3 O... | 119 | 0.059 | 37.7 | 29 | 43 | GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.::GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. | | | | | | | | | | GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.::GO:0004767; F:sphingomyelin phosphodiesterase activity; IEA:EC. | | | | | | | | | | GO:0007049; P:cell cycle; IEA:UniProtKB-KW.::GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW. | 15 | Q59SR6 | 638 | IRS4_CANAL Increased rDNA silencing protein 4... | 28 | 2.1 | 32.7 | 43 | 68 | | | | | | | | | | | GO:0005509; F:calcium ion binding; IEA:InterPro. | | | | | | | | | | GO:0044406; P:adhesion to host; IMP:CGD.::GO:0031505; P:fungal-type cell wall organization; IMP:CGD.::GO:0030448; P:hyphal growth; IMP:CGD.::GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.::GO:0009405; P:pathogenesis; IMP:CGD. |
